Zfp469 (zinc finger protein 469) - Rat Genome Database

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Gene: Zfp469 (zinc finger protein 469) Rattus norvegicus
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Symbol: Zfp469
Name: zinc finger protein 469
RGD ID: 1583874
Description: Predicted to be involved in regulation of extracellular matrix organization. Predicted to act upstream of or within several processes, including extracellular matrix organization; negative regulation of transcription by RNA polymerase II; and substantia propria of cornea development. Human ortholog(s) of this gene implicated in brittle cornea syndrome 1. Orthologous to human ZNF469 (zinc finger protein 469); INTERACTS WITH 17beta-estradiol; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LOC691499; similar to Zinc finger protein 469; Zfp469-ps1; zinc finger protein 469, pseudogene 1; Znf469; Znf469-ps1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81967,190,901 - 67,232,569 (+)NCBIGRCr8
mRatBN7.21950,282,337 - 50,324,010 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1957,075,429 - 57,117,094 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01957,757,281 - 57,798,955 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01959,974,031 - 60,015,706 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01954,843,864 - 55,083,935 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01965,758,945 - 65,800,160 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41952,474,513 - 52,514,139 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1949,329,658 - 49,566,287 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Zfp469
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81967,190,901 - 67,232,569 (+)NCBIGRCr8
mRatBN7.21950,282,337 - 50,324,010 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1957,075,429 - 57,117,094 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01957,757,281 - 57,798,955 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01959,974,031 - 60,015,706 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01954,843,864 - 55,083,935 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01965,758,945 - 65,800,160 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41952,474,513 - 52,514,139 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1949,329,658 - 49,566,287 (+)NCBICelera
Cytogenetic Map19q12NCBI
ZNF469
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381688,100,931 - 88,440,753 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1688,382,959 - 88,440,757 (+)EnsemblGRCh38hg38GRCh38
GRCh371688,449,367 - 88,507,161 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361687,021,380 - 87,034,666 (+)NCBINCBI36Build 36hg18NCBI36
Celera1673,564,290 - 73,577,602 (+)NCBICelera
Cytogenetic Map16q24.2NCBI
HuRef1674,187,210 - 74,200,522 (+)NCBIHuRef
CHM1_11689,905,133 - 89,918,418 (+)NCBICHM1_1
T2T-CHM13v2.01694,449,769 - 94,508,741 (+)NCBIT2T-CHM13v2.0
Zfp469
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398122,770,009 - 122,999,389 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8122,985,359 - 122,999,389 (+)EnsemblGRCm39 Ensembl
GRCm388122,043,123 - 122,272,650 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8122,258,620 - 122,272,650 (+)EnsemblGRCm38mm10GRCm38
MGSCv378124,783,967 - 124,796,550 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368125,146,157 - 125,158,740 (+)NCBIMGSCv36mm8
Celera8126,489,037 - 126,501,620 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map870.85NCBI
Znf469
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555412,404,549 - 2,438,183 (+)NCBIChiLan1.0ChiLan1.0
ZNF469
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21897,864,686 - 98,210,176 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116103,781,045 - 104,124,393 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01668,777,496 - 69,151,995 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11688,800,542 - 88,816,811 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1688,803,202 - 88,815,390 (+)Ensemblpanpan1.1panPan2
ZNF469
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1564,887,534 - 64,903,553 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha564,897,119 - 64,909,874 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0565,106,202 - 65,118,957 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl565,107,572 - 65,118,884 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1565,131,802 - 65,144,557 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0564,963,589 - 64,976,332 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0565,370,098 - 65,382,853 (-)NCBIUU_Cfam_GSD_1.0
Znf469
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934925,439,524 - 25,454,515 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366411,193,085 - 1,205,283 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZNF469
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl61,162,822 - 1,174,257 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.161,161,514 - 1,208,406 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ZNF469
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1573,762,456 - 73,820,262 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660471,866,974 - 1,926,024 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf469
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247461,043,117 - 1,074,776 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zfp469
138 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:60
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000038203
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194997648153225766Rat

Markers in Region
D19Got111  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21950,300,071 - 50,300,243 (+)MAPPERmRatBN7.2
Rnor_6.01955,060,310 - 55,060,477NCBIRnor6.0
Rnor_5.01965,776,535 - 65,776,702UniSTSRnor5.0
RGSC_v3.41952,491,531 - 52,491,698UniSTSRGSC3.4
Celera1949,542,354 - 49,542,521UniSTS
Cytogenetic Map19q12UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: NM_001401088   ⟹   NP_001388017
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81967,190,901 - 67,232,569 (+)NCBI
mRatBN7.21950,282,337 - 50,324,010 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001388017 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001388017   ⟸   NM_001401088


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583874 AgrOrtholog
BioCyc Gene G2FUF-5407 BioCyc
NCBI Gene 691499 ENTREZGENE
PhenoGen Zfp469 PhenoGen


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-07 Zfp469  zinc finger protein 469  Zfp469-ps1  zinc finger protein 469, pseudogene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-11-27 Zfp469-ps1  zinc finger protein 469, pseudogene 1  Znf469-ps1  zinc finger protein 469, pseudogene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-02-24 Znf469-ps1  zinc finger protein 469, pseudogene 1  Znf469  zinc finger protein 469  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-19 Znf469  zinc finger protein 469  LOC691499  similar to Zinc finger protein 469  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC691499  similar to Zinc finger protein 469  LOC687587  similar to Zinc finger protein 469  Data merged from RGD:1584178 1643240 APPROVED
2006-11-19 LOC691499  similar to Zinc finger protein 469      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687587  similar to Zinc finger protein 469      Symbol and Name status set to provisional 70820 PROVISIONAL