Fgf9 (fibroblast growth factor 9) - Rat Genome Database

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Gene: Fgf9 (fibroblast growth factor 9) Rattus norvegicus
Analyze
Symbol: Fgf9
Name: fibroblast growth factor 9
RGD ID: 2610
Description: Enables fibroblast growth factor receptor binding activity and growth factor activity. Involved in several processes, including negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching; positive regulation of vascular associated smooth muscle cell migration; and positive regulation of vascular associated smooth muscle cell proliferation. Located in basement membrane. Human ortholog(s) of this gene implicated in kidney cancer and multiple synostoses syndrome 3. Orthologous to human FGF9 (fibroblast growth factor 9); PARTICIPATES IN fibroblast growth factor signaling pathway; melanoma pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-glucopyranose.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: FGF-9; Fgf4b; fibroblast growth factor 4b; GAF; glia-activating factor; HBGF-9
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81536,325,552 - 36,369,995 (+)NCBIGRCr8
mRatBN7.21532,208,993 - 32,254,952 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1532,210,074 - 32,253,309 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1534,203,142 - 34,243,439 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01535,353,796 - 35,394,102 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01533,611,906 - 33,652,213 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01538,341,657 - 38,386,945 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1538,341,089 - 38,387,316 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01542,177,371 - 42,217,450 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41537,115,068 - 37,155,652 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11537,130,767 - 37,171,321 (+)NCBI
Celera1531,921,635 - 31,961,962 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2,3,7,8-Pentachlorodibenzodioxin  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-Nitrobenzanthrone  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
CHIR 99021  (ISO)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
colforsin daropate hydrochloride  (ISO)
cordycepin  (ISO)
cortisol  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dichloroacetic acid  (ISO)
dieldrin  (EXP)
dimethoxyflavone  (ISO)
dimethylarsinic acid  (EXP)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethylparaben  (ISO)
fenvalerate  (EXP)
fulvestrant  (ISO)
irinotecan  (ISO)
iron dichloride  (ISO)
isopentenyl diphosphate  (ISO)
lipopolysaccharide  (EXP,ISO)
melatonin  (EXP)
mercury dibromide  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
neocuproine  (ISO)
nitrofen  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
pentachlorobiphenyl  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
polycyclic arene  (ISO)
potassium dichromate  (ISO)
pregnenolone  (ISO)
progesterone  (ISO)
Ptaquiloside  (ISO)
raloxifene  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
SB-202190  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trilostane  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activin receptor signaling pathway  (ISO)
angiogenesis  (ISO)
animal organ morphogenesis  (IBA,IEA)
canonical Wnt signaling pathway  (ISO)
cardiac muscle cell proliferation  (ISO)
cell differentiation  (IBA,IEA)
cell population proliferation  (ISO)
cell-cell signaling  (ISO)
chondrocyte differentiation  (ISO)
embryonic digestive tract development  (ISO)
embryonic limb morphogenesis  (ISO)
embryonic skeletal system development  (ISO)
epithelial cell proliferation  (ISO)
eye development  (ISO)
fibroblast growth factor receptor signaling pathway  (IBA,IDA,IEA,ISO)
inner ear morphogenesis  (ISO)
lung development  (IBA,IEA,ISO)
lung-associated mesenchyme development  (ISO)
male gonad development  (IEA,ISO)
male sex determination  (ISO)
mesenchymal cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching  (IMP)
negative regulation of Wnt signaling pathway  (ISO)
osteoblast differentiation  (ISO)
positive regulation of activin receptor signaling pathway  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell division  (IEA)
positive regulation of cell population proliferation  (IBA,IDA,ISO)
positive regulation of epithelial cell proliferation  (IBA,IEA,ISO)
positive regulation of gene expression  (IBA,IEA,IMP,ISO)
positive regulation of MAPK cascade  (IBA)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of protein phosphorylation  (IBA,IEA)
positive regulation of smoothened signaling pathway  (ISO)
positive regulation of stem cell proliferation  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (IMP)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA,IMP,ISO)
positive regulation of vascular endothelial growth factor receptor signaling pathway  (ISO)
protein import into nucleus  (ISO)
regulation of cell migration  (IBA,IEA)
regulation of timing of cell differentiation  (ISO)
Sertoli cell proliferation  (ISO)
signal transduction  (IEA)
smoothened signaling pathway  (ISO)
stem cell proliferation  (ISO)
substantia nigra development  (ISO)
vascular endothelial growth factor receptor signaling pathway  (ISO)
Wnt signaling pathway  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. FGFR3 is a negative regulator of the expansion of pancreatic epithelial cells. Arnaud-Dabernat S, etal., Diabetes. 2007 Jan;56(1):96-106.
2. MicroRNA-182 prevents vascular smooth muscle cell dedifferentiation via FGF9/PDGFRß signaling. Dong N, etal., Int J Mol Med. 2017 Apr;39(4):791-798. doi: 10.3892/ijmm.2017.2905. Epub 2017 Feb 22.
3. Fibroblast growth factor-9, a local regulator of ovarian function. Drummond AE, etal., Endocrinology. 2007 Aug;148(8):3711-21. Epub 2007 May 10.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Directionally specific paracrine communication mediated by epithelial FGF9 to stromal FGFR3 in two-compartment premalignant prostate tumors. Jin C, etal., Cancer Res 2004 Jul 1;64(13):4555-62.
7. MiR-187 suppresses non-small-cell lung cancer cell proliferation by targeting FGF9. Liang Z, etal., Bioengineered. 2020 Dec;11(1):70-80. doi: 10.1080/21655979.2019.1706287.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property. Miyamoto M, etal., Mol Cell Biol 1993 Jul;13(7):4251-9.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19. Potential roles of fibroblast growth factor-9 in the benzo(a)pyrene-induced invasion in vitro and the metastasis of human lung adenocarcinoma. Ueng TH, etal., Arch Toxicol. 2010 Aug;84(8):651-60. doi: 10.1007/s00204-010-0547-3. Epub 2010 May 13.
20. Aryl hydrocarbon receptor activation and overexpression upregulated fibroblast growth factor-9 in human lung adenocarcinomas. Wang CK, etal., Int J Cancer. 2009 Aug 15;125(4):807-15. doi: 10.1002/ijc.24348.
21. MiR-372-3p promotes cell growth and metastasis by targeting FGF9 in lung squamous cell carcinoma. Wang Q, etal., Cancer Med. 2017 Jun;6(6):1323-1330. doi: 10.1002/cam4.1026. Epub 2017 Apr 24.
22. Fibroblast Growth Factor 9 Imparts Hierarchy and Vasoreactivity to the Microcirculation of Renal Tumors and Suppresses Metastases. Yin H, etal., J Biol Chem. 2015 Sep 4;290(36):22127-42. doi: 10.1074/jbc.M115.652222. Epub 2015 Jul 16.
Additional References at PubMed
PMID:8663044   PMID:9847236   PMID:11493531   PMID:15229180   PMID:15292181   PMID:15328018   PMID:15614790   PMID:15621532   PMID:16185683   PMID:16308329   PMID:16540513   PMID:16540514  
PMID:16700629   PMID:16778080   PMID:17544391   PMID:17576930   PMID:17662249   PMID:17848411   PMID:18231602   PMID:18533146   PMID:20615462   PMID:21858205   PMID:22926577   PMID:23034635  
PMID:23376485   PMID:23897418   PMID:25907862   PMID:26351673   PMID:29118903   PMID:31093967   PMID:31708099   PMID:33470768   PMID:35093630   PMID:37705188  


Genomics

Comparative Map Data
Fgf9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81536,325,552 - 36,369,995 (+)NCBIGRCr8
mRatBN7.21532,208,993 - 32,254,952 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1532,210,074 - 32,253,309 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1534,203,142 - 34,243,439 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01535,353,796 - 35,394,102 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01533,611,906 - 33,652,213 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01538,341,657 - 38,386,945 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1538,341,089 - 38,387,316 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01542,177,371 - 42,217,450 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41537,115,068 - 37,155,652 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11537,130,767 - 37,171,321 (+)NCBI
Celera1531,921,635 - 31,961,962 (+)NCBICelera
Cytogenetic Map15p12NCBI
FGF9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381321,671,073 - 21,704,498 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1321,671,073 - 21,704,498 (+)EnsemblGRCh38hg38GRCh38
GRCh371322,245,212 - 22,278,637 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361321,143,875 - 21,174,187 (+)NCBINCBI36Build 36hg18NCBI36
Build 341321,143,874 - 21,174,184NCBI
Celera133,307,609 - 3,341,037 (+)NCBICelera
Cytogenetic Map13q12.11NCBI
HuRef133,046,835 - 3,080,256 (+)NCBIHuRef
CHM1_11322,213,000 - 22,246,423 (+)NCBICHM1_1
T2T-CHM13v2.01320,865,413 - 20,898,835 (+)NCBIT2T-CHM13v2.0
Fgf9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391458,308,543 - 58,350,311 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1458,308,004 - 58,350,177 (+)EnsemblGRCm39 Ensembl
GRCm381458,070,671 - 58,112,854 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1458,070,547 - 58,112,720 (+)EnsemblGRCm38mm10GRCm38
MGSCv371458,691,523 - 58,731,557 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361457,027,028 - 57,063,760 (+)NCBIMGSCv36mm8
Celera1455,871,134 - 55,911,011 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1430.51NCBI
Fgf9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554972,199,409 - 2,235,893 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554972,199,424 - 2,232,088 (+)NCBIChiLan1.0ChiLan1.0
FGF9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21421,271,559 - 21,304,418 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11312,387,563 - 12,420,375 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0132,967,713 - 3,000,554 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11321,273,333 - 21,307,198 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1321,273,333 - 21,307,198 (+)Ensemblpanpan1.1panPan2
FGF9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12516,630,321 - 16,665,935 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2516,632,812 - 16,663,550 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2516,728,400 - 16,763,892 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02516,767,716 - 16,803,279 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2516,767,644 - 16,801,015 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12516,642,693 - 16,678,281 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02516,653,564 - 16,689,105 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02516,710,104 - 16,745,663 (-)NCBIUU_Cfam_GSD_1.0
Fgf9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945118,734,717 - 118,769,086 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936720279,521 - 316,674 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936720282,291 - 316,629 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl111,554,763 - 1,582,408 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1111,554,648 - 1,581,938 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.211693,995 - 718,579 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGF9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.131,779,126 - 1,811,427 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl31,779,192 - 1,812,784 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605742,772,329 - 42,805,568 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477616,019,835 - 16,055,498 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477616,022,118 - 16,055,413 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fgf9
20 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:56
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000015367
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat

Markers in Region
RH78332  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21532,252,198 - 32,252,366 (+)MAPPERmRatBN7.2
Rnor_6.01538,387,029 - 38,387,196NCBIRnor6.0
Rnor_5.01542,217,534 - 42,217,701UniSTSRnor5.0
RGSC_v3.41537,155,736 - 37,155,903UniSTSRGSC3.4
Celera1531,962,046 - 31,962,213UniSTS
Cytogenetic Map15p12UniSTS
Fgf9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21532,251,775 - 32,251,900 (+)MAPPERmRatBN7.2
Rnor_6.01538,386,606 - 38,386,730NCBIRnor6.0
Rnor_5.01542,217,111 - 42,217,235UniSTSRnor5.0
RGSC_v3.41537,155,313 - 37,155,437UniSTSRGSC3.4
Celera1531,961,623 - 31,961,747UniSTS
Cytogenetic Map15p12UniSTS
Fgf9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21532,211,954 - 32,212,147 (+)MAPPERmRatBN7.2
Rnor_6.01538,341,809 - 38,342,001NCBIRnor6.0
Rnor_5.01542,177,523 - 42,177,715UniSTSRnor5.0
RGSC_v3.41537,115,220 - 37,115,412UniSTSRGSC3.4
Celera1531,921,787 - 31,921,979UniSTS
Cytogenetic Map15p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 34 23 7
Low 3 43 29 13 9 13 8 10 40 12 25 11 8
Below cutoff 27 27 10 27 1 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015367   ⟹   ENSRNOP00000015368
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1532,211,194 - 32,252,376 (+)Ensembl
Rnor_6.0 Ensembl1538,341,089 - 38,387,316 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104702   ⟹   ENSRNOP00000094471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1532,210,074 - 32,253,309 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111798   ⟹   ENSRNOP00000083774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1532,211,237 - 32,253,309 (+)Ensembl
RefSeq Acc Id: NM_012952   ⟹   NP_037084
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81536,327,358 - 36,367,665 (+)NCBI
mRatBN7.21532,211,803 - 32,252,115 (+)NCBI
Rnor_6.01538,341,657 - 38,386,945 (+)NCBI
Rnor_5.01542,177,371 - 42,217,450 (+)NCBI
RGSC_v3.41537,115,068 - 37,155,652 (+)RGD
Celera1531,921,635 - 31,961,962 (+)RGD
Sequence:
RefSeq Acc Id: XM_039093009   ⟹   XP_038948937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81536,325,552 - 36,369,995 (+)NCBI
mRatBN7.21532,208,993 - 32,254,952 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_037084   ⟸   NM_012952
- UniProtKB: P36364 (UniProtKB/Swiss-Prot),   A0A7U3JW62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015368   ⟸   ENSRNOT00000015367
RefSeq Acc Id: XP_038948937   ⟸   XM_039093009
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000083774   ⟸   ENSRNOT00000111798
RefSeq Acc Id: ENSRNOP00000094471   ⟸   ENSRNOT00000104702

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P36364-F1-model_v2 AlphaFold P36364 1-208 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2610 AgrOrtholog
BioCyc Gene G2FUF-13585 BioCyc
Ensembl Genes ENSRNOG00000011471 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015367 ENTREZGENE
  ENSRNOT00000015367.6 UniProtKB/Swiss-Prot
  ENSRNOT00000104702.1 UniProtKB/TrEMBL
  ENSRNOT00000111798.1 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7124006 IMAGE-MGC_LOAD
InterPro Fibroblast_GF_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25444 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93094 IMAGE-MGC_LOAD
NCBI Gene 25444 ENTREZGENE
PANTHER FIBROBLAST GROWTH FACTOR 20 UniProtKB/TrEMBL
  PTHR11486 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11486:SF28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB FGF9 RGD
PhenoGen Fgf9 PhenoGen
PRINTS HBGFFGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1HBGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HBGF_FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011471 RatGTEx
SMART FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A7U3JW62 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZZZ1_RAT UniProtKB/TrEMBL
  A0A8I6AJN7_RAT UniProtKB/TrEMBL
  A6KHE0_RAT UniProtKB/TrEMBL
  FGF9_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Fgf9  fibroblast growth factor 9      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain and kidney 69835