Crip1 (cysteine rich protein 1) - Rat Genome Database

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Gene: Crip1 (cysteine rich protein 1) Rattus norvegicus
Analyze
Symbol: Crip1
Name: cysteine rich protein 1
RGD ID: 1597237
Description: Predicted to enable peptide binding activity and zinc ion binding activity. Predicted to be involved in several processes, including cellular response to UV-B; intrinsic apoptotic signaling pathway in response to DNA damage; and prostate gland stromal morphogenesis. Predicted to be located in cytoplasm. Orthologous to human CRIP1 (cysteine rich protein 1); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CRIP; Crp-1; cysteine-rich intestinal protein; cysteine-rich protein 1; cysteine-rich protein 1 (intestinal); LOC691657; RATCRIP; similar to Cysteine-rich protein 1 (Cysteine-rich intestinal protein) (CRIP)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86138,047,801 - 138,055,672 (+)NCBIGRCr8
mRatBN7.26132,226,746 - 132,234,620 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6132,226,746 - 132,234,620 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6132,395,928 - 132,403,668 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,686,073 - 132,693,813 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06132,061,146 - 132,069,019 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,959,171 - 137,967,042 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,959,171 - 137,967,042 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06146,953,514 - 146,961,385 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46138,156,366 - 138,161,127 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16138,162,743 - 138,165,342 (+)NCBI
Celera6129,765,196 - 129,773,068 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
genistein  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (EXP)
lithium atom  (ISO)
lithium hydride  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
N-nitrosodimethylamine  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paricalcitol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO,ISS)

Molecular Function
peptide binding  (ISO,ISS)
zinc ion binding  (IBA,IEA,ISO,ISS,TAS)

References

References - curated
# Reference Title Reference Citation
1. DNA bending by the mammalian high-mobility group protein AT hook 2. Chen B, etal., Biochemistry. 2010 Mar 2;49(8):1590-5. doi: 10.1021/bi901881c.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Identification and rational redesign of peptide ligands to CRIP1, a novel biomarker for cancers. Hao J, etal., PLoS Comput Biol. 2008 Aug 1;4(8):e1000138. doi: 10.1371/journal.pcbi.1000138.
4. Human cysteine-rich intestinal protein: cDNA cloning and expression of recombinant protein and identification in human peripheral blood mononuclear cells. Khoo C, etal., Protein Expr Purif. 1997 Apr;9(3):379-87.
5. Ultraviolet B radiation regulates cysteine-rich protein 1 in human keratinocytes. Latonen L, etal., Photodermatol Photoimmunol Photomed. 2010 Apr;26(2):70-7. doi: 10.1111/j.1600-0781.2010.00488.x.
6. Cloning and initial characterization of the promoter region of the rat cysteine-rich intestinal protein gene. Levenson CW, etal., Biochem J 1994 Nov 1;303 ( Pt 3):731-6.
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Isolation and characterization of a cDNA that codes for a LIM-containing protein which is developmentally regulated in heart. Tsui SK, etal., Biochem Biophys Res Commun. 1994 Nov 30;205(1):497-505.
Additional References at PubMed
PMID:1946385   PMID:3085096   PMID:8632452   PMID:8889548   PMID:9507743   PMID:12006348   PMID:15632090   PMID:17486081  


Genomics

Comparative Map Data
Crip1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86138,047,801 - 138,055,672 (+)NCBIGRCr8
mRatBN7.26132,226,746 - 132,234,620 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6132,226,746 - 132,234,620 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6132,395,928 - 132,403,668 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,686,073 - 132,693,813 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06132,061,146 - 132,069,019 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,959,171 - 137,967,042 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,959,171 - 137,967,042 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06146,953,514 - 146,961,385 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46138,156,366 - 138,161,127 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16138,162,743 - 138,165,342 (+)NCBI
Celera6129,765,196 - 129,773,068 (+)NCBICelera
Cytogenetic Map6q32NCBI
CRIP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814105,486,886 - 105,488,947 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14105,486,317 - 105,488,947 (+)EnsemblGRCh38hg38GRCh38
GRCh3714105,953,223 - 105,955,284 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614105,024,594 - 105,026,171 (+)NCBINCBI36Build 36hg18NCBI36
Build 3414105,024,593 - 105,026,167NCBI
Celera1486,004,651 - 86,006,568 (+)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1486,151,418 - 86,153,286 (+)NCBIHuRef
CHM1_114105,890,975 - 105,892,843 (+)NCBICHM1_1
T2T-CHM13v2.01499,736,255 - 99,738,315 (+)NCBIT2T-CHM13v2.0
Crip1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912113,115,632 - 113,117,499 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12113,109,936 - 113,117,499 (+)EnsemblGRCm39 Ensembl
GRCm3812113,152,012 - 113,153,879 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12113,146,316 - 113,153,879 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712114,390,223 - 114,392,090 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612113,599,820 - 113,601,687 (+)NCBIMGSCv36mm8
Celera12114,367,853 - 114,369,721 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.59NCBI
Crip1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555383,683,747 - 3,686,468 (+)NCBIChiLan1.0ChiLan1.0
CRIP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215106,669,273 - 106,676,689 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114105,891,619 - 105,893,192 (+)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl14105,914,119 - 105,915,365 (+)Ensemblpanpan1.1panPan2
CRIP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1872,784,726 - 72,786,108 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl872,784,788 - 72,786,108 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha872,294,909 - 72,296,297 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0873,072,668 - 73,074,056 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl873,072,736 - 73,074,056 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1872,753,372 - 72,754,760 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0872,801,213 - 72,802,601 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0873,192,688 - 73,194,076 (+)NCBIUU_Cfam_GSD_1.0
Crip1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086401,272,091 - 1,273,738 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936621101,046 - 102,664 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936621101,046 - 102,660 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC110258364
(Sus scrofa - pig)		 No map positions available.
CRIP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12483,385,005 - 83,386,596 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2483,384,529 - 83,386,903 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605370,843,615 - 70,845,255 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crip1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473453,570 - 57,431 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473453,570 - 55,181 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Crip1
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:41
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000006835
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6125628133137801795Rat

Markers in Region
D6Wox21  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26132,232,243 - 132,232,369 (+)MAPPERmRatBN7.2
Rnor_6.06137,964,666 - 137,964,791NCBIRnor6.0
Rnor_5.06146,959,009 - 146,959,134UniSTSRnor5.0
RGSC_v3.46138,158,583 - 138,158,708UniSTSRGSC3.4
Celera6129,770,692 - 129,770,817UniSTS
Cytogenetic Map6q32UniSTS
RH127355  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X16,094,614 - 16,094,816 (+)MAPPERmRatBN7.2
mRatBN7.26132,225,822 - 132,226,023 (+)MAPPERmRatBN7.2
Rnor_6.06137,958,248 - 137,958,448NCBIRnor6.0
Rnor_6.0X16,947,044 - 16,947,245NCBIRnor6.0
Rnor_5.06146,952,591 - 146,952,791UniSTSRnor5.0
Rnor_5.0X17,729,253 - 17,729,454UniSTSRnor5.0
RGSC_v3.46138,152,165 - 138,152,365UniSTSRGSC3.4
RGSC_v3.4X29,089,767 - 29,089,968UniSTSRGSC3.4
CeleraX16,165,278 - 16,165,479UniSTS
Celera6129,764,273 - 129,764,473UniSTS
Cytogenetic MapXq13UniSTS
Cytogenetic Map6q32UniSTS
RH133355  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map6783.4UniSTS
Cytogenetic Map6q32UniSTS
Crip  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26132,234,027 - 132,234,397 (+)MAPPERmRatBN7.2
Rnor_6.06137,966,450 - 137,966,819NCBIRnor6.0
Rnor_5.06146,960,793 - 146,961,162UniSTSRnor5.0
RGSC_v3.46138,160,367 - 138,160,736UniSTSRGSC3.4
Celera6129,772,476 - 129,772,845UniSTS
Cytogenetic Map6q32UniSTS
D10Bir4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26132,232,906 - 132,234,096 (+)MAPPERmRatBN7.2
Rnor_6.06137,965,329 - 137,966,518NCBIRnor6.0
Rnor_5.06146,959,672 - 146,960,861UniSTSRnor5.0
RGSC_v3.46138,159,246 - 138,160,435UniSTSRGSC3.4
Celera6129,771,355 - 129,772,544UniSTS
Cytogenetic Map6q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 3
Medium 43 51 35 19 35 8 11 64 34 41 11 8
Low 6 6 6 10 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006835   ⟹   ENSRNOP00000006835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6132,226,746 - 132,234,620 (+)Ensembl
Rnor_6.0 Ensembl6137,959,171 - 137,967,042 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099774   ⟹   ENSRNOP00000086909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6132,230,040 - 132,234,620 (+)Ensembl
RefSeq Acc Id: NM_001134933   ⟹   NP_001128405
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86138,047,801 - 138,055,672 (+)NCBI
mRatBN7.26132,226,746 - 132,234,620 (+)NCBI
Rnor_6.06137,959,171 - 137,967,042 (+)NCBI
Rnor_5.06146,953,514 - 146,961,385 (+)NCBI
RGSC_v3.46138,156,366 - 138,161,127 (+)ENTREZGENE
Celera6129,765,196 - 129,773,068 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001244867   ⟹   NP_001231796
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86138,053,868 - 138,055,672 (+)NCBI
mRatBN7.26132,232,816 - 132,234,620 (+)NCBI
Rnor_6.06137,965,238 - 137,967,042 (+)NCBI
Rnor_5.06146,953,514 - 146,961,385 (+)NCBI
Celera6129,771,264 - 129,773,068 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063262530   ⟹   XP_063118600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86138,053,743 - 138,055,668 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001128405   ⟸   NM_001134933
- UniProtKB: P63255 (UniProtKB/Swiss-Prot),   A6KBZ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001231796   ⟸   NM_001244867
- UniProtKB: P63255 (UniProtKB/Swiss-Prot),   A6KBZ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006835   ⟸   ENSRNOT00000006835
RefSeq Acc Id: ENSRNOP00000086909   ⟸   ENSRNOT00000099774
RefSeq Acc Id: XP_063118600   ⟸   XM_063262530
- Peptide Label: isoform X1
Protein Domains
LIM zinc-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63255-F1-model_v2 AlphaFold P63255 1-77 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694862
Promoter ID:EPDNEW_R5386
Type:initiation region
Name:Crip1_1
Description:cysteine rich protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06137,959,189 - 137,959,249EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597237 AgrOrtholog
BioCyc Gene G2FUF-35761 BioCyc
Ensembl Genes ENSRNOG00000027990 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055031290 UniProtKB/Swiss-Prot
  ENSRNOG00060018089 UniProtKB/Swiss-Prot
  ENSRNOG00065000626 UniProtKB/Swiss-Prot
  ENSRNOG00065028936 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006835 ENTREZGENE
  ENSRNOT00000006835.6 UniProtKB/Swiss-Prot
  ENSRNOT00000099774.1 UniProtKB/TrEMBL
  ENSRNOT00055054208 UniProtKB/Swiss-Prot
  ENSRNOT00060031084 UniProtKB/Swiss-Prot
  ENSRNOT00065000895 UniProtKB/Swiss-Prot
  ENSRNOT00065050017 UniProtKB/Swiss-Prot
Gene3D-CATH Cysteine Rich Protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Znf_LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:691657 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 691657 ENTREZGENE
PANTHER CYSTEINE-RICH PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYSTEINE-RICH PROTEIN CRIP FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Crip1 PhenoGen
PROSITE LIM_DOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000027990 RatGTEx
  ENSRNOG00055031290 RatGTEx
  ENSRNOG00060018089 RatGTEx
  ENSRNOG00065000626 RatGTEx
  ENSRNOG00065028936 RatGTEx
SMART LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A364_RAT UniProtKB/TrEMBL
  A6KBZ1 ENTREZGENE, UniProtKB/TrEMBL
  CRIP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P04006 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Crip1  cysteine rich protein 1  Crip1  cysteine-rich protein 1 (intestinal)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-09-21 Crip1  cysteine-rich protein 1 (intestinal)  Crip  cysteine-rich intestinal protein  Data merged from RGD:2404 737654 APPROVED
2008-03-06 Crip1  cysteine-rich protein 1 (intestinal)  LOC691657  similar to Cysteine-rich protein 1 (Cysteine-rich intestinal protein) (CRIP)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC691657  similar to Cysteine-rich protein 1 (Cysteine-rich intestinal protein) (CRIP)  LOC686293  similar to Cysteine-rich protein 1 (Cysteine-rich intestinal protein) (CRIP)  Data merged from RGD:1584271 1643240 APPROVED
2006-11-20 LOC691657  similar to Cysteine-rich protein 1 (Cysteine-rich intestinal protein) (CRIP)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC686293  similar to Cysteine-rich protein 1 (Cysteine-rich intestinal protein) (CRIP)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Crip  cysteine-rich intestinal protein      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains LIM motif-containing zinc finger protein 69817
gene_expression expressed in intestinal cells and in cultured intestinal epithelial cells (IEC-6); expression is developmentally regulated 69817
gene_process may be involved in cellular pathway that results in a Th2 type cytokine response 1298800
gene_regulation expression is induced by glucocorticoid hormones and gene contains binding sites for Sp-1, AP-2, OCT and GATA-2 transcription factors as well as glucocorticoid response elements 69817