Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | CCKAR (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | |
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Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | CCKAR (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | |
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# | Reference Title | Reference Citation |
1. | Cholecystokinin-A receptors are involved in food intake suppression in rats after intake of all fats and carbohydrates tested. | Bellissimo N and Anderson GH, J Nutr. 2003 Jul;133(7):2319-25. |
2. | Response to acute food deprivation in OLETF rats lacking CCK-A receptors. | Bi S and Moran TH, Physiol Behav. 2003 Sep;79(4-5):655-61. |
3. | Ontogeny and species differences in the pancreatic expression and localization of the CCK(A) receptors. | Bourassa J, etal., Biochem Biophys Res Commun. 1999 Jul 14;260(3):820-8. |
4. | Decreased gastric mechanodetection, but preserved gastric emptying, in CCK-1 receptor-deficient OLETF rats. | De Jonghe BC, etal., Am J Physiol Gastrointest Liver Physiol. 2006 Oct;291(4):G640-9. Epub 2006 May 25. |
5. | Correlation between gene expression of CCK-A receptor and emptying dysfunction of the gallbladder in patients with gallstones and diabetes mellitus. | Ding X, etal., Hepatobiliary Pancreat Dis Int. 2005 May;4(2):295-8. |
6. | Control of somatostatin (SS) secretion by CCK-1 and CCK-2 receptors' occupation in RIN-14B cells, a rat pancreatic islet cell line. | El-Kouhen K and Morisset J, Pancreas. 2010 Mar;39(2):127-34. |
7. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
8. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
9. | Haemodynamic and exocrine effects of caerulein at submaximal and supramaximal levels on the rat pancreas: role of cholecystokinin receptor subtypes. | Griesbacher T, etal., Pancreatology. 2006;6(1-2):65-75; discussion 75-6. Epub 2005 Dec 2. |
10. | Transient agonist-induced regulation of the cholecystokinin-A and cholecystokinin-B receptor mRNA levels in rat pancreatic acinar AR42J cells. | Gunther R, etal., Pancreatology. 2003;3(1):47-54. |
11. | Altered taste sensitivity in obese, prediabetic OLETF rats lacking CCK-1 receptors. | Hajnal A, etal., Am J Physiol Regul Integr Comp Physiol. 2005 Dec;289(6):R1675-86. Epub 2005 Aug 4. |
12. | Effects of cholecystokinin (CCK)-8 on hypothalamic oxytocin-secreting neurons in rats lacking CCK-A receptor. | Hashimoto H, etal., Auton Neurosci. 2005 Aug 31;121(1-2):16-25. |
13. | Role of cholecystokinin-A and cholecystokinin-B receptors in anxiety. | Hernandez-Gomez AM, etal., Amino Acids 2002;23(1-3):283-90. |
14. | Expression and physiological actions of cholecystokinin in rat taste receptor cells. | Herness S, etal., J Neurosci. 2002 Nov 15;22(22):10018-29. |
15. | CCK-A receptors in the rat interpeduncular nucleus: evidence for a presynaptic location. | Hill DR, etal., Brain Res. 1988 Jun 28;454(1-2):101-5. |
16. | Human cholecystokinin type A receptor gene: cytogenetic localization, physical mapping, and identification of two missense variants in patients with obesity and non-insulin-dependent diabetes mellitus (NIDDM). | Inoue H, etal., Genomics 1997 Jun 1;42(2):331-5. |
17. | Exposition of newborn rats to bacterial endotoxin impairs pancreatic enzyme secretion at adult age. | Jaworek J, etal., J Physiol Pharmacol. 2007 Jun;58(2):287-302. |
18. | Low-affinity CCK-1 receptors inhibit bombesin-stimulated secretion in rat pancreatic acini--implication of the actin cytoskeleton. | Kiehne K, etal., Regul Pept. 2002 May 15;105(2):131-7. |
19. | The difference in mRNA expressions of hypothalamic CCK and CCK-A and -B receptors between responder and non-responder rats to high frequency electroacupuncture analgesia. | Ko ES, etal., Peptides. 2006 Jul;27(7):1841-5. Epub 2006 Feb 10. |
20. | High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. | Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7 |
21. | Adaptation to low-protein diet increases inhibition of gastric emptying by CCK. | Leray V, etal., Peptides. 2003 Dec;24(12):1929-34. |
22. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
23. | Disturbance of response to acute thermal pain in naturally occurring cholecystokinin-a receptor gene knockout Otsuka Long-Evans Tokushima Fatty (OLETF) rats. | Miyasaka K, etal., J Pharmacol Sci. 2006 Aug;101(4):280-5. Epub 2006 Aug 5. |
24. | Cholecystokinin-A receptor messenger RNA expression in human pancreatic cancer. | Moonka R, etal., J Gastrointest Surg. 1999 Mar-Apr;3(2):134-40. |
25. | Hyperphagia and obesity in OLETF rats lacking CCK-1 receptors. | Moran TH and Bi S, Philos Trans R Soc Lond B Biol Sci. 2006 Jul 29;361(1471):1211-8. |
26. | Disordered food intake and obesity in rats lacking cholecystokinin A receptors. | Moran TH, etal., Am J Physiol. 1998 Mar;274(3 Pt 2):R618-25. |
27. | Defects of cholecystokinin (CCK)-A receptor gene expression and CCK-A receptor-mediated biological functions in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. | Nakamura H, etal., J Gastroenterol. 1998 Oct;33(5):702-9. |
28. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
29. | Absence of the cholecystokinin-A receptor deteriorates homeostasis of body temperature in response to changes in ambient temperature. | Nomoto S, etal., Am J Physiol Regul Integr Comp Physiol. 2004 Sep;287(3):R556-61. Epub 2004 Jun 3. |
30. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
31. | Effects of peripheral CCK receptor blockade on feeding responses to duodenal nutrient infusions in rats. | Reidelberger RD, etal., Am J Physiol Regul Integr Comp Physiol 2003 Feb;284(2):R389-98. |
32. | Effects of peripheral CCK receptor blockade on gastric emptying in rats. | Reidelberger RD, etal., Am J Physiol Regul Integr Comp Physiol 2003 Jan;284(1):R66-75. |
33. | Distribution of CCK1 and CCK2 receptors in normal and diseased human pancreatic tissue. | Reubi JC, etal., Gastroenterology. 2003 Jul;125(1):98-106. |
34. | GOA pipeline | RGD automated data pipeline |
35. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
36. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
37. | Transient stabilization of cholecystokinin A receptor mRNA by glucocorticoids in pancreatic AR42J cells. | Rosewicz S, etal., Am J Physiol. 1994 Nov;267(5 Pt 1):G772-7. |
38. | Functional expression of cholecystokinin-A receptor on ventromedial hypothalamic neurons in the immature rat brain. | Sorimachi M, etal., Neurosci Lett. 2001 Mar 9;300(2):91-4. |
39. | Expression of cholecystokinin A receptors in neurons innervating the rat stomach and intestine. | Sternini C, etal., Gastroenterology. 1999 Nov;117(5):1136-46. |
40. | Disrupted cholecystokinin type-A receptor (CCKAR) gene in OLETF rats. | Takiguchi S, etal., Gene 1997 Sep 15;197(1-2):169-75. |
41. | Cholecystokinin-stimulated tyrosine phosphorylation of PKC-delta in pancreatic acinar cells is regulated bidirectionally by PKC activation. | Tapia JA, etal., Biochim Biophys Acta 2002 Dec 16;1593(1):99-113. |
42. | Visualization of G protein-coupled receptor trafficking with the aid of the green fluorescent protein. Endocytosis and recycling of cholecystokinin receptor type A. | Tarasova NI, etal., J Biol Chem. 1997 Jun 6;272(23):14817-24. |
43. | Cholecystokinin, cholecystokinin-A receptor and cholecystokinin-B receptor gene polymorphisms in Parkinson's disease. | Wang J, etal., Pharmacogenetics. 2003 Jun;13(6):365-9. |
44. | Brain and gastrointestinal cholecystokinin receptor family: structure and functional expression. | Wank SA, etal., Proc Natl Acad Sci U S A 1992 Sep 15;89(18):8691-5. |
45. | The CCK-A receptor gene possibly associated with auditory hallucinations in schizophrenia. | Wei J and Hemmings GP, Eur Psychiatry 1999 Apr;14(2):67-70. |
46. | Cholecystokinin A and B receptors are differentially expressed in normal pancreas and pancreatic adenocarcinoma. | Weinberg DS, etal., J Clin Invest. 1997 Aug 1;100(3):597-603. |
47. | Effects of cholecystokinin-58 on type 1 cholecystokinin receptor function and regulation. | Wu SV, etal., Am J Physiol Gastrointest Liver Physiol. 2008 Sep;295(3):G641-7. |
48. | Regulative effects of ovarian steroids on rat gastric motility and sensitivity. | Yang X, etal., Sheng Li Xue Bao. 2006 Jun 25;58(3):275-80. |
49. | Overexpression of messenger RNA for cholecystokinin-A receptor and novel expression of messenger RNA for gastrin (cholecystokinin-B) receptor in azaserine-induced rat pancreatic carcinoma. | Zhou W, etal., Carcinogenesis. 1993 Oct;14(10):2189-92. |
PMID:1313582 | PMID:7654260 | PMID:8024583 | PMID:8503909 | PMID:12016125 | PMID:12457239 | PMID:12562931 | PMID:12651850 | PMID:12800239 | PMID:12855414 | PMID:12916469 | PMID:12932815 |
PMID:14607104 | PMID:14698681 | PMID:14700745 | PMID:14988658 | PMID:15117731 | PMID:15123537 | PMID:15152034 | PMID:15358606 | PMID:16099824 | PMID:16112401 | PMID:16289472 | PMID:16491099 |
PMID:16556659 | PMID:17505309 | PMID:19026634 | PMID:19111529 | PMID:19533109 | PMID:19887078 | PMID:19940076 | PMID:20001102 | PMID:20347877 | PMID:20624386 | PMID:20843811 | PMID:20953702 |
PMID:21728335 | PMID:21984583 | PMID:22981453 | PMID:23545074 | PMID:24564397 | PMID:24978951 | PMID:32699194 | PMID:33422646 | PMID:35691467 | PMID:37298724 |
Cckar (Rattus norvegicus - Norway rat) |
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CCKAR (Homo sapiens - human) |
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Cckar (Mus musculus - house mouse) |
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Cckar (Chinchilla lanigera - long-tailed chinchilla) |
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CCKAR (Pan paniscus - bonobo/pygmy chimpanzee) |
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CCKAR (Canis lupus familiaris - dog) |
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Cckar (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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CCKAR (Sus scrofa - pig) |
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CCKAR (Chlorocebus sabaeus - green monkey) |
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Cckar (Heterocephalus glaber - naked mole-rat) |
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Variants in Cckar
15 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
D14Wox26 |
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D14Wox24 |
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D14Wox25 |
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PMC129753P2 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | |||||||||||||
Low | 1 | 26 | 7 | 6 | 8 | 6 | 47 | 9 | 9 | 2 | |||
Below cutoff | 1 | 24 | 17 | 3 | 17 | 2 | 2 | 21 | 18 | 10 | 8 | 2 |
RefSeq Transcripts | NM_012688 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_008770188 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_017599077 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_017599078 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | CH473963 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
D50608 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
D50610 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000014 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
M88096 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000065366 ⟹ ENSRNOP00000063137 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | NM_012688 ⟹ NP_036820 | ||||||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
Protein RefSeqs | NP_036820 | (Get FASTA) | NCBI Sequence Viewer |
GenBank Protein | AAA40899 | (Get FASTA) | NCBI Sequence Viewer |
BAA09170 | (Get FASTA) | NCBI Sequence Viewer | |
BAA22847 | (Get FASTA) | NCBI Sequence Viewer | |
EDL99868 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000063137 | ||
ENSRNOP00000063137.2 | |||
ENSRNOP00060021578 | |||
GenBank Protein | P30551 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_036820 ⟸ NM_012688 |
- UniProtKB: | P30551 (UniProtKB/Swiss-Prot), F1LQR7 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000063137 ⟸ ENSRNOT00000065366 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-P30551-F1-model_v2 | AlphaFold | P30551 | 1-444 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13699328 | ||||||||
Promoter ID: | EPDNEW_R9853 | ||||||||
Type: | single initiation site | ||||||||
Name: | Cckar_1 | ||||||||
Description: | cholecystokinin A receptor | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:2289 | AgrOrtholog |
BioCyc Gene | G2FUF-15617 | BioCyc |
Ensembl Genes | ENSRNOG00000043124 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
ENSRNOG00060015710 | UniProtKB/Swiss-Prot | |
Ensembl Transcript | ENSRNOT00000065366 | ENTREZGENE |
ENSRNOT00000065366.3 | UniProtKB/TrEMBL | |
ENSRNOT00060026909 | UniProtKB/Swiss-Prot | |
Gene3D-CATH | 4.10.670.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Rhodopsin 7-helix transmembrane proteins | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
InterPro | Cholcskin_rcpt | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Cholcy_rcpt_A | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
CholecystokininA_recpt_N | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
CholecystokininA_recpt_N_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Gastrin_rcpt | UniProtKB/TrEMBL | |
GPCR_Rhodpsn | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GPCR_Rhodpsn_7TM | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:24889 | UniProtKB/Swiss-Prot |
NCBI Gene | 24889 | ENTREZGENE |
PANTHER | CHOLECYSTOKININ-2 RECEPTOR-RELATED | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
G-PROTEIN COUPLED RECEPTOR | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | 7tm_1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
CholecysA-Rec_N | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Cckar | PhenoGen |
PRINTS | CCYSTOKININR | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
CCYSTOKNINAR | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GASTRINR | UniProtKB/TrEMBL | |
GPCRRHODOPSN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PROSITE | G_PROTEIN_RECEP_F1_1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
G_PROTEIN_RECEP_F1_2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
RatGTEx | ENSRNOG00000043124 | RatGTEx |
ENSRNOG00060015710 | RatGTEx | |
SMART | 7TM_GPCR_Srsx | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Superfamily-SCOP | Family A G protein-coupled receptor-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
UniProt | A6IJF5_RAT | UniProtKB/TrEMBL |
CCKAR_RAT | UniProtKB/Swiss-Prot | |
F1LQR7 | ENTREZGENE, UniProtKB/TrEMBL | |
P30551 | ENTREZGENE | |
V9H0R3_RAT | UniProtKB/TrEMBL |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2002-06-10 | Cckar | Cholecystokinin A receptor | Symbol and Name status set to approved | 70586 | APPROVED |
Note Type | Note | Reference |
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gene_disease | deletion in gene may be associated with hyperglycemia, hyperinsulinemia and mild obesity | 634705 |
gene_expression | expressed in pancreatic acinar cells | 631304 |
gene_expression | expressed in the peripheral region of the blood-brain barrier | 631304 |
gene_function | binds sulfated cholecystokinin peptides | 631304 |
gene_function | binds sulfated cholecystokinin peptides | 634707 |
gene_process | inhibits gastric emptying | 628552 |
gene_process | may be involved in inhibiting food intake | 634706 |
gene_process | may be involved in duodenal nutrient-induced inhibition of gastric emptying | 628552 |
gene_process | activation results in the tyrosine phosphorylation of PKC delta | 631304 |
gene_product | member of G protein coupled heptahelical superfamily | 631304 |
gene_regulation | binds and is activated by a carboxy-terminal octapeptide of cholecystokinin | 631304 |