Chrm4 (cholinergic receptor, muscarinic 4)

Gene: Chrm4 (cholinergic receptor, muscarinic 4) Rattus norvegicus

Analyze

Symbol:

Chrm4

Name:

cholinergic receptor, muscarinic 4

RGD ID:

2344

Description:

Enables guanyl-nucleotide exchange factor activity. Involved in response to organic substance. Located in asymmetric synapse; axon terminus; and neuronal cell body. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic membrane. Colocalizes with sarcolemma. Biomarker of congestive heart failure. Orthologous to human CHRM4 (cholinergic receptor muscarinic 4); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family; G protein mediated signaling pathway via Galphai family; INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

cholinergic receptor, muscarin 4; M4; muscarinic acetylcholine receptor M4

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CHRM4 (cholinergic receptor muscarinic 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Chrm4 (cholinergic receptor, muscarinic 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Chrm4 (cholinergic receptor muscarinic 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CHRM4 (cholinergic receptor muscarinic 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CHRM4 (cholinergic receptor muscarinic 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Chrm4 (cholinergic receptor muscarinic 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CHRM4 (cholinergic receptor muscarinic 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CHRM4 (cholinergic receptor muscarinic 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Chrm4 (cholinergic receptor muscarinic 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PRR16 (proline rich 16)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Chrm4 (cholinergic receptor, muscarinic 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CHRM4 (cholinergic receptor muscarinic 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	chrm4a (cholinergic receptor, muscarinic 4a)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gar-3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	mAChR-A	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	98,349,080 - 98,356,821 (+)	NCBI		GRCr8
mRatBN7.2	3	77,893,425 - 77,901,166 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	77,893,425 - 77,901,159 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	81,368,613 - 81,376,348 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	89,967,641 - 89,975,378 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	87,818,870 - 87,826,600 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	80,833,272 - 80,841,165 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	80,833,272 - 80,841,006 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	87,531,619 - 87,539,681 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	76,301,988 - 76,309,729 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	76,203,520 - 76,206,094 (+)	NCBI
Celera	3	77,096,073 - 77,103,815 (+)	NCBI		Celera
Cytogenetic Map	3	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Catatonia (ISO)

congenital disorder of glycosylation type IIc (ISO)

congestive heart failure (IEP)

Developmental Disabilities (ISO)

genetic disease (ISO)

intellectual disability (ISO)

Tremor (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-pilocarpine (EXP,ISO)

(+)-trans-(S)-allethrin (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

3,4-methylenedioxymethamphetamine (ISO)

acetylcholine (ISO)

aflatoxin B1 (ISO)

alcuronium (ISO)

ammonium chloride (EXP)

arsenite(3-) (ISO)

atropine (ISO)

benzo[a]pyrene (ISO)

bethanechol (ISO)

bisphenol A (EXP,ISO)

brucine (ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

carbachol (ISO)

carmustine (ISO)

CGP 52608 (ISO)

chlorohydrocarbon (EXP)

chlorpyrifos (EXP)

cisplatin (ISO)

cocaine (EXP)

Cuprizon (EXP)

DDT (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

diazinon (EXP)

dieldrin (EXP)

Eburnamonine (ISO)

ethanol (ISO)

folic acid (ISO)

furtrethonium (ISO)

haloperidol (ISO)

Licochalcone B (ISO)

lipopolysaccharide (ISO)

methoctramine tetrahydrochloride (ISO)

methscopolamine (ISO)

mevinphos (EXP)

N-acetyl-L-cysteine (ISO)

nickel atom (EXP,ISO)

oxotremorine M (ISO)

pancuronium (ISO)

paracetamol (EXP)

parathion-methyl (EXP)

Pipecuronium (ISO)

quercetin (EXP)

resveratrol (ISO)

risperidone (ISO)

rocuronium (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

scopolamine (ISO)

silicon dioxide (EXP)

sotorasib (ISO)

strychnine (ISO)

sunitinib (ISO)

tetrachloromethane (ISO)

tiotropium bromide (ISO)

titanium dioxide (ISO)

trametinib (ISO)

trichlorfon (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

triptonide (ISO)

tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate (ISO)

Tropicamide (ISO)

valproic acid (ISO)

vecuronium bromide (ISO)

wogonin (ISO)

xanomeline (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway (IBA,IEA,ISO)

chemical synaptic transmission (IBA)

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (IBA,IEA)

G protein-coupled serotonin receptor signaling pathway (IEA)

regulation of locomotion (IEA)

Cellular Component

asymmetric synapse (IDA)

axon terminus (IDA)

dendrite (IBA,IEA)

glutamatergic synapse (IDA)

membrane (ISO)

neuronal cell body (IDA)

plasma membrane (IBA)

postsynaptic density membrane (IDA)

postsynaptic membrane (IEA)

presynaptic membrane (IDA)

sarcolemma (IDA)

synapse (IBA)

Molecular Function

G protein-coupled acetylcholine receptor activity (IBA,IEA,ISO,TAS)

G protein-coupled serotonin receptor activity (IBA,IEA)

guanyl-nucleotide exchange factor activity (IDA)

protein binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family (ISO)

G protein mediated signaling pathway via Galphai family (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Regulation of neuronal type genes in congestive heart failure rats.	Andersson KB, etal., Acta Physiol (Oxf). 2006 Jan;186(1):17-27.
2.	Identification of a family of muscarinic acetylcholine receptor genes.	Bonner TI, etal., Science 1987 Jul 31;237(4814):527-32.
3.	Neuronal damage and changes in the expression of muscarinic acetylcholine receptor subtypes in the neonatal rat cerebral cortical upon exposure to sparteine, a quinolizidine alkaloid.	Flores-Soto ME, etal., Int J Dev Neurosci. 2006 Oct;24(6):401-10. Epub 2006 Jul 14.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	CaMKIIalpha interacts with M4 muscarinic receptors to control receptor and psychomotor function.	Guo ML, etal., EMBO J. 2010 Jun 16;29(12):2070-81. doi: 10.1038/emboj.2010.93. Epub 2010 May 11.
7.	G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes.	Head BP, etal., J Biol Chem. 2005 Sep 2;280(35):31036-44. Epub 2005 Jun 16.
8.	Distribution of m1-m4 muscarinic receptor proteins in the rat striatum: light and electron microscopic immunocytochemistry using subtype-specific antibodies.	Hersch SM, etal., J Neurosci. 1994 May;14(5 Pt 2):3351-63.
9.	Novel interaction between the M4 muscarinic acetylcholine receptor and elongation factor 1A2.	McClatchy DB, etal., J Biol Chem 2002 Aug 9;277(32):29268-74.
10.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
11.	Loss of muscarinic M4 receptors in spinal cord of arthritic rats: implications for a role of M4 receptors in pain response.	Mulugeta E, etal., Brain Res 2003 Aug 29;982(2):284-7.
12.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
13.	GOA pipeline	RGD automated data pipeline
14.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution.	Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
17.	Muscarinic signaling in the brain.	Thiele A Annu Rev Neurosci. 2013 Jul 8;36:271-94. doi: 10.1146/annurev-neuro-062012-170433.

Additional References at PubMed

PMID:7916637	PMID:8617799	PMID:12433399	PMID:15200951	PMID:15326124	PMID:15927789	PMID:15951192	PMID:15979279	PMID:16758365	PMID:17709264	PMID:17845913	PMID:18816796
PMID:19070673	PMID:20551968	PMID:21883220	PMID:21913336	PMID:22803069	PMID:29577888	PMID:31325565	PMID:32798726

Genomics

Comparative Map Data

Chrm4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	98,349,080 - 98,356,821 (+)	NCBI		GRCr8
mRatBN7.2	3	77,893,425 - 77,901,166 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	77,893,425 - 77,901,159 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	81,368,613 - 81,376,348 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	89,967,641 - 89,975,378 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	87,818,870 - 87,826,600 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	80,833,272 - 80,841,165 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	80,833,272 - 80,841,006 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	87,531,619 - 87,539,681 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	76,301,988 - 76,309,729 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	76,203,520 - 76,206,094 (+)	NCBI
Celera	3	77,096,073 - 77,103,815 (+)	NCBI		Celera
Cytogenetic Map	3	q24	NCBI

CHRM4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	46,383,789 - 46,391,776 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	46,383,789 - 46,391,776 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	46,405,339 - 46,413,326 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	46,363,216 - 46,364,683 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	46,363,215 - 46,364,683	NCBI
Celera	11	46,554,217 - 46,555,684 (-)	NCBI		Celera
Cytogenetic Map	11	p11.2	NCBI
HuRef	11	46,113,598 - 46,115,064 (-)	NCBI		HuRef
CHM1_1	11	46,405,093 - 46,406,560 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	46,539,864 - 46,547,851 (-)	NCBI		T2T-CHM13v2.0

Chrm4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	91,752,531 - 91,760,180 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	91,757,594 - 91,759,033 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	91,922,189 - 91,929,835 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	91,927,249 - 91,928,688 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	91,762,346 - 91,769,986 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	91,728,088 - 91,729,527 (+)	NCBI		MGSCv36	mm8
Celera	2	93,312,590 - 93,320,231 (+)	NCBI		Celera
Cytogenetic Map	2	E1	NCBI
cM Map	2	50.63	NCBI

Chrm4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	1,647,663 - 1,655,363 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	1,647,663 - 1,655,363 (+)	NCBI	ChiLan1.0	ChiLan1.0

CHRM4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	48,596,916 - 48,606,737 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	48,603,743 - 48,611,729 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	46,342,384 - 46,350,366 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	46,893,292 - 46,901,074 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	46,894,615 - 46,896,054 (-)	Ensembl	panpan1.1		panPan2

CHRM4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	43,077,115 - 43,084,298 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	43,082,404 - 43,083,840 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	41,805,766 - 41,813,475 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	43,733,324 - 43,740,846 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	43,733,289 - 43,741,042 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	43,218,330 - 43,226,035 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	42,770,212 - 42,777,904 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	43,503,419 - 43,510,935 (+)	NCBI		UU_Cfam_GSD_1.0

Chrm4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	20,567,540 - 20,576,257 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936562	2,493,774 - 2,689,731 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936562	2,685,209 - 2,687,751 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CHRM4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	16,122,704 - 16,130,810 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	16,119,794 - 16,131,080 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	17,468,644 - 17,476,868 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CHRM4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	18,937,455 - 18,945,390 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	18,942,643 - 18,944,079 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	116,222,834 - 116,230,831 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Chrm4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	2,162,712 - 2,171,012 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624767	2,162,719 - 2,170,921 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Chrm4
26 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	156
Count of miRNA genes:	111
Interacting mature miRNAs:	142
Transcripts:	ENSRNOT00000023583
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	10861912	89878372	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
61419	Cia11	Collagen induced arthritis QTL 11	5.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	3	30356773	98535386	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
1354589	Bw31	Body weight QTL 31	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	78196190	Rat
1354604	Bw36	Body weight QTL 36	2.9		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	104104347	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
738019	Anxrr10	Anxiety related response QTL 10	3.9		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	3	38517803	83517803	Rat
1331777	Bw24	Body weight QTL 24	3.503		body mass (VT:0001259)	body weight (CMO:0000012)	3	39454637	89115240	Rat
1331795	Rf30	Renal function QTL 30	3.708		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	3	39454637	89115240	Rat
1354597	Kidm13	Kidney mass QTL 13	2.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	3	41874578	104104347	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1300178	Hrtrt4	Heart rate QTL 4	3.74		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	43827364	90905114	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	50437504	115638231	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	115665732	Rat
61377	Edpm3	Estrogen-dependent pituitary mass QTL 3	7.05	0.038	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	53184692	89878207	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	53781112	91609953	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	3	53781112	91609953	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	53781112	91609953	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	61017749	121056321	Rat
631200	Cm25	Cardiac mass QTL 25	4.8	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	3	61134348	89115068	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	64655305	115665732	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	64655305	115665732	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	70348525	121056321	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	70653097	121056321	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	73376539	118376539	Rat

Markers in Region

RH134207

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	77,900,850 - 77,901,058 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	80,840,698 - 80,840,905	NCBI	Rnor6.0
Rnor_5.0	3	87,539,366 - 87,539,573	UniSTS	Rnor5.0
RGSC_v3.4	3	76,309,414 - 76,309,621	UniSTS	RGSC3.4
Celera	3	77,103,500 - 77,103,707	UniSTS
Cytogenetic Map	3	q32-q35	UniSTS

UniSTS:481077

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	77,898,580 - 77,900,017 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	80,838,428 - 80,839,864	NCBI	Rnor6.0
Rnor_5.0	3	87,537,096 - 87,538,532	UniSTS	Rnor5.0
RGSC_v3.4	3	76,307,144 - 76,308,580	UniSTS	RGSC3.4
Celera	3	77,101,230 - 77,102,666	UniSTS
Cytogenetic Map	3	q32-q35	UniSTS

UniSTS:492564

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	77,898,549 - 77,900,106 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	80,838,397 - 80,839,953	NCBI	Rnor6.0
Rnor_5.0	3	87,537,065 - 87,538,621	UniSTS	Rnor5.0
RGSC_v3.4	3	76,307,113 - 76,308,669	UniSTS	RGSC3.4
Celera	3	77,101,199 - 77,102,755	UniSTS
Cytogenetic Map	3	q32-q35	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									13
Low	2								53		14
Below cutoff	1	16	18	4	16	4	2	3	8	2	26	11	2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031547	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR472483	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D78484	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D78485	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DV213670	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M16409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000023583 ⟹ ENSRNOP00000023586

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	77,893,425 - 77,901,159 (+)	Ensembl
Rnor_6.0 Ensembl	3	80,833,272 - 80,841,006 (+)	Ensembl

RefSeq Acc Id:

NM_031547 ⟹ NP_113735

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	98,349,080 - 98,356,821 (+)	NCBI
mRatBN7.2	3	77,893,425 - 77,901,166 (+)	NCBI
Rnor_6.0	3	80,833,272 - 80,841,013 (+)	NCBI
Rnor_5.0	3	87,531,619 - 87,539,681 (+)	NCBI
RGSC_v3.4	3	76,301,988 - 76,309,729 (+)	RGD
Celera	3	77,096,073 - 77,103,815 (+)	RGD

Sequence:

show sequence

CTGCAGGCGAAGCAGGGGCCGCCCCTTGGCACCCTGTCCCCGCCCCCGGCCCCCGGCCCAGTCG
CCCACCCCACCGACTCGCGGAACCTCTGGCTTGTTCCGCCGTCTGTCCGGCACCAGCAGAGAAA
GACAGAAGCAGCGGCCACTGCCCACCTGTATCCAGTTGGGTTCAGCATGGCCAACTTCACGCCT
GTCAATGGCAGCTCAGCCAATCAGTCTGTGCGCCTGGTCACAGCAGCCCACAACCACCTGGAGA
CAGTGGAGATGGTGTTCATTGCTACAGTGACTGGCTCCCTGAGCCTGGTGACTGTTGTGGGTAA
CATCCTGGTGATGCTGTCCATCAAGGTCAACAGGCAGTTGCAGACGGTCAACAACTACTTCCTC
TTCAGCCTGGCGTGTGCGGATCTCATCATAGGGGCATTCTCTATGAACCTCTACACTTTGTATA
TCATCAAGGGCTACTGGCCCCTGGGTGCCGTGGTCTGTGACTTGTGGCTGGCCCTGGACTATGT
GGTGAGCAATGCCTCTGTCATGAACCTTCTTATCATCAGCTTCGATCGTTACTTCTGCGTCACC
AAACCCCTCACCTATCCCGCCCGCCGCACTACTAAGATGGCAGGTCTCATGATCGCAGCTGCCT
GGGTCTTGTCCTTTGTGCTCTGGGCTCCTGCCATCTTGTTCTGGCAGTTTGTGGTGGGCAAGAG
GACGGTGCCTGATAACCAGTGCTTCATCCAGTTCTTGTCCAACCCGGCAGTGACCTTTGGCACC
GCCATTGCTGCCTTCTACCTGCCTGTGGTCATCATGACGGTACTGTATATTCACATCTCACTGG
CCAGCCGCAGCCGCGTTCACAAGCATCGACCTGAGGGCCCCAAGGAGAAGAAGGCCAAGACTCT
GGCTTTCCTCAAGAGCCCTCTGATGAAGCCGAGTATCAAGAAACCTCCACCAGGGGGCGCTTCT
CGAGAGGAACTGCGCAATGGGAAGCTGGAAGAGGCTCCTCCGCCAGCCCTGCCCCCGCCTCCAC
GCCCAGTGCCTGACAAGGACACTTCCAATGAGTCCAGCTCAGGCAGTGCCACCCAGAACACCAA
GGAACGGCCACCCACAGAGCTGTCCACCGCAGAGGCCACCACTCCAGCGCTGCCTGCCCCTACC
CTGCAGCCACGAACCCTCAACCCAGCCTCCAAATGGTCCAAGATTCAAATTGTAACAAAGCAGA
CAGGCAATGAATGTGTGACGGCCATCGAGATTGTACCTGCCACTCCAGCTGGTATGCGCCCAGC
AGCCAATGTGGCCCGAAAGTTTGCCAGCATTGCTCGCAACCAGGTGCGCAAGAAGCGGCAGATG
GCGGCCCGGGAGCGCAAAGTGACTCGGACAATCTTTGCCATTCTGCTGGCCTTCATCCTCACCT
GGACACCCTACAATGTCATGGTCCTGGTGAACACCTTTTGCCAGAGCTGTATCCCCGAGAGGGT
GTGGTCCATCGGCTACTGGCTCTGCTACGTCAACAGCACCATCAACCCCGCCTGCTATGCACTC
TGCAATGCCACTTTCAAAAAGACCTTCCGGCACCTTTTGCTGTGCCAGTATCGGAACATCGGCA
CAGCCAGGTAGACAGGCAGGTGCCCTAGGAGGTGCTGGTGTCATGAGTGTGTACCGGGGAACCA
CATGGCTCACCGGCTGTGGAGGAGAGAGTAGGCGGCCCCACTCTGAGTTCGCATCTGCTGAAGA
GAACAGGTCTCCCAGACACCGTGAGGTACCAGAGGCCCTTCGCTAGGATGGGAGAGATCTCTAC
TGAAGCCTAGAAGGCTCAGCCCAGGGAGGGTCTGAACTGTCACCACCCGGCCCACATCTGTTAC
CTTGCCTCAGGAAGATGGGGGACAATGGCTGGAGTGGGCAGTGGCTCTACAAAGGCCAACCATC
GGCCGAAGTGCATAGAGCCGAGCCCAGGAGCATCTCGGGAGGAGCAAAAGGAGCCAGGCTTGCA
AGGGCGGGGTCCCCCATGCGCTGTAATCGGTGCTTTCCGCCTTCCTGCACCCTCCTCCCCCTGC
ATGTAGGCTCAGCCCTTCCCCTGACCCCAAGTCCCACTCCAGGGTGAGAGAGTGCCCTGCTAAT
GTTGCTCAGCCAGGCTCTGGGTGGGAAACCAAGACCTTTGGCACTCCCCTGGCCAGCAGTCATA
TCTGGATGGGGCAACTGGGAAATCATGCTAAGCTGAGACAGATTCCAGGGCACTGAGTCAATTA
GTGCTGGATCATATGGTCAAACTGTCAAGAGCCCACCCCCACCCCCAGGTCACACATCAAATGA
GTGGCAGCAGCGTTCCTCTCTCCTCTACAAGGAGGGAGGTGTGGATCCAAGGGAGGAAAGGTGG
TGGTAGGGACCTTGGTGATCTATACAGGCCTCAGTGACAGGTGACACAAGCAAGCACCCTCATT
AGTCCCCAAGGAGAGCATTCCAGACTGGCAGTAGCCTGGACCAGAAAGACTCTTGACTAGGTGA
GGCAGAGTTCAAATGAGTCACCTGGGTTCTCTTCCCTAACCCCAGCCCTGTGGGTCCCTGGGAG
AGATAACACCCAAGGGGCCCTGGAAGACATTTTTGTAAATGTTCTGCTCTTTCCACTAATTGTT
GGGAGCACTTCTTACGTAGCCCTCCGCTCCCCTCAGTACATCTTTCCCCATCCTCCCACCCCCA
ACAAAGCTCCCTGGCAAACTCCCTGGGAAGGGGCTTTTATATATTAAAAAAGAGGCTTTTATTG
GAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_113735	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA40663	(Get FASTA)	NCBI Sequence Viewer
	EDL79547	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000023586
	ENSRNOP00000023586.4
GenBank Protein	P08485	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_113735 ⟸ NM_031547

- UniProtKB:

P08485 (UniProtKB/Swiss-Prot), G3V894 (UniProtKB/TrEMBL), A6HNE6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MANFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQT
VNNYFLFSLACADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNP
AVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKP
PPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTP
ALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQV
RKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTIN
PACYALCNATFKKTFRHLLLCQYRNIGTAR

hide sequence

RefSeq Acc Id:

ENSRNOP00000023586 ⟸ ENSRNOT00000023583

Protein Domains

G-protein coupled receptors family 1 profile

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2344	AgrOrtholog
BioCyc Gene	G2FUF-48718	BioCyc
Ensembl Genes	ENSRNOG00000017556	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000023583	ENTREZGENE
	ENSRNOT00000023583.6	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Musac_Ach_M4_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Musac_Ach_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25111	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	25111	ENTREZGENE
PANTHER	5-HYDROXYTRYPTAMINE RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MUSCARINIC ACETYLCHOLINE RECEPTOR M4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	CHRM4	RGD
PhenoGen	Chrm4	PhenoGen
PRINTS	GPCRRHODOPSN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MUSCARINICR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MUSCRINICM4R	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000017556	RatGTEx
SMART	7TM_GPCR_Srsx	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6HNE6	ENTREZGENE, UniProtKB/TrEMBL
	ACM4_RAT	UniProtKB/Swiss-Prot
	G3V894	ENTREZGENE, UniProtKB/TrEMBL
	P08485	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Chrm4	cholinergic receptor, muscarinic 4		cholinergic receptor, muscarin 4	Name updated	1299863	APPROVED
2002-06-10	Chrm4	cholinergic receptor, muscarin 4			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	colocalized in the soma and neuropil	625569
gene_domains	the m4i3 loop acts as a guanine exchange factor for eEF1A2 (essential GTP-binding protein)	625569
gene_expression	predominant in the central nervous system, also found in exocrine glands and smooth muscle	61489
gene_expression	expressed in the rat striatum	625569
gene_function	G-protein coupled receptor	625569
gene_process	mediates effects of acetylcholine in the central and peripheral nervous system	625569
gene_process	inhibits adenylate cyclase	61489
gene_process	breaks down phosphoinositides & modulates potassium channels	61489
gene_process	may be involved in cholinergic mechanisms of pain relieg	1298759
gene_product	member of the GPCR (G-protein-coupled-receptor) family	625569

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

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RGD Manual Annotations