Fthl17a (ferritin, heavy polypeptide-like 17, member A) - Rat Genome Database

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Gene: Fthl17a (ferritin, heavy polypeptide-like 17, member A) Rattus norvegicus
Analyze
Symbol: Fthl17a (Ensembl: Fthl17e)
Name: ferritin, heavy polypeptide-like 17, member A (Ensembl:ferritin, heavy polypeptide-like 17, member E)
RGD ID: 1584678
Description: Predicted to enable ferric iron binding activity and ferrous iron binding activity. Predicted to be involved in intracellular sequestering of iron ion. Predicted to be active in cytoplasm. Orthologous to human FTHL17 (ferritin heavy chain like 17); INTERACTS WITH (+)-catechin (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog); aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ferritin heavy chain; ferritin heavy polypeptide-like 17; ferritin, heavy polypeptide-like 17, member E; Fthl17e; LOC681066; similar to Ferritin heavy chain (Ferritin H subunit) (Proliferation-inducing gene 15 protein)
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X53,547,274 - 53,548,251 (+)NCBIGRCr8
mRatBN7.2X49,595,422 - 49,596,399 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX49,595,718 - 49,596,266 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X53,628,946 - 53,629,936 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX53,629,255 - 53,629,803 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X53,804,517 - 53,805,461 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X71,792,398 - 71,793,165 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX50,238,132 - 50,239,122 (+)NCBICelera
Cytogenetic MapXq21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Fthl17a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X53,547,274 - 53,548,251 (+)NCBIGRCr8
mRatBN7.2X49,595,422 - 49,596,399 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX49,595,718 - 49,596,266 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X53,628,946 - 53,629,936 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX53,629,255 - 53,629,803 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X53,804,517 - 53,805,461 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X71,792,398 - 71,793,165 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX50,238,132 - 50,239,122 (+)NCBICelera
Cytogenetic MapXq21NCBI
FTHL17
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X31,071,233 - 31,072,041 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX31,071,233 - 31,072,041 (-)EnsemblGRCh38hg38GRCh38
GRCh37X31,089,350 - 31,090,158 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X30,999,279 - 31,000,091 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X30,849,014 - 30,849,827NCBI
CeleraX35,216,874 - 35,217,686 (-)NCBICelera
Cytogenetic MapXp21.2NCBI
HuRefX28,830,197 - 28,831,009 (-)NCBIHuRef
CHM1_1X31,120,780 - 31,121,592 (-)NCBICHM1_1
T2T-CHM13v2.0X30,669,380 - 30,670,188 (-)NCBIT2T-CHM13v2.0
Fthl17a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X84,293,283 - 84,313,897 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX84,293,285 - 84,313,894 (+)EnsemblGRCm39 Ensembl
GRCm38X85,249,677 - 85,270,291 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX85,249,679 - 85,270,288 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X82,495,016 - 82,515,630 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X81,502,396 - 81,523,010 (+)NCBIMGSCv36mm8
CeleraX76,444,586 - 76,464,683 (+)NCBICelera
Cytogenetic MapXC1NCBI
cM MapX39.32NCBI
FTHL17
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X32,882,015 - 32,882,835 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X32,885,394 - 32,886,214 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X23,680,709 - 23,681,515 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X31,232,073 - 31,232,879 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX31,232,234 - 31,232,785 (-)Ensemblpanpan1.1panPan2
LOC101958683
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X19,024,616 - 19,025,469 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365537,117,118 - 7,117,669 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FTHL17
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX26,955,098 - 26,955,649 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X26,955,098 - 26,956,111 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X29,274,687 - 29,275,602 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FTHL17
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X29,502,329 - 29,503,211 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX29,502,489 - 29,503,040 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605631,568,232 - 31,569,091 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Fthl17a
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:157
Count of miRNA genes:116
Interacting mature miRNAs:126
Transcripts:ENSRNOT00000005021
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat

Markers in Region
RH129189  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X49,596,137 - 49,596,329 (+)MAPPERmRatBN7.2
Rnor_6.0X53,629,675 - 53,629,866NCBIRnor6.0
Rnor_5.0X53,805,200 - 53,805,391UniSTSRnor5.0
RGSC_v3.4X71,792,904 - 71,793,095UniSTSRGSC3.4
CeleraX50,238,861 - 50,239,052UniSTS
RH 3.4 MapX659.91UniSTS
Cytogenetic MapXq22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system reproductive system respiratory system
High
Medium
Low 4 20
Below cutoff 15 4 2 3 2 12 13 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005021   ⟹   ENSRNOP00000005021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX49,595,718 - 49,596,266 (+)Ensembl
Rnor_6.0 EnsemblX53,629,255 - 53,629,803 (+)Ensembl
RefSeq Acc Id: NM_001408873   ⟹   NP_001395802
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X53,547,274 - 53,548,251 (+)NCBI
mRatBN7.2X49,595,422 - 49,596,399 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001395802 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL96056 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005021
  ENSRNOP00000005021.5
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000005021   ⟸   ENSRNOT00000005021
RefSeq Acc Id: NP_001395802   ⟸   NM_001408873
- UniProtKB: F1LTX5 (UniProtKB/TrEMBL),   A6IPV7 (UniProtKB/TrEMBL)
Protein Domains
Ferritin-like diiron

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LTX5-F1-model_v2 AlphaFold F1LTX5 1-182 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584678 AgrOrtholog
BioCyc Gene G2FUF-2350 BioCyc
Ensembl Genes ENSRNOG00000003783 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005021 ENTREZGENE
  ENSRNOT00000005021.6 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1260.10 UniProtKB/TrEMBL
InterPro Ferritin UniProtKB/TrEMBL
  Ferritin-like_diiron UniProtKB/TrEMBL
  Ferritin-rel UniProtKB/TrEMBL
  Ferritin/RNR-like UniProtKB/TrEMBL
  Ferritin_DPS_dom UniProtKB/TrEMBL
KEGG Report rno:681066 UniProtKB/TrEMBL
NCBI Gene 681066 ENTREZGENE
PANTHER FERRITIN UniProtKB/TrEMBL
  PTHR11431 UniProtKB/TrEMBL
Pfam Ferritin UniProtKB/TrEMBL
PhenoGen Fthl17a PhenoGen
PROSITE FERRITIN_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003783 RatGTEx
Superfamily-SCOP Ferritin/RR_like UniProtKB/TrEMBL
UniProt A6IPV7 ENTREZGENE, UniProtKB/TrEMBL
  F1LTX5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-02-09 Fthl17a  ferritin, heavy polypeptide-like 17, member A  Fthl17e  ferritin, heavy polypeptide-like 17, member E  Name and Symbol changed 629549 APPROVED
2016-02-17 Fthl17e  ferritin, heavy polypeptide-like 17, member E  LOC681066  similar to Ferritin heavy chain (Ferritin H subunit) (Proliferation-inducing gene 15 protein)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC681066  similar to Ferritin heavy chain (Ferritin H subunit) (Proliferation-inducing gene 15 protein)      Symbol and Name status set to provisional 70820 PROVISIONAL