Lman2l (lectin, mannose-binding 2-like) - Rat Genome Database

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Gene: Lman2l (lectin, mannose-binding 2-like) Rattus norvegicus
Analyze
Symbol: Lman2l
Name: lectin, mannose-binding 2-like
RGD ID: 1311393
Description: Predicted to be involved in protein transport. Predicted to be located in Golgi apparatus and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder and autosomal recessive intellectual developmental disorder 52. Orthologous to human LMAN2L (lectin, mannose binding 2 like); INTERACTS WITH bisphenol A; leflunomide; thioacetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: lectin, mannose binding 2 like; LOC120094667; LOC301343; VIP36-like protein
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8946,157,596 - 46,181,151 (-)NCBIGRCr8
mRatBN7.2938,661,709 - 38,685,244 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl938,661,712 - 38,685,337 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx947,165,415 - 47,188,981 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0952,280,511 - 52,304,041 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0950,562,410 - 50,585,939 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0943,020,940 - 43,023,015 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl942,999,229 - 43,022,999 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0942,674,819 - 42,676,894 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4935,381,997 - 35,384,072 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1935,366,221 - 35,385,543 (-)NCBI
Celera936,449,735 - 36,451,810 (-)NCBICelera
Cytogenetic Map9q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12609988   PMID:12878160  


Genomics

Comparative Map Data
Lman2l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8946,157,596 - 46,181,151 (-)NCBIGRCr8
mRatBN7.2938,661,709 - 38,685,244 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl938,661,712 - 38,685,337 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx947,165,415 - 47,188,981 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0952,280,511 - 52,304,041 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0950,562,410 - 50,585,939 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0943,020,940 - 43,023,015 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl942,999,229 - 43,022,999 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0942,674,819 - 42,676,894 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4935,381,997 - 35,384,072 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1935,366,221 - 35,385,543 (-)NCBI
Celera936,449,735 - 36,451,810 (-)NCBICelera
Cytogenetic Map9q21NCBI
LMAN2L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38296,705,929 - 96,740,064 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl296,705,929 - 96,740,064 (-)EnsemblGRCh38hg38GRCh38
GRCh37297,371,666 - 97,405,801 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36296,735,393 - 96,769,528 (-)NCBINCBI36Build 36hg18NCBI36
Build 34296,793,542 - 96,827,675NCBI
Celera291,812,913 - 91,845,986 (-)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef291,332,308 - 91,366,499 (-)NCBIHuRef
CHM1_1297,376,571 - 97,410,719 (-)NCBICHM1_1
T2T-CHM13v2.0297,212,567 - 97,246,702 (-)NCBIT2T-CHM13v2.0
Lman2l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39136,458,274 - 36,484,352 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl136,458,952 - 36,484,352 (-)EnsemblGRCm39 Ensembl
GRCm38136,418,900 - 36,445,271 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl136,419,871 - 36,445,271 (-)EnsemblGRCm38mm10GRCm38
MGSCv37136,480,031 - 36,502,084 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36136,367,732 - 36,389,785 (-)NCBIMGSCv36mm8
Celera136,209,990 - 36,232,040 (-)NCBICelera
Cytogenetic Map1BNCBI
cM Map115.26NCBI

Variants

.
Variants in Lman2l
77 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:87
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000063781
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat

Markers in Region
RH141137  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2938,676,212 - 38,676,432 (+)MAPPERmRatBN7.2
Rnor_6.0943,013,979 - 43,014,198NCBIRnor6.0
Rnor_5.0942,667,858 - 42,668,077UniSTSRnor5.0
RGSC_v3.4935,375,036 - 35,375,255UniSTSRGSC3.4
RH 3.4 Map10529.09UniSTS
Cytogenetic Map9q21UniSTS
RH140151  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2938,662,037 - 38,662,229 (+)MAPPERmRatBN7.2
Rnor_6.0942,999,550 - 42,999,741NCBIRnor6.0
Rnor_5.0942,653,429 - 42,653,620UniSTSRnor5.0
RGSC_v3.4935,360,214 - 35,360,405UniSTSRGSC3.4
Celera936,429,214 - 36,429,405UniSTS
Cytogenetic Map9q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 41 27 13 27 2 68 32 36 11
Low 8 16 14 6 14 8 9 6 3 5 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000063781   ⟹   ENSRNOP00000060837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl938,661,722 - 38,685,337 (-)Ensembl
Rnor_6.0 Ensembl943,000,167 - 43,022,998 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089843   ⟹   ENSRNOP00000072506
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl938,661,717 - 38,685,233 (-)Ensembl
Rnor_6.0 Ensembl942,999,229 - 43,022,999 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117761   ⟹   ENSRNOP00000081479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl938,661,722 - 38,685,337 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119365   ⟹   ENSRNOP00000086744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl938,661,712 - 38,685,192 (-)Ensembl
RefSeq Acc Id: NM_001402076   ⟹   NP_001389005
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8946,157,596 - 46,181,125 (-)NCBI
mRatBN7.2938,661,715 - 38,685,244 (-)NCBI
RefSeq Acc Id: XM_039084531   ⟹   XP_038940459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8946,157,596 - 46,179,540 (-)NCBI
mRatBN7.2938,661,709 - 38,683,659 (-)NCBI
RefSeq Acc Id: XM_039084532   ⟹   XP_038940460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8946,157,596 - 46,179,540 (-)NCBI
mRatBN7.2938,661,709 - 38,683,659 (-)NCBI
RefSeq Acc Id: XM_063266892   ⟹   XP_063122962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8946,157,596 - 46,181,151 (-)NCBI
RefSeq Acc Id: XR_010054583
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8946,158,847 - 46,181,151 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000060837   ⟸   ENSRNOT00000063781
RefSeq Acc Id: ENSRNOP00000072506   ⟸   ENSRNOT00000089843
RefSeq Acc Id: ENSRNOP00000086744   ⟸   ENSRNOT00000119365
RefSeq Acc Id: ENSRNOP00000081479   ⟸   ENSRNOT00000117761
RefSeq Acc Id: XP_038940460   ⟸   XM_039084532
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A4A4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940459   ⟸   XM_039084531
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A4A4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001389005   ⟸   NM_001402076
- Peptide Label: precursor
- UniProtKB: A6IND3 (UniProtKB/TrEMBL),   F7F3Z1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122962   ⟸   XM_063266892
- Peptide Label: isoform X1
Protein Domains
L-type lectin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7F3Z1-F1-model_v2 AlphaFold F7F3Z1 1-349 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696615
Promoter ID:EPDNEW_R7126
Type:multiple initiation site
Name:Lman2l_1
Description:VIP36-like protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0943,023,012 - 43,023,072EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311393 AgrOrtholog
BioCyc Gene G2FUF-27811 BioCyc
Ensembl Genes ENSRNOG00000015699 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000063781 ENTREZGENE
  ENSRNOT00000063781.4 UniProtKB/TrEMBL
  ENSRNOT00000089843.2 UniProtKB/TrEMBL
  ENSRNOT00000117761.1 UniProtKB/TrEMBL
  ENSRNOT00000119365.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9025901 IMAGE-MGC_LOAD
InterPro ConA-like_dom_sf UniProtKB/TrEMBL
  Lectin_leg UniProtKB/TrEMBL
MGC_CLONE MGC:187745 IMAGE-MGC_LOAD
NCBI Gene 301343 ENTREZGENE
PANTHER VESICULAR MANNOSE-BINDING LECTIN UniProtKB/TrEMBL
  VIP36-LIKE PROTEIN UniProtKB/TrEMBL
Pfam Lectin_leg-like UniProtKB/TrEMBL
PhenoGen Lman2l PhenoGen
PROSITE L_LECTIN_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015699 RatGTEx
Superfamily-SCOP SSF49899 UniProtKB/TrEMBL
UniProt A0A8I6A4A4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G604_RAT UniProtKB/TrEMBL
  A6IND3 ENTREZGENE, UniProtKB/TrEMBL
  B1WBZ8_RAT UniProtKB/TrEMBL
  F7F3Z1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-03-04 Lman2l  lectin, mannose-binding 2-like  LOC120094667  lectin, mannose binding 2 like  Data merged from RGD:41155346 737654 PROVISIONAL
2021-01-27 LOC120094667  lectin, mannose binding 2 like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Lman2l  lectin, mannose-binding 2-like   Lman2l_predicted  lectin, mannose-binding 2-like (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Lman2l_predicted  lectin, mannose-binding 2-like (predicted)      Symbol and Name status set to approved 70820 APPROVED