Hcrtr2 (hypocretin receptor 2) - Rat Genome Database

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Gene: Hcrtr2 (hypocretin receptor 2) Rattus norvegicus
Analyze
Symbol: Hcrtr2
Name: hypocretin receptor 2
RGD ID: 2788
Description: Enables orexin receptor activity and peptide hormone binding activity. Involved in feeding behavior and neuropeptide signaling pathway. Predicted to be located in plasma membrane. Biomarker of hyperglycemia. Orthologous to human HCRTR2 (hypocretin receptor 2); PARTICIPATES IN G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypocretin (orexin) receptor 2; hypocretin receptor type 2; orexin receptor type 2; ox-2-R; ox2-R; ox2r
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8885,870,279 - 85,986,405 (-)NCBIGRCr8
mRatBN7.2876,989,834 - 77,105,953 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl876,989,834 - 77,105,893 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx882,491,451 - 82,601,869 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0880,762,351 - 80,878,493 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0878,590,802 - 78,701,228 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0883,307,684 - 83,421,612 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl883,307,684 - 83,421,612 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0882,883,206 - 82,998,507 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4881,068,303 - 81,196,608 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1881,087,356 - 81,215,662 (-)NCBI
Celera876,775,605 - 76,891,642 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
plasma membrane  (ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Localization of orexins and their receptors in the rat olfactory system: possible modulation of olfactory perception by a neuropeptide synthetized centrally or locally. Caillol M, etal., Brain Res 2003 Jan 17;960(1-2):48-61.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Stimulation of amylase release by Orexin is mediated by Orexin 2 receptor in AR42J cells. Harris DM, etal., Pancreas 2002 Nov;25(4):405-10.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness. Sakurai T Nat Rev Neurosci. 2007 Mar;8(3):171-81. Epub 2007 Feb 14.
10. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Sakurai T, etal., Cell 1998 Feb 20;92(4):573-85.
11. Developmental changes in the orexin 2 receptor mRNA in hypoglossal motoneurons. Volgin DV, etal., Neuroreport 2002 Mar 25;13(4):433-6.
12. The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin 1-type receptor. Wieland HA, etal., Eur J Biochem 2002 Feb;269(4):1128-35.
13. Expressions of the prepro-orexin and orexin type 2 receptor genes in obese rat. Yamamoto Y, etal., Peptides 2002 Sep;23(9):1689-96.
14. Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. Zhu Y, etal., J Pharmacol Sci. 2003 Jul;92(3):259-66.
Additional References at PubMed
PMID:11282968   PMID:11283317   PMID:11340621   PMID:11459774   PMID:12639903   PMID:12650973   PMID:14749141   PMID:15256537   PMID:15282280   PMID:15870901   PMID:15976062   PMID:16357203  
PMID:16763079   PMID:17292491   PMID:17585016   PMID:17638707   PMID:18709662   PMID:18793323   PMID:19261974   PMID:19656173   PMID:19751316   PMID:19889100   PMID:19921532   PMID:20177882  
PMID:21547533   PMID:22588980   PMID:23282008   PMID:23525245   PMID:23601187   PMID:23744436   PMID:24333629   PMID:25239810   PMID:25371350   PMID:26494513   PMID:26653571   PMID:26724374  
PMID:26950369   PMID:26987804   PMID:28549933   PMID:28866050   PMID:28889006   PMID:29258865   PMID:30140065   PMID:30458283   PMID:31655279   PMID:31738930   PMID:32207079   PMID:34718063  
PMID:36470538   PMID:37866644  


Genomics

Comparative Map Data
Hcrtr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8885,870,279 - 85,986,405 (-)NCBIGRCr8
mRatBN7.2876,989,834 - 77,105,953 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl876,989,834 - 77,105,893 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx882,491,451 - 82,601,869 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0880,762,351 - 80,878,493 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0878,590,802 - 78,701,228 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0883,307,684 - 83,421,612 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl883,307,684 - 83,421,612 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0882,883,206 - 82,998,507 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4881,068,303 - 81,196,608 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1881,087,356 - 81,215,662 (-)NCBI
Celera876,775,605 - 76,891,642 (-)NCBICelera
Cytogenetic Map8q24NCBI
HCRTR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38655,106,469 - 55,284,713 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl655,106,460 - 55,282,617 (+)EnsemblGRCh38hg38GRCh38
GRCh37654,971,267 - 55,147,415 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36655,147,028 - 55,255,377 (+)NCBINCBI36Build 36hg18NCBI36
Build 34655,147,029 - 55,255,376NCBI
Celera656,700,614 - 56,808,965 (+)NCBICelera
Cytogenetic Map6p12.1NCBI
HuRef654,873,884 - 54,982,213 (+)NCBIHuRef
CHM1_1655,041,239 - 55,149,538 (+)NCBICHM1_1
T2T-CHM13v2.0654,946,092 - 55,124,321 (+)NCBIT2T-CHM13v2.0
Hcrtr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39976,133,162 - 76,230,905 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl976,133,162 - 76,231,138 (-)EnsemblGRCm39 Ensembl
GRCm38976,225,880 - 76,323,623 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl976,225,880 - 76,323,856 (-)EnsemblGRCm38mm10GRCm38
MGSCv37976,073,687 - 76,171,385 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36976,011,789 - 76,109,487 (-)NCBIMGSCv36mm8
Celera973,390,040 - 73,487,756 (-)NCBICelera
Cytogenetic Map9DNCBI
cM Map942.48NCBI
Hcrtr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955411970,892 - 1,010,138 (-)NCBIChiLan1.0ChiLan1.0
HCRTR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2569,633,319 - 69,752,830 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1665,509,827 - 65,629,203 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0654,722,279 - 54,835,963 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1656,356,601 - 56,468,123 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl656,327,340 - 56,469,901 (+)Ensemblpanpan1.1panPan2
HCRTR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11222,517,482 - 22,623,358 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1222,517,482 - 22,623,358 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1222,407,952 - 22,513,804 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01223,015,406 - 23,120,685 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1223,015,639 - 23,124,140 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11222,505,616 - 22,611,355 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01222,616,100 - 22,721,301 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01222,747,998 - 22,853,462 (+)NCBIUU_Cfam_GSD_1.0
Hcrtr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494658,027,003 - 58,123,297 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364765,838,830 - 5,933,207 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364765,838,663 - 5,933,174 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HCRTR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl725,826,298 - 25,929,702 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1725,830,544 - 25,929,640 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2730,298,326 - 30,398,688 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HCRTR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11716,258,262 - 16,371,576 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1716,258,439 - 16,294,204 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605822,417,788 - 22,535,152 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hcrtr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248502,699,140 - 2,795,350 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248502,698,806 - 2,792,194 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hcrtr2
572 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:248
Count of miRNA genes:154
Interacting mature miRNAs:200
Transcripts:ENSRNOT00000015824
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)87531193882925521Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)87531177784531599Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 5
Low 2 3 64 10 5
Below cutoff 2 24 8 7 2 7 6 7 10 6 21 6 6

Sequence


RefSeq Acc Id: ENSRNOT00000015824   ⟹   ENSRNOP00000015824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl876,989,834 - 77,105,893 (-)Ensembl
Rnor_6.0 Ensembl883,307,684 - 83,421,612 (-)Ensembl
RefSeq Acc Id: NM_001393819   ⟹   NP_001380748
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8885,870,279 - 85,986,405 (-)NCBI
mRatBN7.2876,989,834 - 77,105,953 (-)NCBI
RefSeq Acc Id: NM_013074   ⟹   NP_037206
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8885,870,279 - 85,986,405 (-)NCBI
mRatBN7.2876,989,834 - 77,105,953 (-)NCBI
Rnor_6.0883,307,684 - 83,421,612 (-)NCBI
Rnor_5.0882,883,206 - 82,998,507 (-)NCBI
RGSC_v3.4881,068,303 - 81,196,608 (-)RGD
Celera876,775,605 - 76,891,642 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001380748 (Get FASTA)   NCBI Sequence Viewer  
  NP_037206 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC40042 (Get FASTA)   NCBI Sequence Viewer  
  EDL77772 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015824
  ENSRNOP00000015824.4
  ENSRNOP00055010030
  ENSRNOP00060026619
  ENSRNOP00065022766
GenBank Protein P56719 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037206   ⟸   NM_013074
- Peptide Label: isoform 1
- UniProtKB: P56719 (UniProtKB/Swiss-Prot),   A6I1F5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015824   ⟸   ENSRNOT00000015824
RefSeq Acc Id: NP_001380748   ⟸   NM_001393819
- Peptide Label: isoform 2
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56719-F1-model_v2 AlphaFold P56719 1-460 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2788 AgrOrtholog
BioCyc Gene G2FUF-29800 BioCyc
Ensembl Genes ENSRNOG00000011251 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055007550 UniProtKB/Swiss-Prot
  ENSRNOG00060018872 UniProtKB/Swiss-Prot
  ENSRNOG00065017232 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015824 ENTREZGENE
  ENSRNOT00000015824.5 UniProtKB/Swiss-Prot
  ENSRNOT00055012613 UniProtKB/Swiss-Prot
  ENSRNOT00060032616 UniProtKB/Swiss-Prot
  ENSRNOT00065028759 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Orexin_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Orexin_rcpt_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25605 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25605 ENTREZGENE
PANTHER G PROTEIN-COUPLED RECEPTOR 15-LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LEUCOKININ RECEPTOR-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Orexin_rec2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hcrtr2 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OREXIN2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OREXINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011251 RatGTEx
  ENSRNOG00055007550 RatGTEx
  ENSRNOG00060018872 RatGTEx
  ENSRNOG00065017232 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6I1F5 ENTREZGENE, UniProtKB/TrEMBL
  OX2R_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Hcrtr2  hypocretin receptor 2  Hcrtr2  hypocretin (orexin) receptor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Hcrtr2  hypocretin (orexin) receptor 2    hypocretin receptor 2  Name updated 1299863 APPROVED
2002-06-10 Hcrtr2  Hypocretin (orexin) receptor 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function G-protein-coupled receptor 625512
gene_homology 46% identical to Hcrtr1 625512
gene_process plays an important role in food intake, sleep/wake cycle and neuroendocrine functions domain 625512