Atp1b1 (ATPase Na+/K+ transporting subunit beta 1) - Rat Genome Database

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Gene: Atp1b1 (ATPase Na+/K+ transporting subunit beta 1) Rattus norvegicus
Analyze
Symbol: Atp1b1
Name: ATPase Na+/K+ transporting subunit beta 1
RGD ID: 2170
Description: Enables P-type sodium:potassium-exchanging transporter activity and protein heterodimerization activity. Involved in potassium ion transport; response to hypoxia; and sodium ion transport. Located in apical plasma membrane; basolateral plasma membrane; and caveola. Part of sodium:potassium-exchanging ATPase complex. Biomarker of sensorineural hearing loss. Human ortholog(s) of this gene implicated in essential hypertension. Orthologous to human ATP1B1 (ATPase Na+/K+ transporting subunit beta 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; INTERACTS WITH 1-(5-isoquinolinesulfonyl)-2-methylpiperazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATPase Na+/K+ transporting beta 1 polypeptide; ATPase, Na+/K+ transporting, beta 1 polypeptide; ATPBS; Na,K-ATPase beta 1 subunit; sodium/potassium-dependent ATPase subunit beta-1; sodium/potassium-transporting ATPase subunit beta-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21376,786,580 - 76,807,096 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1376,786,578 - 76,807,459 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1379,404,955 - 79,425,485 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01380,708,953 - 80,729,485 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01377,964,000 - 77,984,560 (-)NCBIRnor_WKY
Rnor_6.01382,737,161 - 82,757,681 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1382,737,159 - 82,758,004 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01387,621,447 - 87,641,967 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41380,214,056 - 80,234,576 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11380,228,241 - 80,249,087 (-)NCBI
Celera1376,517,954 - 76,538,475 (-)NCBICelera
RH 3.4 Map13485.8RGD
Cytogenetic Map13q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
5-aza-2'-deoxycytidine  (ISO)
9-cis-retinoic acid  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
astemizole  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromobenzene  (EXP)
butanal  (ISO)
cadmium dichloride  (ISO)
calcidiol  (EXP)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP,ISO)
CGP 52608  (ISO)
chloroprene  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciglitazone  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (EXP)
dioxygen  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
furan  (EXP)
genistein  (EXP,ISO)
glafenine  (EXP)
glutathione  (EXP)
haloperidol  (EXP)
heparin  (EXP)
inulin  (ISO)
isoflavones  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP)
lycopene  (ISO)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mirex  (EXP)
N-nitrosodiethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
ochratoxin A  (ISO)
ouabain  (EXP)
oxaliplatin  (EXP)
oxycodone  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
pyrogallol  (ISO)
quartz  (EXP)
quercetin  (ISO)
ranitidine  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
sarin  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium dichromate  (ISO)
succimer  (ISO)
tacedinaline  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ATP metabolic process  (IEA,ISO)
blastocyst development  (ISO)
cardiac muscle contraction  (IEA,ISO)
cell adhesion  (IEA)
establishment or maintenance of transmembrane electrochemical gradient  (IEA)
innate immune response  (IEA)
intracellular calcium ion homeostasis  (IEA,ISO)
intracellular potassium ion homeostasis  (IBA,IEA,ISO)
intracellular sodium ion homeostasis  (IBA,IEA,ISO)
membrane repolarization  (IEA,ISO)
metal ion transport  (IDA)
monoatomic cation transmembrane transport  (ISO)
positive regulation of ATP-dependent activity  (ISO)
positive regulation of calcium:sodium antiporter activity  (IEA,ISO)
positive regulation of P-type sodium:potassium-exchanging transporter activity  (IEA,ISO)
positive regulation of potassium ion import across plasma membrane  (IEA,ISO)
positive regulation of potassium ion transmembrane transporter activity  (ISO)
positive regulation of sodium ion export across plasma membrane  (IEA,ISO)
potassium ion import across plasma membrane  (IBA,IEA,ISO)
potassium ion transport  (IDA,IEA)
protein localization to plasma membrane  (IEA,ISO)
protein stabilization  (IEA,ISO)
regulation of calcium ion transmembrane transport  (ISO)
regulation of cardiac muscle contraction by calcium ion signaling  (IEA,ISO)
regulation of gene expression  (IEA,ISO)
relaxation of cardiac muscle  (IEA,ISO)
response to hypoxia  (IDA)
sodium ion export across plasma membrane  (IBA,IEA,ISO)
sodium ion transmembrane transport  (ISO)
sodium ion transport  (IDA,IEA)
transmembrane transport  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
aldosterone signaling pathway  (IEA)
alfentanil pharmacodynamics pathway  (ISO)
amiloride pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
bendroflumethiazide pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bile acid transport pathway  (IEA)
bisoprolol pharmacodynamics pathway  (ISO)
bumetanide pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
chlorothiazide pharmacodynamics pathway  (ISO)
chlorthalidone pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
cystinuria pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
eplerenone pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
etacrynic acid pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
furosemide pharmacodynamics pathway  (ISO)
Hartnup disease pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrochlorothiazide pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydroflumethiazide pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
iminoglycinuria pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
lactose degradation pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lysinuric protein intolerance pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
metolazone pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
spironolactone pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
torasemide pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
trehalose degradation pathway  (ISO)
triamterene pharmacodynamics pathway  (ISO)
trichlormethiazide pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. FXYD7 is a brain-specific regulator of Na,K-ATPase alpha 1-beta isozymes. Beguin P, etal., EMBO J 2002 Jul 1;21(13):3264-73.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Training-induced changes in skeletal muscle Na+-K+ pump number and isoform expression in rats with chronic heart failure. Helwig B, etal., J Appl Physiol 2003 Jun;94(6):2225-36.
5. Induction of mRNAs and proteins for Na/K ATPase alpha1 and beta1 subunits following hypoxia/reoxygenation in astrocytes. Kasai K, etal., Brain Res Mol Brain Res 2003 Jan 31;110(1):38-44.
6. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7. The effect of beta-subunit assembly on function and localization of the colonic H+,K+-ATPase alpha-subunit. Li J, etal., Kidney Int. 2004 Sep;66(3):1068-75.
8. Beta-subunit of cardiac Na+-K+-ATPase dictates the concentration of the functional enzyme in caveolae. Liu L and Askari A, Am J Physiol Cell Physiol. 2006 Oct;291(4):C569-78. Epub 2006 Apr 19.
9. Rat-brain Na,K-ATPase beta-chain gene: primary structure, tissue-specific expression, and amplification in ouabain-resistant HeLa C+ cells. Mercer RW, etal., Mol Cell Biol 1986 Nov;6(11):3884-90.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Identification of the beta-subunit for nongastric H-K-ATPase in rat anterior prostate. Pestov NB, etal., Am J Physiol Cell Physiol. 2004 Jun;286(6):C1229-37. doi: 10.1152/ajpcell.00393.2003. Epub 2004 Jan 28.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. The α2β2 isoform combination dominates the astrocytic Na+ /K+ -ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation. Stoica A, etal., Glia. 2017 Nov;65(11):1777-1793. doi: 10.1002/glia.23194. Epub 2017 Aug 8.
20. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
21. Long-lasting changes in the cochlear K recycling structures after acute energy failure. Takiguchi Y, etal., Neurosci Res. 2013 Jul 1. pii: S0168-0102(13)00159-4. doi: 10.1016/j.neures.2013.06.003.
22. Multiple mRNAs from rat kidney and brain encode a single Na+,K+-ATPase beta subunit protein. Young RM, etal., J Biol Chem 1987 Apr 5;262(10):4905-10.
Additional References at PubMed
PMID:1314096   PMID:10636900   PMID:10837135   PMID:11193188   PMID:12754184   PMID:14761885   PMID:15489334   PMID:16269407   PMID:16708288   PMID:16861705   PMID:17606467   PMID:17634366  
PMID:17673438   PMID:18052210   PMID:18075585   PMID:18522992   PMID:18728015   PMID:19542013   PMID:19683723   PMID:19751721   PMID:19764716   PMID:20100892   PMID:20131911   PMID:20444976  
PMID:20458337   PMID:20937802   PMID:21642423   PMID:21705333   PMID:22328500   PMID:22871113   PMID:23376485   PMID:23392350   PMID:23533145   PMID:23954377   PMID:24769233   PMID:27563007  
PMID:29476059   PMID:29802248   PMID:30746862   PMID:31686426   PMID:32357304   PMID:33805551  


Genomics

Comparative Map Data
Atp1b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21376,786,580 - 76,807,096 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1376,786,578 - 76,807,459 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1379,404,955 - 79,425,485 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01380,708,953 - 80,729,485 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01377,964,000 - 77,984,560 (-)NCBIRnor_WKY
Rnor_6.01382,737,161 - 82,757,681 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1382,737,159 - 82,758,004 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01387,621,447 - 87,641,967 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41380,214,056 - 80,234,576 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11380,228,241 - 80,249,087 (-)NCBI
Celera1376,517,954 - 76,538,475 (-)NCBICelera
RH 3.4 Map13485.8RGD
Cytogenetic Map13q23NCBI
ATP1B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381169,106,690 - 169,132,719 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1169,105,697 - 169,310,992 (+)EnsemblGRCh38hg38GRCh38
GRCh371169,075,928 - 169,101,957 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,342,571 - 167,368,584 (+)NCBINCBI36Build 36hg18NCBI36
Build 341165,807,604 - 165,833,618NCBI
Celera1142,186,000 - 142,212,016 (+)NCBICelera
Cytogenetic Map1q24.2NCBI
HuRef1140,321,997 - 140,348,078 (+)NCBIHuRef
CHM1_11170,498,009 - 170,524,021 (+)NCBICHM1_1
T2T-CHM13v2.01168,462,171 - 168,488,201 (+)NCBIT2T-CHM13v2.0
Atp1b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391164,264,668 - 164,285,924 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1164,264,678 - 164,285,924 (-)EnsemblGRCm39 Ensembl
GRCm381164,437,099 - 164,458,355 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1164,437,109 - 164,458,355 (-)EnsemblGRCm38mm10GRCm38
MGSCv371166,367,398 - 166,388,486 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361166,273,942 - 166,295,030 (-)NCBIMGSCv36mm8
Celera1166,878,624 - 166,899,734 (-)NCBICelera
Cytogenetic Map1H2.2NCBI
cM Map171.75NCBI
Atp1b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554628,073,679 - 8,094,880 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554628,072,519 - 8,095,311 (-)NCBIChiLan1.0ChiLan1.0
ATP1B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1180,299,320 - 80,328,363 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01144,592,667 - 144,621,052 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11148,314,700 - 148,343,205 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1148,314,793 - 148,342,050 (+)Ensemblpanpan1.1panPan2
ATP1B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1729,464,132 - 29,487,124 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl729,464,132 - 29,487,947 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha728,995,904 - 29,019,080 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0729,266,289 - 29,289,513 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl729,265,440 - 29,289,555 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1729,114,027 - 29,137,166 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0729,155,842 - 29,179,013 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0729,386,814 - 29,410,001 (-)NCBIUU_Cfam_GSD_1.0
Atp1b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934499,591,400 - 99,613,578 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648117,436,270 - 17,460,348 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493648117,438,146 - 17,460,329 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP1B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl481,911,561 - 81,991,840 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1481,912,543 - 81,937,015 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2489,530,583 - 89,550,423 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap4q1.3-q2.1NCBI
ATP1B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12559,898,745 - 59,925,166 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2559,895,341 - 59,925,522 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605561,575,309 - 61,602,086 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp1b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248267,054,371 - 7,076,919 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248267,058,046 - 7,076,919 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atp1b1
84 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:385
Count of miRNA genes:223
Interacting mature miRNAs:273
Transcripts:ENSRNOT00000003932
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)135949252277046890Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)136906051977046890Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)137402391880753406Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat

Markers in Region
D13Wox25  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21376,804,907 - 76,805,053 (+)MAPPERmRatBN7.2
Rnor_6.01382,755,491 - 82,755,638NCBIRnor6.0
Rnor_5.01387,639,777 - 87,639,924UniSTSRnor5.0
RGSC_v3.41380,232,386 - 80,232,533UniSTSRGSC3.4
Celera1376,536,285 - 76,536,432UniSTS
Cytogenetic Map13q23UniSTS
RH132763  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21376,800,031 - 76,800,232 (+)MAPPERmRatBN7.2
Rnor_6.01382,750,613 - 82,750,813NCBIRnor6.0
Rnor_5.01387,634,899 - 87,635,099UniSTSRnor5.0
RGSC_v3.41380,227,508 - 80,227,708UniSTSRGSC3.4
Celera1376,531,407 - 76,531,607UniSTS
RH 3.4 Map13485.8UniSTS
Cytogenetic Map13q23UniSTS
RH94466  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21376,787,096 - 76,787,291 (+)MAPPERmRatBN7.2
Rnor_6.01382,737,678 - 82,737,872NCBIRnor6.0
Rnor_5.01387,621,964 - 87,622,158UniSTSRnor5.0
RGSC_v3.41380,214,573 - 80,214,767UniSTSRGSC3.4
Celera1376,518,471 - 76,518,665UniSTS
RH 3.4 Map13485.8UniSTS
Cytogenetic Map13q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 15 15
Medium 3 43 57 41 19 41 8 11 57 20 41 11 8
Low 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003932   ⟹   ENSRNOP00000003932
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1376,786,581 - 76,807,459 (-)Ensembl
Rnor_6.0 Ensembl1382,737,159 - 82,758,004 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000075948   ⟹   ENSRNOP00000068146
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1376,786,578 - 76,795,173 (-)Ensembl
Rnor_6.0 Ensembl1382,739,406 - 82,753,438 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076578
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1382,738,252 - 82,745,761 (-)Ensembl
RefSeq Acc Id: NM_013113   ⟹   NP_037245
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21376,786,580 - 76,807,096 (-)NCBI
Rnor_6.01382,737,161 - 82,757,681 (-)NCBI
Rnor_5.01387,621,447 - 87,641,967 (-)NCBI
RGSC_v3.41380,214,056 - 80,234,576 (-)RGD
Celera1376,517,954 - 76,538,475 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037245   ⟸   NM_013113
- UniProtKB: Q63062 (UniProtKB/Swiss-Prot),   P07340 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068146   ⟸   ENSRNOT00000075948
RefSeq Acc Id: ENSRNOP00000003932   ⟸   ENSRNOT00000003932

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07340-F1-model_v2 AlphaFold P07340 1-304 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698957
Promoter ID:EPDNEW_R9481
Type:multiple initiation site
Name:Atp1b1_1
Description:ATPase Na+/K+ transporting subunit beta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9482  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01382,757,692 - 82,757,752EPDNEW
RGD ID:13698958
Promoter ID:EPDNEW_R9482
Type:multiple initiation site
Name:Atp1b1_2
Description:ATPase Na+/K+ transporting subunit beta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9481  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01382,758,044 - 82,758,104EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2170 AgrOrtholog
BioCyc Gene G2FUF-17596 BioCyc
Ensembl Genes ENSRNOG00000002934 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000003932 ENTREZGENE
  ENSRNOP00000003932.4 UniProtKB/TrEMBL
  ENSRNOP00000068146.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003932 ENTREZGENE
  ENSRNOT00000003932.8 UniProtKB/TrEMBL
  ENSRNOT00000075948.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1660 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7111949 IMAGE-MGC_LOAD
InterPro Na/K_ATPase_sub_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na/K_ATPase_sub_beta_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25650 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93649 IMAGE-MGC_LOAD
NCBI Gene 25650 ENTREZGENE
PANTHER PTHR11523 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11523:SF10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Na_K-ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Atp1b1 PhenoGen
PROSITE ATPASE_NA_K_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPASE_NA_K_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs Na_K_ATPase_bet UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A096MJI9_RAT UniProtKB/TrEMBL
  A0A8L2Q0J0_RAT UniProtKB/TrEMBL
  AT1B1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63062 ENTREZGENE
UniProt Secondary Q63062 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Atp1b1  ATPase Na+/K+ transporting subunit beta 1  Atp1b1  ATPase, Na+/K+ transporting, beta 1 polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Atp1b1  ATPase, Na+/K+ transporting, beta 1 polypeptide    ATPase Na+/K+ transporting beta 1 polypeptide  Name updated 1299863 APPROVED
2002-06-10 Atp1b1  ATPase Na+/K+ transporting beta 1 polypeptide      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process may help maintain the cellular environment of astrocytes subjected to hypoxia/reoxygenation 631759
gene_process may play an important role in Na,K-ATPase structure-function and aid in cellular resistance to cardiac glycosides 632210
gene_regulation may be regulated by FXYD7 in brain 631775
gene_transcript multiple mRNA species exist due to transcription from multiple initiation sites 631776