Angptl6 (angiopoietin-like 6) - Rat Genome Database

Name: Angptl6
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: Angptl6 (angiopoietin-like 6) Rattus norvegicus

Analyze

Symbol:

Angptl6

Name:

angiopoietin-like 6

RGD ID:

1311141

Description:

Predicted to enable signaling receptor binding activity. Predicted to be located in secretory granule. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to human ANGPTL6 (angiopoietin like 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

angiopoietin-related protein 6; LOC298698

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ANGPTL6 (angiopoietin like 6)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Angptl6 (angiopoietin-like 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Angptl6 (angiopoietin like 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ANGPTL6 (angiopoietin like 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ANGPTL6 (angiopoietin like 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Angptl6 (angiopoietin like 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ANGPTL6 (angiopoietin like 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ANGPTL6 (angiopoietin like 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Angptl6 (angiopoietin like 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ANGPTL6 (angiopoietin like 6)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Angptl6 (angiopoietin-like 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	angptl6 (angiopoietin-like 6)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	sca	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	19,413,617 - 19,419,925 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	19,413,619 - 19,419,925 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	23,432,985 - 23,439,290 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	21,730,832 - 21,737,137 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	19,643,302 - 19,649,607 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	21,895,523 - 21,902,002 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	21,895,524 - 21,901,829 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	21,951,838 - 21,958,144 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	19,899,121 - 19,905,696 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	19,899,197 - 19,904,566 (-)	NCBI
Celera	8	20,808,621 - 20,814,926 (-)	NCBI		Celera
Cytogenetic Map	8	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

genetic disease (ISO)

gestational diabetes (ISO)

hepatocellular carcinoma (ISO)

obesity (ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

4,4'-sulfonyldiphenol (EXP,ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

amitrole (EXP)

antimycin A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

cannabidiol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

choline (ISO)

cisplatin (ISO)

cyclosporin A (EXP,ISO)

dioxygen (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

flutamide (EXP)

folic acid (ISO)

gentamycin (EXP)

isoprenaline (ISO)

ivermectin (ISO)

L-methionine (ISO)

leflunomide (EXP)

levofloxacin (EXP)

methimazole (EXP)

N-methyl-4-phenylpyridinium (ISO)

nickel atom (ISO)

orphenadrine (EXP)

paracetamol (EXP,ISO)

pentachlorophenol (ISO)

phenobarbital (ISO)

progesterone (ISO)

resveratrol (ISO)

rotenone (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sirolimus (EXP)

sulfadimethoxine (EXP)

tacrolimus hydrate (EXP)

testosterone (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

trovafloxacin (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

collagen-containing extracellular matrix (IBA)

extracellular space (IBA)

secretory granule (ISO)

Molecular Function

signaling receptor binding (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Angiopoietin-related growth factor (AGF) promotes angiogenesis.	Oike Y, etal., Blood. 2004 May 15;103(10):3760-5. Epub 2004 Feb 5.
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Relationship of ANGPTL6 With Neonatal Glucose Homeostasis and Fat Mass Is Disrupted in Gestational Diabetic Pregnancies.	Valencia-Martínez A, etal., J Clin Endocrinol Metab. 2022 Sep 28;107(10):e4078-e4085. doi: 10.1210/clinem/dgac414.

Additional References at PubMed

PMID:12477932	PMID:12871997	PMID:23533145

Genomics

Comparative Map Data

Angptl6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	19,413,617 - 19,419,925 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	19,413,619 - 19,419,925 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	23,432,985 - 23,439,290 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	21,730,832 - 21,737,137 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	19,643,302 - 19,649,607 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	21,895,523 - 21,902,002 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	21,895,524 - 21,901,829 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	21,951,838 - 21,958,144 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	19,899,121 - 19,905,696 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	19,899,197 - 19,904,566 (-)	NCBI
Celera	8	20,808,621 - 20,814,926 (-)	NCBI		Celera
Cytogenetic Map	8	q13	NCBI

ANGPTL6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	10,092,338 - 10,106,190 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	10,092,338 - 10,102,678 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	10,203,014 - 10,216,866 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	10,064,013 - 10,074,425 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	10,064,012 - 10,074,425	NCBI
Celera	19	10,098,503 - 10,108,914 (-)	NCBI		Celera
Cytogenetic Map	19	p13.2	NCBI
HuRef	19	9,783,670 - 9,794,081 (-)	NCBI		HuRef
CHM1_1	19	10,203,288 - 10,213,699 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	10,218,556 - 10,232,399 (-)	NCBI		T2T-CHM13v2.0

Angptl6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	20,785,104 - 20,791,116 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	20,785,104 - 20,791,023 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	20,873,808 - 20,879,822 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	20,873,808 - 20,879,727 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	20,678,253 - 20,684,154 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	20,624,211 - 20,630,112 (-)	NCBI		MGSCv36	mm8
Celera	9	18,142,507 - 18,148,408 (-)	NCBI		Celera
Cytogenetic Map	9	A3	NCBI
cM Map	9	7.66	NCBI

Angptl6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	1,437,239 - 1,441,236 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	1,437,024 - 1,446,328 (-)	NCBI	ChiLan1.0	ChiLan1.0

ANGPTL6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	19	14,007,988 - 14,015,407 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	9,641,164 - 9,651,909 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	10,300,184 - 10,303,937 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

ANGPTL6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	50,953,029 - 50,961,598 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	50,953,498 - 50,961,576 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	50,822,536 - 50,831,158 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	51,474,790 - 51,483,407 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	51,475,288 - 51,483,383 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	50,682,677 - 50,691,304 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	51,109,694 - 51,118,314 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	51,350,586 - 51,359,216 (+)	NCBI		UU_Cfam_GSD_1.0

Angptl6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	209,854,975 - 209,863,376 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936659	487,983 - 499,448 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936659	491,330 - 499,409 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ANGPTL6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	68,947,071 - 68,958,766 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	68,947,067 - 68,958,820 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	69,275,242 - 69,286,962 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ANGPTL6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	9,162,219 - 9,175,163 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666074	10,894,920 - 10,899,106 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Angptl6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	2,290,511 - 2,296,341 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624828	2,291,682 - 2,301,165 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Angptl6
27 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	63
Count of miRNA genes:	58
Interacting mature miRNAs:	60
Transcripts:	ENSRNOT00000027963
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9590084	Insglur5	Insulin/glucose ratio QTL 5	18.54	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	8	1	24597739	Rat
2317882	Alcrsp24	Alcohol response QTL 24	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	8	1	25902202	Rat
12880023	Bw184	Body weight QTL 184		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	2097640	47097640	Rat
12880025	Cm102	Cardiac mass QTL 102		0.044	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	8	2097640	47097640	Rat
12880028	Cm103	Cardiac mass QTL 103		0.02	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	2097640	47097640	Rat
12880044	Am9	Aortic mass QTL 9		0.007	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	2097640	47097640	Rat
2317032	Ginf2	Gastrointestinal inflammation QTL 2	3.21	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	8	4705810	49705810	Rat
2317036	Livw3	Liver weight QTL 3	2.43	0.01	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	8	4705810	49705810	Rat
2317048	Ginf1	Gastrointestinal inflammation QTL 1	3.52	0.005	cecum mucosa thickness (VT:0010234)	enterocolitis severity score (CMO:0002138)	8	4705810	49705810	Rat
2301416	Bp315	Blood pressure QTL 315		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	7670578	52670578	Rat
1354595	Despr4	Despair related QTL 4	2.16	0.0036	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	8	7688955	52688955	Rat
1354627	Despr14	Despair related QTL 14		0.0056	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	7688955	52688955	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
2317030	Wbc5	White blood cell count QTL 5	3.21	0.005	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	8	8736635	53736635	Rat
2317051	Aia18	Adjuvant induced arthritis QTL 18	2.42		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	8	8736635	53736635	Rat
1598824	Memor4	Memory QTL 4	2.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	8	9712220	53356647	Rat
1357398	Slep3	Serum leptin concentration QTL 3	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	9712463	41866876	Rat
2302367	Slep5	Serum leptin concentration QTL 5	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	9712463	41866876	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
1558646	Swd5	Spike wave discharge measurement QTL 5	3.45	0.00036	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge frequency (CMO:0001742)	8	14906751	59906751	Rat
61373	Mcs4	Mammary carcinoma susceptibility QTL 4	1.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	8	16290444	61290444	Rat
631271	Lecl1	Lens clarity QTL 1		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	8	18984168	84531599	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	19331152	93965294	Rat

Markers in Region

RH130656

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	19,413,815 - 19,414,003 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	21,895,721 - 21,895,908	NCBI	Rnor6.0
Rnor_5.0	8	21,952,036 - 21,952,223	UniSTS	Rnor5.0
RGSC_v3.4	8	19,899,318 - 19,899,505	UniSTS	RGSC3.4
Celera	8	20,808,818 - 20,809,005	UniSTS
RH 3.4 Map	8	179.6	UniSTS
Cytogenetic Map	8	q13	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			23	23		23
Low	3		30	18	19	18			46	20	18	9
Below cutoff		27	4				7	10	28	15	22	2	7

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106702	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008765921	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080978	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC135310	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC166828	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473993	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000190	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000027963 ⟹ ENSRNOP00000027963

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	19,413,619 - 19,419,925 (-)	Ensembl
Rnor_6.0 Ensembl	8	21,895,524 - 21,901,829 (-)	Ensembl

RefSeq Acc Id:

NM_001106702 ⟹ NP_001100172

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	19,413,619 - 19,419,925 (-)	NCBI
Rnor_6.0	8	21,895,524 - 21,901,829 (-)	NCBI
Rnor_5.0	8	21,951,838 - 21,958,144 (-)	NCBI
RGSC_v3.4	8	19,899,121 - 19,905,696 (-)	RGD
Celera	8	20,808,621 - 20,814,926 (-)	RGD

Sequence:

show sequence

CTCCCAGTCCTCCATCCTGGTCCTCTATCCCGGTCCTTCAGGCTTTACTCCGATTTTGTGGGCT
TGCGGCAAACCTCACTGGCGCCAGCACCCGCGCCGGGCCGTTGGAGGTGGCGGCCATGGGGACT
GCTGTGCTGCGCAAGCTGCAGCTGGTGCTCCTGCTGGGCGCTTGGAAGGCGCTTGGAGATGCCG
CGCGGTGCCGCGTCACCCTTGTTCTGTCCCCGCAGATGGCGACTAGCGCGGTCTGCAGGAGCTC
AGAAGCTTCCCAAGACAGCGAACTGGCCACGCTGCGCATGCGCCTGGGCCGTCACGAGGAGCTG
CTGCGCGCGCTGCAAAGGCGTGCGGCCGAGGGTGGTGCGCTCGCGGGCGAGGTGCGCGCGCTGC
GCGAGCACAGTCTCACCCTAAACACACGTCTGGGCCAGCTGCGCGCGCAACTGCAGCAGGAGGC
GGGGGCGGAGCCTGATCTGGGGGCGGAGCCTGCTGCCGCGCTTGGTTTGCTAGCAGAGCGCGCG
CTGGGTGCGGAGGCCGAAGCGCGCCGGACGACCGCGCGCCTGCAGCAGCTGGAGGAGCAGCTCC
GTGAGCATGCGCAGCTCATGAGCCAGCATAGCAGCCTCCTCGGCCGCCTGCAACGCGCGTGCGC
GAGCCCGGAACGGGGCCAGCAGCAGGTCCTGCCACTGCCCCTGGTGCCTTTGGTTCCTCTGAGT
CTAGTGGGAAGTGCCAGCAACACCAGCCGGAGGCTGGACCAAATTCCAGAGCACCAGAGAGAGC
AGAGCTTGAGACAGCAGGGGCCTCCATCTTCTCCGCTGCCCACAGGGCACGTTGCTGTCCCCAC
CAGGCCAGTGGGCCCATGGAGGGATTGTGCGGAGGCCCAGGGGGCAGGTCACTGGCAGAGTGGA
GTGTATGAACTGCGGTTGGGCCGTCGTGTGGTACCCGTGTGGTGTGAACAGCAGCAGGAGGGTG
GAGGCTGGACCGTCATCCAGAGGCGGCAAGATGGCTCTGTCAACTTCTTCACCAACTGGCAACA
TTACAAGGTGGGCTTTGGACGACCGGATGGAGAATACTGGCTGGGCTTGGAACCCGTGCATCAG
GTGACTAGCCGCGGGGACCACGAGCTGCTGATACTCTTAAAGGACTGGGGGGGCCGTGGGGCAC
GCGCCCACTATGACAGCTTCTCCTTGGAACCCGAGAGTGACCACTACCGGCTGCGGCTTGGCCA
GTACCATGGTGATGCTGGAGATTCCCTCTCCTGGCACAGTGACAAACCTTTCAACACTGTGGAT
AGGGACAGAGACTCATATTCTGGCAACTGTGCCCTCTACCATCGTGGGGGCTGGTGGTACCATG
CCTGCGCCCACTCCAACCTCAATGGTGTATGGTATCACGGAGGTCATTACCGGAGCCGATACCA
GGACGGGGTCTACTGGGCCGAGTTCCGTGGTGGGGCGTACTCTCTGAAGAAGGCTGCTATGCTG
ACCCGGCTTGTTCGGTTGTGACTGTCCCATGAGTACCCCCCCAAGGGTGCTCCTATCTCCTTGA
GCTGGTATCTTATAGCAACAGGAGGTGTCCATTC

hide sequence

RefSeq Acc Id:

XM_039080978 ⟹ XP_038936906

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	19,413,617 - 19,418,246 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100172	(Get FASTA)	NCBI Sequence Viewer
	XP_038936906	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI66828	(Get FASTA)	NCBI Sequence Viewer
	EDL78347	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001100172 ⟸ NM_001106702
- Peptide Label:	precursor
- UniProtKB:	A6JNL9 (UniProtKB/TrEMBL), B2RYM1 (UniProtKB/TrEMBL), F1LME9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGTAVLRKLQLVLLLGAWKALGDAARCRVTLVLSPQMATSAVCRSSEASQDSELATLRMRLGRH EELLRALQRRAAEGGALAGEVRALREHSLTLNTRLGQLRAQLQQEAGAEPDLGAEPAAALGLLA ERALGAEAEARRTTARLQQLEEQLREHAQLMSQHSSLLGRLQRACASPERGQQQVLPLPLVPLV PLSLVGSASNTSRRLDQIPEHQREQSLRQQGPPSSPLPTGHVAVPTRPVGPWRDCAEAQGAGHW QSGVYELRLGRRVVPVWCEQQQEGGGWTVIQRRQDGSVNFFTNWQHYKVGFGRPDGEYWLGLEP VHQVTSRGDHELLILLKDWGGRGARAHYDSFSLEPESDHYRLRLGQYHGDAGDSLSWHSDKPFN TVDRDRDSYSGNCALYHRGGWWYHACAHSNLNGVWYHGGHYRSRYQDGVYWAEFRGGAYSLKKA AMLTRLVRL hide sequence

RefSeq Acc Id:

ENSRNOP00000027963 ⟸ ENSRNOT00000027963

RefSeq Acc Id:	XP_038936906 ⟸ XM_039080978
- Peptide Label:	isoform X1

Protein Domains

Fibrinogen C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B2RYM1-F1-model_v2	AlphaFold	B2RYM1	1-457	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311141	AgrOrtholog
BioCyc Gene	G2FUF-31456	BioCyc
Ensembl Genes	ENSRNOG00000020603	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000027963	ENTREZGENE
	ENSRNOP00000027963.6	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000027963	ENTREZGENE
	ENSRNOT00000027963.7	UniProtKB/TrEMBL
Gene3D-CATH	3.90.215.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:8373153	IMAGE-MGC_LOAD
InterPro	Fibrinogen-like_C	UniProtKB/TrEMBL
	Fibrinogen_a/b/g_C	UniProtKB/TrEMBL
	Fibrinogen_a/b/g_C_1	UniProtKB/TrEMBL
	Fibrinogen_CS	UniProtKB/TrEMBL
MGC_CLONE	MGC:188711	IMAGE-MGC_LOAD
NCBI Gene	298698	ENTREZGENE
PANTHER	ANGIOPOIETIN-RELATED PROTEIN 6	UniProtKB/TrEMBL
	FIBRINOGEN/TENASCIN/ANGIOPOEITIN	UniProtKB/TrEMBL
Pfam	Fibrinogen_C	UniProtKB/TrEMBL
PhenoGen	Angptl6	PhenoGen
PROSITE	FIBRINOGEN_C_1	UniProtKB/TrEMBL
	FIBRINOGEN_C_2	UniProtKB/TrEMBL
SMART	FBG	UniProtKB/TrEMBL
Superfamily-SCOP	Fibrinogen_a/b/g_C	UniProtKB/TrEMBL
UniProt	A6JNL9	ENTREZGENE, UniProtKB/TrEMBL
	B2RYM1	ENTREZGENE, UniProtKB/TrEMBL
	F1LME9	ENTREZGENE
UniProt Secondary	F1LME9	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Angptl6	angiopoietin-like 6	Angptl6_predicted	angiopoietin-like 6 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Angptl6_predicted	angiopoietin-like 6 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI