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Gene: Adam10 (ADAM metallopeptidase domain 10) Rattus norvegicus
Symbol: Adam10
Name: ADAM metallopeptidase domain 10
RGD ID: 2032
Description: Exhibits metalloendopeptidase activity. Involved in several processes, including amyloid-beta formation; regulation of dendritic spine morphogenesis; and response to antineoplastic agent. Localizes to several cellular components, including glutamatergic synapse; synaptic vesicle; and trans-Golgi network. Biomarker of Alzheimer's disease; cardiomyopathy; cataract; status epilepticus; and thoracic aortic aneurysm. Human ortholog(s) of this gene implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura. Orthologous to human ADAM10 (ADAM metallopeptidase domain 10); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; interleukin-6 signaling pathway; Notch signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrolein.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: a disintegrin and metallopeptidase domain 10; a disintegrin and metalloprotease domain (ADAM) 10; a disintegrin and metalloprotease domain 10; ADAM 10; disintegrin and metalloproteinase domain-containing protein 10; kuzbanian; kuzbanian protein homolog; LOC501019; MADM; mammalian disintegrin-metalloprotease; RGD1566370; RGD1566370
Homo sapiens (human) : ADAM10 (ADAM metallopeptidase domain 10)  HGNC  Alliance
Mus musculus (house mouse) : Adam10 (a disintegrin and metallopeptidase domain 10)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adam10 (ADAM metallopeptidase domain 10)
Pan paniscus (bonobo/pygmy chimpanzee) : ADAM10 (ADAM metallopeptidase domain 10)
Canis lupus familiaris (dog) : ADAM10 (ADAM metallopeptidase domain 10)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adam10 (ADAM metallopeptidase domain 10)
Sus scrofa (pig) : ADAM10 (ADAM metallopeptidase domain 10)
Chlorocebus sabaeus (African green monkey) : ADAM10 (ADAM metallopeptidase domain 10)
Heterocephalus glaber (naked mole-rat) : Adam10 (ADAM metallopeptidase domain 10)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0877,107,355 - 77,237,483 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl877,107,536 - 77,237,483 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0875,842,118 - 75,974,564 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4875,200,657 - 75,289,572 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1875,307,687 - 75,310,191 (+)NCBI
Celera870,259,195 - 70,383,316 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Adam10
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2032
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.