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Gene: Arsb (arylsulfatase B) Rattus norvegicus
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Symbol: Arsb
Name: arylsulfatase B
Description: Exhibits sulfuric ester hydrolase activity. Involved in several processes, including autophagy; nervous system development; and response to methylmercury. Localizes to the cell surface and cytoplasm. Used to study mucopolysaccharidosis VI. Human ortholog(s) of this gene implicated in mucopolysaccharidosis VI. Orthologous to human ARSB (arylsulfatase B); PARTICIPATES IN glycosaminoglycan degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Arylsulfatase B (MPS VI); ASB; G4S; N-acetylgalactosamine-4-sulfatase
Orthologs:
Homo sapiens (human) : ARSB (arylsulfatase B)  HGNC  Alliance
Mus musculus (house mouse) : Arsb (arylsulfatase B)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Arsb (arylsulfatase B)
Pan paniscus (bonobo/pygmy chimpanzee) : ARSB (arylsulfatase B)
Canis lupus familiaris (dog) : ARSB (arylsulfatase B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Arsb (arylsulfatase B)
Sus scrofa (pig) : ARSB (arylsulfatase B)
more info ...
Allele / Splice: ArsbMPR  
Genetic Models: WIAR.MPR-Arsbabd/Ncchd MPR/Iar
Is Marker For: Strains:   MPR/Iar   WIAR.MPR-Arsbabd/Ncchd  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0223,385,154 - 23,543,028 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0242,559,079 - 42,717,753 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4224,067,560 - 24,223,821 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1223,988,194 - 24,144,190 (+)NCBI
Celera221,077,645 - 21,235,680 (+)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Arsb
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2158
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.