Gene: Gck (glucokinase) Rattus norvegicus
Symbol: Gck
Name: glucokinase
Description: ENCODES a protein that exhibits ADP binding; ATP binding; glucokinase activity; INVOLVED IN carbohydrate phosphorylation; cellular glucose homeostasis; cellular response to glucose starvation; PARTICIPATES IN glycogen biosynthetic pathway; glycogen metabolic pathway; glycolysis pathway; ASSOCIATED WITH decreased circulating glucose level; increased circulating free fatty acid level; increased circulating triglyceride level; ASSOCIATED WITH Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fatty Liver; FOUND IN actin filament; basal cortex; cell cortex; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: GLK; glucokinase variant 3; GLUKA; hexokinase type IV; hexokinase-4; hexokinase-D; HK IV; HK4; RNGK2
Homo sapiens (human) : GCK (glucokinase)  HGNC  AGR
Mus musculus (house mouse) : Gck (glucokinase)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Gck (glucokinase)
Pan paniscus (bonobo/pygmy chimpanzee) : GCK (glucokinase)
Canis lupus familiaris (dog) : GCK (glucokinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gck (glucokinase)
more info ...
Is Marker For: QTLs:   Pancm5   Niddm37  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01486,149,146 - 86,191,589 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01486,832,735 - 86,875,295 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41486,572,518 - 86,587,723 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11486,591,662 - 86,606,868 (-)NCBI
Celera1479,669,432 - 79,710,739 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Gck
AGR Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2670
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2017-10-03
Status: ACTIVE