Med14 (mediator complex subunit 14) - Rat Genome Database

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Gene: Med14 (mediator complex subunit 14) Rattus norvegicus
Analyze
Symbol: Med14
Name: mediator complex subunit 14
RGD ID: 1560170
Description: Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription initiation by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II and somatic stem cell population maintenance. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Orthologous to human MED14 (mediator complex subunit 14); PARTICIPATES IN cortisol signaling pathway; RNA polymerase II transcription pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC317343; mediator of RNA polymerase II transcription subunit 14; RGD1560170; similar to cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X12,709,406 - 12,800,642 (+)NCBIGRCr8
mRatBN7.2X10,036,749 - 10,127,910 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX10,036,805 - 10,126,240 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX10,218,536 - 10,307,723 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X13,715,703 - 13,804,884 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X9,984,906 - 10,074,005 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X10,964,035 - 11,082,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX10,963,809 - 11,082,565 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X11,762,671 - 11,880,963 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X22,116,986 - 22,205,877 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX10,562,309 - 10,650,954 (+)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Novel glucocorticoid receptor coactivator effector mechanisms. Jenkins BD, etal., Trends Endocrinol Metab. 2001 Apr;12(3):122-6.
3. The Mediator complex and transcription regulation. Poss ZC, etal., Crit Rev Biochem Mol Biol. 2013 Nov-Dec;48(6):575-608. doi: 10.3109/10409238.2013.840259. Epub 2013 Oct 3.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:10198638   PMID:10235267   PMID:11867769   PMID:12037571   PMID:12218053   PMID:15340084   PMID:15632090   PMID:19946888   PMID:20508642   PMID:20720539  


Genomics

Comparative Map Data
Med14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X12,709,406 - 12,800,642 (+)NCBIGRCr8
mRatBN7.2X10,036,749 - 10,127,910 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX10,036,805 - 10,126,240 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX10,218,536 - 10,307,723 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X13,715,703 - 13,804,884 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X9,984,906 - 10,074,005 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X10,964,035 - 11,082,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX10,963,809 - 11,082,565 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X11,762,671 - 11,880,963 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X22,116,986 - 22,205,877 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX10,562,309 - 10,650,954 (+)NCBICelera
Cytogenetic MapXq12NCBI
MED14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X40,648,305 - 40,736,159 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX40,648,305 - 40,735,858 (-)EnsemblGRCh38hg38GRCh38
GRCh37X40,507,557 - 40,594,794 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X40,393,739 - 40,479,748 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X40,263,811 - 40,351,037NCBI
CeleraX44,649,421 - 44,734,350 (-)NCBICelera
Cytogenetic MapXp11.4NCBI
HuRefX38,238,905 - 38,324,580 (-)NCBIHuRef
CHM1_1X40,540,939 - 40,626,911 (-)NCBICHM1_1
T2T-CHM13v2.0X40,049,523 - 40,137,378 (-)NCBIT2T-CHM13v2.0
Med14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X12,541,607 - 12,628,813 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX12,541,608 - 12,628,312 (-)EnsemblGRCm39 Ensembl
GRCm38X12,675,368 - 12,762,594 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX12,675,369 - 12,762,073 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X12,252,497 - 12,339,099 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X11,836,708 - 11,919,032 (-)NCBIMGSCv36mm8
CeleraX10,369,353 - 10,456,055 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX7.52NCBI
Med14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555651,888,443 - 1,959,141 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555651,888,442 - 1,959,141 (+)NCBIChiLan1.0ChiLan1.0
MED14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X42,295,715 - 42,382,302 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X42,299,121 - 42,385,610 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X33,097,206 - 33,183,322 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X40,800,526 - 40,886,291 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX40,798,363 - 40,886,270 (-)Ensemblpanpan1.1panPan2
MED14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X35,125,270 - 35,191,260 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX35,125,774 - 35,191,122 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX22,474,041 - 22,539,564 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X35,174,164 - 35,239,687 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX35,173,665 - 35,239,865 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X35,253,230 - 35,318,741 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X35,225,934 - 35,291,428 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X35,268,730 - 35,334,253 (-)NCBIUU_Cfam_GSD_1.0
Med14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X27,440,116 - 27,510,048 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365027,280,534 - 7,350,435 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365027,280,606 - 7,350,750 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MED14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX36,354,061 - 36,424,715 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X36,354,057 - 36,424,837 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X40,452,288 - 40,523,049 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MED14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X37,810,996 - 37,898,114 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX37,810,710 - 37,897,929 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660763,008,786 - 3,096,622 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Med14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476214,832,816 - 14,904,882 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476214,832,485 - 14,903,119 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Med14
303 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:81
Interacting mature miRNAs:82
Transcripts:ENSRNOT00000066480
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
70166Bp65Blood pressure QTL 655.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144797211374346Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat

Markers in Region
DXS7582  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X10,123,351 - 10,123,465 (+)MAPPERmRatBN7.2
Rnor_6.0X11,078,007 - 11,078,120NCBIRnor6.0
Rnor_5.0X11,876,564 - 11,876,677UniSTSRnor5.0
RGSC_v3.4X22,203,013 - 22,203,126UniSTSRGSC3.4
CeleraX10,648,066 - 10,648,179UniSTS
Cytogenetic MapXq13UniSTS
RH127471  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X10,127,565 - 10,127,768 (+)MAPPERmRatBN7.2
Rnor_6.0X11,082,221 - 11,082,423NCBIRnor6.0
Rnor_5.0X11,880,778 - 11,880,980UniSTSRnor5.0
RGSC_v3.4X22,207,227 - 22,207,429UniSTSRGSC3.4
CeleraX10,652,280 - 10,652,482UniSTS
RH 3.4 MapX30.4UniSTS
Cytogenetic MapXq13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 21 36 20 19 20 2 2 74 29 34 11 2
Low 22 21 21 21 6 9 6 7 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000066480   ⟹   ENSRNOP00000063505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX10,036,984 - 10,126,240 (+)Ensembl
Rnor_6.0 EnsemblX10,964,187 - 11,080,871 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093176   ⟹   ENSRNOP00000076161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX10,036,805 - 10,123,533 (+)Ensembl
Rnor_6.0 EnsemblX10,963,809 - 11,078,188 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093181   ⟹   ENSRNOP00000076132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX10,036,984 - 10,126,240 (+)Ensembl
Rnor_6.0 EnsemblX10,964,067 - 11,082,565 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX10,036,984 - 10,089,581 (+)Ensembl
Rnor_6.0 EnsemblX10,964,056 - 11,044,319 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093450
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX10,964,215 - 11,023,876 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093665   ⟹   ENSRNOP00000076292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX11,050,121 - 11,077,448 (+)Ensembl
RefSeq Acc Id: NM_001191727   ⟹   NP_001178656
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X12,709,721 - 12,798,972 (+)NCBI
mRatBN7.2X10,036,984 - 10,126,240 (+)NCBI
Rnor_6.0X10,964,035 - 11,080,895 (+)NCBI
Rnor_5.0X11,762,671 - 11,880,963 (+)NCBI
CeleraX10,562,309 - 10,650,954 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099757   ⟹   XP_038955685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X12,709,406 - 12,800,642 (+)NCBI
mRatBN7.2X10,036,749 - 10,127,910 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001178656   ⟸   NM_001191727
- UniProtKB: D4A020 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000076292   ⟸   ENSRNOT00000093665
RefSeq Acc Id: ENSRNOP00000063505   ⟸   ENSRNOT00000066480
RefSeq Acc Id: ENSRNOP00000076132   ⟸   ENSRNOT00000093181
RefSeq Acc Id: ENSRNOP00000076161   ⟸   ENSRNOT00000093176
RefSeq Acc Id: XP_038955685   ⟸   XM_039099757
- Peptide Label: isoform X1
- UniProtKB: A0A1W2Q643 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A020-F1-model_v2 AlphaFold D4A020 1-1459 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701719
Promoter ID:EPDNEW_R12234
Type:multiple initiation site
Name:Med14_2
Description:mediator complex subunit 14
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12235  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X10,963,854 - 10,963,914EPDNEW
RGD ID:13701712
Promoter ID:EPDNEW_R12235
Type:initiation region
Name:Med14_1
Description:mediator complex subunit 14
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12234  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X10,964,089 - 10,964,149EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560170 AgrOrtholog
BioCyc Gene G2FUF-3066 BioCyc
Ensembl Genes ENSRNOG00000003792 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066480 ENTREZGENE
  ENSRNOT00000066480.3 UniProtKB/TrEMBL
  ENSRNOT00000093176.2 UniProtKB/TrEMBL
  ENSRNOT00000093181.2 UniProtKB/TrEMBL
  ENSRNOT00000093346.2 UniProtKB/TrEMBL
InterPro Mediator_Med14 UniProtKB/TrEMBL
KEGG Report rno:317343 UniProtKB/TrEMBL
NCBI Gene 317343 ENTREZGENE
PANTHER MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14 UniProtKB/TrEMBL
  PTHR12809 UniProtKB/TrEMBL
Pfam MED14 UniProtKB/TrEMBL
PhenoGen Med14 PhenoGen
RatGTEx ENSRNOG00000003792 RatGTEx
UniProt A0A1W2Q643 ENTREZGENE, UniProtKB/TrEMBL
  A0A1W2Q682_RAT UniProtKB/TrEMBL
  A0A8I5ZQ17_RAT UniProtKB/TrEMBL
  D4A020 ENTREZGENE, UniProtKB/TrEMBL
  W8C3Y3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-28 Med14  mediator complex subunit 14  RGD1560170_predicted  similar to cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560170_predicted  similar to cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa (predicted)  LOC317343  similar to cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC317343  similar to cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa      Symbol and Name status set to provisional 70820 PROVISIONAL