Abcb5 (ATP binding cassette subfamily B member 5)

Gene: Abcb5 (ATP binding cassette subfamily B member 5) Rattus norvegicus

Analyze

Symbol:

Abcb5

Name:

ATP binding cassette subfamily B member 5

RGD ID:

1566342

Description:

Predicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Predicted to be involved in eye development; regulation of membrane potential; and transmembrane transport. Predicted to be located in plasma membrane. Orthologous to human ABCB5 (ATP binding cassette subfamily B member 5); INTERACTS WITH glyphosate; N,N-diethyl-m-toluamide; permethrin.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ATP-binding cassette sub-family B member 5; ATP-binding cassette, sub-family B (MDR/TAP), member 5; ATP-binding cassette, subfamily B (MDR/TAP), member 5; LOC314537; RGD1566342; similar to ATP-binding cassette, sub-family B, member 5

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ABCB5 (ATP binding cassette subfamily B member 5)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Abcb5 (ATP-binding cassette, sub-family B member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Abcb5 (ATP binding cassette subfamily B member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ABCB5 (ATP binding cassette subfamily B member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ABCB5 (ATP binding cassette subfamily B member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Abcb5 (ATP binding cassette subfamily B member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ABCB5 (ATP binding cassette subfamily B member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ABCB5 (ATP binding cassette subfamily B member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Abcb5 (ATP binding cassette subfamily B member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SIGLEC10 (sialic acid binding Ig like lectin 10)	HGNC	OMA
Homo sapiens (human):	SIGLEC11 (sialic acid binding Ig like lectin 11)	HGNC	OMA
Homo sapiens (human):	GDPD4 (glycerophosphodiester phosphodiesterase domain containing 4)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	ABCB5 (ATP binding cassette subfamily B member 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Abcb5 (ATP-binding cassette, sub-family B member 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Mdr50	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	STE6	Alliance	DIOPT (InParanoid\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	pgp-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Caenorhabditis elegans (roundworm):	pgp-6	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	pgp-7	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	pgp-8	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	pgp-9	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG10226	Alliance	DIOPT (Hieranoid\|OMA\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Mdr49	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Mdr65	Alliance	DIOPT (Hieranoid\|OMA\|PhylomeDB)
Caenorhabditis elegans (roundworm):	pgp-3	Alliance	DIOPT (OMA\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	pgp-4	Alliance	DIOPT (OMA\|OrthoFinder\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	145,978,860 - 146,075,776 (-)	NCBI		GRCr8
mRatBN7.2	6	139,836,528 - 139,932,830 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	139,835,949 - 139,932,830 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	6	146,805,481 - 146,902,339 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	146,805,599 - 146,902,339 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	155,713,932 - 155,809,554 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	146,177,114 - 146,287,478 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	6	137,483,710 - 137,579,013 (-)	NCBI		Celera
Cytogenetic Map	6	q33	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Colorectal Neoplasms (ISO)

genetic disease (ISO)

melanoma (ISO)

pleomorphic xanthoastrocytoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,4,6-tribromophenol (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

bisphenol A (ISO)

calcitriol (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

doxorubicin (ISO)

folic acid (ISO)

fulvestrant (ISO)

glyphosate (EXP)

hydralazine (ISO)

lipopolysaccharide (ISO)

methotrexate (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N,N-diethyl-m-toluamide (EXP)

permethrin (EXP)

propanal (ISO)

quinolin-8-ol (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

eye development (ISO)

regulation of membrane potential (ISO)

transmembrane transport (IBA,ISO)

Cellular Component

membrane (IBA)

plasma membrane (ISO)

Molecular Function

ABC-type oligopeptide transporter activity (IEA)

ABC-type transporter activity (IEA)

ATP binding (IEA)

ATP hydrolysis activity (IEA)

ATPase-coupled transmembrane transporter activity (IBA)

efflux transmembrane transporter activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12960149	PMID:25030174	PMID:35738589

Genomics

Comparative Map Data

Abcb5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	145,978,860 - 146,075,776 (-)	NCBI		GRCr8
mRatBN7.2	6	139,836,528 - 139,932,830 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	139,835,949 - 139,932,830 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	6	146,805,481 - 146,902,339 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	146,805,599 - 146,902,339 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	155,713,932 - 155,809,554 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	146,177,114 - 146,287,478 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	6	137,483,710 - 137,579,013 (-)	NCBI		Celera
Cytogenetic Map	6	q33	NCBI

ABCB5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	20,615,667 - 20,757,008 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	20,615,667 - 20,777,038 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	20,655,290 - 20,796,631 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	20,653,741 - 20,761,821 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	20,460,284 - 20,568,487	NCBI
Celera	7	20,639,480 - 20,782,083 (+)	NCBI		Celera
Cytogenetic Map	7	p21.1	NCBI
HuRef	7	20,544,004 - 20,681,429 (+)	NCBI		HuRef
CHM1_1	7	20,655,593 - 20,797,106 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	20,750,588 - 20,892,996 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	20,706,592 - 20,847,927 (+)	NCBI

Abcb5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	118,831,221 - 118,930,169 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	118,831,559 - 118,930,156 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	118,867,486 - 118,966,434 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	118,867,824 - 118,966,421 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	120,106,297 - 120,204,894 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	113,093,355 - 113,192,288 (-)	NCBI		MGSCv36	mm8
MGSCv36	12	119,311,950 - 119,410,523 (-)	NCBI		MGSCv36	mm8
Cytogenetic Map	12	F2	NCBI
cM Map	12	63.48	NCBI

Abcb5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955410	23,283,263 - 23,379,000 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955410	23,283,263 - 23,379,000 (+)	NCBI	ChiLan1.0	ChiLan1.0

ABCB5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	25,481,726 - 25,611,293 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	73,798,836 - 73,937,469 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	21,302,954 - 21,432,569 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	20,617,567 - 20,746,683 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	20,620,875 - 20,746,634 (+)	Ensembl	panpan1.1		panPan2

ABCB5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	34,645,722 - 34,760,636 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	34,637,196 - 34,760,433 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	34,141,285 - 34,303,183 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	34,525,456 - 34,686,254 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	34,528,356 - 34,686,261 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	34,643,386 - 34,806,295 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	34,343,924 - 34,506,781 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	34,654,940 - 34,841,620 (+)	NCBI		UU_Cfam_GSD_1.0

Abcb5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	78,898,499 - 79,045,176 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936546	6,605,381 - 6,720,294 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936546	6,573,617 - 6,720,294 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ABCB5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	89,632,204 - 89,738,606 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	89,620,783 - 89,751,876 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	98,854,311 - 99,073,375 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ABCB5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	37,491,638 - 37,620,002 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	37,492,483 - 37,619,527 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	66,955,825 - 67,084,061 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Abcb5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624739	9,802,817 - 9,976,572 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Abcb5
455 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	75
Count of miRNA genes:	64
Interacting mature miRNAs:	72
Transcripts:	ENSRNOT00000050893, ENSRNOT00000074197
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
731173	Uae22	Urinary albumin excretion QTL 22	10.1		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
2290393	Uae37	Urinary albumin excretion QTL 37		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
12801411	Schws8	Schwannoma susceptibility QTL 8			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	94968928	139968928	Rat
8552796	Vie3	Viral induced encephalitis QTL 3	2.6		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	6	96833997	140994061	Rat
1358355	Srcrt4	Stress Responsive Cort QTL 4	6.39		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	100364669	140994061	Rat
71111	Iddm8	Insulin dependent diabetes mellitus QTL 8	1.9	0.002	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	6	105156861	140994061	Rat
737976	Pia24	Pristane induced arthritis QTL 24			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	6	112636280	140994061	Rat
2293085	Iddm29	Insulin dependent diabetes mellitus QTL 29	7.66		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	6	122549046	140286318	Rat
61329	Eae9	Experimental allergic encephalomyelitis QTL 9	3.7		body mass (VT:0001259)	change in body weight (CMO:0002045)	6	122549046	140994061	Rat

Markers in Region

BE107320

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	139,824,332 - 139,824,491 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	146,792,986 - 146,793,142	NCBI	Rnor6.0
Rnor_5.0	6	155,701,502 - 155,701,658	UniSTS	Rnor5.0
RGSC_v3.4	6	146,177,297 - 146,177,454	UniSTS	RGSC3.4
Celera	6	137,471,213 - 137,471,370	UniSTS
RH 3.4 Map	6	905.7	UniSTS
Cytogenetic Map	6	q33	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	nervous system	reproductive system
High
Medium
Low		3
Below cutoff	3	8

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_006225905	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006240713	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474038	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000050893 ⟹ ENSRNOP00000045152

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	139,835,949 - 139,932,830 (-)	Ensembl
Rnor_6.0 Ensembl	6	146,805,599 - 146,902,339 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000074197 ⟹ ENSRNOP00000066405

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	6	146,826,451 - 146,861,787 (-)	Ensembl

RefSeq Acc Id:

XM_006240713 ⟹ XP_006240775

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	145,978,860 - 146,075,776 (-)	NCBI
mRatBN7.2	6	139,836,528 - 139,932,830 (-)	NCBI
Rnor_6.0	6	146,805,481 - 146,902,339 (-)	NCBI
Rnor_5.0	6	155,713,932 - 155,809,554 (-)	NCBI

Sequence:

show sequence

ATGGCACATTCTGAAAGAGCCAACGGGTTGCAAGAAAGTAATCAGAGATATGGATCTCTGCAAG
AACAACTGCCTAAAGCAGGAAATCAAGCTGTCGGACCTATTGAGATATTCCGTTTTGCTGATAA
TCTGGACATTGTCCTCATGACTCTGGGAATACTAGCATCGATGATAAATGGAGCCACTGTTCCT
TTAATGTCCCTGGTTTTAGGAGAAATAAGTGACCATTTTATTAATGGATGCCTAGTCCAAACTA
ACAAAACTAAATATCAGAACTGTTCTCAGTCTCAAGAAAAGTTGAATGAAGATATCATTATGTT
GACTCTCTATTATGTTGGGATAGGAGCAGCTGCCCTCGTTTTGGGCTACGTGCAGATTTCCTTT
TGGGTCATAACCGCAGCCCGGCAAACCACAAGAATCCGAAAACAGTTTTTTCATTCGATTTTGG
CACAAGACATCAGCTGGTTTGATGGCACTGACATCTGTGAACTTAACACCCGCATGAATGGTGA
CATCAGCAAACTCTGTGATGGTATTGGAGATAAGATCCCTCTGATGTTTCAGAATATATCTGGG
TTTTCTATTGGCCTCGTGATAAGCTTGATAAAGAGCTGGAAACTCTCGCTGGCGATTCTGTCCA
CGTCTCCTCTCATAATGGCTGCATCAGCACTGTGCTCTAGGATGGTCATCTCATTGACCAGTAA
GGAGCTGGATGCCTATTCCAAAGCTGGGGCTGTAGCTGAAGAAGCTTTGTCATCAATCCGAACA
GTCACAGCCTTTGGAGCCCAAGAGAAAGAAATTCAAAGGTATACACAGAATCTAAAGGACGCCA
AGGACGCTGGCATAAAGAGGGCTATAGCTTCAAAGCTGTCTCTTGGAGCCGTCTACTTCTTTAT
GAATGGAGCCTACGGACTGGCTTTTTGGTATGGAACCTCCTTGATTTTTGGTGGAGAACCTGGT
TACACCGTCGGGACTATTCTTGCTGTTTTCTTCAGTGTGATCCACAGTAGTTACTGCATCGGGT
CTGTAGCCCCTCACTTGGAAACCTTCACTATAGCCAGAGGAGCCGCTTTTAATATCTTTCATGT
TATTGATAAGAAACCCAATATAGATAACTTTTCAACAGCTGGATATAAACCTGAATCTATAGAA
GGAAACATAGAATTTAAAAACGTTTCTTTCAGCTATCCATCAAGACCTTCTGCCAAGATTCTGA
AAGGCTTCAATCTCAAGATTAAGTCTGGAGAGACAGTAGCTTTGGTTGGTCCCAGTGGCAGTGG
CAAGACTACCACAGTCCAGCTTCTGCAGAGGCTGTATGACCCAGAAGAGGGCTGTATCACGGTA
GATGAGAATGACATCCGAACCCAAAACGTGCGACATTACCGAGAGCAAATTGGAGTGGTCAGCC
AAGAGCCGGTTTTGTTTGGTACCACCATCGGTAACAATATTAAGTTTGGCCGTGAAGGCGTGAG
TGAAGAAGAAATGGAGCAGGCAGCGAGGGAGGCAAACGCCTACGACTTCATAATGGCCTTTCCT
AAGAAATTTAATACACTAGTAGGGGAAAAAGGAGCTCAGATGAGTGGAGGCCAGAAACAGAGAA
TCGCCATTGCTCGAGCGCTAGTTCGAAACCCCAAAATTCTAATCCTAGATGAGGCTACATCTGC
CCTCGACACAGAGAGTGAGTCACTTGTTCAAGCCGCACTGGAGAAGGCAAGCAAAGGCCGGACT
ACACTTGTGGTAGCACACCGGCTCTCCACTATTCGTGGGGCAGACCTGATTGTGACGATGAAGG
ATGGCGAGGTGGTGGAGAAAGGGATCCATGCTGAACTAATGGCAAAGCAGGGACTGTACTACTC
CCTCGCTGTGGCACAGGATATTAAAAAGGTCGATGAACAAATGGAGTCAAGGACATGCTCCGCT
GCAGGGAATGCCAGCAATGGTTCTCTGTGCAATGTGAATAGCGCCAAGTCCCCCTGCACTGACC
AGTTTGAGGAAGCTGTACCCCATCAAAAGACAACTCTTCCTGAAGTTTCACTATTAAAAATATT
TAAATTAAGCAAGTCCGAGTGGCCTTTTGTGGTTCTGGGAACTTTGGCTTCTGCTTTAAATGGG
TCTGTTCACCCAGCATTTTCCATCATCTTTGGAAAATTGGTCACTATGTTCGAAGATAAAAATA
AAACTACATTAAAGCAGGATGCAGAGCTCTACTCTATGATGTTAGTCGTCTTGGGCATAGTGGC
TCTTGTCACCTACTTGATGCAGGGGTTGTTTTATGGCAGAGCAGAAGAAATTTTAGCCATGAGG
TTAAGACACTCAGCATTCAAAGCCATGCTCTATCAGGATATGGCCTGGTATGATGAGAAAGACA
ACAGCACTGGAGCCCTGACCACAACGTTAGCTGTGGACGTAGCACAGATCCGGGGTGCAGCAAC
TTCAAGGCTTGGTATCATAACACAAGATGTGACCAACATGAGTTTGTCCATCCTTATCTCCTTC
GTCTATGGATGGGAGATGACACTCCTGATTCTCAGCTTTGCACCTATACTTGCAGTGACAGGAA
TGATTCAAACTGCAGCAATGGCTGGCTTCGCCAACAAGGATAAGCAAGAGCTTAAGCGTGCCGG
GAAGATAGCAACAGAAGCTGTGGAGAACATACGTACGGTAGTGTCATTAACAAGAGAGAAAGCC
TTTGAGCACATGTATGAGGAGACGCTACGGACCCAACACAGAAATGCCTTGAAGAGAGCACATA
TCACTGGAAGCTGTTATGCGGTCAGCCATGCTTTTGTGCATTTCGCCCACGCAGCAGGTTTCCG
GTTTGGAGCCTATTTGATTCAAGCTGGACGGATGACGCCCGAAGGCATGTTCATAGTCTTTACT
GCCATTGCATATGGGGCTATGGCCATTGGAGAAACGCTTGTTTGGGCTCCTGAATATTCCAAAG
CCAAGGCTGGAGCTGCACATCTGTTTGCTTTGCTGAAAAATAAGCCAAGTATAGACAGCTGCAG
TCAAAATGGAGAAAAACCAGACGCCTGTGAAGGGAACTTAGAATTTCGAGAAGTCTCGTTCTTC
TATCCTTGTCGGCCAGAAGTTCCTGTCCTTCAAGACATGTCCCTCAGCATTGAGAAAGGGAAGA
CAGTAGCATTTGTTGGGAGCAGTGGCTGTGGGAAAAGCACGTGTGTTCAACTGCTACAAAGATT
TTATGACCCCATGAAAGGACAAGTGCTGCTTGACGGCGTCGATGTGAAAGAATTGAACGTGCAA
TGGCTGCGTTCCCAGACAGCCATCGTCTCCCAAGAGCCTGTGCTCTTCAACTGTAGCATTGCTG
AGAACATTGCCTATGGTGATAACAGCCGCATGGTGCCCTTAGAGGAGATCAAAGAGGTCGCAGA
TGCAGCCAACATCCATTCTTTCATTGAAGGGCTCCCCGGGAAATACAGCACCCAAGTGGGACTA
AGAGGCATGCACCTTTCTGGCGGCCAGAAACAAAGACTGGCTATTGCAAGGGCTCTTCTCCGGA
AGCCGAAAATTTTACTGCTGGATGAGGCCACTTCAGCCCTTGACAATGAGAGCGAGAAGATGGT
TCAACAGGCCCTCGACAAAGCCCGGAGAGGGAGGACCTGCCTAGTAGTGGCTCACAGACTCTCC
ACAATACAGAATGCAGATATGATCGTCGTTCTGCAAAATGGAAGAATCAAGGAGCAGGGGACTC
ATCAGGAGCTCCTGAGAAATGGAGAGACTTACTTTAAATTAGCAACCGCGCATTAGTAGTGGCG
CCAGCAGGTGCACTGACGCTGCCGGCCTTGCTTGCACTTGGATCTTGGCGGAATGAAGAGTACA
CAGTCATTTCTTGGCCTGCTCTAGACTCTTACTGCAATGTCAATAC

hide sequence

Protein Sequences


Protein RefSeqs	XP_006240775	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL89093	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000045152
	ENSRNOP00000045152.3

RefSeq Acc Id:

XP_006240775 ⟸ XM_006240713

- UniProtKB:

D4AEL4 (UniProtKB/TrEMBL), A6KDM8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAHSERANGLQESNQRYGSLQEQLPKAGNQAVGPIEIFRFADNLDIVLMTLGILASMINGATVP
LMSLVLGEISDHFINGCLVQTNKTKYQNCSQSQEKLNEDIIMLTLYYVGIGAAALVLGYVQISF
WVITAARQTTRIRKQFFHSILAQDISWFDGTDICELNTRMNGDISKLCDGIGDKIPLMFQNISG
FSIGLVISLIKSWKLSLAILSTSPLIMAASALCSRMVISLTSKELDAYSKAGAVAEEALSSIRT
VTAFGAQEKEIQRYTQNLKDAKDAGIKRAIASKLSLGAVYFFMNGAYGLAFWYGTSLIFGGEPG
YTVGTILAVFFSVIHSSYCIGSVAPHLETFTIARGAAFNIFHVIDKKPNIDNFSTAGYKPESIE
GNIEFKNVSFSYPSRPSAKILKGFNLKIKSGETVALVGPSGSGKTTTVQLLQRLYDPEEGCITV
DENDIRTQNVRHYREQIGVVSQEPVLFGTTIGNNIKFGREGVSEEEMEQAAREANAYDFIMAFP
KKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDTESESLVQAALEKASKGRT
TLVVAHRLSTIRGADLIVTMKDGEVVEKGIHAELMAKQGLYYSLAVAQDIKKVDEQMESRTCSA
AGNASNGSLCNVNSAKSPCTDQFEEAVPHQKTTLPEVSLLKIFKLSKSEWPFVVLGTLASALNG
SVHPAFSIIFGKLVTMFEDKNKTTLKQDAELYSMMLVVLGIVALVTYLMQGLFYGRAEEILAMR
LRHSAFKAMLYQDMAWYDEKDNSTGALTTTLAVDVAQIRGAATSRLGIITQDVTNMSLSILISF
VYGWEMTLLILSFAPILAVTGMIQTAAMAGFANKDKQELKRAGKIATEAVENIRTVVSLTREKA
FEHMYEETLRTQHRNALKRAHITGSCYAVSHAFVHFAHAAGFRFGAYLIQAGRMTPEGMFIVFT
AIAYGAMAIGETLVWAPEYSKAKAGAAHLFALLKNKPSIDSCSQNGEKPDACEGNLEFREVSFF
YPCRPEVPVLQDMSLSIEKGKTVAFVGSSGCGKSTCVQLLQRFYDPMKGQVLLDGVDVKELNVQ
WLRSQTAIVSQEPVLFNCSIAENIAYGDNSRMVPLEEIKEVADAANIHSFIEGLPGKYSTQVGL
RGMHLSGGQKQRLAIARALLRKPKILLLDEATSALDNESEKMVQQALDKARRGRTCLVVAHRLS
TIQNADMIVVLQNGRIKEQGTHQELLRNGETYFKLATAH

hide sequence

RefSeq Acc Id:

ENSRNOP00000045152 ⟸ ENSRNOT00000050893

RefSeq Acc Id:

ENSRNOP00000066405 ⟸ ENSRNOT00000074197

Protein Domains

ABC transmembrane type-1 ABC transporter

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4AEL4-F1-model_v2	AlphaFold	D4AEL4	1-1255	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1566342	AgrOrtholog
BioCyc Gene	G2FUF-35459	BioCyc
Ensembl Genes	ENSRNOG00000006398	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000050893.6	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1560.10	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
InterPro	AAA+_ATPase	UniProtKB/TrEMBL
	ABC1_TM_sf	UniProtKB/TrEMBL
	ABC_transporter-like	UniProtKB/TrEMBL
	ABC_transporter_CS	UniProtKB/TrEMBL
	ABC_transptrTM_dom_typ1	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	Type_I_exporter	UniProtKB/TrEMBL
KEGG Report	rno:314537	UniProtKB/TrEMBL
NCBI Gene	314537	ENTREZGENE
PANTHER	ALPHA-FACTOR-TRANSPORTING ATPASE	UniProtKB/TrEMBL
	ATP-BINDING CASSETTE SUB-FAMILY B	UniProtKB/TrEMBL
	ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL	UniProtKB/TrEMBL
	MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT	UniProtKB/TrEMBL
Pfam	ABC_membrane	UniProtKB/TrEMBL
	ABC_tran	UniProtKB/TrEMBL
PhenoGen	Abcb5	PhenoGen
PROSITE	ABC_TM1F	UniProtKB/TrEMBL
	ABC_TRANSPORTER_1	UniProtKB/TrEMBL
	ABC_TRANSPORTER_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000006398	RatGTEx
SMART	AAA	UniProtKB/TrEMBL
Superfamily-SCOP	ABC_TM_1	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A6KDM8	ENTREZGENE, UniProtKB/TrEMBL
	D4AEL4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-09	Abcb5	ATP binding cassette subfamily B member 5	Abcb5	ATP-binding cassette, subfamily B (MDR/TAP), member 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-11-16	Abcb5	ATP-binding cassette, subfamily B (MDR/TAP), member 5	Abcb5	ATP-binding cassette, sub-family B (MDR/TAP), member 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Abcb5	ATP-binding cassette, sub-family B (MDR/TAP), member 5	RGD1566342_predicted	similar to ATP-binding cassette, sub-family B, member 5 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1566342_predicted	similar to ATP-binding cassette, sub-family B, member 5 (predicted)	LOC314537	similar to ATP-binding cassette, sub-family B, member 5	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC314537	similar to ATP-binding cassette, sub-family B, member 5			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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