Gjc2 (gap junction protein, gamma 2)

Gene: Gjc2 (gap junction protein, gamma 2) Rattus norvegicus

Analyze

Symbol:

Gjc2

Name:

gap junction protein, gamma 2

RGD ID:

1562712

Description:

Predicted to enable gap junction channel activity involved in cell communication by electrical coupling. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; positive regulation of calcium ion transmembrane transport; and positive regulation of oligodendrocyte progenitor proliferation. Located in several cellular components, including paranode region of axon; perikaryon; and proximal neuron projection. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in hereditary lymphedema IC; hereditary spastic paraplegia 44; hypomyelinating leukodystrophy 2; and lymphedema. Orthologous to human GJC2 (gap junction protein gamma 2); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 6-propyl-2-thiouracil; amitrole.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

connexin-47; Cx47; gap junction alpha-12 protein; gap junction gamma-2 protein; gap junction membrane channel protein alpha 12; gap junction protein, alpha 12; gap junction protein, alpha 12, 47kDa; Gja12

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GJC2 (gap junction protein gamma 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Gjc2 (gap junction protein, gamma 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gjc2 (gap junction protein gamma 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GJC2 (gap junction protein gamma 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GJC2 (gap junction protein gamma 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gjc2 (gap junction protein gamma 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GJC2 (gap junction protein gamma 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GJC2 (gap junction protein gamma 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gjc2 (gap junction protein gamma 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	GJC1 (gap junction protein gamma 1)	HGNC	OrthoDB
Homo sapiens (human):	HEATR6 (HEAT repeat containing 6)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	GJC2 (gap junction protein gamma 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gjc2 (gap junction protein, gamma 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cx47.1 (connexin 47.1)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	gpm6a	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	gjc2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	44,462,203 - 44,470,924 (-)	NCBI		GRCr8
mRatBN7.2	10	43,962,642 - 43,971,358 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	43,962,642 - 43,970,467 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	48,656,460 - 48,664,272 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	48,146,818 - 48,154,630 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	43,650,415 - 43,658,227 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	45,526,740 - 45,535,520 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	45,526,745 - 45,534,570 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	45,282,830 - 45,291,628 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	45,480,937 - 45,488,651 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	43,225,920 - 43,233,731 (-)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amyotrophic lateral sclerosis (ISO)

dystonia (ISO)

Experimental Autoimmune Encephalomyelitis (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

hereditary lymphedema IC (ISO)

hereditary spastic paraplegia (ISO)

hereditary spastic paraplegia 44 (ISO)

hypomyelinating leukodystrophy 2 (ISO,ISS)

intellectual disability (ISO)

lymphedema (ISO)

multiple mitochondrial dysfunctions syndrome 3 (ISO)

Nervous System Malformations (ISO)

paraplegia (ISO)

parathyroid carcinoma (ISO)

Parkinson's disease (IEP)

Pelizaeus-Merzbacher disease (ISO)

spastic ataxia (ISO)

Spinal Cord Injuries (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

2,2',5,5'-tetrachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

amitrole (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

atrazine (ISO)

benzo[a]pyrene (EXP,ISO)

bisphenol A (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cypermethrin (EXP)

dicrotophos (ISO)

ethanol (ISO)

ethylparaben (ISO)

folic acid (ISO)

gentamycin (EXP)

lead diacetate (EXP,ISO)

minocycline (EXP)

morphine (ISO)

N-nitrosodiethylamine (EXP)

nicotine (ISO)

paracetamol (EXP)

PCB138 (EXP)

phenethyl caffeate (EXP)

pirinixic acid (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

tenofovir disoproxil fumarate (EXP)

tetraphene (ISO)

thioacetamide (EXP)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell communication by electrical coupling (ISO)

cell-cell signaling (IBA,ISO)

negative regulation of G1/S transition of mitotic cell cycle (IMP)

positive regulation of calcium ion transmembrane transport (IMP)

positive regulation of gene expression (IMP)

positive regulation of oligodendrocyte progenitor proliferation (IMP)

regulation of protein phosphorylation (IMP)

response to toxic substance (ISO)

transmembrane transport (IEA)

Cellular Component

connexin complex (IBA)

gap junction (IDA,ISO)

myelin sheath (ISO)

neuronal cell body (IDA)

paranode region of axon (IDA)

perikaryon (IDA)

proximal neuron projection (IDA)

Molecular Function

gap junction channel activity (IBA,ISO)

gap junction channel activity involved in cell communication by electrical coupling (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	GJA12 mutations in children with recessive hypomyelinating leukoencephalopathy.	Bugiani M, etal., Neurology. 2006 Jul 25;67(2):273-9. Epub 2006 May 17.
2.	Cellular expression of connexins in the rat brain: neuronal localization, effects of kainate-induced seizures and expression in apoptotic neuronal cells.	Condorelli DF, etal., Eur J Neurosci 2003 Oct;18(7):1807-27.
3.	Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model.	Cui Y, etal., J Neuroinflammation. 2014 Mar 6;11:42. doi: 10.1186/1742-2094-11-42.
4.	GJC2 missense mutations cause human lymphedema.	Ferrell RE, etal., Am J Hum Genet. 2010 Jun 11;86(6):943-8. doi: 10.1016/j.ajhg.2010.04.010. Epub 2010 May 27.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	GJA12 mutations are a rare cause of Pelizaeus-Merzbacher-like disease.	Henneke M, etal., Neurology. 2008 Mar 4;70(10):748-54. Epub 2007 Dec 19.
7.	Connexin-47 and connexin-32 in gap junctions of oligodendrocyte somata, myelin sheaths, paranodal loops and Schmidt-Lanterman incisures: implications for ionic homeostasis and potassium siphoning.	Kamasawa N, etal., Neuroscience. 2005;136(1):65-86. Epub 2005 Oct 3.
8.	Unique distributions of the gap junction proteins connexin29, connexin32, and connexin47 in oligodendrocytes.	Kleopa KA, etal., Glia. 2004 Sep;47(4):346-57.
9.	Astrocytes induce proliferation of oligodendrocyte progenitor cells via connexin 47-mediated activation of the ERK/Id4 pathway.	Liu Z, etal., Cell Cycle. 2017 Apr 3;16(7):714-722. doi: 10.1080/15384101.2017.1295183. Epub 2017 Feb 22.
10.	Disruption of oligodendrocyte gap junctions in experimental autoimmune encephalomyelitis.	Markoullis K, etal., Glia. 2012 Jul;60(7):1053-66. doi: 10.1002/glia.22334. Epub 2012 Mar 27.
11.	Promoter mutation is a common variant in GJC2-associated Pelizaeus-Merzbacher-like disease.	Meyer E, etal., Mol Genet Metab. 2011 Dec;104(4):637-43. doi: 10.1016/j.ymgme.2011.08.032. Epub 2011 Sep 8.
12.	Adenoviral vector carrying glial cell-derived neurotrophic factor for direct gene therapy in comparison with human umbilical cord blood cell-mediated therapy of spinal cord injury in rat.	Mukhamedshina YO, etal., Spinal Cord. 2016 May;54(5):347-59. doi: 10.1038/sc.2015.161. Epub 2015 Sep 29.
13.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
14.	Hereditary spastic paraplegia is a novel phenotype for GJA12/GJC2 mutations.	Orthmann-Murphy JL, etal., Brain. 2009 Feb;132(Pt 2):426-38. doi: 10.1093/brain/awn328. Epub 2008 Dec 4.
15.	Rapid identification of mutations in GJC2 in primary lymphoedema using whole exome sequencing combined with linkage analysis with delineation of the phenotype.	Ostergaard P, etal., J Med Genet. 2011 Apr;48(4):251-5. doi: 10.1136/jmg.2010.085563. Epub 2011 Jan 25.
16.	GOA pipeline	RGD automated data pipeline
17.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
19.	Comprehensive gene review and curation	RGD comprehensive gene curation
20.	Nigrostriatal proteomics of cypermethrin-induced dopaminergic neurodegeneration: microglial activation-dependent and -independent regulations.	Singh AK, etal., Toxicol Sci. 2011 Aug;122(2):526-38. doi: 10.1093/toxsci/kfr115. Epub 2011 May 10.
21.	Pathologic and phenotypic alterations in a mouse expressing a connexin47 missense mutation that causes Pelizaeus-Merzbacher-like disease in humans.	Tress O, etal., PLoS Genet. 2011 Jul;7(7):e1002146. doi: 10.1371/journal.pgen.1002146. Epub 2011 Jul 7.
22.	Mutations in the gene encoding gap junction protein alpha 12 (connexin 46.6) cause Pelizaeus-Merzbacher-like disease.	Uhlenberg B, etal., Am J Hum Genet. 2004 Aug;75(2):251-60. Epub 2004 Jun 10.

Additional References at PubMed

PMID:11160382	PMID:15057822	PMID:16194882	PMID:17344063	PMID:20578039	PMID:22871113	PMID:28634078	PMID:31002152

Genomics

Comparative Map Data

Gjc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	44,462,203 - 44,470,924 (-)	NCBI		GRCr8
mRatBN7.2	10	43,962,642 - 43,971,358 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	43,962,642 - 43,970,467 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	48,656,460 - 48,664,272 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	48,146,818 - 48,154,630 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	43,650,415 - 43,658,227 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	45,526,740 - 45,535,520 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	45,526,745 - 45,534,570 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	45,282,830 - 45,291,628 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	45,480,937 - 45,488,651 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	43,225,920 - 43,233,731 (-)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

GJC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	228,149,930 - 228,159,826 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	228,149,930 - 228,159,826 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	228,337,631 - 228,347,527 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	226,404,176 - 226,414,150 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	224,644,287 - 224,654,260	NCBI
Celera	1	201,527,795 - 201,537,768 (+)	NCBI		Celera
Cytogenetic Map	1	q42.13	NCBI
HuRef	1	198,852,444 - 198,862,502 (+)	NCBI		HuRef
CHM1_1	1	229,609,739 - 229,619,848 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	227,338,927 - 227,348,822 (+)	NCBI		T2T-CHM13v2.0

Gjc2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	59,066,390 - 59,074,039 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	59,066,394 - 59,074,039 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	59,175,564 - 59,183,213 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	59,175,568 - 59,183,213 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	58,989,066 - 58,996,715 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	58,991,761 - 58,999,408 (-)	NCBI		MGSCv36	mm8
Celera	11	63,940,632 - 63,948,320 (-)	NCBI		Celera
Cytogenetic Map	11	B1.3	NCBI
cM Map	11	37.05	NCBI

Gjc2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955581	291,537 - 294,752 (-)	NCBI	ChiLan1.0	ChiLan1.0

GJC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	21,446,828 - 21,456,976 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	21,385,126 - 21,395,272 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	203,551,556 - 203,561,702 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	208,762,974 - 208,772,229 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

GJC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	810,388 - 819,248 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	810,386 - 820,420 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	332,072 - 340,760 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	531,302 - 539,994 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	14	722,120 - 730,807 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	502,958 - 511,636 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	488,819 - 497,515 (-)	NCBI		UU_Cfam_GSD_1.0

Gjc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	87,727,408 - 87,735,276 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936864	69,445 - 70,752 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936864	67,608 - 71,543 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GJC2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	51,258,207 - 51,267,962 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	51,257,623 - 51,267,969 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	53,844,201 - 53,854,379 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GJC2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	1,568,664 - 1,579,279 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	1,569,427 - 1,570,752 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	1,449,049 - 1,451,620 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gjc2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624937	898,876 - 905,247 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gjc2
35 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	271
Count of miRNA genes:	170
Interacting mature miRNAs:	198
Transcripts:	ENSRNOT00000058362
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15028513	60430477	Rat
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15275955	60275955	Rat
6893350	Bw99	Body weight QTL 99	0.87	0.16	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
6893352	Bw100	Body weight QTL 100	0.33	0.6	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	17907113	51786432	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18167841	63167841	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	19606483	64606483	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	19606483	64606483	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	19816042	99406971	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21329805	61345413	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22427500	90627625	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	26521957	61345413	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	26521957	98003205	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	26521957	98952741	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	26944628	71944628	Rat
10402859	Bp381	Blood pressure QTL 381		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
2292441	Bp308	Blood pressure QTL 308			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28453136	73453136	Rat
1600371	Mcs21	Mammary carcinoma susceptibility QTL 21	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	28875650	52200160	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29299504	64155584	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat
631557	Bp136	Blood pressure QTL 136		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	30632053	75632053	Rat
1576311	Pia26	Pristane induced arthritis QTL 26			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	31224026	75632053	Rat
1578779	Tcas10	Tongue tumor susceptibility QTL 10	3.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	10	31297439	76297439	Rat
1576319	Cia29	Collagen induced arthritis QTL 29			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	33973921	78973921	Rat
61332	Eau3	Experimental allergic uveoretinitis QTL 3		0.004	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	34490559	45579777	Rat
1354614	Hpcl1	Hepatic cholesterol level QTL 1	3.3		liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	35392267	51793994	Rat
1358897	Stresp6	Stress response QTL 6	4.17	0.022	blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	35392267	64155584	Rat
61441	Btemp1	Thermal response to stress QTL 1	4		body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	10	35392457	63642539	Rat
2317042	Aia20	Adjuvant induced arthritis QTL 20	3.38		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	10	37565079	82565079	Rat
2317043	Aia7	Adjuvant induced arthritis QTL 7	3.82		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	10	37565079	82565079	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40035094	102359817	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
631552	Vetf2	Vascular elastic tissue fragility QTL 2	4.5	0.0002	aorta elastic tissue integrity trait (VT:0010556)	artery internal elastic lamina non-tumorous lesion count (CMO:0001913)	10	41142633	86142633	Rat
61463	Bp12	Blood pressure QTL 12	6.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	41333258	86333258	Rat
8552805	Bw145	Body weight QTL 145	2.2		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	10	41944526	78307017	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42045676	104670812	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	42323132	87323132	Rat
70198	BpQTLcluster9	Blood pressure QTL cluster 9	2.94		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	42323132	87323132	Rat
6893342	Cm78	Cardiac mass QTL 78	0.1	0.88	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	10	42876766	79813922	Rat

Markers in Region

RH129753

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	43,971,537 - 43,971,732 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	45,535,641 - 45,535,835	NCBI	Rnor6.0
Rnor_5.0	10	45,291,726 - 45,291,920	UniSTS	Rnor5.0
RH 3.4 Map	10	500.29	UniSTS
Cytogenetic Map	10	q22	UniSTS

RH143586

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	43,963,867 - 43,964,007 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	45,527,971 - 45,528,110	NCBI	Rnor6.0
Rnor_5.0	10	45,284,056 - 45,284,195	UniSTS	Rnor5.0
RGSC_v3.4	10	45,481,648 - 45,481,787	UniSTS	RGSC3.4
Celera	10	43,227,132 - 43,227,271	UniSTS
RH 3.4 Map	10	481.2	UniSTS
Cytogenetic Map	10	q22	UniSTS

RH140806

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	43,963,269 - 43,963,405 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	45,527,373 - 45,527,508	NCBI	Rnor6.0
Rnor_5.0	10	45,283,458 - 45,283,593	UniSTS	Rnor5.0
RGSC_v3.4	10	45,481,050 - 45,481,185	UniSTS	RGSC3.4
Celera	10	43,226,548 - 43,226,683	UniSTS
RH 3.4 Map	10	503.4	UniSTS
Cytogenetic Map	10	q22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									24
Low	3	26	9	5	12	5	3	5	34	4	37	11	3
Below cutoff		17	45	33	7	33	5	6	16	31	4		5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001100784	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006246512	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006246515	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597444	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597445	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597446	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597447	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039086565	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039086566	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063269613	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC142478	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY233216	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000058362 ⟹ ENSRNOP00000064383

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	43,962,642 - 43,970,467 (-)	Ensembl
Rnor_6.0 Ensembl	10	45,526,745 - 45,534,570 (-)	Ensembl

RefSeq Acc Id:

NM_001100784 ⟹ NP_001094254

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	44,462,203 - 44,470,028 (-)	NCBI
mRatBN7.2	10	43,962,642 - 43,970,467 (-)	NCBI
Rnor_6.0	10	45,526,745 - 45,534,570 (-)	NCBI
Rnor_5.0	10	45,282,830 - 45,291,628 (-)	NCBI
Celera	10	43,225,920 - 43,233,731 (-)	NCBI

Sequence:

show sequence

CCAGTATCCAGCCGACAGGTGGAAGGGCTCATCAGAAGGTTTGCATTTCCAGCCTGGAGAAGGT
CCCACCTGCCCGCTCCCATGACCAACATGAGCTGGAGCTTCCTGACGCGGCTGCTGGAGGAGAT
CCACAATCATTCCACCTTCGTGGGCAAAGTTTGGCTCACTGTACTGGTGGTCTTCCGCATTGTG
CTAACGGCTGTCGGTGGTGAGTCCATCTATTCAGATGAGCAATCCAAGTTCACCTGCAACACGC
GCCAACCGGGTTGTGACAACGTCTGCTACGACGCCTTTGCGCCCCTGTCTCATGTGCGCTTCTG
GGTCTTCCAGATAGTGGTCATCTCTACACCTTCTGTCATGTACCTGGGCTATGCTGTCCATCGC
CTGGCGCGCGCCTCGGAGCAGGAGCGCAGGCGGGCCCTCCGACGTCGCCCTGGCCCCCGGCGCT
TGCCCAGGGCGCAGCTGCCACCGCCACCACCTGGCTGGCCGGACACCACCGATCTGGGCGAGGC
GGAGCCCATACTGGCGCTGGAGGAGGATGAGGACGAGGAACCAGGGGCGCCCGAGGGCCCCGGG
GAAGACACGGAGGAGGAGCGAACGGAAGATGTGGCTGCCAAGGGGGGCGGAGGTGATGGAAAGA
CGGTGGTCACTCCTGGCCCGGCCGGGCAGCATGACGGGCGGCGGCGCATCCAGAGGGAGGGCCT
GATGCGCGTGTACGTAGCTCAGCTGGTGGTTAGGGCGGCCTTCGAGGTGGCCTTTCTGGTGGGC
CAGTACCTACTGTATGGCTTCGAGGTGCCGCCCTTCTTTGCCTGCAGCCGCCAGCCTTGCCCAC
ACGTAGTGGACTGCTTCGTGTCGCGGCCAACCGAGAAGACTGTCTTCTTGCTGGTTATGTATGT
GGTTAGCTGCCTATGCCTGTTGCTCAACCTTTGTGAAATGGCACACCTGGGTCTCGGCAGTGCG
CAGGACGCTGTGCGCGGCCGTCGGGGAGCCTCAGCGGCTGGTCCTGGTCCCGCGCCGCGCCCAC
CGCCCTGCGCTTTCCCGGCTGCGGCCGCGGGCCTGGCTTGCCCTCCGGACTACAGCCTGGTAGT
GCGTGCAGCTGAGCGCGCGCGAGCGCACGATCAGAACCTGGCGAACCTGGCACTGCAGGCGCTG
CGTGATGGGGCGGCGGTGGCGGCGGTTTCCGCGGATCGCGACAGTCCGCCGTGTTCAGGGCTCA
ATGCAACCTCTCGGGGACCACCCAGGGCGGGCGGCCCAGCTTCCGGAACCGGTAGCGCCACGTC
GGGGGGTACCGTTGGAGAGCAGGGCAGGTCGGGAGCTCAGGAACAGCTCGCCACTAAGCCCAGG
GTTGGCTCTGAGAAGGGCAGTACAGGCAGCAGAGACGGCAAGGCCACCGTGTGGATCTGAGGGC
ACTGCGGAGAGATCAGGGAGGGCCTGGCATGAGGATTCAGTTGAAATCTTTCTGCCCTCAACCA
GTGATCTCTGGCAAACCCTGTTAGGGATCTTTAAAGGAGGAGCTGAAGCCCCTTAGGAGGTGCT
GGCTCGGGTACCTCTCTGCAGGATAGGAAGGGGAATGCCAGGGCCTTATATGTGGCCTCTGAGG
TGGGGAGTGGGCAGAACTGTGTCCCAGGAATTGCCCCTCCAGGCTATACTACACAGGAATGACC
TCTCTGCTGGGCCTGCCAGCCCTTCCTTCTGGGCTCTTATGCAGTTTCCCCATAGGATTGGAGG
TGTCTGGCATGAATCCTCACAGAGAGAGCCAGAGAAAAGTCCGGTGCAGGCAGACAGCGTTAGT
TACTCCCAGCCCTTGGCTCCCTACTTGAGGCAGCAGACTGAGTGAGACCTGAAGGAGGCCTTTA
GAGAAAAGTCCTTTCATTGAGCTGAGATCGCTTGGCATGACTCCTTAGAAGTTCTGTTGCCCCT
TGCTGCCTAGTTGCCTCAGGCTGTGGTCCAGGGCTGTGGCTTTGGCCATGCTGAAAAATTAGAG
CTCTGGGGAGCCTGTCCCCATCCCCTGTGACCTTCCCCTGTTTTAAAGCCAACTTCCAGAACAA
AGGAAGTAAAATAAAACTAACCTTTTGTTTACA

hide sequence

RefSeq Acc Id:

XM_006246515 ⟹ XP_006246577

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	44,462,203 - 44,470,924 (-)	NCBI
mRatBN7.2	10	43,962,642 - 43,971,358 (-)	NCBI
Rnor_6.0	10	45,526,740 - 45,535,520 (-)	NCBI
Rnor_5.0	10	45,282,830 - 45,291,628 (-)	NCBI

Sequence:

show sequence

GGCCCTTGTCCCTGCCCACATCCGGGGTCCACCAGTCATCAGAATGCTGGCTAGGGTTGCTTGT
GTTCTCATCTTCCCCTAGGAGCAGTCACCTGAGACACTCAGCGTAGGCTGGAATGGACAACTAG
TGCTGCTGCCTCTTTGCAGTTTGTGAGCCATTTGGGGACTCAGGGACAGACACCACTTGCCAGG
AAGGAAAGTGCCCAACCACAGGGGAAGAGCTAAGGTCATAATGCTGGCTCTGGACCTGTGGGTG
CTGTGTGCTCTTGTCCTTGTGTATAGCCAGCCAACCCAAGGAAGGGCAAGTGAACCCTGTTAGG
GCTGGTAGAGGGGCAGAGCCCTAGGGCTTCTGTAAAGGTCCCAAATTTCAAGCTCTAGAGGTTG
TAGTGGGGTGCAGCATTCCTGAGGGAGATGTCCCTCCCCTCCTGCCCAAGATGAGATATTCTGA
GTGTCTGGGTTCTGCTCTCCTCCCCTCTTCCCCTGGGCTCTCGGCCCAGGCTGCCTGGCTCCGC
CCAAGAGAGCAATCCCAGCAGGGAGGGCAGTGGTTGTTGCCAGCTACCCCACCCGGTGGTCAGC
CACAGCTCTGCCTTGTGCATCTCCAGGTCCCACCTGCCCGCTCCCATGACCAACATGAGCTGGA
GCTTCCTGACGCGGCTGCTGGAGGAGATCCACAATCATTCCACCTTCGTGGGCAAAGTTTGGCT
CACTGTACTGGTGGTCTTCCGCATTGTGCTAACGGCTGTCGGTGGTGAGTCCATCTATTCAGAT
GAGCAATCCAAGTTCACCTGCAACACGCGCCAACCGGGTTGTGACAACGTCTGCTACGACGCCT
TTGCGCCCCTGTCTCATGTGCGCTTCTGGGTCTTCCAGATAGTGGTCATCTCTACACCTTCTGT
CATGTACCTGGGCTATGCTGTCCATCGCCTGGCGCGCGCCTCGGAGCAGGAGCGCAGGCGGGCC
CTCCGACGTCGCCCTGGCCCCCGGCGCTTGCCCAGGGCGCAGCTGCCACCGCCACCACCTGGCT
GGCCGGACACCACCGATCTGGGCGAGGCGGAGCCCATACTGGCGCTGGAGGAGGATGAGGACGA
GGAACCAGGGGCGCCCGAGGGCCCCGGGGAAGACACGGAGGAGGAGCGAACGGAAGATGTGGCT
GCCAAGGGGGGCGGAGGTGATGGAAAGACGGTGGTCACTCCTGGCCCGGCCGGGCAGCATGACG
GGCGGCGGCGCATCCAGAGGGAGGGCCTGATGCGCGTGTACGTAGCTCAGCTGGTGGTTAGGGC
GGCCTTCGAGGTGGCCTTTCTGGTGGGCCAGTACCTACTGTATGGCTTCGAGGTGCCGCCCTTC
TTTGCCTGCAGCCGCCAGCCTTGCCCACACGTAGTGGACTGCTTCGTGTCGCGGCCAACCGAGA
AGACTGTCTTCTTGCTGGTTATGTATGTGGTTAGCTGCCTATGCCTGTTGCTCAACCTTTGTGA
AATGGCACACCTGGGTCTCGGCAGTGCGCAGGACGCTGTGCGCGGCCGTCGGGGAGCCTCAGCG
GCTGGTCCTGGTCCCGCGCCGCGCCCACCGCCCTGCGCTTTCCCGGCTGCGGCCGCGGGCCTGG
CTTGCCCTCCGGACTACAGCCTGGTAGTGCGTGCAGCTGAGCGCGCGCGAGCGCACGATCAGAA
CCTGGCGAACCTGGCACTGCAGGCGCTGCGTGATGGGGCGGCGGTGGCGGCGGTTTCCGCGGAT
CGCGACAGTCCGCCGTGTTCAGGGCTCAATGCAACCTCTCGGGGACCACCCAGGGCGGGCGGCC
CAGCTTCCGGAACCGGTAGCGCCACGTCGGGGGGTACCGTTGGAGAGCAGGGCAGGTCGGGAGC
TCAGGAACAGCTCGCCACTAAGCCCAGGGTTGGCTCTGAGAAGGGCAGTACAGGCAGCAGAGAC
GGCAAGGCCACCGTGTGGATCTGAGGGCACTGCGGAGAGATCAGGGAGGGCCTGGCATGAGGAT
TCAGTTGAAATCTTTCTGCCCTCAACCAGTGATCTCTGGCAAACCCTGTTAGGGATCTTTAAAG
GAGGAGCTGAAGCCCCTTAGGAGGTGCTGGCTCGGGTACCTCTCTGCAGGATAGGAAGGGGAAT
GCCAGGGCCTTATATGTGGCCTCTGAGGTGGGGAGTGGGCAGAACTGTGTCCCAGGAATTGCCC
CTCCAGGCTATACTACACAGGAATGACCTCTCTGCTGGGCCTGCCAGCCCTTCCTTCTGGGCTC
TTATGCAGTTTCCCCATAGGATTGGAGGTGTCTGGCATGAATCCTCACAGAGAGAGCCAGAGAA
AAGTCCGGTGCAGGCAGACAGCGTTAGTTACTCCCAGCCCTTGGCTCCCTACTTGAGGCAGCAG
ACTGAGTGAGACCTGAAGGAGGCCTTTAGAGAAAAGTCCTTTCATTGAGCTGAGATCGCTTGGC
ATGACTCCTTAGAAGTTCTGTTGCCCCTTGCTGCCTAGTTGCCTCAGGCTGTGGTCCAGGGCTG
TGGCTTTGGCCATGCTGAAAAATTAGAGCTCTGGGGAGCCTGTCCCCATCCCCTGTGACCTTCC
CCTGTTTTAAAGCCAACTTCCAGAACAAAGGAAGTAAAATAAAACTAACCTTTTGTTTACACTC
AA

hide sequence

RefSeq Acc Id:

XM_039086565 ⟹ XP_038942493

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	44,462,203 - 44,470,352 (-)	NCBI
mRatBN7.2	10	43,962,642 - 43,970,795 (-)	NCBI

RefSeq Acc Id:

XM_039086566 ⟹ XP_038942494

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	44,462,203 - 44,464,207 (-)	NCBI
mRatBN7.2	10	43,962,642 - 43,964,654 (-)	NCBI

RefSeq Acc Id:

XM_063269613 ⟹ XP_063125683

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	44,462,203 - 44,470,040 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001094254	(Get FASTA)	NCBI Sequence Viewer
	XP_006246577	(Get FASTA)	NCBI Sequence Viewer
	XP_038942493	(Get FASTA)	NCBI Sequence Viewer
	XP_038942494	(Get FASTA)	NCBI Sequence Viewer
	XP_063125683	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAP04733	(Get FASTA)	NCBI Sequence Viewer
	EDM04584	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000064383
	ENSRNOP00000064383.1
	ENSRNOP00055042890
	ENSRNOP00060044385
	ENSRNOP00065009549
GenBank Protein	Q80XF7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001094254 ⟸ NM_001100784

- UniProtKB:

Q80XF7 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MTNMSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGESIYSDEQSKFTCNTRQPGCD
NVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGPRRLPRAQL
PPPPPGWPDTTDLGEAEPILALEEDEDEEPGAPEGPGEDTEEERTEDVAAKGGGGDGKTVVTPG
PAGQHDGRRRIQREGLMRVYVAQLVVRAAFEVAFLVGQYLLYGFEVPPFFACSRQPCPHVVDCF
VSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRRGASAAGPGPAPRPPPCAFP
AAAAGLACPPDYSLVVRAAERARAHDQNLANLALQALRDGAAVAAVSADRDSPPCSGLNATSRG
PPRAGGPASGTGSATSGGTVGEQGRSGAQEQLATKPRVGSEKGSTGSRDGKATVWI

hide sequence

RefSeq Acc Id:	XP_006246577 ⟸ XM_006246515
- Peptide Label:	isoform X3
- UniProtKB:	Q80XF7 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MTNMSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGESIYSDEQSKFTCNTRQPGCD NVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGPRRLPRAQL PPPPPGWPDTTDLGEAEPILALEEDEDEEPGAPEGPGEDTEEERTEDVAAKGGGGDGKTVVTPG PAGQHDGRRRIQREGLMRVYVAQLVVRAAFEVAFLVGQYLLYGFEVPPFFACSRQPCPHVVDCF VSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRRGASAAGPGPAPRPPPCAFP AAAAGLACPPDYSLVVRAAERARAHDQNLANLALQALRDGAAVAAVSADRDSPPCSGLNATSRG PPRAGGPASGTGSATSGGTVGEQGRSGAQEQLATKPRVGSEKGSTGSRDGKATVWI hide sequence

RefSeq Acc Id:

ENSRNOP00000064383 ⟸ ENSRNOT00000058362

RefSeq Acc Id:	XP_038942493 ⟸ XM_039086565
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038942494 ⟸ XM_039086566
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063125683 ⟸ XM_063269613
- Peptide Label:	isoform X2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q80XF7-F1-model_v2	AlphaFold	Q80XF7	1-440	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1562712	AgrOrtholog
BioCyc Gene	G2FUF-24910	BioCyc
Ensembl Genes	ENSRNOG00000038328	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOG00055029981	UniProtKB/Swiss-Prot
	ENSRNOG00060030750	UniProtKB/Swiss-Prot
	ENSRNOG00065008190	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000058362	ENTREZGENE
	ENSRNOT00000058362.4	UniProtKB/Swiss-Prot
	ENSRNOT00055051953	UniProtKB/Swiss-Prot
	ENSRNOT00060053423	UniProtKB/Swiss-Prot
	ENSRNOT00065012967	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.1440.80	UniProtKB/Swiss-Prot
InterPro	Connexin	UniProtKB/Swiss-Prot
	Connexin_CCC	UniProtKB/Swiss-Prot
	Connexin_CS	UniProtKB/Swiss-Prot
	Connexin_N	UniProtKB/Swiss-Prot
	Connexin_N_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:497913	UniProtKB/Swiss-Prot
NCBI Gene	497913	ENTREZGENE
PANTHER	GAP JUNCTION GAMMA-2 PROTEIN	UniProtKB/Swiss-Prot
	PTHR11984	UniProtKB/Swiss-Prot
Pfam	Connexin	UniProtKB/Swiss-Prot
PhenoGen	Gjc2	PhenoGen
PRINTS	CONNEXIN	UniProtKB/Swiss-Prot
PROSITE	CONNEXINS_1	UniProtKB/Swiss-Prot
	CONNEXINS_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000038328	RatGTEx
	ENSRNOG00055029981	RatGTEx
	ENSRNOG00060030750	RatGTEx
	ENSRNOG00065008190	RatGTEx
SMART	CNX	UniProtKB/Swiss-Prot
	Connexin_CCC	UniProtKB/Swiss-Prot
UniProt	CXG2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-25	Gjc2	gap junction protein, gamma 2	Gja12	gap junction membrane channel protein alpha 12	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-14	Gja12	gap junction membrane channel protein alpha 12	Gja12	gap junction protein, alpha 12	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-11	Gja12	gap junction protein, alpha 12	Gjc2	gap junction protein, gamma 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-04	Gjc2	gap junction protein, gamma 2	Gja12_predicted	gap junction protein, alpha 12, 47kDa (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	Gja12_predicted	gap junction protein, alpha 12, 47kDa (predicted)	Gja12	gap junction protein, alpha 12, 47kDa	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	Gja12	gap junction protein, alpha 12, 47kDa			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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