Eif4a3 (eukaryotic translation initiation factor 4A3) - Rat Genome Database

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Gene: Eif4a3 (eukaryotic translation initiation factor 4A3) Rattus norvegicus
Analyze
Symbol: Eif4a3
Name: eukaryotic translation initiation factor 4A3
RGD ID: 1591139
Description: Enables RNA stem-loop binding activity; ribonucleoprotein complex binding activity; and selenocysteine insertion sequence binding activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; cellular response to selenite ion; and regulation of translation. Located in dendrite and neuronal cell body. Part of ribonucleoprotein complex. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human EIF4A3 (eukaryotic translation initiation factor 4A3); PARTICIPATES IN spliceosome pathway; mRNA decay pathway; RNA transport pathway; INTERACTS WITH 2,4-dibromophenyl 2,4,5-tribromophenyl ether; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP-dependent RNA helicase DDX48; ATP-dependent RNA helicase eIF4A-3; DEAD box protein 48; eIF-4A-III; eIF4A-III; eukaryotic initiation factor 4A-III; eukaryotic translation initiation factor 4A, isoform 3; LOC688288; similar to DEAD (Asp-Glu-Ala-Asp) box polypeptide 48
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810105,047,567 - 105,057,561 (-)NCBIGRCr8
mRatBN7.210104,549,038 - 104,559,032 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10104,549,038 - 104,559,057 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10109,651,698 - 109,661,700 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010109,114,724 - 109,124,726 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010104,469,667 - 104,479,661 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010108,415,201 - 108,425,195 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10108,415,202 - 108,425,206 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010108,027,035 - 108,037,029 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10103,096,825 - 103,106,820 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of the core exon-junction complex factor eukaryotic initiation factor 4A3 is increased during spatial exploration and striatally-mediated learning. Barker-Haliski ML, etal., Neuroscience. 2012 Dec 13;226:51-61. doi: 10.1016/j.neuroscience.2012.09.003. Epub 2012 Sep 12.
2. Eukaryotic initiation factor 4a3 is a selenium-regulated RNA-binding protein that selectively inhibits selenocysteine incorporation. Budiman ME, etal., Mol Cell. 2009 Aug 28;35(4):479-89. doi: 10.1016/j.molcel.2009.06.026.
3. Identification of a signature motif for the eIF4a3-SECIS interaction. Budiman ME, etal., Nucleic Acids Res. 2011 Sep 1;39(17):7730-9. doi: 10.1093/nar/gkr446. Epub 2011 Jun 17.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. The EJC factor eIF4AIII modulates synaptic strength and neuronal protein expression. Giorgi C, etal., Cell. 2007 Jul 13;130(1):179-91.
6. Contribution of copy number variants involving nonsense-mediated mRNA decay pathway genes to neuro-developmental disorders. Nguyen LS, etal., Hum Mol Genet. 2013 May 1;22(9):1816-25. doi: 10.1093/hmg/ddt035. Epub 2013 Jan 31.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. The ever-increasing complexities of the exon junction complex. Tange TO, etal., Curr Opin Cell Biol. 2004 Jun;16(3):279-84.
13. Proteomics-based identification of DEAD-box protein 48 as a novel autoantigen, a prospective serum marker for pancreatic cancer. Xia Q, etal., Biochem Biophys Res Commun. 2005 May 6;330(2):526-32.
Additional References at PubMed
PMID:10523622   PMID:11991638   PMID:12477932   PMID:15632090   PMID:16209946   PMID:16601204   PMID:18423201   PMID:18480465   PMID:19946888   PMID:22658674   PMID:22681889   PMID:22961380  
PMID:24360810   PMID:24625528   PMID:29301961   PMID:30053369   PMID:37839527  


Genomics

Comparative Map Data
Eif4a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810105,047,567 - 105,057,561 (-)NCBIGRCr8
mRatBN7.210104,549,038 - 104,559,032 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10104,549,038 - 104,559,057 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10109,651,698 - 109,661,700 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010109,114,724 - 109,124,726 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010104,469,667 - 104,479,661 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010108,415,201 - 108,425,195 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10108,415,202 - 108,425,206 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010108,027,035 - 108,037,029 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10103,096,825 - 103,106,820 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
EIF4A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381780,134,369 - 80,147,128 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1780,134,369 - 80,147,151 (-)EnsemblGRCh38hg38GRCh38
GRCh371778,108,168 - 78,120,927 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361775,723,612 - 75,735,533 (-)NCBINCBI36Build 36hg18NCBI36
Build 341775,723,612 - 75,735,533NCBI
Celera1774,737,992 - 74,749,960 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1773,549,709 - 73,561,680 (-)NCBIHuRef
CHM1_11778,195,223 - 78,207,193 (-)NCBICHM1_1
T2T-CHM13v2.01781,034,760 - 81,047,523 (-)NCBIT2T-CHM13v2.0
Eif4a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911119,179,189 - 119,190,869 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11119,179,189 - 119,190,915 (-)EnsemblGRCm39 Ensembl
GRCm3811119,288,363 - 119,300,043 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11119,288,363 - 119,300,089 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711119,149,677 - 119,161,357 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611119,104,453 - 119,116,133 (-)NCBIMGSCv36mm8
Celera11131,033,290 - 131,044,990 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1183.35NCBI
Eif4a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555062,749,534 - 2,760,873 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555062,749,534 - 2,760,873 (+)NCBIChiLan1.0ChiLan1.0
LOC100988043
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21996,549,687 - 96,561,728 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117101,614,275 - 101,626,237 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01774,221,793 - 74,233,738 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
EIF4A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.191,582,950 - 1,593,893 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl91,582,993 - 1,593,892 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha92,222,792 - 2,233,743 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.092,215,271 - 2,226,216 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl92,215,233 - 2,226,208 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.192,238,677 - 2,249,620 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.092,364,112 - 2,375,060 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.092,445,388 - 2,456,373 (+)NCBIUU_Cfam_GSD_1.0
Eif4a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056022,251,664 - 2,263,559 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365944,147,685 - 4,160,293 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365944,148,401 - 4,160,290 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF4A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl122,285,579 - 2,313,874 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1122,285,679 - 2,311,750 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2122,267,492 - 2,293,229 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF4A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11672,097,692 - 72,113,112 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607743,403,306 - 43,418,370 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif4a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248019,240,780 - 9,250,863 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248019,240,780 - 9,250,864 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eif4a3
57 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:30
Count of miRNA genes:29
Interacting mature miRNAs:30
Transcripts:ENSRNOT00000073140
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
631539Oia6Oil induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1097010147104670812Rat

Markers in Region
D10Got223  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210104,552,104 - 104,552,234 (+)MAPPERmRatBN7.2
Rnor_6.010108,418,268 - 108,418,397NCBIRnor6.0
Rnor_5.010108,030,102 - 108,030,231UniSTSRnor5.0
Celera10103,099,893 - 103,100,022UniSTS
RH137027  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210104,549,126 - 104,549,399 (+)MAPPERmRatBN7.2
Rnor_6.010108,415,290 - 108,415,562NCBIRnor6.0
Rnor_5.010108,027,124 - 108,027,396UniSTSRnor5.0
Celera10103,096,914 - 103,097,186UniSTS
RH129599  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210104,549,065 - 104,549,373 (+)MAPPERmRatBN7.2
Rnor_6.010108,415,229 - 108,415,536NCBIRnor6.0
Rnor_5.010108,027,063 - 108,027,370UniSTSRnor5.0
Celera10103,096,853 - 103,097,160UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000073140   ⟹   ENSRNOP00000066302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10104,549,038 - 104,559,057 (-)Ensembl
Rnor_6.0 Ensembl10108,415,202 - 108,425,206 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095583   ⟹   ENSRNOP00000080401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10104,549,038 - 104,559,057 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114380   ⟹   ENSRNOP00000081737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10104,549,045 - 104,559,019 (-)Ensembl
RefSeq Acc Id: NM_001100158   ⟹   NP_001093628
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810105,047,567 - 105,057,561 (-)NCBI
mRatBN7.210104,549,038 - 104,559,032 (-)NCBI
Rnor_6.010108,415,201 - 108,425,195 (-)NCBI
Rnor_5.010108,027,035 - 108,037,029 (-)NCBI
Celera10103,096,825 - 103,106,820 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001093628   ⟸   NM_001100158
- UniProtKB: Q3B8Q2 (UniProtKB/Swiss-Prot),   A0A8I5ZT01 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066302   ⟸   ENSRNOT00000073140
RefSeq Acc Id: ENSRNOP00000080401   ⟸   ENSRNOT00000095583
RefSeq Acc Id: ENSRNOP00000081737   ⟸   ENSRNOT00000114380
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3B8Q2-F1-model_v2 AlphaFold Q3B8Q2 1-411 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697944
Promoter ID:EPDNEW_R8468
Type:initiation region
Name:Eif4a3_1
Description:eukaryotic translation initiation factor 4A3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010108,425,157 - 108,425,217EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1591139 AgrOrtholog
BioCyc Gene G2FUF-22495 BioCyc
Ensembl Genes ENSRNOG00000045791 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055032767 UniProtKB/Swiss-Prot
  ENSRNOG00060026889 UniProtKB/Swiss-Prot
  ENSRNOG00065004580 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000073140 ENTREZGENE
  ENSRNOT00000073140.3 UniProtKB/Swiss-Prot
  ENSRNOT00000095583.1 UniProtKB/TrEMBL
  ENSRNOT00000114380.1 UniProtKB/TrEMBL
  ENSRNOT00055056649 UniProtKB/Swiss-Prot
  ENSRNOT00060046639 UniProtKB/Swiss-Prot
  ENSRNOT00065006668 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7130292 IMAGE-MGC_LOAD
InterPro DEAD/DEAH_box_helicase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA-helicase_DEAD-box_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA_helicase_DEAD_Q_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:688288 UniProtKB/Swiss-Prot
MGC_CLONE MGC:125040 IMAGE-MGC_LOAD
NCBI Gene 688288 ENTREZGENE
PANTHER ATP-DEPENDENT RNA HELICASE DBP3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EUKARYOTIC INITIATION FACTOR 4A-III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DEAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Eif4a3 PhenoGen
PROSITE DEAD_ATP_HELICASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICASE_ATP_BIND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Q_MOTIF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000045791 RatGTEx
  ENSRNOG00055032767 RatGTEx
  ENSRNOG00060026889 RatGTEx
  ENSRNOG00065004580 RatGTEx
SMART DEXDc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZSA0_RAT UniProtKB/TrEMBL
  A0A8I5ZT01 ENTREZGENE, UniProtKB/TrEMBL
  IF4A3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-01 Eif4a3  eukaryotic translation initiation factor 4A3  Eif4a3  eukaryotic translation initiation factor 4A, isoform 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-23 Eif4a3  eukaryotic translation initiation factor 4A, isoform 3  LOC688288  similar to DEAD (Asp-Glu-Ala-Asp) box polypeptide 48  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC688288  similar to DEAD (Asp-Glu-Ala-Asp) box polypeptide 48      Symbol and Name status set to provisional 70820 PROVISIONAL