Hrh2 (histamine receptor H 2) - Rat Genome Database

Name: Hrh2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Hrh2 (histamine receptor H 2) Rattus norvegicus

Analyze

Symbol:

Hrh2

Name:

histamine receptor H 2

RGD ID:

2831

Description:

Enables heterocyclic compound binding activity and histamine receptor activity. Involved in cellular response to histamine and negative regulation of arachidonic acid secretion. Predicted to be located in plasma membrane and synapse. Predicted to be active in dendrite. Biomarker of transient cerebral ischemia. Orthologous to human HRH2 (histamine receptor H2); PARTICIPATES IN cimetidine pharmacodynamics pathway; cimetidine pharmacokinetics pathway; esomeprazole pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

gastric receptor I; H2R; HH2R; histamine H2 receptor

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HRH2 (histamine receptor H2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Hrh2 (histamine receptor H2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Hrh2 (histamine receptor H2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	HRH2 (histamine receptor H2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HRH2 (histamine receptor H2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Hrh2 (histamine receptor H2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HRH2 (histamine receptor H2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HRH2 (histamine receptor H2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Hrh2 (histamine receptor H2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Hrh2 (histamine receptor H2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	HRH2 (histamine receptor H2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	hrh2a (histamine receptor H2a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	hrh2b (histamine receptor H2b)	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	10,371,083 - 10,412,979 (-)	NCBI		GRCr8
mRatBN7.2	17	10,366,004 - 10,407,791 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	10,368,298 - 10,407,631 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	10,398,835 - 10,399,911 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	11,932,184 - 11,933,260 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	10,395,275 - 10,396,351 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	10,912,959 - 10,931,389 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	10,921,507 - 10,952,441 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	13,025,894 - 13,065,409 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	16,497,967 - 16,499,043 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	16,497,966 - 16,499,043 (-)	NCBI
Celera	17	10,455,208 - 10,456,284 (-)	NCBI		Celera
Cytogenetic Map	17	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chemical and Drug Induced Liver Injury (ISO)

congestive heart failure (ISO)

coronary stenosis (ISO)

Experimental Neoplasms (ISO)

genetic disease (ISO)

hypertension (ISO)

Left Ventricular Hypertrophy (ISO)

Myocardial Reperfusion Injury (ISO)

myoepithelioma (ISO)

Neoplasm Metastasis (ISO)

transient cerebral ischemia (IEP)

transitional cell carcinoma (ISO)

withdrawal disorder (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1-(5-isoquinolinesulfonyl)-2-methylpiperazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3',5'-cyclic AMP (ISO)

4-methylhistamine (ISO)

5-(2-methylpiperazine-1-sulfonyl)isoquinoline (ISO)

6-propyl-2-thiouracil (EXP)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

arsenite(3-) (ISO)

asbestos (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

Burimamide (ISO)

CGP 52608 (ISO)

chlorphenamine (ISO)

cimetidine (EXP,ISO)

clobenpropit (EXP,ISO)

colforsin daropate hydrochloride (ISO)

cyclosporin A (ISO)

D-mannitol (ISO)

Dimaprit (EXP,ISO)

dioxygen (ISO)

doxorubicin (ISO)

ethanol (ISO)

famotidine (EXP,ISO)

fenvalerate (EXP)

fonofos (ISO)

furan (EXP)

histamine (EXP,ISO)

ionomycin (ISO)

lipopolysaccharide (ISO)

melittin (EXP)

metformin (ISO)

morphine (ISO)

N-alpha-Methylhistamine (EXP,ISO)

N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine (EXP,ISO)

naphthalene (ISO)

parathion (ISO)

perfluorohexanesulfonic acid (ISO)

phorbol 13-acetate 12-myristate (ISO)

pirinixic acid (EXP)

promethazine (ISO)

prostaglandin E2 (ISO)

ranitidine (EXP,ISO)

Roxane (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

scopolamine (EXP)

sodium arsenite (ISO)

terbufos (ISO)

testosterone (EXP)

Thioperamide (EXP)

triclosan (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to histamine (IEP)

chemical synaptic transmission (IBA,IEA)

digestive tract development (ISO)

epithelial cell morphogenesis (ISO)

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (IBA,IEA)

G protein-coupled serotonin receptor signaling pathway (IEA)

gastric acid secretion (IEA,ISO)

gastrin-induced gastric acid secretion (ISO)

gland development (ISO)

histamine-induced gastric acid secretion (ISO)

memory (ISO)

negative regulation of arachidonic acid secretion (IDA)

positive regulation of vasoconstriction (IEA)

regulation of synaptic plasticity (ISO)

visual learning (ISO)

Cellular Component

dendrite (IBA,IEA)

plasma membrane (IEA)

synapse (IEA)

Molecular Function

G protein-coupled serotonin receptor activity (IBA,IEA)

heterocyclic compound binding (IDA)

histamine receptor activity (IDA,IEA)

neurotransmitter receptor activity (IBA,IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

calcium/calcium-mediated signaling pathway (IEA)

cimetidine pharmacodynamics pathway (ISO)

cimetidine pharmacokinetics pathway (ISO)

esomeprazole pharmacodynamics pathway (ISO)

famotidine pharmacodynamics pathway (ISO)

histamine signaling pathway, immunological (ISO)

lansoprazole pharmacodynamics pathway (ISO)

nizatidine pharmacodynamics pathway (ISO)

omeprazole pharmacodynamics pathway (ISO)

pantoprazole pharmacodynamics pathway (ISO)

pirenzepine pharmacodynamics pathway (ISO)

rabeprazole pharmacodynamics pathway (ISO)

ranitidine pharmacodynamics pathway (ISO)

roxatidine acetate pharmacodynamics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Expression of mRNA encoding the H1, H2, and H3 histamine receptors in the rat cochlea.	Azuma H, etal., Neuroreport 2003 Mar 3;14(3):423-5.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Postischemic regulation of central histamine receptors.	Lozada A, etal., Neuroscience. 2005;136(1):371-9. Epub 2005 Sep 21.
5.	Histamine H2 receptor activation exacerbates myocardial ischemia/reperfusion injury by disturbing mitochondrial and endothelial function.	Luo T, etal., Basic Res Cardiol. 2013 May;108(3):342. doi: 10.1007/s00395-013-0342-4. Epub 2013 Mar 7.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
10.	GOA pipeline	RGD automated data pipeline
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Cloning and tissue expression of a rat histamine H2-receptor gene.	Ruat M, etal., Biochem Biophys Res Commun 1991 Sep 30;179(3):1470-8.
13.	Expression of a cloned rat histamine H2 receptor mediating inhibition of arachidonate release and activation of cAMP accumulation.	Traiffort E, etal., Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2649-53.
14.	Disruption of histamine H2 receptor slows heart failure progression through reducing myocardial apoptosis and fibrosis.	Zeng Z, etal., Clin Sci (Lond). 2014 Oct;127(7):435-48. doi: 10.1042/CS20130716.

Additional References at PubMed

PMID:10862789	PMID:15086532	PMID:15476751	PMID:16858644	PMID:17145090	PMID:18345502	PMID:21211106	PMID:21602597	PMID:22986235	PMID:23077168	PMID:23713466	PMID:23716698
PMID:24702851	PMID:28964277	PMID:29498008

Genomics

Comparative Map Data

Hrh2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	10,371,083 - 10,412,979 (-)	NCBI		GRCr8
mRatBN7.2	17	10,366,004 - 10,407,791 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	10,368,298 - 10,407,631 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	10,398,835 - 10,399,911 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	11,932,184 - 11,933,260 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	10,395,275 - 10,396,351 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	10,912,959 - 10,931,389 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	10,921,507 - 10,952,441 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	13,025,894 - 13,065,409 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	16,497,967 - 16,499,043 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	16,497,966 - 16,499,043 (-)	NCBI
Celera	17	10,455,208 - 10,456,284 (-)	NCBI		Celera
Cytogenetic Map	17	p14	NCBI

HRH2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	175,658,071 - 175,710,756 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	175,658,030 - 175,710,756 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	175,085,074 - 175,137,759 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	175,042,318 - 175,044,164 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	175,042,317 - 175,044,162	NCBI
Celera	5	171,124,127 - 171,152,332 (+)	NCBI		Celera
Cytogenetic Map	5	q35.2	NCBI
HuRef	5	170,183,933 - 170,212,137 (+)	NCBI		HuRef
CHM1_1	5	174,517,757 - 174,545,962 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	176,201,850 - 176,254,534 (+)	NCBI		T2T-CHM13v2.0

Hrh2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	54,345,990 - 54,390,201 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	54,346,148 - 54,390,199 (+)	Ensembl		GRCm39 Ensembl
GRCm38	13	54,191,970 - 54,236,182 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	54,192,129 - 54,236,180 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	54,287,498 - 54,317,801 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	54,201,750 - 54,232,053 (+)	NCBI		MGSCv36	mm8
Celera	13	55,266,772 - 55,297,106 (+)	NCBI		Celera
Cytogenetic Map	13	B1	NCBI
cM Map	13	28.4	NCBI

Hrh2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	28,186,249 - 28,229,411 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955408	28,186,316 - 28,225,146 (+)	NCBI	ChiLan1.0	ChiLan1.0

HRH2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	170,788,692 - 170,841,335 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	168,928,231 - 168,980,873 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	171,004,893 - 171,057,539 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	177,928,039 - 177,955,714 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	177,928,039 - 177,931,566 (+)	Ensembl	panpan1.1		panPan2

HRH2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	37,333,843 - 37,407,146 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	37,275,852 - 37,386,072 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	37,330,979 - 37,332,058 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	37,699,668 - 37,772,370 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	37,641,724 - 37,772,357 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	37,574,680 - 37,575,759 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	37,762,745 - 37,763,824 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	38,272,467 - 38,273,546 (-)	NCBI		UU_Cfam_GSD_1.0

Hrh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	91,901,767 - 91,941,401 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936609	622,311 - 664,084 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936609	624,446 - 664,049 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HRH2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	81,883,673 - 81,932,275 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	81,883,670 - 81,932,464 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	83,505,532 - 83,554,274 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HRH2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	77,808,108 - 77,858,936 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	77,807,998 - 77,841,467 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	729,121 - 782,228 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hrh2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	14,260,720 - 14,308,217 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624733	14,261,799 - 14,308,320 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Hrh2
185 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	26
Count of miRNA genes:	24
Interacting mature miRNAs:	26
Transcripts:	ENSRNOT00000024580
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9590316	Scort21	Serum corticosterone level QTL 21	4.75	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	1	22871563	Rat
10401807	Kidm52	Kidney mass QTL 52			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	1	31701463	Rat
70184	BpQTLcluster14	Blood pressure QTL cluster 14	3.38		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	1	31990913	Rat
631207	Niddm41	Non-insulin dependent diabetes mellitus QTL 41			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	1	37830672	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	60781592	Rat
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	69599340	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	69599340	Rat
1641902	Colcr7	Colorectal carcinoma resistance QTL 7	3.35	0.0044	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	17	2115149	21881669	Rat
1300123	Bp194	Blood pressure QTL 194	2.82		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	2115149	34551001	Rat
631499	Stl1	Serum triglyceride level QTL 1	3.6		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	3271398	27389946	Rat
2324619	Coatc4	Coat color QTL 4		0.001	coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	17	4299130	21293263	Rat
2324619	Coatc4	Coat color QTL 4		0.001	coat/hair pigmentation trait (VT:0010463)	pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)	17	4299130	21293263	Rat
1354613	Kidm14	Kidney mass QTL 14	6.2		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	17	4299130	35837242	Rat
1354596	Bw32	Body weight QTL 32	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	17	4299130	60781592	Rat
1354630	Cm34	Cardiac mass QTL 34	8.7		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	4299130	69599340	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	4299130	69599340	Rat
1354651	Lmblg2	Limb length QTL 2	6		tibia length (VT:0004357)	tibia length (CMO:0000450)	17	4299130	69599340	Rat
2293648	Bmd31	Bone mineral density QTL 31	4.5	0.0001	femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	17	4354487	27028127	Rat
2293664	Bmd28	Bone mineral density QTL 28	5.1	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	17	4354487	27028127	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4528038	49528038	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4528038	49528038	Rat
1581553	Pur14	Proteinuria QTL 14	5.3	0.0001	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	17	7979968	16317111	Rat
2303561	Bw91	Body weight QTL 91	2		body mass (VT:0001259)	body weight (CMO:0000012)	17	8868462	53868462	Rat
1582199	Insul5	Insulin level QTL 5	3.4	0.0119	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	17	9201365	23653323	Rat
1582208	Kidm32	Kidney mass QTL 32	3.9	0.0018	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	9201365	23653323	Rat
1582224	Epfw4	Epididymal fat weight QTL 4	3.5	0.0058	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	17	9201365	23653323	Rat
1582225	Bw67	Body weight QTL 67	6.2	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
1582226	Bw64	Body weight QTL 64	4.2	0.0017	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
1582241	Bw70	Body weight QTL 70	4.6	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
1582245	Bw73	Body weight QTL 73	4.6	0.0004	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
1582258	Bw76	Body weight QTL 76	4.6	0.0005	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
2300002	Iddm36	Insulin dependent diabetes mellitus QTL 36	1.98		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	9991286	40540197	Rat

Markers in Region

Hrh2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	10,385,019 - 10,385,515 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	10,929,564 - 10,930,059	NCBI	Rnor6.0
Rnor_5.0	17	13,042,372 - 13,042,867	UniSTS	Rnor5.0
RGSC_v3.4	17	16,498,546 - 16,499,041	UniSTS	RGSC3.4
Celera	17	10,455,787 - 10,456,282	UniSTS
Cytogenetic Map	17	p14	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium
Low			5	2	14	2			58	14	8	6
Below cutoff	3	20	23	10	5	10	8	9	8	19	18	5	8

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001413011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005495238	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_596619	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S57565	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000024580 ⟹ ENSRNOP00000024580

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	10,368,298 - 10,407,631 (-)	Ensembl
Rnor_6.0 Ensembl	17	10,921,507 - 10,952,441 (-)	Ensembl

RefSeq Acc Id:

NM_001413011 ⟹ NP_001399940

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	10,371,083 - 10,412,724 (-)	NCBI
mRatBN7.2	17	10,366,004 - 10,407,643 (-)	NCBI

RefSeq Acc Id:

XM_063276079 ⟹ XP_063132149

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	10,371,083 - 10,391,904 (-)	NCBI

RefSeq Acc Id:

XR_005495238

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	10,371,083 - 10,412,979 (-)	NCBI
mRatBN7.2	17	10,368,355 - 10,407,791 (-)	NCBI

RefSeq Acc Id:

XR_596619

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	10,371,083 - 10,412,979 (-)	NCBI
mRatBN7.2	17	10,368,355 - 10,407,788 (-)	NCBI
Rnor_6.0	17	10,912,959 - 10,931,389 (-)	NCBI

Sequence:

show sequence

AGAGAGGGAGGGAAGGAAAATCACTAAAATGCCTGAGAAGGTGATACAGTGGTAGAGTAACCAC
TTCCGGTCACACGATGGGCTGTTATACAGCCATTAGAATTGAGTGAGCTGTGTACCAGCTGACT
TGGAAGCAGAAATGTTTACACTGCTAAATAAAAAAAAAATGAGACTTAGACATGGGTGTTGAAC
CCTACGCAAGGATGGAGTTGACAGATCATGAAGACATTAGGTGACAAAATCAAAACCAAGACTA
GCCCTGTGCTTGCTTTTTTTCCAGATTGTTGGGGGATAAAGGAAATCATGATGATTTTGTAGCA
GAAAAAAAACAATATGAAATTTACAGTTCCACATCCACCATGAAGCTTGACCAGAGCAGAGTCC
CATGGCTGCTTTTAGGCTACAGTAGCAGAGTTGTCATTTCAGCAAACACCCTGCAGGCTACAAA
GAAAAGAATACAGGCTGCCTGGTTCTTTCTCGGAAAAACTTGTCAGTTCCTGGTTTACTGTTTC
CCACACTTAATAATTCAGTAAATTGAGTGCATTTATTTATCTACTCATCCAATGCATCATTTAA
TCAACTGAGGACAAATGTCTACCAGTGGGGTTGGGCAGCAACCAGAGGCAAATGAAAGCAGTCT
TGTCCTAGATCTGCCCCTCCACTTTTTTTCCTCATGGTACCATAGACTTACATCCTGGTCCCCT
TCACCATCCATCATGTGCCCTGACCATCTTGGTCTTTCCTAAGGAGGGATACCTAAAAGAGTCC
CCATTGACTCCTGATCTCTCATCTCATGATTGATGTCTAGAAAGACTCACCTTGAAACAGGTCA
TGCTGTTGGTATAATTCTGAAGTTCTAAACACTCAATCTTTACATTTACAGCTTCTATGACCCC
CCAGAGAGGGTAGCTAATAGTTTTCTACCTTAAGTCATCGATGGGAGCAGGTACCAGCCATGGA
GAAGGACATGACAGCCTATGTGTGTGAACCCTTGCATATAAAACCTAAGCCACTTCAAGACATA
TCCAGCAGTGCCTCAGACTCCATGAGGAACCTAGAAGGTAGATATGTATTACAGACCTGGGAGA
AGTCTGGCTTGGAAGACCAGCTAAGGACTGGGGTGTGAGCTTTTAAGGCCCTGTCTTACTTTCG
TCTTATCCATGTCCTGCACTTCACAAGGAACAGCTTGATCTATTGTTAGAACAGCATTGGGTCA
GTCACTAAGCCTTCCCCAACTTGCCTTTAGCTTGGTTGGAAGCCCAATTGTCAGAGCTGGAAGA
GAAGTGGCCAAGACCAAGAGGTGAATGTAGAAGCCACAGGGCCCCAGAATGGAGCCCAATGGCA
CAGTTCATTCCTGCTGCTTGGACTCTATGGCATTGAAAGTCACCATCAGTGTGGTCCTTACCAC
GCTCATCCTCATCACCATTGCTGGCAATGTGGTCGTCTGCCTGGCTGTCAGCTTGAACCGTCGG
CTCCGCAGTCTGACCAATTGCTTCATTGTGTCCCTGGCAGCCACTGACCTGCTTCTTGGACTCC
TGGTGCTGCCCTTCTCTGCCATTTACCAGCTGTCCTTCAAGTGGAGTTTTGGCCACGTCTTCTG
CAACATCTACACCAGCTTGGATGTGATGCTCTGCACGGCCTCCATCCTCAACCTCTTCATGATC
AGCTTGGACCGCTACTGCGCTGTCACGGACCCACTGCGGTACCCTGTGCTGGTCACCCCAGTTC
GAGTTGCCATCTCTTTGGTCTTTATTTGGGTTATTTCTATCACCCTATCCTTCCTCTCTATTCA
CCTAGGATGGAACAGCAGAAATGGGACCAGAGGGGGCAATGACACCTTCAAGTGCAAAGTCCAG
GTCAATGAGGTGTACGGACTGGTGGATGGGCTGGTCACCTTCTACCTGCCTCTTCTCATCATGT
GTGTCACTTACTACAGAATCTTTAAGATTGCCAGGGAGCAGGCCAAACGGATCAACCACATCAG
CTCCTGGAAGGCAGCCACCATCAGAGAGCACAAAGCCACCGTGACACTGGCGGCCGTCATGGGA
GCGTTCATCATCTGCTGGTTTCCTTACTTCACTGCATTCGTTTACCGTGGGCTGAGAGGGGATG
ATGCCATCAATGAGGCGGTCGAGGGCATTGTCCTATGGTTGGGCTATGCCAATTCAGCCCTGAA
CCCCATCCTGTACGCTGCTCTCAACAGAGACTTCCGCACGGCGTACCAACAGCTCTTCCACTGC
AAGTTCGCAAGCCACAACTCTCACAAAACTTCCCTGAGGTTGAACAACTCTCTGCTGCCCAGGA
GCCAGAGCCGAGAAGGTAGATGGCAGGAGGAGAAGCCCTTGAAGCTCCAAGTGTGGAGTGGGAC
AGAACTCACACACCCCCAGGGAAACCCAATCAGGGAGCAGACACACCATGATGTCACAGATGAA
GGAAAACCCTAAGTTTCCAGTGTCTGACAACGATGTCACTTCCATTTGTGACCCCAGTGACTCT
GGATGCTGAAGGCAGTCACTACAGGACTCACCCCACCTCCAGCCTTTGGGGAAAACAACACTGT
CTTGCACCACACGCTCCAATGGCCTCCCAAGCTGCTGCAAGAGCCTGTGGAGGCTTCGTTTCCT
CAGGCAACACCTACAAGGAACCTCAGAGGAGCAATCGGGGGAGCCACTGTCTGAGTAGACAGAA
AGGACACATCACAGGAAGGAATGGGGGCGTTGCCCTATGAGGCTGTCTAGATCCTGCCCAGGAC
ACCAAGATACTGGCCTTATTTCTTGGATCTCTTTTCTGGAGCCCCTGTAGATCAAGCCCCACCA
AAACTACCAAGGACAAACTTCAGCCTGGAGGCTCACAGAACATACAGATCAGCTTCCCTGAGAG
CAGATTCCAGACAGGTACTTAGGCTTACTTAGGCTGAATTCCCTGGGTTCAAAGCTCACGTTGG
TGCTGGCCCTAGGAGTCATGAGCAGAGAGAGCAGGGCAGAGACGTTTACACATGTGTGCATGGA
CACACTTCTATAGAAAACATGCACATCTGCTGAGCAGGGCAAGGAATGCGATTATACAGCACTG
GCCCCACTCACTTCCTTGTGGGGGTCTCGATATGAGCAGAAAAAAAGAGAAGAGAATGGGAGAG
AAGGAAGAGGAGAAAAATTGCCCTCCCTGAACACCTAACTAAGTTCTAGGTACTTTGCCTATAC
AGGCTCTCATAATTTATATACATACGCTTCGGATAAACATCACTGTCCAGACTTTACAGAGTCA
GGGTAGTATGGAATGTACCTCAGGCCACTCAGCCAGAAAATGTGCCTGAGATAGAGGTACGCAG
GGAATACTCGGTGAGTGAAAGGGTGTGTGGGAAGATGGATGGATGGATGGTTGGATATATAGAT
GGATGGACGATGGATGGATGGATGATGGGT

hide sequence

Protein Sequences


Protein RefSeqs	NP_001399940	(Get FASTA)	NCBI Sequence Viewer
	XP_063132149	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB19935	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000024580.2
GenBank Protein	P25102	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

ENSRNOP00000024580 ⟸ ENSRNOT00000024580

RefSeq Acc Id:	NP_001399940 ⟸ NM_001413011
- UniProtKB:	P25102 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_063132149 ⟸ XM_063276079
- Peptide Label:	isoform X1

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P25102-F1-model_v2	AlphaFold	P25102	1-358	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2831	AgrOrtholog
BioCyc Gene	G2FUF-10162	BioCyc
Ensembl Genes	ENSRNOG00000018260	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000024580.4	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Histamine_H2_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25461	UniProtKB/Swiss-Prot
NCBI Gene	25461	ENTREZGENE
PANTHER	5-HYDROXYTRYPTAMINE RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HISTAMINE H2 RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Hrh2	PhenoGen
PRINTS	GPCRRHODOPSN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HISTAMINEH2R	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000018260	RatGTEx
SMART	7TM_GPCR_Srsx	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	F1LNK8_RAT	UniProtKB/TrEMBL
	HRH2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Hrh2	Histamine H2 receptor			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	highly expressed in brain and stomach	728427
gene_protein	358 amino acid protein	728427
gene_transcript	intronless gene	728427

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)