Pabir3 (PABIR family member 3) - Rat Genome Database

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Gene: Pabir3 (PABIR family member 3) Rattus norvegicus
Analyze
Symbol: Pabir3
Name: PABIR family member 3
RGD ID: 1590266
Description: Predicted to enable protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in mitotic G2/M transition checkpoint. Predicted to be active in cytoplasm and nucleus. Orthologous to human PABIR3 (PABIR family member 3); INTERACTS WITH bisphenol A; 1,2-dichloroethane (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Fam122c; family with sequence similarity 122, member C; family with sequence similarity 122C; hypothetical protein LOC685701; LOC100909942; LOC685701; PABIR family member 1; protein FAM122A-like; similar to CG4497-PA; uncharacterized protein LOC685701
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X137,939,690 - 138,003,322 (+)NCBIGRCr8
mRatBN7.2X133,020,162 - 133,083,801 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX133,020,190 - 133,083,805 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X157,786,558 - 157,848,875 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX157,786,730 - 157,848,842 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X152,412,029 - 152,474,170 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X140,228,974 - 140,288,556 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic MapXq36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
nucleus  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Pabir3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X137,939,690 - 138,003,322 (+)NCBIGRCr8
mRatBN7.2X133,020,162 - 133,083,801 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX133,020,190 - 133,083,805 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X157,786,558 - 157,848,875 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX157,786,730 - 157,848,842 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X152,412,029 - 152,474,170 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X140,228,974 - 140,288,556 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic MapXq36NCBI
PABIR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X134,796,364 - 134,864,771 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX134,796,395 - 134,854,835 (+)EnsemblGRCh38hg38GRCh38
GRCh37X133,930,394 - 133,998,801 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X133,768,890 - 133,816,282 (+)NCBINCBI36Build 36hg18NCBI36
CeleraX134,317,202 - 134,375,405 (+)NCBICelera
Cytogenetic MapXq26.3NCBI
HuRefX123,328,560 - 123,386,388 (+)NCBIHuRef
CHM1_1X133,841,887 - 133,900,001 (+)NCBICHM1_1
T2T-CHM13v2.0X133,121,428 - 133,189,846 (+)NCBIT2T-CHM13v2.0
Pabir3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X52,362,296 - 52,420,063 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX52,362,301 - 52,420,062 (+)EnsemblGRCm39 Ensembl
GRCm38X53,273,419 - 53,331,186 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX53,273,424 - 53,331,185 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X50,626,610 - 50,654,678 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X49,518,060 - 49,575,812 (+)NCBIMGSCv36mm8
MGSCv36X38,891,703 - 38,948,725 (+)NCBIMGSCv36mm8
CeleraX40,698,754 - 40,726,909 (+)NCBICelera
Cytogenetic MapXA5NCBI
cM MapX29.45NCBI
PABIR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X134,231,707 - 134,291,435 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X134,235,305 - 134,295,501 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X123,945,305 - 124,005,318 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X134,241,021 - 134,300,941 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX134,241,315 - 134,300,941 (+)Ensemblpanpan1.1panPan2
LOC611751
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X105,418,344 - 105,496,195 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX105,418,393 - 105,464,613 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX91,529,088 - 91,607,149 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X107,280,786 - 107,359,012 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX107,280,834 - 107,327,140 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X104,691,672 - 104,769,745 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X106,557,848 - 106,629,587 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X106,349,350 - 106,427,344 (+)NCBIUU_Cfam_GSD_1.0
PABIR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X110,619,227 - 110,682,249 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X126,483,972 - 126,547,196 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PABIR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X109,971,573 - 110,034,004 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606547,578,030 - 47,659,784 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Pabir3
38 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:140
Count of miRNA genes:108
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000035398
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium 7
Low
Below cutoff 3 4 1 3 1 3 5 4 1 3 3

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_006257649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001842827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001842828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001842829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005498083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005498084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005498085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_597821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000035398   ⟹   ENSRNOP00000034281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX133,020,190 - 133,083,805 (+)Ensembl
Rnor_6.0 EnsemblX157,786,730 - 157,848,842 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109893   ⟹   ENSRNOP00000083072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX133,020,190 - 133,083,805 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118738   ⟹   ENSRNOP00000088909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX133,020,190 - 133,083,805 (+)Ensembl
RefSeq Acc Id: XM_006257651   ⟹   XP_006257713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X137,939,691 - 138,003,322 (+)NCBI
mRatBN7.2X133,020,163 - 133,083,801 (+)NCBI
Rnor_6.0X157,786,749 - 157,848,875 (-)NCBI
Rnor_5.0X152,412,029 - 152,474,170 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773644   ⟹   XP_008771866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X137,939,691 - 138,003,322 (+)NCBI
mRatBN7.2X133,020,163 - 133,083,801 (+)NCBI
Rnor_6.0X157,786,771 - 157,848,875 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039100141   ⟹   XP_038956069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X137,939,775 - 137,973,197 (+)NCBI
mRatBN7.2X133,020,252 - 133,053,662 (+)NCBI
RefSeq Acc Id: XM_039100142   ⟹   XP_038956070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X137,939,690 - 137,973,197 (+)NCBI
mRatBN7.2X133,020,162 - 133,053,663 (+)NCBI
RefSeq Acc Id: XM_063280539   ⟹   XP_063136609
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X137,939,691 - 137,973,197 (+)NCBI
RefSeq Acc Id: XM_063280540   ⟹   XP_063136610
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X137,939,691 - 137,972,967 (+)NCBI
RefSeq Acc Id: XR_001842827
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X137,939,691 - 138,003,322 (+)NCBI
mRatBN7.2X133,020,163 - 133,083,801 (+)NCBI
Rnor_6.0X157,786,732 - 157,848,875 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001842829
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X137,939,691 - 138,003,322 (+)NCBI
mRatBN7.2X133,020,163 - 133,083,801 (+)NCBI
Rnor_6.0X157,786,772 - 157,848,875 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005498083
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X137,939,691 - 138,003,322 (+)NCBI
mRatBN7.2X133,020,163 - 133,083,801 (+)NCBI
RefSeq Acc Id: XR_005498084
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X137,939,691 - 138,003,322 (+)NCBI
mRatBN7.2X133,020,163 - 133,083,801 (+)NCBI
RefSeq Acc Id: XR_005498085
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X137,939,691 - 138,003,322 (+)NCBI
mRatBN7.2X133,020,163 - 133,083,801 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_006257713   ⟸   XM_006257651
- Peptide Label: isoform X2
- UniProtKB: D3ZNP4 (UniProtKB/TrEMBL),   A0A8I6GGQ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771866   ⟸   XM_008773644
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZYL0 (UniProtKB/TrEMBL),   A0A8I6GGQ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000034281   ⟸   ENSRNOT00000035398
RefSeq Acc Id: XP_038956070   ⟸   XM_039100142
- Peptide Label: isoform X4
- UniProtKB: A0A8I6GGQ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956069   ⟸   XM_039100141
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZYL0 (UniProtKB/TrEMBL),   A0A8I6GGQ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000083072   ⟸   ENSRNOT00000109893
RefSeq Acc Id: ENSRNOP00000088909   ⟸   ENSRNOT00000118738
RefSeq Acc Id: XP_063136609   ⟸   XM_063280539
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063136610   ⟸   XM_063280540
- Peptide Label: isoform X3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZNP4-F1-model_v2 AlphaFold D3ZNP4 1-180 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1590266 AgrOrtholog
BioCyc Gene G2FUF-977 BioCyc
Ensembl Genes ENSRNOG00000028011 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035398 ENTREZGENE
  ENSRNOT00000035398.6 UniProtKB/TrEMBL
  ENSRNOT00000109893 ENTREZGENE
  ENSRNOT00000109893.1 UniProtKB/TrEMBL
  ENSRNOT00000118738 ENTREZGENE
  ENSRNOT00000118738.1 UniProtKB/TrEMBL
InterPro FAM122 UniProtKB/TrEMBL
KEGG Report rno:685701 UniProtKB/TrEMBL
NCBI Gene 685701 ENTREZGENE
PANTHER FAM122C PROTEIN UniProtKB/TrEMBL
  PTHR22227 UniProtKB/TrEMBL
PhenoGen Pabir3 PhenoGen
RatGTEx ENSRNOG00000028011 RatGTEx
UniProt A0A8I5ZYL0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GGQ1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZNP4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Pabir3  PABIR family member 3  LOC100909942  protein FAM122A-like  Data merged from RGD:6501024 737654 PROVISIONAL
2020-10-27 Pabir3  PABIR family member 3  Fam122c  family with sequence similarity 122C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-01 Fam122c  family with sequence similarity 122C  Fam122c  family with sequence similarity 122, member C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100909942  protein FAM122A-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-11-25 Fam122c  family with sequence similarity 122, member C  Fam122c  family with sequence similarity 122C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Fam122c  family with sequence similarity 122C  LOC685701  similar to CG4497-PA  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC685701  similar to CG4497-PA      Symbol and Name status set to provisional 70820 PROVISIONAL