Amer3 (APC membrane recruitment protein 3) - Rat Genome Database

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Gene: Amer3 (APC membrane recruitment protein 3) Rattus norvegicus
Analyze
Symbol: Amer3
Name: APC membrane recruitment protein 3
RGD ID: 1560420
Description: Predicted to enable beta-catenin binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in regulation of canonical Wnt signaling pathway. Predicted to be active in plasma membrane. Orthologous to human AMER3 (APC membrane recruitment protein 3); INTERACTS WITH bisphenol A; 2,2',4,4',5,5'-hexachlorobiphenyl (ortholog); 2,2',5,5'-tetrachlorobiphenyl (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fam123c; family with sequence similarity 123C; LOC501122; RGD1560420; similar to RIKEN cDNA 9430069J07 gene
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8944,286,274 - 44,298,246 (+)NCBIGRCr8
mRatBN7.2936,790,355 - 36,802,341 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl936,790,932 - 36,802,419 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx945,287,877 - 45,299,262 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0950,419,049 - 50,430,431 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0948,700,966 - 48,712,348 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0941,089,417 - 41,101,108 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl941,096,835 - 41,099,189 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0940,759,302 - 40,770,856 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4933,332,869 - 33,335,223 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera934,576,198 - 34,586,661 (+)NCBICelera
Cytogenetic Map9q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Amer3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8944,286,274 - 44,298,246 (+)NCBIGRCr8
mRatBN7.2936,790,355 - 36,802,341 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl936,790,932 - 36,802,419 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx945,287,877 - 45,299,262 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0950,419,049 - 50,430,431 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0948,700,966 - 48,712,348 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0941,089,417 - 41,101,108 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl941,096,835 - 41,099,189 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0940,759,302 - 40,770,856 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4933,332,869 - 33,335,223 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera934,576,198 - 34,586,661 (+)NCBICelera
Cytogenetic Map9q21NCBI
AMER3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382130,755,540 - 130,768,134 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2130,755,540 - 130,768,134 (+)EnsemblGRCh38hg38GRCh38
GRCh372131,513,113 - 131,525,707 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362131,229,547 - 131,242,177 (+)NCBINCBI36Build 36hg18NCBI36
Celera2125,047,974 - 125,060,604 (-)NCBICelera
Cytogenetic Map2q21.1NCBI
HuRef2123,586,259 - 123,598,889 (+)NCBIHuRef
CHM1_12131,517,083 - 131,529,713 (+)NCBICHM1_1
T2T-CHM13v2.02131,189,705 - 131,202,299 (+)NCBIT2T-CHM13v2.0
Amer3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39134,617,988 - 34,630,025 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl134,618,738 - 34,630,025 (+)EnsemblGRCm39 Ensembl
GRCm38134,578,907 - 34,590,944 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl134,579,657 - 34,590,944 (+)EnsemblGRCm38mm10GRCm38
MGSCv37134,636,538 - 34,647,789 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36134,524,273 - 34,535,487 (+)NCBIMGSCv36mm8
Celera134,345,622 - 34,356,836 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map113.34NCBI
Amer3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955459267,754 - 277,422 (+)NCBIChiLan1.0ChiLan1.0
AMER3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21344,874,912 - 44,885,928 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B44,889,887 - 44,900,903 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B29,429,382 - 29,440,406 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B131,515,406 - 131,527,622 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B131,521,603 - 131,524,188 (+)Ensemblpanpan1.1panPan2
AMER3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11920,444,794 - 20,455,969 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1920,450,384 - 20,452,789 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.01921,767,141 - 21,778,279 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1921,766,706 - 21,775,711 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11920,408,233 - 20,419,367 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01920,668,504 - 20,679,638 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01921,709,925 - 21,721,063 (+)NCBIUU_Cfam_GSD_1.0
Amer3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303100,373,849 - 100,383,953 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646941,238,646 - 41,244,623 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646941,234,187 - 41,244,603 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMER3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1557,034,878 - 57,044,524 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11557,035,442 - 57,047,427 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215156,704,675 - 156,714,569 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AMER3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_023666037410,471 - 421,307 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Amer3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473214,798,872 - 14,809,682 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Amer3
177 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:51
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000033700
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 64
Low 8 2
Below cutoff 3 2 8 1 1 2 5 14 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000033700   ⟹   ENSRNOP00000037826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl936,790,932 - 36,802,419 (+)Ensembl
Rnor_6.0 Ensembl941,096,835 - 41,099,189 (+)Ensembl
RefSeq Acc Id: NM_001399352   ⟹   NP_001386281
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8944,286,870 - 44,298,246 (+)NCBI
mRatBN7.2936,790,959 - 36,802,341 (+)NCBI
RefSeq Acc Id: XM_006244725   ⟹   XP_006244787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8944,286,274 - 44,298,246 (+)NCBI
mRatBN7.2936,790,355 - 36,802,341 (+)NCBI
Rnor_6.0941,089,417 - 41,101,108 (+)NCBI
Rnor_5.0940,759,302 - 40,770,856 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063267585   ⟹   XP_063123655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8944,290,043 - 44,298,246 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001386281 (Get FASTA)   NCBI Sequence Viewer  
  XP_006244787 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123655 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000037826
  ENSRNOP00000037826.4
Reference Protein Sequences
RefSeq Acc Id: XP_006244787   ⟸   XM_006244725
- Peptide Label: isoform X1
- UniProtKB: D3ZHS8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000037826   ⟸   ENSRNOT00000033700
RefSeq Acc Id: NP_001386281   ⟸   NM_001399352
- UniProtKB: D3ZHS8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123655   ⟸   XM_063267585
- Peptide Label: isoform X1
- UniProtKB: D3ZHS8 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZHS8-F1-model_v2 AlphaFold D3ZHS8 1-784 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560420 AgrOrtholog
BioCyc Gene G2FUF-27854 BioCyc
Ensembl Genes ENSRNOG00000023603 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033700 ENTREZGENE
  ENSRNOT00000033700.5 UniProtKB/TrEMBL
InterPro WTX_protein UniProtKB/TrEMBL
KEGG Report rno:501122 UniProtKB/TrEMBL
NCBI Gene 501122 ENTREZGENE
PANTHER APC MEMBRANE RECRUITMENT PROTEIN 3 UniProtKB/TrEMBL
  PTHR22237 UniProtKB/TrEMBL
Pfam WTX UniProtKB/TrEMBL
PhenoGen Amer3 PhenoGen
RatGTEx ENSRNOG00000023603 RatGTEx
UniProt D3ZHS8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-18 Amer3  APC membrane recruitment protein 3  Fam123c  family with sequence similarity 123C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Fam123c  family with sequence similarity 123C  RGD1560420_predicted  similar to RIKEN cDNA 9430069J07 gene (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560420_predicted  similar to RIKEN cDNA 9430069J07 gene (predicted)  LOC501122  similar to RIKEN cDNA 9430069J07 gene  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501122  similar to RIKEN cDNA 9430069J07 gene      Symbol and Name status set to provisional 70820 PROVISIONAL