Llgl2 (LLGL scribble cell polarity complex component 2) - Rat Genome Database

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Gene: Llgl2 (LLGL scribble cell polarity complex component 2) Rattus norvegicus
Analyze
Symbol: Llgl2
Name: LLGL scribble cell polarity complex component 2
RGD ID: 1560307
Description: Predicted to enable GTPase activator activity; PDZ domain binding activity; and myosin II binding activity. Predicted to be involved in several processes, including cytoskeleton organization; leucine transport; and regulation of Notch signaling pathway. Predicted to act upstream of or within establishment or maintenance of polarity of embryonic epithelium; labyrinthine layer development; and post-embryonic development. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in cortical actin cytoskeleton and plasma membrane. Orthologous to human LLGL2 (LLGL scribble cell polarity complex component 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; all-trans-retinoic acid; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: lethal giant larvae homolog 2; lethal giant larvae homolog 2 (Drosophila); lethal giant larvae homolog 2, scribble cell polarity complex component; lethal(2) giant larvae protein homolog 2; LLGL2, scribble cell polarity complex component; LOC360661; RGD1560307; similar to Lethal giant larvae homolog 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810101,549,911 - 101,585,466 (+)NCBIGRCr8
mRatBN7.210101,050,978 - 101,086,527 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,051,408 - 101,086,525 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10106,113,225 - 106,148,349 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010105,576,308 - 105,611,431 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010100,972,367 - 101,007,490 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010104,367,826 - 104,403,726 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,368,247 - 104,403,724 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010103,882,297 - 103,918,187 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410105,925,312 - 105,960,550 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1099,626,409 - 99,661,484 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12725730   PMID:15632202   PMID:21606200   PMID:30996345  


Genomics

Comparative Map Data
Llgl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810101,549,911 - 101,585,466 (+)NCBIGRCr8
mRatBN7.210101,050,978 - 101,086,527 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,051,408 - 101,086,525 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10106,113,225 - 106,148,349 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010105,576,308 - 105,611,431 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010100,972,367 - 101,007,490 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010104,367,826 - 104,403,726 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,368,247 - 104,403,724 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010103,882,297 - 103,918,187 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410105,925,312 - 105,960,550 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1099,626,409 - 99,661,484 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
LLGL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381775,525,002 - 75,575,209 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1775,525,080 - 75,575,209 (+)EnsemblGRCh38hg38GRCh38
GRCh371773,521,778 - 73,571,290 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361771,033,378 - 71,082,885 (+)NCBINCBI36Build 36hg18NCBI36
Build 341771,033,401 - 71,082,884NCBI
Celera1770,142,313 - 70,161,385 (+)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1768,945,338 - 68,995,200 (+)NCBIHuRef
CHM1_11773,586,820 - 73,635,995 (+)NCBICHM1_1
T2T-CHM13v2.01776,418,368 - 76,468,378 (+)NCBIT2T-CHM13v2.0
Llgl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911115,714,855 - 115,746,606 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11115,714,875 - 115,746,606 (+)EnsemblGRCm39 Ensembl
GRCm3811115,824,029 - 115,855,780 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11115,824,049 - 115,855,780 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711115,685,372 - 115,717,094 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611115,640,198 - 115,671,870 (+)NCBIMGSCv36mm8
MGSCv3611116,717,343 - 116,749,245 (+)NCBIMGSCv36mm8
Celera11127,584,531 - 127,618,413 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1180.91NCBI
Llgl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555532,378,101 - 2,415,152 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555532,377,640 - 2,415,152 (+)NCBIChiLan1.0ChiLan1.0
LLGL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21991,568,851 - 91,618,027 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11796,391,188 - 96,442,908 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01769,474,804 - 69,524,797 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11775,025,223 - 75,075,240 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1775,025,235 - 75,075,240 (+)Ensemblpanpan1.1panPan2
LLGL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.194,975,309 - 5,008,383 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl94,975,660 - 4,996,775 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha95,654,768 - 5,687,829 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.095,645,523 - 5,678,606 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl95,645,526 - 5,668,389 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.195,684,655 - 5,717,735 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.095,794,832 - 5,827,905 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.095,855,938 - 5,888,985 (-)NCBIUU_Cfam_GSD_1.0
Llgl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056025,619,466 - 5,629,867 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936594765,310 - 792,155 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936594754,140 - 792,493 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LLGL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl125,809,069 - 5,846,162 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1125,809,066 - 5,846,165 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LLGL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11646,103,080 - 46,151,576 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1646,102,939 - 46,135,594 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607716,865,930 - 16,917,202 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Llgl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248015,329,916 - 5,370,345 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248015,329,988 - 5,376,368 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Llgl2
121 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:263
Count of miRNA genes:163
Interacting mature miRNAs:179
Transcripts:ENSRNOT00000006519
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
631539Oia6Oil induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1097010147104670812Rat

Markers in Region
RH130982  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210101,049,740 - 101,049,920 (+)MAPPERmRatBN7.2
Rnor_6.010104,366,580 - 104,366,759NCBIRnor6.0
Rnor_5.010103,919,264 - 103,919,443UniSTSRnor5.0
RGSC_v3.410105,923,645 - 105,923,824UniSTSRGSC3.4
Celera1099,624,742 - 99,624,921UniSTS
Cytogenetic Map10q32.3UniSTS
RH141143  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210101,086,237 - 101,086,426 (+)MAPPERmRatBN7.2
Rnor_6.010104,403,437 - 104,403,625NCBIRnor6.0
Rnor_5.010103,882,398 - 103,882,586UniSTSRnor5.0
RGSC_v3.410105,960,261 - 105,960,449UniSTSRGSC3.4
Celera1099,661,195 - 99,661,383UniSTS
Cytogenetic Map10q32.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 12 39 39 39 35 13 11
Low 31 18 2 19 2 8 11 46 28 8
Below cutoff 28

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006519   ⟹   ENSRNOP00000006519
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10101,051,408 - 101,086,525 (+)Ensembl
Rnor_6.0 Ensembl10104,368,247 - 104,403,724 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080714   ⟹   ENSRNOP00000068912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10101,051,408 - 101,086,525 (+)Ensembl
Rnor_6.0 Ensembl10104,377,748 - 104,403,715 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107003   ⟹   ENSRNOP00000090333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10101,051,408 - 101,086,082 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111761   ⟹   ENSRNOP00000077420
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10101,061,519 - 101,086,082 (+)Ensembl
RefSeq Acc Id: NM_001127549   ⟹   NP_001121021
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,550,343 - 101,585,466 (+)NCBI
mRatBN7.210101,051,408 - 101,086,527 (+)NCBI
Rnor_6.010104,368,247 - 104,403,726 (+)NCBI
Rnor_5.010103,882,297 - 103,918,187 (-)NCBI
RGSC_v3.410105,925,312 - 105,960,550 (+)RGD
Celera1099,626,409 - 99,661,484 (+)RGD
Sequence:
RefSeq Acc Id: XM_006247724   ⟹   XP_006247786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,560,449 - 101,585,466 (+)NCBI
mRatBN7.210101,061,526 - 101,086,527 (+)NCBI
Rnor_6.010104,377,752 - 104,403,726 (+)NCBI
Rnor_5.010103,882,297 - 103,918,187 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247725   ⟹   XP_006247787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,560,412 - 101,585,466 (+)NCBI
mRatBN7.210101,061,528 - 101,086,527 (+)NCBI
Rnor_6.010104,377,753 - 104,403,726 (+)NCBI
Rnor_5.010103,882,297 - 103,918,187 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247728   ⟹   XP_006247790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,549,911 - 101,585,466 (+)NCBI
mRatBN7.210101,050,978 - 101,086,527 (+)NCBI
Rnor_6.010104,367,826 - 104,403,726 (+)NCBI
Rnor_5.010103,882,297 - 103,918,187 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247729   ⟹   XP_006247791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,550,234 - 101,585,466 (+)NCBI
mRatBN7.210101,051,340 - 101,086,527 (+)NCBI
Rnor_6.010104,368,025 - 104,403,726 (+)NCBI
Rnor_5.010103,882,297 - 103,918,187 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086428   ⟹   XP_038942356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,560,448 - 101,585,466 (+)NCBI
mRatBN7.210101,061,526 - 101,086,527 (+)NCBI
RefSeq Acc Id: XM_039086429   ⟹   XP_038942357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,560,448 - 101,585,466 (+)NCBI
mRatBN7.210101,061,526 - 101,086,527 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001121021   ⟸   NM_001127549
- UniProtKB: B2GV09 (UniProtKB/TrEMBL),   A0A0G2JU05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247790   ⟸   XM_006247728
- Peptide Label: isoform X5
- UniProtKB: F7F3E6 (UniProtKB/TrEMBL),   A0A0G2JU05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247791   ⟸   XM_006247729
- Peptide Label: isoform X5
- UniProtKB: F7F3E6 (UniProtKB/TrEMBL),   A0A0G2JU05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247787   ⟸   XM_006247725
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006247786   ⟸   XM_006247724
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000068912   ⟸   ENSRNOT00000080714
RefSeq Acc Id: ENSRNOP00000006519   ⟸   ENSRNOT00000006519
RefSeq Acc Id: XP_038942356   ⟸   XM_039086428
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038942357   ⟸   XM_039086429
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000090333   ⟸   ENSRNOT00000107003
RefSeq Acc Id: ENSRNOP00000077420   ⟸   ENSRNOT00000111761
Protein Domains
Lethal giant larvae homologue

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JU05-F1-model_v2 AlphaFold A0A0G2JU05 1-1077 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560307 AgrOrtholog
BioCyc Gene G2FUF-22647 BioCyc
Ensembl Genes ENSRNOG00000004834 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006519.5 UniProtKB/TrEMBL
  ENSRNOT00000080714.2 UniProtKB/TrEMBL
  ENSRNOT00000107003 ENTREZGENE
  ENSRNOT00000107003.1 UniProtKB/TrEMBL
  ENSRNOT00000111761.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7097977 IMAGE-MGC_LOAD
InterPro Lethal2_giant UniProtKB/TrEMBL
  LLGL2 UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report rno:360661 UniProtKB/TrEMBL
MGC_CLONE MGC:187956 IMAGE-MGC_LOAD
NCBI Gene 360661 ENTREZGENE
PANTHER LETHAL 2 GIANT LARVAE PROTEIN UniProtKB/TrEMBL
  LLGL SCRIBBLE CELL POLARITY COMPLEX COMPONENT 2 UniProtKB/TrEMBL
Pfam LLGL UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PhenoGen Llgl2 PhenoGen
PRINTS LETHAL2GIANT UniProtKB/TrEMBL
PROSITE WD_REPEATS_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004834 RatGTEx
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP Tricorn protease domain 2 UniProtKB/TrEMBL
  WD40_like UniProtKB/TrEMBL
UniProt A0A0G2JU05 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y153_RAT UniProtKB/TrEMBL
  A0A8I6ACA1_RAT UniProtKB/TrEMBL
  B2GV09 ENTREZGENE, UniProtKB/TrEMBL
  F7F3E6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-12-04 Llgl2  LLGL scribble cell polarity complex component 2  Llgl2  LLGL2, scribble cell polarity complex component  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-04-13 Llgl2  LLGL2, scribble cell polarity complex component  Llgl2  lethal giant larvae homolog 2, scribble cell polarity complex component  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-01 Llgl2  lethal giant larvae homolog 2, scribble cell polarity complex component  Llgl2  lethal giant larvae homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-28 Llgl2  lethal giant larvae homolog 2 (Drosophila)  RGD1560307_predicted  similar to Lethal giant larvae homolog 2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560307_predicted  similar to Lethal giant larvae homolog 2 (predicted)  LOC360661  similar to Lethal giant larvae homolog 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC360661  similar to Lethal giant larvae homolog 2      Symbol and Name status set to provisional 70820 PROVISIONAL