Ggt5 (gamma-glutamyltransferase 5) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Ggt5 (gamma-glutamyltransferase 5) Rattus norvegicus
Analyze
Symbol: Ggt5 (Ensembl: AABR07044631.2)
Name: gamma-glutamyltransferase 5
RGD ID: 2684
Description: Predicted to enable glutathione hydrolase activity; leukotriene-C(4) hydrolase; and peptidyltransferase activity. Involved in response to organonitrogen compound. Predicted to be active in plasma membrane. Orthologous to human GGT5 (gamma-glutamyltransferase 5); PARTICIPATES IN arachidonic acid metabolic pathway; cyanoamino acid metabolic pathway; glutathione metabolic pathway; INTERACTS WITH 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: gamma-glutamyl leukotrienase; gamma-glutamyl transpeptidase-related enzyme; gamma-glutamyltransferase-like activity 1; gamma-glutamyltranspeptidase 5; GGL; GGT 5; GGT-rel; Ggta1; Ggtla1; glutathione hydrolase 5; glutathione hydrolase 5 proenzyme; leukotriene-C4 hydrolase; MGC93485
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82013,042,694 - 13,070,960 (-)NCBIGRCr8
mRatBN7.22013,043,255 - 13,071,523 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2013,043,257 - 13,071,450 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,749,839 - 13,778,030 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02013,110,786 - 13,138,974 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,583,284 - 13,611,483 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,988,444 - 14,001,296 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02016,178,488 - 16,191,069 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01962,302,144 - 62,302,579 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2014,531,284 - 14,557,667 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
plasma membrane  (IBA,IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Expression and regulation of gamma-glutamyl transpeptidase-related enzyme in tracheal cells. Potdar PD, etal., Am J Physiol 1997 Nov;273(5 Pt 1):L1082-9.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:1676842   PMID:9774450   PMID:12163373   PMID:12477932   PMID:21447318  


Genomics

Comparative Map Data
Ggt5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82013,042,694 - 13,070,960 (-)NCBIGRCr8
mRatBN7.22013,043,255 - 13,071,523 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2013,043,257 - 13,071,450 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,749,839 - 13,778,030 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02013,110,786 - 13,138,974 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,583,284 - 13,611,483 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,988,444 - 14,001,296 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02016,178,488 - 16,191,069 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01962,302,144 - 62,302,579 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2014,531,284 - 14,557,667 (-)NCBICelera
Cytogenetic Map20p12NCBI
GGT5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382224,219,654 - 24,245,142 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2224,219,654 - 24,245,108 (-)EnsemblGRCh38hg38GRCh38
GRCh372224,615,622 - 24,641,110 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362222,945,622 - 22,971,110 (-)NCBINCBI36Build 36hg18NCBI36
Build 342222,940,192 - 22,965,582NCBI
Celera228,416,020 - 8,441,502 (-)NCBICelera
Cytogenetic Map22q11.23NCBI
HuRef227,564,739 - 7,590,237 (-)NCBIHuRef
CHM1_12224,574,371 - 24,599,750 (-)NCBICHM1_1
T2T-CHM13v2.02224,681,268 - 24,706,753 (-)NCBIT2T-CHM13v2.0
Ggt5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,425,161 - 75,453,034 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,425,174 - 75,453,034 (+)EnsemblGRCm39 Ensembl
GRCm381075,589,327 - 75,617,200 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,589,340 - 75,617,200 (+)EnsemblGRCm38mm10GRCm38
MGSCv371075,052,126 - 75,079,713 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361075,033,097 - 75,060,684 (+)NCBIMGSCv36mm8
Celera1076,634,075 - 76,661,662 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.55NCBI
Ggt5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554558,102,499 - 8,125,966 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554558,101,251 - 8,125,597 (+)NCBIChiLan1.0ChiLan1.0
GGT5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22334,004,643 - 34,033,738 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12236,738,366 - 36,767,475 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0225,025,740 - 5,053,074 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12223,110,461 - 23,125,629 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2223,110,780 - 23,125,632 (-)Ensemblpanpan1.1panPan2
GGT5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12628,316,022 - 28,343,928 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2628,317,989 - 28,343,611 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2627,390,911 - 27,419,099 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02629,720,313 - 29,748,512 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12627,804,270 - 27,832,467 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02627,421,067 - 27,449,253 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02628,411,249 - 28,439,354 (+)NCBIUU_Cfam_GSD_1.0
Ggt5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118141,916,314 - 141,959,384 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936619794,889 - 837,736 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936619794,876 - 837,748 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GGT5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,640,586 - 49,663,003 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11449,638,184 - 49,663,007 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,080,650 - 53,104,965 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Ggt5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474710,051,553 - 10,071,983 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474710,050,765 - 10,072,255 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ggt5
261 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804241017617956Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20903971913461775Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000093720   ⟹   ENSRNOP00000076334
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2013,043,257 - 13,071,450 (-)Ensembl
RefSeq Acc Id: NM_019235   ⟹   NP_062108
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82013,042,694 - 13,070,892 (-)NCBI
mRatBN7.22013,043,255 - 13,071,450 (-)NCBI
Rnor_6.02013,988,444 - 14,001,296 (-)NCBI
Rnor_5.01962,302,144 - 62,302,579 (-)NCBI
Rnor_5.02016,178,488 - 16,191,069 (-)NCBI
Celera2014,531,284 - 14,557,667 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039098626   ⟹   XP_038954554
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82013,046,412 - 13,070,960 (-)NCBI
mRatBN7.22013,046,654 - 13,071,523 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_062108   ⟸   NM_019235
- UniProtKB: Q9QWE9 (UniProtKB/Swiss-Prot),   Q5PQV0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038954554   ⟸   XM_039098626
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000076334   ⟸   ENSRNOT00000093720

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QWE9-F1-model_v2 AlphaFold Q9QWE9 1-572 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2684 AgrOrtholog
BioCyc Gene G2FUF-4152 BioCyc
Ensembl Genes ENSRNOG00000062276 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055021257 UniProtKB/Swiss-Prot
  ENSRNOG00060017767 UniProtKB/Swiss-Prot
  ENSRNOG00065026665 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000093720 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000093720.2 UniProtKB/Swiss-Prot
  ENSRNOT00055036313 UniProtKB/Swiss-Prot
  ENSRNOT00060030408 UniProtKB/Swiss-Prot
  ENSRNOT00065046033 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.246.130 UniProtKB/Swiss-Prot
  3.60.20.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7191011 IMAGE-MGC_LOAD
InterPro GGT_lsub_C UniProtKB/Swiss-Prot
  GGT_peptidase UniProtKB/Swiss-Prot
  GGT_ssub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ntn_hydrolases_N UniProtKB/Swiss-Prot
KEGG Report rno:29566 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93485 IMAGE-MGC_LOAD
NCBI Gene 29566 ENTREZGENE
PANTHER GLUTATHIONE HYDROLASE 5 PROENZYME UniProtKB/Swiss-Prot
  PTHR11686 UniProtKB/Swiss-Prot
  PTHR45027:SF2 UniProtKB/TrEMBL
  PUTATIVE GLUTATHIONE HYDROLASE LIGHT CHAIN UniProtKB/TrEMBL
Pfam G_glu_transpept UniProtKB/Swiss-Prot
PhenoGen Ggt5 PhenoGen
PRINTS GGTRANSPTASE UniProtKB/Swiss-Prot
PROSITE G_GLU_TRANSPEPTIDASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000062276 RatGTEx
  ENSRNOG00055021257 RatGTEx
  ENSRNOG00060017767 RatGTEx
  ENSRNOG00065026665 RatGTEx
Superfamily-SCOP SSF56235 UniProtKB/Swiss-Prot
UniProt A0A1W2Q6M5_RAT UniProtKB/TrEMBL
  GGT5_RAT UniProtKB/Swiss-Prot
  Q5PQV0 ENTREZGENE
  Q9QWE9 ENTREZGENE
UniProt Secondary Q5PQV0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-31 Ggt5  gamma-glutamyltransferase 5  Ggtla1  gamma-glutamyltransferase-like activity 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ggtla1  gamma-glutamyltransferase-like activity 1      Name updated 70584 APPROVED
2002-02-27 Ggtla1  gamma-glutamyltransferase-like activity 1      Symbol updated 70292 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in rat tracheal epithelial cultured cells 69846
gene_function protein cleaves the gamma-glutamyl peptide bond of glutathione 69846
gene_transcript 2.6 Kb cDNA which is 79% identical to human 69846