Adcy4 (adenylate cyclase 4) - Rat Genome Database

Name: Adcy4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Adcy4 (adenylate cyclase 4) Rattus norvegicus

Analyze

Symbol:

Adcy4

Name:

adenylate cyclase 4

RGD ID:

2034

Description:

Enables G-protein beta/gamma-subunit complex binding activity and adenylate cyclase activity. Involved in cAMP biosynthetic process and intracellular signal transduction. Located in membrane. Part of protein-containing complex. Orthologous to human ADCY4 (adenylate cyclase 4); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

adenylate cyclase type 4; adenylate cyclase type IV; adenylyl cyclase 4; ATP pyrophosphate-lyase 4; MGC93493

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ADCY4 (adenylate cyclase 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):	Adcy4 (adenylate cyclase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Adcy4 (adenylate cyclase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ADCY4 (adenylate cyclase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ADCY4 (adenylate cyclase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Adcy4 (adenylate cyclase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ADCY4 (adenylate cyclase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ADCY4 (adenylate cyclase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Adcy4 (adenylate cyclase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TMPRSS11F (transmembrane serine protease 11F)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Adcy4 (adenylate cyclase 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ADCY4 (adenylate cyclase 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	acy-4	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	Ac76E	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG32305	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	adcy4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	33,236,201 - 33,252,070 (-)	NCBI		GRCr8
mRatBN7.2	15	29,266,280 - 29,282,153 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	29,266,287 - 29,282,108 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	31,111,969 - 31,127,788 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	32,259,179 - 32,274,998 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	30,501,528 - 30,517,347 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	34,453,917 - 34,469,779 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	34,453,915 - 34,469,746 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	38,342,429 - 38,358,268 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	33,930,531 - 33,946,352 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	33,946,233 - 33,962,015 (-)	NCBI
Celera	15	28,841,216 - 28,857,037 (-)	NCBI		Celera
Cytogenetic Map	15	p13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brain-Lung-Thyroid Syndrome (ISO)

genetic disease (ISO)

lysinuric protein intolerance (ISO)

Specific Granule Deficiency (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (EXP,ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

all-trans-retinoic acid (ISO)

amitrole (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (EXP,ISO)

chromium(6+) (ISO)

clothianidin (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

diazinon (EXP)

dibutyl phthalate (EXP)

dichlorine (EXP)

divanadium pentaoxide (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

fenvalerate (EXP)

genistein (EXP)

indometacin (ISO)

methamphetamine (ISO)

methimazole (EXP)

methoxychlor (EXP)

mono(2-ethylhexyl) phthalate (ISO)

nitrates (EXP)

oxaliplatin (EXP)

ozone (EXP,ISO)

paracetamol (EXP,ISO)

phenobarbital (EXP)

picrotoxin (EXP)

resveratrol (EXP)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

testosterone (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

triticonazole (EXP)

undecane (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IBA,IEA)

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (IBA,IEA)

adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ISO)

cAMP biosynthetic process (IBA,IDA,IEA)

intracellular signal transduction (IDA,IEA)

Cellular Component

cytoplasm (ISO)

dendrite (ISO)

membrane (IDA)

plasma membrane (IBA,IEA)

protein-containing complex (IDA)

Molecular Function

adenylate cyclase activity (IBA,IDA,IEA)

ATP binding (IEA)

G-protein beta/gamma-subunit complex binding (IPI)

metal ion binding (IEA)

protein binding (ISO)

protein kinase C binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

bile acid transport pathway (IEA)

calcium/calcium-mediated signaling pathway (IEA)

chemokine mediated signaling pathway (IEA)

dilated cardiomyopathy pathway (IEA)

endothelin signaling pathway (ISO)

G protein mediated signaling pathway via Galphas family (ISO)

glutamate signaling pathway (IEA)

gonadotropin-releasing hormone signaling pathway (IEA)

protein kinase A (PKA) signaling pathway (ISO)

purine metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Distribution of adenylyl cyclases in the rat ovary by immunofluorescence microscopy.	Bagavandoss P and Grimshaw S, Anat Rec (Hoboken). 2012 Oct;295(10):1717-26. doi: 10.1002/ar.22550. Epub 2012 Aug 16.
2.	Cloning and expression of a widely distributed (type IV) adenylyl cyclase.	Gao BN and Gilman AG, Proc Natl Acad Sci U S A 1991 Nov 15;88(22):10178-82.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts.	Ostrom RS, etal., J Biol Chem. 2003 Jul 4;278(27):24461-8. Epub 2003 Apr 23.
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies.	Sadana R and Dessauer CW, Neurosignals. 2009;17(1):5-22. Epub 2008 Oct 24.
14.	Differences in type II, IV, V and VI adenylyl cyclase isoform expression between rat preadipocytes and adipocytes.	Serazin-Leroy V, etal., Biochim Biophys Acta. 2001 Nov 26;1550(1):37-51.
15.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17.	Gbetagamma that interacts with adenylyl cyclase in opioid tolerance originates from a Gs protein.	Wang HY and Burns LH, J Neurobiol. 2006 Oct;66(12):1302-10.
18.	Protein kinase C alters the responsiveness of adenylyl cyclases to G protein alpha and betagamma subunits.	Zimmermann G and Taussig R, J Biol Chem. 1996 Oct 25;271(43):27161-6.

Additional References at PubMed

PMID:9870949	PMID:11549699	PMID:17081159

Genomics

Comparative Map Data

Adcy4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	33,236,201 - 33,252,070 (-)	NCBI		GRCr8
mRatBN7.2	15	29,266,280 - 29,282,153 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	29,266,287 - 29,282,108 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	31,111,969 - 31,127,788 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	32,259,179 - 32,274,998 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	30,501,528 - 30,517,347 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	34,453,917 - 34,469,779 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	34,453,915 - 34,469,746 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	38,342,429 - 38,358,268 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	33,930,531 - 33,946,352 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	33,946,233 - 33,962,015 (-)	NCBI
Celera	15	28,841,216 - 28,857,037 (-)	NCBI		Celera
Cytogenetic Map	15	p13	NCBI

ADCY4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	24,318,359 - 24,335,071 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	24,318,349 - 24,335,093 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	24,787,565 - 24,804,277 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	23,857,410 - 23,873,704 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	23,857,410 - 23,873,704	NCBI
Celera	14	4,652,191 - 4,668,489 (-)	NCBI		Celera
Cytogenetic Map	14	q12	NCBI
HuRef	14	4,902,443 - 4,919,171 (-)	NCBI		HuRef
CHM1_1	14	24,786,147 - 24,802,872 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	18,516,694 - 18,533,416 (-)	NCBI		T2T-CHM13v2.0

Adcy4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	56,006,513 - 56,021,552 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	56,006,514 - 56,021,552 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	55,769,056 - 55,784,095 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	55,769,057 - 55,784,095 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	56,387,929 - 56,402,856 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	54,723,163 - 54,738,090 (-)	NCBI		MGSCv36	mm8
Celera	14	53,574,126 - 53,589,052 (-)	NCBI		Celera
Cytogenetic Map	14	C3	NCBI
cM Map	14	28.19	NCBI

Adcy4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	35,966,332 - 35,982,218 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	35,966,529 - 35,982,839 (+)	NCBI	ChiLan1.0	ChiLan1.0

ADCY4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	25,673,520 - 25,690,270 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	24,890,012 - 24,906,738 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	5,094,899 - 5,111,603 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	23,218,178 - 23,234,861 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	23,218,178 - 23,234,861 (-)	Ensembl	panpan1.1		panPan2

ADCY4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	4,288,708 - 4,304,092 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	4,288,714 - 4,304,589 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	4,210,485 - 4,226,167 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	4,399,506 - 4,415,189 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	4,399,531 - 4,415,386 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	4,089,855 - 4,105,524 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	4,151,682 - 4,167,531 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	4,414,264 - 4,429,941 (-)	NCBI		UU_Cfam_GSD_1.0

Adcy4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	36,158,190 - 36,175,109 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936722	213,916 - 230,906 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936722	213,916 - 230,802 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ADCY4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	74,956,220 - 74,972,196 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	74,955,410 - 74,972,440 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	80,226,295 - 80,243,376 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ADCY4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	1,301,445 - 1,318,171 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	1,301,506 - 1,316,868 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666036	12,985,965 - 13,001,961 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Adcy4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624820	8,169,816 - 8,189,168 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624820	8,170,258 - 8,186,214 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Adcy4
21 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	90
Count of miRNA genes:	41
Interacting mature miRNAs:	43
Transcripts:	ENSRNOT00000027719, ENSRNOT00000067536
Prediction methods:	Microtar, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354657	Despr13	Despair related QTL 13		0.0022	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	15	1	29912054	Rat
8552920	Pigfal8	Plasma insulin-like growth factor 1 level QTL 8	3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	15	1	34723002	Rat
8694361	Abfw6	Abdominal fat weight QTL 6	10.2	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	15	1	34723002	Rat
9589149	Insul29	Insulin level QTL 29	9.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	15	1	34723002	Rat
731170	Pur3	Proteinuria QTL 3	2.3	0.0005	urine protein amount (VT:0005160)	urine protein excretion rate (CMO:0000759)	15	1	41686771	Rat
1641887	Alcrsp14	Alcohol response QTL 14			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	15	1	42356671	Rat
2298549	Neuinf12	Neuroinflammation QTL 12	3.5		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	15	1	55302115	Rat
10401805	Kidm51	Kidney mass QTL 51			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	15	306329	45306329	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2266368	46921453	Rat
1582251	Gluco24	Glucose level QTL 24	3.2	0.0008	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	15	5530756	50530756	Rat
631273	Lecl2	Lens clarity QTL 2		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	15	10596089	55596089	Rat
2300167	Bmd63	Bone mineral density QTL 63	5.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
2300173	Bmd62	Bone mineral density QTL 62	12.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
2293688	Bss29	Bone structure and strength QTL 29	5.31	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	15	11111142	56111142	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	12496141	65205939	Rat
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	16725528	80672115	Rat
1331729	Rf42	Renal function QTL 42	3.071		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	15	17362897	73690657	Rat
631550	Bw7	Body weight QTL 7	3.6		body mass (VT:0001259)	body weight (CMO:0000012)	15	19856566	34924750	Rat
2324620	Coatc3	Coat color QTL 3			coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	15	19856566	46187442	Rat
10054130	Srcrt8	Stress Responsive Cort QTL 8	2.18	0.0085	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	15	22117933	67117933	Rat
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	22806240	98288169	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	22806240	98288169	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	22806240	98288169	Rat
1582214	Stl21	Serum triglyceride level QTL 21	3.1	0.022	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	15	28030665	82262678	Rat
1582227	Gluco30	Glucose level QTL 30	3.6	0.0003	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	15	28030665	82262678	Rat
1582228	Epfw3	Epididymal fat weight QTL 3	4.1	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat
1582242	Gluco28	Glucose level QTL 28	3.3	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	15	28030665	82262678	Rat
1582244	Bw79	Body weight QTL 79	4	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat

Markers in Region

RH129786

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	29,283,184 - 29,283,381 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	34,470,819 - 34,471,015	NCBI	Rnor6.0
Rnor_5.0	15	38,359,330 - 38,359,526	UniSTS	Rnor5.0
RGSC_v3.4	15	33,947,429 - 33,947,625	UniSTS	RGSC3.4
Celera	15	28,858,114 - 28,858,310	UniSTS
RH 3.4 Map	15	260.81	UniSTS
Cytogenetic Map	15	p13	UniSTS

Adcy4

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	29,266,291 - 29,266,420 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	34,453,929 - 34,454,057	NCBI	Rnor6.0
Rnor_5.0	15	38,342,441 - 38,342,569	UniSTS	Rnor5.0
RGSC_v3.4	15	33,930,539 - 33,930,667	UniSTS	RGSC3.4
Celera	15	28,841,224 - 28,841,352	UniSTS
Cytogenetic Map	15	p13	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		31	2	2	11	2				14	17	11
Low	3	12	55	39	8	39	8	11	74	21	17		8
Below cutoff											7

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_019285	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599787	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093610	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093611	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063274588	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC116083	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC081813	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474049	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223268	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223451	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M80633	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000027719 ⟹ ENSRNOP00000027719

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	29,266,287 - 29,282,108 (-)	Ensembl
Rnor_6.0 Ensembl	15	34,453,915 - 34,469,746 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000067536 ⟹ ENSRNOP00000059696

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	15	34,453,977 - 34,469,350 (-)	Ensembl

RefSeq Acc Id:

NM_019285 ⟹ NP_062158

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	33,236,205 - 33,252,026 (-)	NCBI
mRatBN7.2	15	29,266,284 - 29,282,108 (-)	NCBI
Rnor_6.0	15	34,453,921 - 34,469,742 (-)	NCBI
Rnor_5.0	15	38,342,429 - 38,358,268 (-)	NCBI
RGSC_v3.4	15	33,930,531 - 33,946,352 (-)	RGD
Celera	15	28,841,216 - 28,857,037 (-)	RGD

Sequence:

show sequence

CAGGCCCTGAGCCACTAGCAAAGCAGCGAGGGTGAGTGGCAGCCAGCCTACCCAGGTTCCCTCC
TGGAGCCTAGCTTTGCTACGAGAACTTCAGGAGCTTAACACAAAGCAGGCAGGGGCTCCGGGCT
GGGGCGGGGGATATCATGGCCCGCCTCTTCAGTCCCCGGCCTCCTCCCAGCGAAGATCTCTTCT
ACGAGACTTACTACAGCCTGAGCCAACAGTATCCACTGCTAATTCTGCTTCTGGTCATTGTGCT
CTGCGCGATCGTGGCACTGCCCGCCGTCGCCTGGGCCAGCGGCAGGGAGCTGACCTCAGACCCA
AGCTTCCTGACAACTGTGCTGTGTGCTTTGGGTGGCTTCTCCCTGCTTTTGGGGCTCGCTTCCC
GGGAGCAGCAACTGCAGCGATGGACACGACCTCTTTCTGGCCTCATATGGGCTGCATTGCTGGC
TCTGGGCTATGGGTTTCTATTCACTGGGGGTGTGGTGAGCGCCTGGGATCAGGTGTCCTTTTTC
CTCTTCATCATTTTCACCGTGTACGCCATGCTGCCCTTGGGCATGCGGGATGCTGCTGCCGCGG
GGGTCATCTCATCCCTCTCACACCTGCTGGTCCTTGGACTGTACCTTGGGTGGCGGCCTGAGTC
GCAGAGGGATCTGCTACCACAGTTGGCAGCGAATGCGGTGTTGTTCCTGTGTGGGAACGTGGTG
GGAGCATACCACAAGGCCCTGATGGAGCGAGCATTGCGCGCCACGTTCCGGGAGGCTCTTAGCT
CCCTGCATTCACGCCGGAGGTTGGACACTGAGAAAAAGCACCAGGAGCACCTCCTCTTGTCTAT
CCTTCCTGCCTACCTGGCCCGAGAGATGAAGGCAGAGATCATGGCTCGGCTGCAGGCTGGACAG
AGCTCACGGCCAGAGAACACAAACAACTTTCACAGCCTGTATGTCAAGAGGCACCAAGGAGTGA
GTGTGCTGTATGCTGACATCGTGGGCTTCACACGGCTGGCCAGTGAGTGTTCCCCTAAGGAGCT
GGTGCTAATGCTCAATGAACTCTTCGGCAAATTCGACCAAATTGCAAAGGAGCACGAATGCATG
CGGATCAAGATCCTGGGAGACTGTTACTACTGTGTATCCGGGCTGCCCCTCTCTCTGCCTGACC
ACGCCATCAATTGCGTGCGCATGGGACTGGACATGTGCCGGGCCATCAGGAAACTTCGGGTAGC
CACCGGTGTGGATATCAACATGCGTGTCGGTGTGCACTCAGGCAGCGTCCTCTGTGGAGTCATC
GGGCTACAGAAGTGGCAGTATGATGTCTGGTCCCATGATGTCACATTGGCCAACCATATGGAAG
CAGGCGGCGTTCCAGGACGAGTGCACATCACAGGGGCCACGCTGGCCCTGCTGGCAGGAGCTTA
TGCTGTGGAGAGAGCAGACATGGAGCATCGAGACCCATACCTTCGGGAGCTAGGGGAACCCACA
TACCTGGTCATTGATCCTTGGGCTGAGGAGGAAGACGAGAAGGGCACCGAGAGAGGATTGCTGT
CTTCTCTAGAGGGGCACACGATGCGTCCGTCACTACTGATGACTCGTTATCTGGAGTCTTGGGG
TGCAGCCAAGCCTTTCGCCCACCTAAGCCACGTCGACAGTCCTGCATCCACATCCACTCCACTC
CCGGAGAAAGCCTTCAGCCCCCAGTGGAGCCTGGACCGGAGTCGCACCCCCCGCGGGCTACACG
ATGAACTGGACACTGGAGATGCCAAGTTCTTCCAGGTCATCGAACAACTCAACTCTCAAAAACA
GTGGAAACAGTCGAAGGACTTCAACCTCCTGACGCTCTACTTCAGAGAGAAGGAGATGGAGAAA
CAGTATCGGCTGTCTGCGCTCCCCGCCTTCAAATACTACGCAGCCTGCACCTTCCTGGTTTTTC
TGTCCAACTTCACAATCCAAATGCTGGTGACAACCAGGCCCCCAGCTCTGGCCACCACCTACAG
CATCACCTTCCTTCTCTTCCTTCTCCTCCTCTTCGTCTGCTTCTCAGAGCACCTGACGAAGTGC
GTCCAGAAAGGCCCCAAGATGTTGCACTGGCTGCCTGCGCTGTCTGTCCTGGTGGCCACACGGC
CGGGATTGCGAGTAGCCCTGGGCACAGCCACCATCCTCCTGGTGTTCACTATGGCCGTCGTCAG
CCTGCTCTTCTTACCAGTGTCGTCAGACTGCCCTTTCCTGGCTCCCAATGTGTCGTCAGTGGCT
TTTAATACTTCCTGGGAGCTGCCAGCATCCCTGCCTCTCATCAGCATCCCATACTCCATGCATT
GTTGCGTGCTGGGTTTCCTTTCCTGCTCCCTTTTTCTGCACATGAGCTTCGAACTGAAGCTGCT
TCTGCTTCTGCTGTGGCTGGTGGCATCTTGTTCCCTATTTCTGCACTCCCACGCCTGGCTGTCC
GACTGCCTCATTGCCCGCCTTTATCAAGGCTCATTGGGCTCCAGGCCGGGGGTACTGAAGGAAC
CGAAACTGATGGGAGCTATCTACTTCTTCATCTTCTTCTTCACACTCCTCGTCCTGGCTCGGCA
GAATGAGTATTACTGTCGCCTGGACTTCCTATGGAAAAAGAAACTGAGGCAGGAGCGAGAGGAA
ACTGAGACAATGGAGAACCTGACCCGGCTCCTCCTGGAGAATGTACTCCCTGCACACGTGGCGC
CCCAGTTCATCGGCCAGAACCGGCGCAATGAGGACCTCTACCATCAGTCGTACGAATGTGTTTG
TGTCCTCTTTGCATCCATCCCAGACTTTAAGGAATTCTACTCGGAATCCAACATCAACCATGAG
GGGCTAGAGTGTCTGCGGCTGCTCAATGAGATCATTGCCGACTTTGATGAGCTGCTCTCCAAGC
CAAAGTTCAGTGGAGTAGAGAAGATCAAAACTATCGGCAGCACCTACATGGCGGCCACAGGCCT
AAATGCCACCCCTGGGCAGGACACACAACAGGACGCTGAGAGAAGCTGCAGCCATCTGGGCACC
ATGGTGGAATTTGCAGTGGCCCTGGGGTCTAAGCTGGGTGTCATCAATAAGCACTCGTTCAACA
ACTTCCGCCTGCGTGTGGGGTTAAACCATGGACCAGTCGTAGCAGGGGTGATTGGGGCGCAGAA
GCCACAATATGACATCTGGGGGAATACAGTGAACGTGGCCAGCCGCATGGAGAGCACAGGAGTT
CTCGGCAAGATCCAAGTGACCGAGGAGACAGCTAGGGCTCTGCAATCCCTGGGTTACACATGCT
ACAGCCGAGGTGTCATCAAGGTCAAGGGCAAAGGGCAACTCTGTACCTACTTCCTGAACACAGA
CCTGACACGAACCGGATCTCCCTCAGCATCCTAGACACCTGAGCTCCCCTTCTCCAAGATCCTC
AATAAAATGTCTCCAGGCATCTGAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039093610 ⟹ XP_038949538

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	33,236,201 - 33,249,960 (-)	NCBI
mRatBN7.2	15	29,266,280 - 29,280,040 (-)	NCBI

RefSeq Acc Id:

XM_039093611 ⟹ XP_038949539

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	33,236,201 - 33,247,551 (-)	NCBI
mRatBN7.2	15	29,266,280 - 29,277,631 (-)	NCBI

RefSeq Acc Id:

XM_063274588 ⟹ XP_063130658

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	33,237,127 - 33,252,070 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_062158	(Get FASTA)	NCBI Sequence Viewer
	XP_038949538	(Get FASTA)	NCBI Sequence Viewer
	XP_038949539	(Get FASTA)	NCBI Sequence Viewer
	XP_063130658	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA40665	(Get FASTA)	NCBI Sequence Viewer
	AAH81813	(Get FASTA)	NCBI Sequence Viewer
	EDM14282	(Get FASTA)	NCBI Sequence Viewer
	EDM14283	(Get FASTA)	NCBI Sequence Viewer
	EDM14284	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000027719
	ENSRNOP00000027719.4
GenBank Protein	P26770	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_062158 ⟸ NM_019285

- UniProtKB:

P26770 (UniProtKB/Swiss-Prot), Q66HK5 (UniProtKB/TrEMBL), A6KH53 (UniProtKB/TrEMBL), F7EY48 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MARLFSPRPPPSEDLFYETYYSLSQQYPLLILLLVIVLCAIVALPAVAWASGRELTSDPSFLTT
VLCALGGFSLLLGLASREQQLQRWTRPLSGLIWAALLALGYGFLFTGGVVSAWDQVSFFLFIIF
TVYAMLPLGMRDAAAAGVISSLSHLLVLGLYLGWRPESQRDLLPQLAANAVLFLCGNVVGAYHK
ALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQSSRPE
NTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKIL
GDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRVATGVDINMRVGVHSGSVLCGVIGLQKW
QYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVERADMEHRDPYLRELGEPTYLVID
PWAEEEDEKGTERGLLSSLEGHTMRPSLLMTRYLESWGAAKPFAHLSHVDSPASTSTPLPEKAF
SPQWSLDRSRTPRGLHDELDTGDAKFFQVIEQLNSQKQWKQSKDFNLLTLYFREKEMEKQYRLS
ALPAFKYYAACTFLVFLSNFTIQMLVTTRPPALATTYSITFLLFLLLLFVCFSEHLTKCVQKGP
KMLHWLPALSVLVATRPGLRVALGTATILLVFTMAVVSLLFLPVSSDCPFLAPNVSSVAFNTSW
ELPASLPLISIPYSMHCCVLGFLSCSLFLHMSFELKLLLLLLWLVASCSLFLHSHAWLSDCLIA
RLYQGSLGSRPGVLKEPKLMGAIYFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETME
NLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASIPDFKEFYSESNINHEGLECL
RLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATPGQDTQQDAERSCSHLGTMVEFA
VALGSKLGVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQ
VTEETARALQSLGYTCYSRGVIKVKGKGQLCTYFLNTDLTRTGSPSAS

hide sequence

RefSeq Acc Id:

ENSRNOP00000059696 ⟸ ENSRNOT00000067536

RefSeq Acc Id:

ENSRNOP00000027719 ⟸ ENSRNOT00000027719

RefSeq Acc Id:	XP_038949538 ⟸ XM_039093610
- Peptide Label:	isoform X1
- UniProtKB:	P26770 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038949539 ⟸ XM_039093611
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063130658 ⟸ XM_063274588
- Peptide Label:	isoform X2

Protein Domains

Guanylate cyclase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P26770-F1-model_v2	AlphaFold	P26770	1-1064	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699690

Promoter ID:

EPDNEW_R10213

Type:

single initiation site

Name:

Adcy4_1

Description:

adenylate cyclase 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	15	34,469,729 - 34,469,789	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2034	AgrOrtholog
BioCyc Gene	G2FUF-13686	BioCyc
Ensembl Genes	ENSRNOG00000020401	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000027719	ENTREZGENE
	ENSRNOT00000027719.8	UniProtKB/TrEMBL
Gene3D-CATH	3.30.70.1230	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7125413	IMAGE-MGC_LOAD
InterPro	A/G_cyclase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	A/G_cyclase_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AC_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Adcy	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Adcy_conserved_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Nucleotide_cyclase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:54223	UniProtKB/TrEMBL
MGC_CLONE	MGC:93493	IMAGE-MGC_LOAD
NCBI Gene	54223	ENTREZGENE
PANTHER	ADENYLATE CYCLASE TYPE 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ADENYLATE CYCLASE TYPE 4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	AC_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DUF1053	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Guanylate_cyc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Adcy4	PhenoGen
PIRSF	Ade_cyc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	GUANYLATE_CYCLASE_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GUANYLATE_CYCLASE_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000020401	RatGTEx
SMART	CYCc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF55073	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC208929
UniProt	A6KH53	ENTREZGENE, UniProtKB/TrEMBL
	A6KH54_RAT	UniProtKB/TrEMBL
	A6KH55_RAT	UniProtKB/TrEMBL
	ADCY4_RAT	UniProtKB/Swiss-Prot
	F7EY48	ENTREZGENE, UniProtKB/TrEMBL
	P26770	ENTREZGENE
	Q66HK5	ENTREZGENE
UniProt Secondary	Q66HK5	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Adcy4	adenylate cyclase 4		adenylyl cyclase 4	Name updated	1299863	APPROVED
2002-06-10	Adcy4	adenylyl cyclase 4			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in the central nervous system and other tissues	69739
gene_function	catalyzes the conversion of ATP to 3,5-cyclic AMP + diphosphate	69739
gene_process	plays a role in intracellular signaling	69739
gene_regulation	not regulated by calmodulin	69739
gene_regulation	activated by the Gs alpha and G-protein beta gamma subunit complex	69739

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)