Gene: Gadd45a (growth arrest and DNA-damage-inducible, alpha) Rattus norvegicus
Symbol: Gadd45a
Name: growth arrest and DNA-damage-inducible, alpha
Description: ENCODES a protein that exhibits kinase binding (ortholog); protein heterodimerization activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN G2/M transition of mitotic cell cycle; activation of MAPKKK activity (ortholog); cellular response to ionizing radiation (ortholog); PARTICIPATES IN p38 MAPK signaling pathway; cell cycle pathway, mitotic; mitogen activated protein kinase signaling pathway; ASSOCIATED WITH Arthritis, Juvenile (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Chloracne (ortholog); FOUND IN cytoplasm (ortholog); nuclear speck (ortholog); nucleus (ortholog); INTERACTS WITH (+)-alpha-tocopherol; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-colchicine
Type: protein-coding
Also known as: DDIT-1; Ddit1; DNA damage-inducible transcript 1 protein; DNA-damage-inducible transcript 1; Gadd45; growth arrest and DNA damage-inducible protein GADD45 alpha; growth arrest and DNA-damage-inducible 45 alpha; Growth arrest and DNA-damage-inducible protein; growth arrest and DNA-damage-inducible protein GADD45 alpha
Homo sapiens (human) : GADD45A (growth arrest and DNA damage inducible alpha)  HGNC  Alliance
Mus musculus (house mouse) : Gadd45a (growth arrest and DNA-damage-inducible 45 alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gadd45a (growth arrest and DNA damage inducible alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : GADD45A (growth arrest and DNA damage inducible alpha)
Canis lupus familiaris (dog) : GADD45A (growth arrest and DNA damage inducible alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gadd45a (growth arrest and DNA damage inducible alpha)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0497,782,512 - 97,784,814 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04162,568,472 - 162,570,774 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4496,649,941 - 96,652,243 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1496,894,423 - 96,896,724 (-)NCBI
Celera490,851,517 - 90,853,819 (-)NCBICelera
Cytogenetic Map4q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Gadd45a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2654
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2018-03-13
Status: ACTIVE