Cst8 (cystatin 8) - Rat Genome Database

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Gene: Cst8 (cystatin 8) Rattus norvegicus
Analyze
Symbol: Cst8
Name: cystatin 8
RGD ID: 2434
Description: Predicted to enable cysteine-type endopeptidase inhibitor activity. Predicted to be active in cell surface; cytoplasm; and extracellular region. Orthologous to human CST8 (cystatin 8); INTERACTS WITH ammonium chloride; bisphenol A; dibutyl phthalate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cystatin 8 (cystatin-related epididymal specific); cystatin 8 (cystatin-related epididymal spermatogenic); cystatin-8; cystatin-related epididymal spermatogenic protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83156,697,776 - 156,704,413 (+)NCBIGRCr8
mRatBN7.23136,244,586 - 136,255,412 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3136,244,636 - 136,251,273 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3140,196,466 - 140,203,102 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03148,780,616 - 148,787,252 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03146,470,265 - 146,476,902 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03143,129,240 - 143,141,000 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3143,129,248 - 143,156,177 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03149,538,085 - 149,544,758 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43137,557,637 - 137,564,274 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13137,463,209 - 137,469,847 (+)NCBI
Celera3135,086,042 - 135,092,679 (+)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IBA,IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
extracellular region  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Structure, alternative splicing and chromosomal localization of the cystatin-related epididymal spermatogenic gene. Cornwall GA, etal., Biochem J 1999 May 15;340 ( Pt 1):85-93.
2. The CRES gene: a unique testis-regulated gene related to the cystatin family is highly restricted in its expression to the proximal region of the mouse epididymis. Cornwall GA, etal., Mol Endocrinol 1992 Oct;6(10):1653-64.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:7619504  


Genomics

Comparative Map Data
Cst8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83156,697,776 - 156,704,413 (+)NCBIGRCr8
mRatBN7.23136,244,586 - 136,255,412 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3136,244,636 - 136,251,273 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3140,196,466 - 140,203,102 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03148,780,616 - 148,787,252 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03146,470,265 - 146,476,902 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03143,129,240 - 143,141,000 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3143,129,248 - 143,156,177 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03149,538,085 - 149,544,758 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43137,557,637 - 137,564,274 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13137,463,209 - 137,469,847 (+)NCBI
Celera3135,086,042 - 135,092,679 (+)NCBICelera
Cytogenetic Map3q41NCBI
CST8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382023,491,117 - 23,507,124 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2023,491,101 - 23,496,010 (+)EnsemblGRCh38hg38GRCh38
GRCh372023,471,754 - 23,476,647 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362023,419,766 - 23,424,660 (+)NCBINCBI36Build 36hg18NCBI36
Build 342023,419,765 - 23,424,655NCBI
Celera2023,545,174 - 23,550,066 (+)NCBICelera
Cytogenetic Map20p11.21NCBI
HuRef2023,433,213 - 23,438,100 (+)NCBIHuRef
CHM1_12023,471,620 - 23,476,507 (+)NCBICHM1_1
T2T-CHM13v2.02023,550,642 - 23,566,685 (+)NCBIT2T-CHM13v2.0
Cst8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392148,640,759 - 148,647,516 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2148,640,705 - 148,647,515 (+)EnsemblGRCm39 Ensembl
GRCm382148,798,839 - 148,805,596 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2148,798,785 - 148,805,595 (+)EnsemblGRCm38mm10GRCm38
MGSCv372148,624,575 - 148,631,320 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362148,490,280 - 148,497,025 (+)NCBIMGSCv36mm8
Celera2150,061,820 - 150,068,609 (+)NCBICelera
Cytogenetic Map2G3NCBI
cM Map273.56NCBI
Cst8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541530,459,008 - 30,466,128 (+)NCBIChiLan1.0ChiLan1.0
LOC100995839
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22124,371,757 - 24,376,320 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12024,368,590 - 24,372,905 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02023,439,644 - 23,444,834 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12023,790,322 - 23,795,242 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2023,790,119 - 23,795,457 (+)Ensemblpanpan1.1panPan2
CST8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.124110,591 - 119,626 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl24110,702 - 119,172 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha24126,471 - 135,500 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.024496,784 - 505,980 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl24496,429 - 505,530 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12499,424 - 108,445 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.024198,712 - 207,736 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.024482,526 - 491,563 (-)NCBIUU_Cfam_GSD_1.0
LOC101963932
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640148,662,168 - 148,669,612 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366202,082,698 - 2,089,062 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366202,082,698 - 2,089,062 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CST8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11730,430,698 - 30,435,612 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21734,519,770 - 34,524,772 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Cst8
73 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:20
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000006667
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 18
Low 1 1 1 7 1
Below cutoff 2 8 1 10 1 3 5 1 2 9 3 3

Sequence


RefSeq Acc Id: ENSRNOT00000006667   ⟹   ENSRNOP00000006667
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3136,244,636 - 136,251,273 (+)Ensembl
Rnor_6.0 Ensembl3143,129,248 - 143,156,177 (+)Ensembl
RefSeq Acc Id: NM_019258   ⟹   NP_062131
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83156,697,776 - 156,704,413 (+)NCBI
mRatBN7.23136,244,636 - 136,251,273 (+)NCBI
Rnor_6.03143,129,281 - 143,135,918 (+)NCBI
Rnor_5.03149,538,085 - 149,544,758 (+)NCBI
RGSC_v3.43137,557,637 - 137,564,274 (+)RGD
Celera3135,086,042 - 135,092,679 (+)RGD
Sequence:
RefSeq Acc Id: XM_063283533   ⟹   XP_063139603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83156,698,886 - 156,704,412 (+)NCBI
RefSeq Acc Id: NP_062131   ⟸   NM_019258
- Peptide Label: precursor
- UniProtKB: O88969 (UniProtKB/Swiss-Prot),   A6K7D3 (UniProtKB/TrEMBL),   A0A0H2UHD7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006667   ⟸   ENSRNOT00000006667
RefSeq Acc Id: XP_063139603   ⟸   XM_063283533
- Peptide Label: isoform X1
Protein Domains
Cystatin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88969-F1-model_v2 AlphaFold O88969 1-142 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692503
Promoter ID:EPDNEW_R3026
Type:multiple initiation site
Name:Cst8_1
Description:cystatin 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03143,129,260 - 143,129,320EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2434 AgrOrtholog
BioCyc Gene G2FUF-47490 BioCyc
Ensembl Genes ENSRNOG00000004989 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055023172 UniProtKB/Swiss-Prot
  ENSRNOG00060002006 UniProtKB/Swiss-Prot
  ENSRNOG00065021795 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006667 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000006667.4 UniProtKB/Swiss-Prot
  ENSRNOT00055039805 UniProtKB/Swiss-Prot
  ENSRNOT00060003136 UniProtKB/Swiss-Prot
  ENSRNOT00065037050 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.450.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystatin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cystatin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29679 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29679 ENTREZGENE
PANTHER CYSTATIN-8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYSTATIN-8-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cystatin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cst8 PhenoGen
RatGTEx ENSRNOG00000004989 RatGTEx
  ENSRNOG00055023172 RatGTEx
  ENSRNOG00060002006 RatGTEx
  ENSRNOG00065021795 RatGTEx
SMART SM00043 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC210848
UniProt A0A0H2UHD7 ENTREZGENE, UniProtKB/TrEMBL
  A6K7D3 ENTREZGENE, UniProtKB/TrEMBL
  A6K7D5_RAT UniProtKB/TrEMBL
  CST8_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Cst8  cystatin 8  Cst8  cystatin 8 (cystatin-related epididymal specific)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Cst8  cystatin 8 (cystatin-related epididymal specific)  Cst8  cystatin 8 (cystatin-related epididymal spermatogenic)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Cst8  cystatin 8 (cystatin-related epididymal spermatogenic)    cystatin 8  Name updated 1299863 APPROVED
2003-04-09 Cst8  cystatin 8    cystatin 8 (cystatin-related epididymal spermatogenic)  Name updated 629478 APPROVED
2002-06-10 Cst8  cystatin 8 (cystatin-related epididymal spermatogenic)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of the cystatin family of cysteine protease inhibitors 727561