Gene: Apc (APC, WNT signaling pathway regulator) Rattus norvegicus
Symbol: Apc
Name: APC, WNT signaling pathway regulator
Description: ENCODES a protein that exhibits microtubule binding; protein-containing complex binding; beta-catenin binding (ortholog); INVOLVED IN cellular response to nerve growth factor stimulus; establishment or maintenance of cell polarity; negative regulation of cardiac muscle cell proliferation; PARTICIPATES IN altered Wnt signaling, canonical pathway; colorectal cancer pathway; endometrial cancer pathway; ASSOCIATED WITH colon adenocarcinoma; Colonic Neoplasms; familial adenomatous polyposis; FOUND IN axonal growth cone; cell body fiber; cell cortex; INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4'-Tetrabromodiphenyl ether; 2,6-dinitrotoluene
Type: protein-coding
Also known as: adenomatosis polyposis coli; adenomatous polyposis coli protein; RATAPC; WNT signaling pathway regulator
Homo sapiens (human) : APC (APC, WNT signaling pathway regulator)  HGNC  Alliance
Mus musculus (house mouse) : Apc (adenomatosis polyposis coli)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apc (APC, WNT signaling pathway regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : APC (APC, WNT signaling pathway regulator)
Canis lupus familiaris (dog) : APC (APC, WNT signaling pathway regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apc (APC, WNT signaling pathway regulator)
more info ...
Allele / Splice: ApcPirc   Apcm1Kyo  
Genetic Models: F344-ApcPircUwm ACI.F344-ApcPircUwm BN.F344-ApcPirc F344-Apcm1Kyo
Is Marker For: Strains:   F344-Apcm1Kyo  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01827,011,710 - 27,106,323 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01826,725,560 - 26,820,837 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41826,732,147 - 26,790,383 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11826,758,792 - 26,817,029 (+)NCBI
Celera1825,606,119 - 25,663,749 (+)NCBICelera
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


Nucleotide Sequences