Apeh (acylaminoacyl-peptide hydrolase) - Rat Genome Database

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Gene: Apeh (acylaminoacyl-peptide hydrolase) Rattus norvegicus
Analyze
Symbol: Apeh
Name: acylaminoacyl-peptide hydrolase
RGD ID: 2125
Description: Predicted to enable identical protein binding activity; omega peptidase activity; and serine-type endopeptidase activity. Predicted to be involved in amyloid-beta metabolic process and proteolysis. Predicted to be located in cytosol and nuclear membrane. Orthologous to human APEH (acylaminoacyl-peptide hydrolase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AARE; acyl-peptide hydrolase; acylamino-acid-releasing enzyme; acylaminoacyl-peptidase; acylpeptide hydrolase; Apeh14; Apeh17; APH; N-acylaminoacyl-peptide hydrolase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,652,390 - 117,661,502 (-)NCBIGRCr8
mRatBN7.28108,773,791 - 108,782,903 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,773,794 - 108,782,933 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,400,007 - 114,409,117 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,599,331 - 112,608,441 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,441,972 - 110,451,082 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,862,664 - 116,871,776 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,862,625 - 116,872,215 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,216,745 - 116,225,857 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,353,151 - 113,362,263 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18113,372,606 - 113,381,718 (-)NCBI
Celera8108,078,004 - 108,087,116 (-)NCBICelera
RH 3.4 Map81116.3RGD
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
atrazine  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbapenems  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dichlorvos  (EXP,ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (EXP)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lithium chloride  (ISO)
methimazole  (EXP)
mitomycin C  (ISO)
naled  (ISO)
nicotine  (ISO)
Nonylphenol  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraoxon  (ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (EXP)
selenium atom  (ISO)
sulfadimethoxine  (EXP)
temozolomide  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
topotecan  (EXP)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
Valproic acid glucuronide  (ISO)
vancomycin  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO)
nuclear membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Cloning and sequence analysis of a rat liver cDNA encoding acyl-peptide hydrolase. Kobayashi K, etal., J Biol Chem 1989 May 25;264(15):8892-9.
4. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:2578023   PMID:12477932   PMID:16189514   PMID:17241160   PMID:20458337   PMID:22640895   PMID:22658674   PMID:23533145   PMID:25416956   PMID:31515488  


Genomics

Comparative Map Data
Apeh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,652,390 - 117,661,502 (-)NCBIGRCr8
mRatBN7.28108,773,791 - 108,782,903 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,773,794 - 108,782,933 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,400,007 - 114,409,117 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,599,331 - 112,608,441 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,441,972 - 110,451,082 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,862,664 - 116,871,776 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,862,625 - 116,872,215 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,216,745 - 116,225,857 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,353,151 - 113,362,263 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18113,372,606 - 113,381,718 (-)NCBI
Celera8108,078,004 - 108,087,116 (-)NCBICelera
RH 3.4 Map81116.3RGD
Cytogenetic Map8q32NCBI
APEH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,673,117 - 49,683,971 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl349,674,014 - 49,683,971 (+)EnsemblGRCh38hg38GRCh38
GRCh37349,711,784 - 49,721,404 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,686,439 - 49,695,938 (+)NCBINCBI36Build 36hg18NCBI36
Build 34349,686,438 - 49,695,937NCBI
Celera349,676,127 - 49,685,626 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef349,770,415 - 49,779,914 (+)NCBIHuRef
CHM1_1349,663,491 - 49,672,990 (+)NCBICHM1_1
T2T-CHM13v2.0349,702,408 - 49,713,255 (+)NCBIT2T-CHM13v2.0
Apeh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,962,613 - 107,971,736 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9107,962,612 - 107,971,805 (-)EnsemblGRCm39 Ensembl
GRCm389108,085,413 - 108,094,490 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,085,413 - 108,094,606 (-)EnsemblGRCm38mm10GRCm38
MGSCv379107,987,745 - 107,996,811 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369107,943,514 - 107,952,552 (-)NCBIMGSCv36mm8
Celera9107,695,183 - 107,704,249 (-)NCBICelera
Cytogenetic Map9F1NCBI
cM Map959.07NCBI
Apeh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,580,553 - 1,590,138 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,580,473 - 1,590,274 (+)NCBIChiLan1.0ChiLan1.0
APEH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2249,659,511 - 49,670,341 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1349,665,230 - 49,675,114 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0349,606,294 - 49,615,896 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1350,843,968 - 50,853,516 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,843,220 - 50,853,516 (+)Ensemblpanpan1.1panPan2
APEH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,587,316 - 39,596,324 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,587,279 - 39,596,228 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2039,508,241 - 39,517,291 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02039,944,841 - 39,953,890 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2039,944,843 - 39,953,810 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12039,311,923 - 39,320,973 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02039,715,279 - 39,724,328 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02039,995,110 - 40,004,158 (-)NCBIUU_Cfam_GSD_1.0
Apeh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560264,529,248 - 64,538,312 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365291,289,827 - 1,298,798 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365291,289,810 - 1,298,798 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APEH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,205,609 - 32,214,518 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11332,205,863 - 32,214,517 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,385,067 - 35,393,717 (+)NCBISscrofa10.2Sscrofa10.2susScr3
APEH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,067,966 - 11,078,258 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041155,922,305 - 155,931,881 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apeh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247303,601,714 - 3,612,048 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247303,601,792 - 3,612,048 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Apeh
16 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:86
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000045410
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8102370617108923645Rat

Markers in Region
D8Wox5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2858,081,909 - 58,082,156 (+)MAPPERmRatBN7.2
Rnor_6.0862,457,899 - 62,458,145NCBIRnor6.0
Rnor_5.0862,234,858 - 62,235,104UniSTSRnor5.0
Celera857,547,607 - 57,547,857UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic Map8q32UniSTS
D8Wox11  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.48113,364,040 - 113,364,148UniSTSRGSC3.4
Celera8108,088,893 - 108,089,001UniSTS
RH 3.4 Map81120.8UniSTS
RH 3.4 Map81120.8RGD
RH 2.0 Map8873.1RGD
Cytogenetic Map8q32UniSTS
D8Arb20  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,776,825 - 108,777,230 (+)MAPPERmRatBN7.2
Rnor_6.08116,865,699 - 116,866,103NCBIRnor6.0
Rnor_5.08116,219,780 - 116,220,184UniSTSRnor5.0
RGSC_v3.48113,356,185 - 113,356,590RGDRGSC3.4
RGSC_v3.48113,356,186 - 113,356,590UniSTSRGSC3.4
RGSC_v3.18113,375,640 - 113,376,045RGD
Celera8108,081,039 - 108,081,443UniSTS
RH 3.4 Map81119.3RGD
RH 3.4 Map81119.3UniSTS
RH 2.0 Map8889.4RGD
SHRSP x BN Map871.89RGD
Cytogenetic Map8q32UniSTS
D8Wox7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,776,880 - 108,777,075 (+)MAPPERmRatBN7.2
Rnor_6.08116,865,754 - 116,865,948NCBIRnor6.0
Rnor_5.08116,219,835 - 116,220,029UniSTSRnor5.0
RGSC_v3.48113,356,240 - 113,356,435RGDRGSC3.4
RGSC_v3.48113,356,241 - 113,356,435UniSTSRGSC3.4
RGSC_v3.18113,375,695 - 113,375,890RGD
Celera8108,081,094 - 108,081,288UniSTS
RH 3.4 Map81119.5UniSTS
RH 3.4 Map81119.5RGD
RH 2.0 Map8875.4RGD
Cytogenetic Map8q32UniSTS
RH94462  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,773,819 - 108,773,919 (+)MAPPERmRatBN7.2
Rnor_6.08116,862,693 - 116,862,792NCBIRnor6.0
Rnor_5.08116,216,774 - 116,216,873UniSTSRnor5.0
RGSC_v3.48113,353,180 - 113,353,279UniSTSRGSC3.4
Celera8108,078,033 - 108,078,132UniSTS
RH 3.4 Map81116.3UniSTS
Cytogenetic Map8q32UniSTS
RH132558  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8q32UniSTS
D8Wox11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,784,680 - 108,784,789 (+)MAPPERmRatBN7.2
Rnor_6.08116,873,553 - 116,873,661NCBIRnor6.0
Rnor_5.08116,227,634 - 116,227,742UniSTSRnor5.0
RGSC_v3.48113,364,040 - 113,364,148UniSTSRGSC3.4
Celera8108,088,893 - 108,089,001UniSTS
Cytogenetic Map8q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 57 41 19 41 1 4 74 35 40 11 1
Low 7 7 7 1 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000045410   ⟹   ENSRNOP00000043843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8108,773,794 - 108,782,927 (-)Ensembl
Rnor_6.0 Ensembl8116,862,625 - 116,872,215 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095731   ⟹   ENSRNOP00000080692
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8108,773,794 - 108,782,933 (-)Ensembl
RefSeq Acc Id: NM_012500   ⟹   NP_036632
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,652,390 - 117,661,502 (-)NCBI
mRatBN7.28108,773,791 - 108,782,903 (-)NCBI
Rnor_6.08116,862,664 - 116,871,776 (-)NCBI
Rnor_5.08116,216,745 - 116,225,857 (-)NCBI
RGSC_v3.48113,353,151 - 113,362,263 (-)RGD
Celera8108,078,004 - 108,087,116 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_036632   ⟸   NM_012500
- UniProtKB: P14320 (UniProtKB/Swiss-Prot),   P70479 (UniProtKB/Swiss-Prot),   P13676 (UniProtKB/Swiss-Prot),   B2GVB7 (UniProtKB/TrEMBL),   A6I335 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000043843   ⟸   ENSRNOT00000045410
RefSeq Acc Id: ENSRNOP00000080692   ⟸   ENSRNOT00000095731
Protein Domains
Acylamino-acid-releasing enzyme N-terminal   Peptidase S9 prolyl oligopeptidase catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13676-F1-model_v2 AlphaFold P13676 1-732 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696290
Promoter ID:EPDNEW_R6815
Type:multiple initiation site
Name:Apeh_1
Description:acylaminoacyl-peptide hydrolase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08116,871,806 - 116,871,866EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2125 AgrOrtholog
BioCyc Gene G2FUF-29157 BioCyc
BioCyc Pathway PWY-7799 [Arg/N-end rule pathway (eukaryotic)] BioCyc
BioCyc Pathway Image PWY-7799 BioCyc
Ensembl Genes ENSRNOG00000029572 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045410 ENTREZGENE
  ENSRNOT00000045410.4 UniProtKB/TrEMBL
  ENSRNOT00000095731.1 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7937766 IMAGE-MGC_LOAD
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AARE_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_S9_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:188384 IMAGE-MGC_LOAD
NCBI Gene 24206 ENTREZGENE
PANTHER ACYLAMINO-ACID-RELEASING ENZYME UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE PEPTIDASE S9 FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam APEH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Apeh PhenoGen
PROSITE PRO_ENDOPEP_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029572 RatGTEx
Superfamily-SCOP Peptidase/esterase 'gauge' domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC219864
UniProt A0A8I5ZQM6_RAT UniProtKB/TrEMBL
  A6I335 ENTREZGENE, UniProtKB/TrEMBL
  A6I336_RAT UniProtKB/TrEMBL
  ACPH_RAT UniProtKB/Swiss-Prot
  B2GVB7 ENTREZGENE, UniProtKB/TrEMBL
  G3V9E4_RAT UniProtKB/TrEMBL
  P13676 ENTREZGENE
  P14320 ENTREZGENE
  P70479 ENTREZGENE
UniProt Secondary P14320 UniProtKB/Swiss-Prot
  P70479 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-06-05 Apeh  acylaminoacyl-peptide hydrolase  Apeh  N-acylaminoacyl-peptide hydrolase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Apeh  N-acylaminoacyl-peptide hydrolase  Apeh  acylpeptide hydrolase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Apeh  acylpeptide hydrolase    N-acylaminoacyl-peptide hydrolase  Name updated 1299863 APPROVED
2002-06-10 Apeh  N-acylaminoacyl-peptide hydrolase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function catalyzes the removal of an N alpha-acetylated amino acid residue from a peptide 634651
gene_transcript 2.7 kb transcript is detected 634651