Insyn2b (inhibitory synaptic factor family member 2B) - Rat Genome Database

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Gene: Insyn2b (inhibitory synaptic factor family member 2B) Rattus norvegicus
Analyze
Symbol: Insyn2b
Name: inhibitory synaptic factor family member 2B
RGD ID: 2320105
Description: Orthologous to human INSYN2B (inhibitory synaptic factor family member 2B); INTERACTS WITH bisphenol A; lidocaine; 1,2-dichloroethane (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: AABR07029269.1; Fam196b; family with sequence similarity 196, member B; hypothetical protein LOC100361460; LOC100361460
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81019,420,561 - 19,528,006 (+)NCBIGRCr8
mRatBN7.21018,916,721 - 19,023,859 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1019,003,131 - 19,022,139 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01019,270,956 - 19,392,214 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1019,366,793 - 19,368,532 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01019,149,321 - 19,265,167 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41019,383,104 - 19,401,226 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1018,549,000 - 18,660,453 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Insyn2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81019,420,561 - 19,528,006 (+)NCBIGRCr8
mRatBN7.21018,916,721 - 19,023,859 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1019,003,131 - 19,022,139 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01019,270,956 - 19,392,214 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1019,366,793 - 19,368,532 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01019,149,321 - 19,265,167 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41019,383,104 - 19,401,226 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1018,549,000 - 18,660,453 (+)NCBICelera
Cytogenetic Map10q12NCBI
INSYN2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385169,861,303 - 169,980,495 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5169,861,303 - 169,980,495 (-)EnsemblGRCh38hg38GRCh38
GRCh375169,288,307 - 169,407,499 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365169,223,297 - 169,340,322 (-)NCBINCBI36Build 36hg18NCBI36
Celera5165,322,310 - 165,439,373 (-)NCBICelera
Cytogenetic Map5q35.1NCBI
HuRef5164,388,897 - 164,505,800 (-)NCBIHuRef
CHM1_15168,723,110 - 168,840,179 (-)NCBICHM1_1
T2T-CHM13v2.05170,396,711 - 170,518,930 (-)NCBIT2T-CHM13v2.0
Insyn2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391134,264,822 - 34,372,642 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1134,264,758 - 34,372,640 (+)EnsemblGRCm39 Ensembl
GRCm381134,314,822 - 34,422,642 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1134,314,758 - 34,422,640 (+)EnsemblGRCm38mm10GRCm38
MGSCv371134,214,822 - 34,322,640 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361134,214,822 - 34,322,640 (+)NCBIMGSCv36mm8
Celera1136,726,207 - 36,834,375 (+)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1119.72NCBI
Insyn2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540822,841,584 - 22,863,256 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540822,842,645 - 22,864,156 (-)NCBIChiLan1.0ChiLan1.0
INSYN2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24165,024,830 - 165,143,499 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15163,164,374 - 163,283,055 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05165,227,463 - 165,346,288 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15171,987,796 - 172,105,936 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5171,988,980 - 172,009,754 (-)Ensemblpanpan1.1panPan2
INSYN2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1441,871,751 - 41,987,310 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl441,964,892 - 42,024,748 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha441,824,091 - 41,939,533 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0442,248,028 - 42,399,305 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl442,248,073 - 42,442,172 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1442,065,489 - 42,180,888 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0442,251,962 - 42,367,449 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0442,762,931 - 42,878,508 (+)NCBIUU_Cfam_GSD_1.0
Insyn2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721396,079,657 - 96,189,263 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366094,890,470 - 4,911,947 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366094,802,587 - 4,911,945 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INSYN2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1653,941,568 - 54,057,671 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11653,939,487 - 54,057,671 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21658,457,046 - 58,507,714 (+)NCBISscrofa10.2Sscrofa10.2susScr3
INSYN2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12372,078,442 - 72,197,715 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2372,080,294 - 72,100,012 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660346,464,019 - 6,584,554 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Insyn2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473320,076,826 - 20,100,153 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473319,982,815 - 20,099,782 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Insyn2b
686 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
737823Alc12Alcohol consumption QTL 124.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)101724551319388279Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000050610   ⟹   ENSRNOP00000049022
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1019,003,131 - 19,022,139 (+)Ensembl
RefSeq Acc Id: XM_008767623   ⟹   XP_008765845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81019,420,561 - 19,528,006 (+)NCBI
mRatBN7.21018,916,721 - 19,023,859 (+)NCBI
Rnor_6.01019,270,956 - 19,392,214 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039087144   ⟹   XP_038943072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81019,498,707 - 19,528,006 (+)NCBI
mRatBN7.21019,000,315 - 19,023,859 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008765845 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943072 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000049022
  ENSRNOP00000049022.3
Reference Protein Sequences
RefSeq Acc Id: XP_008765845   ⟸   XM_008767623
- UniProtKB: D3ZZH5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038943072   ⟸   XM_039087144
- UniProtKB: D3ZZH5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000049022   ⟸   ENSRNOT00000050610

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZZH5-F1-model_v2 AlphaFold D3ZZH5 1-447 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2320105 AgrOrtholog
BioCyc Gene G2FUF-25586 BioCyc
Ensembl Genes ENSRNOG00000032329 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050610.3 UniProtKB/TrEMBL
InterPro INSYN2 UniProtKB/TrEMBL
KEGG Report rno:100361460 UniProtKB/TrEMBL
NCBI Gene 100361460 ENTREZGENE
PANTHER PROTEIN INSYN2B UniProtKB/TrEMBL
  PTHR28682 UniProtKB/TrEMBL
Pfam FAM196 UniProtKB/TrEMBL
PhenoGen Insyn2b PhenoGen
RatGTEx ENSRNOG00000032329 RatGTEx
UniProt D3ZZH5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Insyn2b  inhibitory synaptic factor family member 2B  AABR07029269.1    Data merged from RGD:15003947 737654 PROVISIONAL
2019-11-08 AABR07029269.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2018-06-21 Insyn2b  inhibitory synaptic factor family member 2B  Fam196b  family with sequence similarity 196, member B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-08-13 Fam196b  family with sequence similarity 196, member B  LOC100361460  hypothetical protein LOC100361460  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100361460  hypothetical protein LOC100361460      Symbol and Name status set to provisional 70820 PROVISIONAL