 Gene-Chemical Interaction Annotations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations |
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Analyze GeneStrainQTL List
 Functional Annotation unavailable |
 Annotation Distribution unavailable |
 Genomic Variants unavailble for Mouse Genomic Variants unavailable |
Functional Annotation |
Annotation Distribution |
Genomic Variants |
 Protein-Protein Interactions unavailable |
 Genome Viewer unavailable |
 Damaging Variants unavailble for Mouse Damaging Variants unavailable |
Protein-Protein Interactions |
Genome Viewer |
Damaging Variants |
 Annotation Comparison unavailable |
 OLGA unavailable |
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Annotation Comparison |
OLGA |
Excel (Download) |
 Gene Enrichment unavailable |
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Gene Enrichment |
Gene Ontology AnnotationsMolecular Pathway AnnotationsDisease AnnotationsGene-Chemical Interaction Annotations
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Gene Ontology AnnotationsBiological Process
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Cellular Component
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Molecular Function
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Molecular Pathway AnnotationsReferences - curated| 1. | Chen S, etal., J Cereb Blood Flow Metab. 2007 May;27(5):939-49. Epub 2006 Aug 30. |
| 2. | Gaestel M Nat Rev Mol Cell Biol. 2006 Feb;7(2):120-30. |
| 3. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 4. | Niknami M, etal., Int J Biochem Cell Biol. 2009 May;41(5):994-7. doi: 10.1016/j.biocel.2008.07.017. Epub 2008 Aug 8. |
| 5. | Origanti S and Shantz LM, Cancer Res. 2007 May 15;67(10):4834-42. |
| 6. | Pipeline to import KEGG annotations from KEGG into RGD |
| 7. | RGD automated data pipeline |
| 8. | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 9. | RGD automated import pipeline for gene-chemical interactions |
| 10. | Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
References - uncuratedRGD Disease Portals| Mknk1 has been annotated in the following RGD Disease Portals. |
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Genomics
Comparative Map Data| Mknk1 (Rattus norvegicus - Norway rat) |
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| MKNK1 (Homo sapiens - human) |
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| Mknk1 (Mus musculus - house mouse) |
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| Mknk1 (Chinchilla lanigera - long-tailed chinchilla) |
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| MKNK1 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| MKNK1 (Canis lupus familiaris - dog) |
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| Mknk1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| MKNK1 (Sus scrofa - pig) |
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Position Markers| D5Mco7 |
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| BI301014 |
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QTLs in Region (Rnor_6.0)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
miRNA Target Status
Predicted Target Of
| The detailed report is available here: | | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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Sequence
Nucleotide Sequences| RefSeq Transcripts | NM_001044267 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| XM_006238694 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006238695 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006238696 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006238697 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006238698 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006238699 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017593578 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017593579 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR07049736 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| AABR07073138 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01039293 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01039294 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01039295 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01039296 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| BC098754 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CH474008 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Reference Sequences
| RefSeq Acc Id: | NM_001044267 ⟹ NP_001037732 | ||||||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||||||
| Position: |
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| Sequence: |
TGCAGGTGGGGGTGCGCGCGGCCGTTCCCGCGGTGGTCAACTAAGAGATGGGCAGCAGTGAGCChide sequence |
| RefSeq Acc Id: | XM_006238694 ⟹ XP_006238756 | ||||||||||||||
| RefSeq Status: | |||||||||||||||
| Type: | CODING | ||||||||||||||
| Position: |
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| Sequence: |
TGTCTTTGTGTGGGAAGCCATAAAATATAATATTGAGTATGTGGCTCTGCCCAGGGTTATGCTGhide sequence |
| RefSeq Acc Id: | XM_006238695 ⟹ XP_006238757 | ||||||||||||||
| RefSeq Status: | |||||||||||||||
| Type: | CODING | ||||||||||||||
| Position: |
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| Sequence: |
TGTCTTTGTGTGGGAAGCCATAAAATATAATATTGAGTATGTGGCTCTGCCCAGGGTTATGCTGhide sequence |
| RefSeq Acc Id: | XM_006238696 ⟹ XP_006238758 | ||||||||||||||
| RefSeq Status: | |||||||||||||||
| Type: | CODING | ||||||||||||||
| Position: |
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| Sequence: |
GCCAGGGCCCTCCCCCTGAGTTTAGCTCCACCTCTTCCGCGTTCTCGACTGAGACCTGCAGGTGhide sequence |
| RefSeq Acc Id: | XM_006238697 ⟹ XP_006238759 | ||||||||||||||
| RefSeq Status: | |||||||||||||||
| Type: | CODING | ||||||||||||||
| Position: |
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| Sequence: |
CTTCTGCCAGGGCCCTCCCCCTGAGTTTAGCTCCACCTCTTCCGCGTTCTCGACTGAGACCTGChide sequence |
| RefSeq Acc Id: | XM_006238698 ⟹ XP_006238760 | ||||||||||||||
| RefSeq Status: | |||||||||||||||
| Type: | CODING | ||||||||||||||
| Position: |
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| Sequence: |
GCCAGGGCCCTCCCCCTGAGTTTAGCTCCACCTCTTCCGCGTTCTCGACTGAGACCTGCAGGTGhide sequence |
| RefSeq Acc Id: | XM_006238699 ⟹ XP_006238761 | ||||||||||||||
| RefSeq Status: | |||||||||||||||
| Type: | CODING | ||||||||||||||
| Position: |
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| Sequence: |
TGTCTTTGTGTGGGAAGCCATAAAATATAATATTGAGTATGTGGCTCTGCCCAGGGTTATGCTGhide sequence |
| RefSeq Acc Id: | XM_017593578 ⟹ XP_017449067 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
TGTCTTTGTGTGGGAAGCCATAAAATATAATATTGAGTATGTGGCTCTGCCCAGGGTTATGCTGhide sequence |
| RefSeq Acc Id: | XM_017593579 ⟹ XP_017449068 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
TGTCTTTGTGTGGGAAGCCATAAAATATAATATTGAGTATGTGGCTCTGCCCAGGGTTATGCTGhide sequence |
Protein Sequences| Protein RefSeqs | NP_001037732 | (Get FASTA) | NCBI Sequence Viewer |
| XP_006238756 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006238757 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006238758 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006238759 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006238760 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006238761 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017449067 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017449068 | (Get FASTA) | NCBI Sequence Viewer | |
| GenBank Protein | AAH98754 | (Get FASTA) | NCBI Sequence Viewer |
| EDL90300 | (Get FASTA) | NCBI Sequence Viewer | |
| EDL90301 | (Get FASTA) | NCBI Sequence Viewer | |
| EDL90302 | (Get FASTA) | NCBI Sequence Viewer | |
| Q4G050 | (Get FASTA) | NCBI Sequence Viewer |
Reference Sequences
| RefSeq Acc Id: | NP_001037732 ⟸ NM_001044267 |
| - UniProtKB: | Q4G050 (UniProtKB/Swiss-Prot) |
| - Sequence: |
MGSSEPLPIVDSDKRRKKKRKTRATDSLPGKFEDVYQLTSELLGEGAYAKVQGAVSLQSGKEYAhide sequence |
| RefSeq Acc Id: | XP_006238759 ⟸ XM_006238697 |
| - Peptide Label: | isoform X3 |
| - UniProtKB: | A0A0G2K3K7 (UniProtKB/TrEMBL) |
| - Sequence: |
MQNRPEMGSSEPLPIVDSDKRRKKKRKTRATDSLPGKFEDVYQLTSELLGEGAYAKVQGAVSLQhide sequence |
| RefSeq Acc Id: | XP_006238758 ⟸ XM_006238696 |
| - Peptide Label: | isoform X3 |
| - UniProtKB: | A0A0G2K3K7 (UniProtKB/TrEMBL) |
| - Sequence: |
MQNRPEMGSSEPLPIVDSDKRRKKKRKTRATDSLPGKFEDVYQLTSELLGEGAYAKVQGAVSLQhide sequence |
| RefSeq Acc Id: | XP_006238760 ⟸ XM_006238698 |
| - Peptide Label: | isoform X4 |
| - UniProtKB: | Q4G050 (UniProtKB/Swiss-Prot) |
| - Sequence: |
MGSSEPLPIVDSDKRRKKKRKTRATDSLPGKFEDVYQLTSELLGEGAYAKVQGAVSLQSGKEYAhide sequence |
| RefSeq Acc Id: | XP_006238757 ⟸ XM_006238695 |
| - Peptide Label: | isoform X2 |
| - Sequence: |
MEILLSFLISRFYSCSLLTQFAAPGTVFLMITEMGSSEPLPIVDSDKRRKKKRKTRATDSLPGKhide sequence |
| RefSeq Acc Id: | XP_006238756 ⟸ XM_006238694 |
| - Peptide Label: | isoform X1 |
| - Sequence: |
MEILLSFLISRFYSCSLLTQFAAPGTVFLMITEMGSSEPLPIVDSDKRRKKKRKTRATDSLPGKhide sequence |
| RefSeq Acc Id: | XP_006238761 ⟸ XM_006238699 |
| - Peptide Label: | isoform X4 |
| - UniProtKB: | Q4G050 (UniProtKB/Swiss-Prot) |
| - Sequence: |
MGSSEPLPIVDSDKRRKKKRKTRATDSLPGKFEDVYQLTSELLGEGAYAKVQGAVSLQSGKEYAhide sequence |
| RefSeq Acc Id: | XP_017449067 ⟸ XM_017593578 |
| - Peptide Label: | isoform X5 |
| - Sequence: |
MEILLSFLISRFYSCSLLTQFAAPGTVFLMITEMGSSEPLPIVDSDKRRKKKRKTRATDSLPGKhide sequence |
| RefSeq Acc Id: | XP_017449068 ⟸ XM_017593579 |
| - Peptide Label: | isoform X6 |
| - Sequence: |
MEILLSFLISRFYSCSLLTQFAAPGTVFLMITEMGSSEPLPIVDSDKRRKKKRKTRATDSLPGKhide sequence |
TranscriptomePromoters| RGD ID: | 13693932 | |||||||||
| Promoter ID: | EPDNEW_R4449 | |||||||||
| Type: | multiple initiation site | |||||||||
| Name: | Mknk1_1 | |||||||||
| Description: | MAP kinase-interacting serine/threonine kinase 1 | |||||||||
| SO ACC ID: | SO:0000170 | |||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | |||||||||
| Experiment Methods: | Single-end sequencing. | |||||||||
| Position: |
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Strain Variation
Strain Sequence Variants (Rnor 5.0)
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Damaging VariantsAssembly: Rnor_5.0
| Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
| 5 | 138513278 | 138513279 | C | G | snv | COP/CrCrl (MCW & UW) |
Assembly: Rnor_6.0
| Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
| 5 | 134729804 | 134729805 | C | G | snv | COP/CrCrl (MCW & UW) |
Additional Information
External Database Links| Database | Acc Id | Source(s) |
| AGR Gene | RGD:1559603 | AgrOrtholog |
| Ensembl Genes | ENSRNOG00000010381 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000061535 | ENTREZGENE, UniProtKB/Swiss-Prot |
| ENSRNOP00000072679 | ENTREZGENE, UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000067655 | ENTREZGENE, UniProtKB/Swiss-Prot |
| ENSRNOT00000091543 | ENTREZGENE, UniProtKB/TrEMBL | |
| IMAGE_CLONE | IMAGE:7370127 | IMAGE-MGC_LOAD |
| InterPro | Kinase-like_dom_sf | UniProtKB/Swiss-Prot |
| Prot_kinase_dom | UniProtKB/Swiss-Prot | |
| Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot | |
| Ser/Thr_kinase_AS | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:500526 | UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:112775 | IMAGE-MGC_LOAD |
| NCBI Gene | 500526 | ENTREZGENE |
| Pfam | Pkinase | UniProtKB/Swiss-Prot |
| PhenoGen | Mknk1 | PhenoGen |
| PROSITE | PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot |
| PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_ST | UniProtKB/Swiss-Prot | |
| SMART | S_TKc | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | SSF56112 | UniProtKB/Swiss-Prot |
| UniGene | Rn.230218 | ENTREZGENE |
| UniProt | A0A0G2K3K7 | ENTREZGENE, UniProtKB/TrEMBL |
| MKNK1_RAT | UniProtKB/Swiss-Prot, ENTREZGENE |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-03-06 | Mknk1 | MAP kinase-interacting serine/threonine kinase 1 | MGC112775 | similar to map kinase interacting kinase | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2006-02-09 | MGC112775 | similar to map kinase interacting kinase | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
| More on Mknk1 | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: rn5 rn6 |
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NCBI Genome Data Viewer |
| RGD Object Information | |
| RGD ID: | 1559603 |
| Created: | 2006-02-09 |
| Species: | Rattus norvegicus |
| Last Modified: | 2019-04-23 |
| Status: | ACTIVE |
