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Gene: Adam12 (ADAM metallopeptidase domain 12) Rattus norvegicus
Symbol: Adam12
Name: ADAM metallopeptidase domain 12
RGD ID: 1583652
Description: Predicted to have SH3 domain binding activity. Predicted to be involved in positive regulation of angiogenesis. Predicted to localize to nucleoplasm and plasma membrane. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to human ADAM12 (ADAM metallopeptidase domain 12); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; Notch signaling pathway; syndecan signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; atrazine.
Type: protein-coding
RefSeq Status: MODEL
Also known as: a disintegrin and metallopeptidase domain 12; a disintegrin and metallopeptidase domain 12 (meltrin alpha); disintegrin and metalloproteinase domain-containing protein 12; LOC309072; LOC679837; meltrin alpha; similar to ADAM 12 precursor (A disintegrin and metalloproteinase domain 12) (Meltrin alpha)
Homo sapiens (human) : ADAM12 (ADAM metallopeptidase domain 12)  HGNC  Alliance
Mus musculus (house mouse) : Adam12 (a disintegrin and metallopeptidase domain 12 (meltrin alpha))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adam12 (ADAM metallopeptidase domain 12)
Pan paniscus (bonobo/pygmy chimpanzee) : ADAM12 (ADAM metallopeptidase domain 12)
Canis lupus familiaris (dog) : ADAM12 (ADAM metallopeptidase domain 12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adam12 (ADAM metallopeptidase domain 12)
Sus scrofa (pig) : ADAM12 (ADAM metallopeptidase domain 12)
Chlorocebus sabaeus (African green monkey) : ADAM12 (ADAM metallopeptidase domain 12)
Heterocephalus glaber (naked mole-rat) : Adam12 (ADAM metallopeptidase domain 12)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01205,951,840 - 206,286,294 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1205,956,342 - 206,282,575 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01212,899,587 - 213,227,846 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41193,384,457 - 193,650,892 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11193,533,921 - 193,999,142 (-)NCBI
Celera1186,424,760 - 186,758,584 (-)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Adam12
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1583652
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.