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Gene: Mknk1 (MAP kinase-interacting serine/threonine kinase 1) Rattus norvegicus
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Symbol: Mknk1
Name: MAP kinase-interacting serine/threonine kinase 1
Description: Exhibits protein serine/threonine kinase activity. Involved in peptidyl-serine phosphorylation and regulation of translational initiation. Predicted to localize to the cytoplasm and nucleoplasm. Orthologous to human MKNK1 (MAPK interacting serine/threonine kinase 1); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; cyclooxygenase mediated pathway of arachidonic acid metabolism; p38 MAPK signaling pathway; INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MAP kinase signal-integrating kinase 1; MAP kinase-interacting serine/threonine-protein kinase 1; MAPK signal-integrating kinase 1; MGC112775; mnk1; similar to map kinase interacting kinase
Orthologs:
Homo sapiens (human) : MKNK1 (MAPK interacting serine/threonine kinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Mknk1 (MAP kinase-interacting serine/threonine kinase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mknk1 (MAPK interacting serine/threonine kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MKNK1 (MAPK interacting serine/threonine kinase 1)
Canis lupus familiaris (dog) : MKNK1 (MAPK interacting serine/threonine kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mknk1 (MAPK interacting serine/threonine kinase 1)
Sus scrofa (pig) : MKNK1 (MAPK interacting serine/threonine kinase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05134,691,852 - 134,730,887 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05138,476,301 - 138,514,361 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45136,100,236 - 136,141,344 (+)NCBIRGSC3.4rn4RGSC3.4
Celera5127,849,685 - 127,888,824 (+)NCBICelera
Cytogenetic Map5q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Mknk1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1559603
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.