Exhibits protein serine/threonine kinase activity. Involved in peptidyl-serine phosphorylation and regulation of translational initiation. Predicted to localize to cytoplasm and nucleoplasm. Orthologous to human MKNK1 (MAPK interacting serine/threonine kinase 1); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; cyclooxygenase mediated pathway of arachidonic acid metabolism; p38 MAPK signaling pathway; INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; acrylamide.
[Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MKNK1 protein] which results in increased phosphorylation of EIF4E protein more ...
[Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MKNK1 protein] which results in increased phosphorylation of EIF4E protein more ...
[SB 203580 co-treated with U 0126] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MKNK1 protein], IRAK2 protein promotes the reaction [Lipopolysaccharides results in increased activity of MKNK1 protein]
2-2-amino-3-methoxyphenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MKNK1 protein] more ...
2-2-amino-3-methoxyphenyl-4H-1-benzopyran-4-one promotes the reaction [SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MKNK1 protein]] more ...
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin