Idh1 (isocitrate dehydrogenase (NADP(+)) 1) - Rat Genome Database

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Gene: Idh1 (isocitrate dehydrogenase (NADP(+)) 1) Rattus norvegicus
Analyze
Symbol: Idh1
Name: isocitrate dehydrogenase (NADP(+)) 1
RGD ID: 2862
Description: Enables NADP binding activity and isocitrate dehydrogenase (NADP+) activity. Involved in female gonad development; isocitrate metabolic process; and response to steroid hormone. Located in peroxisome. Human ortholog(s) of this gene implicated in autoimmune disease; hematologic cancer (multiple); hepatocellular clear cell carcinoma; and high grade glioma (multiple). Orthologous to human IDH1 (isocitrate dehydrogenase (NADP(+)) 1); PARTICIPATES IN citric acid cycle pathway; glutathione metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cytosolic NADP-isocitrate dehydrogenase; IDH; IDP; IDPc; isocitrate dehydrogenase (NADP(+)) 1, cytosolic; isocitrate dehydrogenase 1; isocitrate dehydrogenase 1 (NADP+); isocitrate dehydrogenase 1 (NADP+), soluble; isocitrate dehydrogenase 1 soluble; isocitrate dehydrogenase 1, soluble; isocitrate dehydrogenase [NADP] cytoplasmic; NADP(+)-specific ICDH; oxalosuccinate decarboxylase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2966,534,146 - 66,563,703 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl966,534,146 - 66,563,708 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx975,040,843 - 75,062,176 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0980,176,139 - 80,197,291 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0978,586,353 - 78,607,819 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0971,882,108 - 71,911,645 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,882,105 - 71,900,044 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0970,660,443 - 70,689,968 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4963,769,401 - 63,790,622 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1963,916,382 - 63,937,604 (-)NCBI
Celera963,929,810 - 63,951,008 (-)NCBICelera
Cytogenetic Map9q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxyglutaric acid  (ISO)
2-methylcholine  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aniline  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
astaxanthin  (ISO)
azathioprine  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
chloroprene  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cumene hydroperoxide  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
imidazoles  (ISO)
inulin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
lutein  (ISO)
medroxyprogesterone acetate  (ISO)
metam  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenols  (ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
Pyridostigmine bromide  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
sunitinib  (ISO)
T-2 toxin  (EXP,ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
troglitazone  (EXP)
tunicamycin  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
cytosol  (IBA,ISO)
mitochondrion  (IBA,ISO)
peroxisome  (IBA,IDA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Wild-Type Isocitrate Dehydrogenase 1 Over-Expression is Related to Cancer Stem Cells Survival in Lung Adenocarcinoma. Al-Amodi HSAB, etal., Cancer Invest. 2018 Mar 16;36(3):185-189. doi: 10.1080/07357907.2018.1445262. Epub 2018 Mar 14.
2. Concerning the mechanism of increased thermogenesis in rats treated with dehydroepiandrosterone. Bobyleva V, etal., J Bioenerg Biomembr. 1993 Jun;25(3):313-21.
3. Chemical modification of rat liver cytosolic NADP(+)-linked isocitrate dehydrogenase by N-ethylmaleimide. Evidence for essential sulphydryl groups. Fatania HR, etal., FEBS Lett. 1993 May 17;322(3):245-8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Prognosis and Clinicopathologic Features of Patients With Advanced Stage Isocitrate Dehydrogenase (IDH) Mutant and IDH Wild-Type Intrahepatic Cholangiocarcinoma. Goyal L, etal., Oncologist. 2015 Sep;20(9):1019-27. doi: 10.1634/theoncologist.2015-0210. Epub 2015 Aug 5.
7. Cytosolic NADP(+)-dependent isocitrate dehydrogenase. Isolation of rat cDNA and study of tissue-specific and developmental expression of mRNA. Jennings GT, etal., J Biol Chem 1994 Sep 16;269(37):23128-34.
8. Prognostic value of isocitrate dehydrogenase mutations in myelodysplastic syndromes: a retrospective cohort study and meta-analysis. Jin J, etal., PLoS One. 2014 Jun 17;9(6):e100206. doi: 10.1371/journal.pone.0100206. eCollection 2014.
9. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
10. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
11. IDH2 mutation in gliomas including novel mutation. Koh J, etal., Neuropathology. 2015 Jun;35(3):236-44. doi: 10.1111/neup.12187. Epub 2014 Dec 12.
12. IDH1 R132C mutation is detected in clear cell hepatocellular carcinoma by pyrosequencing. Lee JH, etal., World J Surg Oncol. 2017 Apr 12;15(1):82. doi: 10.1186/s12957-017-1144-1.
13. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. Marcucci G, etal., J Clin Oncol. 2010 May 10;28(14):2348-55. doi: 10.1200/JCO.2009.27.3730. Epub 2010 Apr 5.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Anti-diabetic effects of DA-11004, a synthetic IDPc inhibitor in high fat high sucrose diet-fed C57BL/6J mice. Shin CY, etal., Arch Pharm Res. 2004 Jan;27(1):48-52.
22. Analysis of IDH1 and IDH2 mutations in Japanese glioma patients. Sonoda Y, etal., Cancer Sci. 2009 Oct;100(10):1996-8. doi: 10.1111/j.1349-7006.2009.01270.x.
23. Isocitrate dehydrogenase 1 is a novel plasma biomarker for the diagnosis of non-small cell lung cancer. Sun N, etal., Clin Cancer Res. 2013 Sep 15;19(18):5136-45. doi: 10.1158/1078-0432.CCR-13-0046.
24. Effect of Anabolic Steroid Nandrolone Decanoate on the Properties of Certain Enzymes in the Heart, Liver, and Muscle of Rats, and their Effect on Rats' Cardiac Electrophysiology. Tylicki A, etal., Horm Metab Res. 2007 Apr;39(4):268-72.
25. Distinct histomorphological features are associated with IDH1 mutation in intrahepatic cholangiocarcinoma. Wang T, etal., Hum Pathol. 2019 Sep;91:19-25. doi: 10.1016/j.humpath.2019.05.002. Epub 2019 May 21.
26. Mutations in the isocitrate dehydrogenase 2 gene and IDH1 SNP 105C > T have a prognostic value in acute myeloid leukemia. Willander K, etal., Biomark Res. 2014 Oct 8;2:18. doi: 10.1186/2050-7771-2-18. eCollection 2014.
27. Genetic variations in IDH gene as prognosis predictors in TACE-treated hepatocellular carcinoma patients. Zhang H, etal., Med Oncol. 2014 Nov;31(11):278. doi: 10.1007/s12032-014-0278-z. Epub 2014 Oct 22.
Additional References at PubMed
PMID:1180875   PMID:1914521   PMID:7787968   PMID:10521434   PMID:12031902   PMID:12960146   PMID:15173171   PMID:15606980   PMID:16751257   PMID:16912049   PMID:18275837   PMID:18614015  
PMID:19056867   PMID:19935646   PMID:20012373   PMID:20171178   PMID:20178365   PMID:21240341   PMID:21516116   PMID:22309944   PMID:23376485   PMID:23533145   PMID:23904609   PMID:24130841  
PMID:25218477   PMID:25468996   PMID:26316108   PMID:26436839   PMID:27568302   PMID:33599048  


Genomics

Comparative Map Data
Idh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2966,534,146 - 66,563,703 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl966,534,146 - 66,563,708 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx975,040,843 - 75,062,176 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0980,176,139 - 80,197,291 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0978,586,353 - 78,607,819 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0971,882,108 - 71,911,645 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,882,105 - 71,900,044 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0970,660,443 - 70,689,968 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4963,769,401 - 63,790,622 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1963,916,382 - 63,937,604 (-)NCBI
Celera963,929,810 - 63,951,008 (-)NCBICelera
Cytogenetic Map9q32NCBI
IDH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382208,236,227 - 208,255,071 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2208,236,229 - 208,266,074 (-)EnsemblGRCh38hg38GRCh38
GRCh372209,100,951 - 209,119,795 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362208,809,198 - 208,828,051 (-)NCBINCBI36Build 36hg18NCBI36
Build 342208,926,459 - 208,945,312NCBI
Celera2202,868,863 - 202,887,731 (-)NCBICelera
Cytogenetic Map2q34NCBI
HuRef2200,949,019 - 200,967,890 (-)NCBIHuRef
CHM1_12209,106,806 - 209,125,662 (-)NCBICHM1_1
T2T-CHM13v2.02208,716,002 - 208,734,866 (-)NCBIT2T-CHM13v2.0
Idh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39165,197,775 - 65,225,638 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl165,197,775 - 65,225,659 (-)EnsemblGRCm39 Ensembl
GRCm38165,158,616 - 65,186,479 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl165,158,616 - 65,186,500 (-)EnsemblGRCm38mm10GRCm38
MGSCv37165,205,190 - 65,233,053 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36165,092,904 - 65,113,390 (-)NCBIMGSCv36mm8
Celera165,649,214 - 65,677,085 (-)NCBICelera
Cytogenetic Map1C2- C3NCBI
cM Map132.91NCBI
Idh1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554576,851,517 - 6,872,367 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554576,851,542 - 6,869,452 (+)NCBIChiLan1.0ChiLan1.0
IDH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12B110,861,000 - 110,891,100 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B95,475,320 - 95,494,286 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B213,599,036 - 213,628,840 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B213,599,036 - 213,617,175 (-)Ensemblpanpan1.1panPan2
IDH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13716,512,027 - 16,531,269 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3716,512,770 - 16,531,219 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3717,394,694 - 17,413,933 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03716,447,690 - 16,466,938 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3716,447,695 - 16,466,985 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13716,391,770 - 16,406,979 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03716,365,144 - 16,384,346 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03716,374,393 - 16,393,573 (-)NCBIUU_Cfam_GSD_1.0
Idh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303164,878,089 - 164,892,414 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936950334,934 - 348,363 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936950334,894 - 349,221 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IDH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15111,341,153 - 111,362,296 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115111,341,153 - 111,362,330 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215122,861,672 - 122,883,887 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IDH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11094,021,002 - 94,039,997 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1094,020,818 - 94,039,975 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040105,331,403 - 105,350,750 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Idh1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247657,806,560 - 7,825,520 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Idh1
178 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:87
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000020322
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)94996854671098346Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat

Markers in Region
RH140721  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2966,534,470 - 66,534,642 (+)MAPPERmRatBN7.2
Rnor_6.0971,882,439 - 71,882,610NCBIRnor6.0
Rnor_5.0970,689,466 - 70,689,637UniSTSRnor5.0
RGSC_v3.4963,769,360 - 63,769,531UniSTSRGSC3.4
Celera963,929,769 - 63,929,940UniSTS
RH 3.4 Map9575.0UniSTS
Cytogenetic Map9q32UniSTS
RH137238  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2966,534,173 - 66,534,369 (+)MAPPERmRatBN7.2
Rnor_6.0971,882,142 - 71,882,337NCBIRnor6.0
Rnor_5.0970,689,739 - 70,689,934UniSTSRnor5.0
RGSC_v3.4963,769,063 - 63,769,258UniSTSRGSC3.4
Celera963,929,472 - 63,929,667UniSTS
RH 3.4 Map9576.9UniSTS
Cytogenetic Map9q32UniSTS
PMC55400P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2966,536,622 - 66,537,280 (+)MAPPERmRatBN7.2
Rnor_6.0971,884,591 - 71,885,248NCBIRnor6.0
Rnor_5.0970,686,828 - 70,687,485UniSTSRnor5.0
RGSC_v3.4963,771,512 - 63,772,169UniSTSRGSC3.4
Celera963,931,921 - 63,932,578UniSTS
Cytogenetic Map9q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2
Medium 3 43 57 41 19 41 8 10 74 35 39 11 8
Low 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000020322   ⟹   ENSRNOP00000020322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl966,534,147 - 66,555,795 (-)Ensembl
Rnor_6.0 Ensembl971,882,105 - 71,900,044 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108404   ⟹   ENSRNOP00000081635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl966,534,146 - 66,563,708 (-)Ensembl
RefSeq Acc Id: NM_031510   ⟹   NP_113698
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2966,534,512 - 66,555,733 (-)NCBI
Rnor_6.0971,882,480 - 71,903,723 (-)NCBI
Rnor_5.0970,660,443 - 70,689,968 (+)NCBI
RGSC_v3.4963,769,401 - 63,790,622 (-)RGD
Celera963,929,810 - 63,951,008 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245049   ⟹   XP_006245111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2966,534,146 - 66,563,703 (-)NCBI
Rnor_6.0971,882,108 - 71,911,645 (-)NCBI
Rnor_5.0970,660,443 - 70,689,968 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767076   ⟹   XP_008765298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2966,534,146 - 66,563,584 (-)NCBI
Rnor_6.0971,882,108 - 71,911,605 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_113698   ⟸   NM_031510
- UniProtKB: P80300 (UniProtKB/Swiss-Prot),   P41562 (UniProtKB/Swiss-Prot),   A6IPJ5 (UniProtKB/TrEMBL),   A0A8L2QA85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245111   ⟸   XM_006245049
- Peptide Label: isoform X1
- UniProtKB: P80300 (UniProtKB/Swiss-Prot),   P41562 (UniProtKB/Swiss-Prot),   A6IPJ5 (UniProtKB/TrEMBL),   A0A8L2QA85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765298   ⟸   XM_008767076
- Peptide Label: isoform X1
- UniProtKB: P80300 (UniProtKB/Swiss-Prot),   P41562 (UniProtKB/Swiss-Prot),   A6IPJ5 (UniProtKB/TrEMBL),   A0A8L2QA85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020322   ⟸   ENSRNOT00000020322
RefSeq Acc Id: ENSRNOP00000081635   ⟸   ENSRNOT00000108404
Protein Domains
Isopropylmalate dehydrogenase-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41562-F1-model_v2 AlphaFold P41562 1-414 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2862 AgrOrtholog
BioCyc Gene G2FUF-27300 BioCyc
Ensembl Genes ENSRNOG00000015020 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000020322 ENTREZGENE
  ENSRNOP00000020322.3 UniProtKB/TrEMBL
  ENSRNOP00000081635 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020322 ENTREZGENE
  ENSRNOT00000020322.6 UniProtKB/TrEMBL
  ENSRNOT00000108404 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH Isopropylmalate Dehydrogenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IsoCit/isopropylmalate_DH_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Isocitrate_DH_NADP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IsoPropMal-DH-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24479 UniProtKB/Swiss-Prot
NCBI Gene 24479 ENTREZGENE
PANTHER ISOCITRATE DEHYDROGENASE [NADP] CYTOPLASMIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Iso_dh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Idh1 PhenoGen
PIRSF IDH_NADP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IDH_IMDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Iso_dh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Isocitrate/Isopropylmalate dehydrogenase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QA85 ENTREZGENE, UniProtKB/TrEMBL
  A6IPJ5 ENTREZGENE, UniProtKB/TrEMBL
  A6IPJ9_RAT UniProtKB/TrEMBL
  IDHC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P80300 ENTREZGENE
  Q0QER8_RAT UniProtKB/TrEMBL
UniProt Secondary P80300 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Idh1  isocitrate dehydrogenase (NADP(+)) 1  Idh1  isocitrate dehydrogenase (NADP(+)) 1, cytosolic  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-04 Idh1  isocitrate dehydrogenase (NADP(+)) 1, cytosolic  Idh1  isocitrate dehydrogenase 1 (NADP+)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-02 Idh1  isocitrate dehydrogenase 1 (NADP+)  Idh1  isocitrate dehydrogenase 1 (NADP+), soluble  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Idh1  isocitrate dehydrogenase 1 (NADP+), soluble    isocitrate dehydrogenase 1  Name updated 1299863 APPROVED
2002-11-06 Idh1  isocitrate dehydrogenase 1    Isocitrate dehydrogenase 1, soluble  Name updated 625702 APPROVED
2002-06-10 Idh1  Isocitrate dehydrogenase 1, soluble      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein protein has a peroxisomal targeting sequence at the COOH terminus 633072
gene_regulation mRNA expression increases 13-fold during gonadotropin-induced development of the immature rat ovary 633072
gene_transcript cDNA is 1.72 kb 633072