Adgrg4 (adhesion G protein-coupled receptor G4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Adgrg4 (adhesion G protein-coupled receptor G4) Rattus norvegicus
Analyze
Symbol: Adgrg4
Name: adhesion G protein-coupled receptor G4
RGD ID: 1564057
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Orthologous to human ADGRG4 (adhesion G protein-coupled receptor G4); INTERACTS WITH bisphenol A; aflatoxin B1 (ortholog); aldehydo-D-glucose (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adhesion G-protein coupled receptor G4; G protein-coupled receptor 112; G protein-coupled receptor 112 like; Gpr112; Gpr112l; LOC302860; RGD1564057; similar to G protein-coupled receptor 112
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X139,771,962 - 139,901,771 (+)NCBIGRCr8
mRatBN7.2X134,734,610 - 134,864,449 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX134,854,736 - 134,864,449 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X159,286,775 - 159,437,536 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX159,427,745 - 159,437,453 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X153,924,975 - 154,068,544 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X141,451,375 - 141,597,555 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX142,781,508 - 142,906,513 (+)NCBICelera
Cytogenetic MapXq36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15632090  


Genomics

Comparative Map Data
Adgrg4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X139,771,962 - 139,901,771 (+)NCBIGRCr8
mRatBN7.2X134,734,610 - 134,864,449 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX134,854,736 - 134,864,449 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X159,286,775 - 159,437,536 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX159,427,745 - 159,437,453 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X153,924,975 - 154,068,544 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X141,451,375 - 141,597,555 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX142,781,508 - 142,906,513 (+)NCBICelera
Cytogenetic MapXq36NCBI
ADGRG4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X136,300,963 - 136,416,890 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX136,300,963 - 136,416,890 (+)EnsemblGRCh38hg38GRCh38
GRCh37X135,383,122 - 135,499,049 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X135,210,788 - 135,326,713 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X135,108,641 - 135,224,567NCBI
CeleraX135,745,772 - 135,861,718 (+)NCBICelera
Cytogenetic MapXq26.3NCBI
HuRefX124,653,324 - 124,769,965 (+)NCBIHuRef
CHM1_1X135,294,203 - 135,410,110 (+)NCBICHM1_1
T2T-CHM13v2.0X134,609,302 - 134,725,270 (+)NCBIT2T-CHM13v2.0
Adgrg4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X55,939,594 - 56,025,719 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX55,915,523 - 56,046,918 (+)EnsemblGRCm39 Ensembl
GRCm38X56,894,234 - 56,980,359 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX56,870,163 - 57,001,558 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X54,147,411 - 54,233,529 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X53,310,190 - 53,327,136 (+)NCBIMGSCv36mm8
CeleraX43,376,636 - 43,462,027 (+)NCBICelera
Cytogenetic MapXA6NCBI
cM MapX30.34NCBI
Adgrg4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554898,701,814 - 8,801,358 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554898,690,268 - 8,801,358 (-)NCBIChiLan1.0ChiLan1.0
ADGRG4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X135,713,412 - 135,835,218 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X135,717,012 - 135,838,818 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X125,424,181 - 125,546,128 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X135,694,148 - 135,812,388 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX135,694,869 - 135,812,388 (+)Ensemblpanpan1.1panPan2
ADGRG4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X106,700,740 - 106,784,092 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX106,680,887 - 106,785,009 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX92,501,419 - 92,605,447 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X108,692,746 - 108,753,182 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX108,694,167 - 108,760,972 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X105,801,984 - 105,905,558 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X107,981,101 - 108,084,673 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X107,633,993 - 107,737,716 (+)NCBIUU_Cfam_GSD_1.0
Adgrg4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X104,679,790 - 104,769,021 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651310,845,610 - 10,947,288 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651310,837,036 - 10,934,833 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADGRG4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X111,490,544 - 111,534,000 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ADGRG4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X111,318,533 - 111,425,759 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX111,318,763 - 111,425,617 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606548,985,048 - 49,097,870 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adgrg4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480810,738,181 - 10,851,641 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480810,732,068 - 10,837,678 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adgrg4
269 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat

Markers in Region
DXRat119  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X134,846,591 - 134,846,842 (+)MAPPERmRatBN7.2
Rnor_6.0X159,420,472 - 159,420,720NCBIRnor6.0
Rnor_5.0X154,051,508 - 154,051,756UniSTSRnor5.0
RGSC_v3.4X141,596,274 - 141,596,522UniSTSRGSC3.4
RGSC_v3.4X141,596,098 - 141,596,590RGDRGSC3.4
RGSC_v3.1X141,669,707 - 141,669,955RGD
CeleraX142,888,652 - 142,888,900UniSTS
RH 3.4 MapX985.3RGD
RH 3.4 MapX985.3UniSTS
RH 2.0 Map21768.0RGD
FHH x ACI MapX40.17RGD
Cytogenetic MapXq36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system renal system reproductive system respiratory system
High
Medium
Low 1 12 1
Below cutoff 1 5 4 1 4 10 13 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000078226   ⟹   ENSRNOP00000070356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX134,854,736 - 134,864,449 (+)Ensembl
Rnor_6.0 EnsemblX159,427,745 - 159,437,453 (+)Ensembl
RefSeq Acc Id: XM_039100558   ⟹   XP_038956486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X139,771,962 - 139,901,771 (+)NCBI
mRatBN7.2X134,734,610 - 134,864,449 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038956486 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL75134 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070356.2
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000070356   ⟸   ENSRNOT00000078226
RefSeq Acc Id: XP_038956486   ⟸   XM_039100558

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JXP6-F1-model_v2 AlphaFold A0A0G2JXP6 1-219 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564057 AgrOrtholog
BioCyc Gene G2FUF-913 BioCyc
Ensembl Genes ENSRNOG00000054401 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078226.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_2_secretin-like UniProtKB/TrEMBL
NCBI Gene 302860 ENTREZGENE
PANTHER ADHESION G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  ADHESION G-PROTEIN COUPLED RECEPTOR G4 UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/TrEMBL
PhenoGen Adgrg4 PhenoGen
RatGTEx ENSRNOG00000054401 RatGTEx
UniProt A0A0G2JXP6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-03-16 Adgrg4  adhesion G protein-coupled receptor G4  Gpr112  G protein-coupled receptor 112  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-20 Gpr112  G protein-coupled receptor 112  Gpr112l  G protein-coupled receptor 112 like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-02 Gpr112l  G protein-coupled receptor 112 like  Gpr112_predicted  G protein-coupled receptor 112 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Gpr112_predicted  G protein-coupled receptor 112 (predicted)  RGD1564057_predicted  similar to G protein-coupled receptor 112 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1564057_predicted  similar to G protein-coupled receptor 112 (predicted)  LOC302860  similar to G protein-coupled receptor 112  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC302860  similar to G protein-coupled receptor 112      Symbol and Name status set to provisional 70820 PROVISIONAL