Aasdhppt (aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase) - Rat Genome Database

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Gene: Aasdhppt (aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase) Rattus norvegicus
Analyze
Symbol: Aasdhppt
Name: aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
RGD ID: 1311360
Description: Predicted to enable holo-[acyl-carrier-protein] synthase activity and magnesium ion binding activity. Predicted to be involved in lysine biosynthetic process via aminoadipic acid and protein maturation. Predicted to act upstream of with a positive effect on 10-formyltetrahydrofolate catabolic process. Predicted to be active in cytosol. Orthologous to human AASDHPPT (aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase); PARTICIPATES IN pantothenic acid metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 4'-phosphopantetheinyl transferase; AASD-PPT; alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase; L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; LOC300328
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr889,731,592 - 9,748,934 (-)NCBIGRCr8
mRatBN7.281,453,226 - 1,463,990 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl81,452,282 - 1,463,966 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx85,440,710 - 5,451,469 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.083,738,445 - 3,749,204 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.081,684,588 - 1,695,353 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.081,432,757 - 1,450,175 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl81,439,340 - 1,450,138 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.081,427,206 - 1,444,610 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48847,236 - 858,000 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18847,227 - 858,772 (-)NCBI
Celera81,336,501 - 1,347,265 (-)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:18022563   PMID:19056867  


Genomics

Comparative Map Data
Aasdhppt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr889,731,592 - 9,748,934 (-)NCBIGRCr8
mRatBN7.281,453,226 - 1,463,990 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl81,452,282 - 1,463,966 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx85,440,710 - 5,451,469 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.083,738,445 - 3,749,204 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.081,684,588 - 1,695,353 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.081,432,757 - 1,450,175 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl81,439,340 - 1,450,138 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.081,427,206 - 1,444,610 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48847,236 - 858,000 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18847,227 - 858,772 (-)NCBI
Celera81,336,501 - 1,347,265 (-)NCBICelera
Cytogenetic Map8q11NCBI
AASDHPPT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811106,077,662 - 106,098,695 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11106,075,501 - 106,098,699 (+)EnsemblGRCh38hg38GRCh38
GRCh3711105,948,389 - 105,969,422 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611105,453,502 - 105,474,629 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411105,453,501 - 105,474,629NCBI
Celera11103,112,558 - 103,133,685 (+)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef11101,879,392 - 101,900,516 (+)NCBIHuRef
CHM1_111105,831,261 - 105,852,385 (+)NCBICHM1_1
T2T-CHM13v2.011106,082,274 - 106,103,304 (+)NCBIT2T-CHM13v2.0
Aasdhppt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3994,294,793 - 4,309,656 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl94,294,793 - 4,309,471 (-)EnsemblGRCm39 Ensembl
GRCm3894,294,793 - 4,309,617 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl94,294,793 - 4,309,471 (-)EnsemblGRCm38mm10GRCm38
MGSCv3794,294,793 - 4,309,494 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3694,295,093 - 4,309,456 (-)NCBIMGSCv36mm8
Celera3118,393,880 - 118,408,581 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
Aasdhppt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554128,723,828 - 8,748,701 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554128,723,828 - 8,747,684 (+)NCBIChiLan1.0ChiLan1.0
AASDHPPT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29106,825,729 - 106,846,912 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111107,920,503 - 107,941,473 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011100,969,185 - 100,990,296 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111104,452,913 - 104,474,063 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11104,452,913 - 104,474,063 (+)Ensemblpanpan1.1panPan2
AASDHPPT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1526,172,888 - 26,193,639 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl526,169,716 - 26,193,952 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha526,098,001 - 26,118,561 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0526,201,267 - 26,221,842 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl526,196,578 - 26,221,816 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1526,251,875 - 26,272,446 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0526,137,189 - 26,157,749 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0526,286,786 - 26,307,333 (-)NCBIUU_Cfam_GSD_1.0
Aasdhppt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494789,200,699 - 89,224,007 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365512,312,489 - 2,335,815 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365512,312,510 - 2,335,810 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AASDHPPT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl935,839,917 - 35,948,575 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1935,903,902 - 35,948,573 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2939,940,273 - 39,984,838 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AASDHPPT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1197,475,415 - 97,498,522 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl197,475,481 - 97,499,573 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604328,386,144 - 28,408,210 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aasdhppt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624784869,214 - 893,237 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624784869,202 - 894,929 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aasdhppt
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:81
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000008062
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)813402289Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008062   ⟹   ENSRNOP00000008062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl81,452,282 - 1,463,966 (-)Ensembl
Rnor_6.0 Ensembl81,439,340 - 1,450,138 (-)Ensembl
RefSeq Acc Id: NM_001106798   ⟹   NP_001100268
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr889,738,170 - 9,748,934 (-)NCBI
mRatBN7.281,453,226 - 1,463,990 (-)NCBI
Rnor_6.081,439,330 - 1,450,095 (-)NCBI
Rnor_5.081,427,206 - 1,444,610 (-)NCBI
RGSC_v3.48847,236 - 858,000 (-)RGD
Celera81,336,501 - 1,347,265 (-)RGD
Sequence:
RefSeq Acc Id: XM_063265042   ⟹   XP_063121112
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr889,731,592 - 9,748,914 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001100268   ⟸   NM_001106798
- UniProtKB: B2RYJ4 (UniProtKB/Swiss-Prot),   A0A8L2Q484 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008062   ⟸   ENSRNOT00000008062
RefSeq Acc Id: XP_063121112   ⟸   XM_063265042
- Peptide Label: isoform X1
Protein Domains
4'-phosphopantetheinyl transferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RYJ4-F1-model_v2 AlphaFold B2RYJ4 1-309 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695723
Promoter ID:EPDNEW_R6248
Type:initiation region
Name:Aasdhppt_1
Description:aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.081,450,111 - 1,450,171EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311360 AgrOrtholog
BioCyc Gene G2FUF-31838 BioCyc
Ensembl Genes ENSRNOG00000005795 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055006055 UniProtKB/Swiss-Prot
  ENSRNOG00060015633 UniProtKB/Swiss-Prot
  ENSRNOG00065002635 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008062 ENTREZGENE
  ENSRNOT00000008062.8 UniProtKB/TrEMBL
  ENSRNOT00055009790 UniProtKB/Swiss-Prot
  ENSRNOT00060026780 UniProtKB/Swiss-Prot
  ENSRNOT00065003520 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.470.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7938259 IMAGE-MGC_LOAD
InterPro 4-PPantetheinyl_Trfase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4-PPantetheinyl_Trfase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:300328 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188599 IMAGE-MGC_LOAD
NCBI Gene 300328 ENTREZGENE
PANTHER L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHOSPHOPANTETHEINE TRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ACPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aasdhppt PhenoGen
RatGTEx ENSRNOG00000005795 RatGTEx
  ENSRNOG00055006055 RatGTEx
  ENSRNOG00060015633 RatGTEx
  ENSRNOG00065002635 RatGTEx
Superfamily-SCOP SSF56214 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2Q484 ENTREZGENE, UniProtKB/TrEMBL
  ADPPT_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Aasdhppt  aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase   Aasdhppt_predicted  aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Aasdhppt_predicted  aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (predicted)      Symbol and Name status set to approved 70820 APPROVED