Igfbp6 (insulin-like growth factor binding protein 6) - Rat Genome Database

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Gene: Igfbp6 (insulin-like growth factor binding protein 6) Rattus norvegicus
Analyze
Symbol: Igfbp6
Name: insulin-like growth factor binding protein 6
RGD ID: 2877
Description: Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Predicted to be involved in cell migration; positive regulation of stress-activated MAPK cascade; and regulation of insulin-like growth factor receptor signaling pathway. Located in extracellular space. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP6 (insulin like growth factor binding protein 6); PARTICIPATES IN insulin-like growth factor signaling pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IBP-6; IGF-binding protein 6; IGF-BP6; IGFBP-6; insulin-like growth factor-binding protein 6; RBP6A; RBP6G
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,154,919 - 135,159,550 (+)NCBIGRCr8
mRatBN7.27133,276,309 - 133,280,944 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,276,234 - 133,280,966 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7135,037,687 - 135,042,318 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,267,054 - 137,271,685 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,251,681 - 137,256,317 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,749,385 - 143,754,018 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,749,221 - 143,754,054 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,546,235 - 141,551,043 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,885,388 - 140,890,028 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,961,824 - 140,966,465 (+)NCBI
Celera7129,711,141 - 129,715,726 (+)NCBICelera
RH 3.4 Map71051.71RGD
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trimethylbenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-nitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dichloroaniline  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromochloroacetic acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cantharidin  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorohydrocarbon  (EXP)
chloropicrin  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
Cuprizon  (EXP)
Cyclopamine  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
diethylstilbestrol  (EXP,ISO)
diiodine  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
fipronil  (EXP)
folpet  (ISO)
fonofos  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
hydrazine  (EXP)
indometacin  (ISO)
ketoconazole  (EXP)
lead nitrate  (ISO)
mercury dibromide  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methylazoxymethanol  (ISO)
methylmercury chloride  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
naphthalene  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
raloxifene  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetradecane  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zearalenone  (ISO)
zinc pyrithione  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Gene expression studies provide clues to the pathogenesis of uterine leiomyoma: new evidence and a systematic review. Arslan AA, etal., Hum Reprod. 2005 Apr;20(4):852-63. Epub 2005 Feb 10.
2. Rat PC12 pheochromocytoma cells synthesize insulin-like growth factor-binding protein-6. Bach LA, etal., Endocrinology. 1993 Sep;133(3):990-5.
3. Dysregulation of energy homeostasis in mice overexpressing insulin-like growth factor-binding protein 6 in the brain. Bienvenu G, etal., Diabetologia. 2005 Jun;48(6):1189-97. Epub 2005 May 12.
4. Structure-function relationships of insulin-like growth factor binding protein 6 (IGFBP-6) and its chimeras. Boes M, etal., Growth Horm IGF Res 2002 Apr;12(2):91-8.
5. Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions. Duan C and Xu Q, Gen Comp Endocrinol. 2005 May 15;142(1-2):44-52. Epub 2005 Feb 5.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Identification of genes differentially expressed in testes containing carcinoma in situ. Hoei-Hansen CE, etal., Mol Hum Reprod. 2004 Jun;10(6):423-31.
9. Serum IGF-binding protein-6 and prostate specific antigen in breast cancer. Kaulsay KK, etal., Eur J Endocrinol. 1999 Feb;140(2):164-8.
10. Insulin-like growth factor-binding protein 6 inhibits survival and differentiation of rat oligodendrocyte precursor cells. Kuhl NM, etal., Glia. 2003 Nov;44(2):91-101.
11. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Growth hormone-binding protein is directly and IGFBP-3 is inversely associated with risk of female breast cancer. Pazaitou-Panayiotou K, etal., Eur J Endocrinol. 2007 Feb;156(2):187-94.
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. Isolation and molecular cloning of insulin-like growth factor-binding protein-6. Shimasaki S, etal., Mol Endocrinol 1991 Jul;5(7):938-48.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Kininogen 1 and insulin-like growth factor binding protein 6: candidate serum biomarkers of proliferative vitreoretinopathy. Yu J, etal., Clin Exp Optom. 2014 Jan;97(1):72-9. doi: 10.1111/cxo.12088. Epub 2013 Jul 1.
Additional References at PubMed
PMID:1709938   PMID:7682065   PMID:12477932   PMID:15308688   PMID:17978469   PMID:21598309   PMID:23376485   PMID:24006456   PMID:27888466   PMID:28044240  


Genomics

Comparative Map Data
Igfbp6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,154,919 - 135,159,550 (+)NCBIGRCr8
mRatBN7.27133,276,309 - 133,280,944 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,276,234 - 133,280,966 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7135,037,687 - 135,042,318 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,267,054 - 137,271,685 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,251,681 - 137,256,317 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,749,385 - 143,754,018 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,749,221 - 143,754,054 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,546,235 - 141,551,043 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,885,388 - 140,890,028 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,961,824 - 140,966,465 (+)NCBI
Celera7129,711,141 - 129,715,726 (+)NCBICelera
RH 3.4 Map71051.71RGD
Cytogenetic Map7q36NCBI
IGFBP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381253,097,667 - 53,102,340 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1253,097,436 - 53,102,345 (+)EnsemblGRCh38hg38GRCh38
GRCh371253,491,451 - 53,496,124 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,777,703 - 51,782,395 (+)NCBINCBI36Build 36hg18NCBI36
Build 341251,777,702 - 51,782,395NCBI
Celera1253,139,331 - 53,144,023 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,534,468 - 50,539,160 (+)NCBIHuRef
CHM1_11253,457,851 - 53,462,553 (+)NCBICHM1_1
T2T-CHM13v2.01253,062,042 - 53,066,717 (+)NCBIT2T-CHM13v2.0
Igfbp6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915102,052,621 - 102,057,947 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15102,052,797 - 102,057,946 (+)EnsemblGRCm39 Ensembl
GRCm3815102,144,186 - 102,149,512 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,144,362 - 102,149,511 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715101,974,617 - 101,979,943 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615101,972,396 - 101,977,546 (+)NCBIMGSCv36mm8
Celera15104,299,101 - 104,304,446 (+)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1557.32NCBI
Igfbp6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955458377,929 - 382,567 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955458377,929 - 382,109 (+)NCBIChiLan1.0ChiLan1.0
IGFBP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21041,086,775 - 41,093,738 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11241,083,538 - 41,088,488 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01235,654,172 - 35,659,115 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11236,435,221 - 36,440,132 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,435,221 - 36,440,132 (-)Ensemblpanpan1.1panPan2
IGFBP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,063,548 - 2,067,366 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,989,772 - 2,067,298 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2744,181,845 - 44,185,650 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,067,593 - 2,071,467 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl271,954,623 - 2,071,412 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1272,084,643 - 2,088,505 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,071,186 - 2,075,014 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,580,850 - 44,584,731 (+)NCBIUU_Cfam_GSD_1.0
Igfbp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494562,745,135 - 62,749,876 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651210,414,807 - 10,419,741 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651210,415,004 - 10,419,698 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGFBP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,352,400 - 18,357,225 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1518,352,884 - 18,357,225 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,767,759 - 18,772,057 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IGFBP6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11149,209,135 - 49,213,803 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1149,209,136 - 49,213,858 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037196,852,389 - 196,857,209 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igfbp6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249041,154,882 - 1,159,209 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249041,153,890 - 1,159,095 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Igfbp6
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:50
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000014807
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat

Markers in Region
D7Wox40  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,275,973 - 133,276,107 (+)MAPPERmRatBN7.2
Rnor_6.07143,749,051 - 143,749,183NCBIRnor6.0
Rnor_5.07141,545,901 - 141,546,033UniSTSRnor5.0
RGSC_v3.47140,885,054 - 140,885,186UniSTSRGSC3.4
Celera7129,710,807 - 129,710,939UniSTS
Cytogenetic Map7q36UniSTS
RH131180  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,280,727 - 133,280,912 (+)MAPPERmRatBN7.2
Rnor_6.07143,753,802 - 143,753,986NCBIRnor6.0
Rnor_5.07141,550,827 - 141,551,011UniSTSRnor5.0
RGSC_v3.47140,889,812 - 140,889,996UniSTSRGSC3.4
Celera7129,715,510 - 129,715,694UniSTS
RH 3.4 Map71062.1UniSTS
Cytogenetic Map7q36UniSTS
RH94790  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,276,335 - 133,276,565 (+)MAPPERmRatBN7.2
Rnor_6.07143,749,412 - 143,749,641NCBIRnor6.0
Rnor_5.07141,546,262 - 141,546,491UniSTSRnor5.0
RGSC_v3.47140,885,415 - 140,885,644UniSTSRGSC3.4
Celera7129,711,168 - 129,711,397UniSTS
RH 3.4 Map71051.71UniSTS
Cytogenetic Map7q36UniSTS
BF404305  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,276,348 - 133,276,565 (+)MAPPERmRatBN7.2
Rnor_6.07143,749,425 - 143,749,641NCBIRnor6.0
Rnor_5.07141,546,275 - 141,546,491UniSTSRnor5.0
RGSC_v3.47140,885,428 - 140,885,644UniSTSRGSC3.4
Celera7129,711,181 - 129,711,397UniSTS
RH 3.4 Map71065.8UniSTS
Cytogenetic Map7q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 25 11 3 8 11 18 14 33 10 8
Low 1 8 46 41 16 41 48 21 8 1
Below cutoff 10 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014807   ⟹   ENSRNOP00000014807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7133,276,234 - 133,280,966 (+)Ensembl
Rnor_6.0 Ensembl7143,749,221 - 143,754,054 (+)Ensembl
RefSeq Acc Id: NM_013104   ⟹   NP_037236
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,154,919 - 135,159,550 (+)NCBI
mRatBN7.27133,276,309 - 133,280,944 (+)NCBI
Rnor_6.07143,749,385 - 143,754,018 (+)NCBI
Rnor_5.07141,546,235 - 141,551,043 (+)NCBI
RGSC_v3.47140,885,388 - 140,890,028 (+)RGD
Celera7129,711,141 - 129,715,726 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037236 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH99742 (Get FASTA)   NCBI Sequence Viewer  
  AAN87109 (Get FASTA)   NCBI Sequence Viewer  
  EDL86863 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014807
  ENSRNOP00000014807.3
  ENSRNOP00055038508
  ENSRNOP00060019654
  ENSRNOP00065028235
GenBank Protein P35572 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_037236   ⟸   NM_013104
- Peptide Label: precursor
- UniProtKB: Q499W1 (UniProtKB/Swiss-Prot),   P35572 (UniProtKB/Swiss-Prot),   A6KCS9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014807   ⟸   ENSRNOT00000014807
Protein Domains
IGFBP N-terminal   Thyroglobulin type-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35572-F1-model_v2 AlphaFold P35572 1-226 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695690
Promoter ID:EPDNEW_R6215
Type:initiation region
Name:Igfbp6_1
Description:insulin-like growth factor binding protein 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,749,315 - 143,749,375EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2877 AgrOrtholog
BioCyc Gene G2FUF-31949 BioCyc
Ensembl Genes ENSRNOG00000010977 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055027109 UniProtKB/Swiss-Prot
  ENSRNOG00060014439 UniProtKB/Swiss-Prot
  ENSRNOG00065020716 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014807 ENTREZGENE
  ENSRNOT00000014807.7 UniProtKB/Swiss-Prot
  ENSRNOT00055046880 UniProtKB/Swiss-Prot
  ENSRNOT00060024670 UniProtKB/Swiss-Prot
  ENSRNOT00065035116 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.800.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7937967 IMAGE-MGC_LOAD
InterPro Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP-6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_1-6_chordata UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thyroglobulin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thyroglobulin_1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25641 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:124535 IMAGE-MGC_LOAD
NCBI Gene 25641 ENTREZGENE
PANTHER INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 6 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam Thyroglobulin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Igfbp6 PhenoGen
PRINTS IGFBPFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBPFAMILY6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IGFBP_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYROGLOBULIN_1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYROGLOBULIN_1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010977 RatGTEx
  ENSRNOG00055027109 RatGTEx
  ENSRNOG00060014439 RatGTEx
  ENSRNOG00065020716 RatGTEx
SMART SM00121 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00211 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Growth factor receptor domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SSF57610 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228455
UniProt A6KCS9 ENTREZGENE, UniProtKB/TrEMBL
  IBP6_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q499W1 ENTREZGENE
UniProt Secondary Q499W1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Igfbp6  Insulin-like growth factor binding protein 6      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in testis, intestine, adrenal, kidney, stomach, spleen, heart, lung, brain, and liver 729257