Arhgap21 (Rho GTPase activating protein 21) - Rat Genome Database

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Gene: Arhgap21 (Rho GTPase activating protein 21) Rattus norvegicus
Analyze
Symbol: Arhgap21
Name: Rho GTPase activating protein 21
RGD ID: 1311028
Description: Predicted to have GTPase activator activity. Predicted to be involved in several processes, including Golgi organization; establishment of Golgi localization; and maintenance of Golgi location. Predicted to localize to several cellular components, including Golgi apparatus; actin cytoskeleton; and cell junction. Orthologous to human ARHGAP21 (Rho GTPase activating protein 21); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; bisphenol A; Brodifacoum.
Type: protein-coding
RefSeq Status: INFERRED
Also known as: LOC307178; rho GTPase-activating protein 21
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21783,348,673 - 83,472,202 (-)NCBI
Rnor_6.0 Ensembl1787,725,867 - 87,826,421 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01787,725,978 - 87,797,436 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01789,415,087 - 89,486,545 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41794,817,558 - 94,941,088 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11794,828,397 - 94,951,968 (-)NCBI
Celera1782,609,823 - 82,732,937 (-)NCBICelera
Cytogenetic Map17q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:18662671   PMID:20525016   PMID:24792215  


Genomics

Comparative Map Data
Arhgap21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21783,348,673 - 83,472,202 (-)NCBI
Rnor_6.0 Ensembl1787,725,867 - 87,826,421 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01787,725,978 - 87,797,436 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01789,415,087 - 89,486,545 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41794,817,558 - 94,941,088 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11794,828,397 - 94,951,968 (-)NCBI
Celera1782,609,823 - 82,732,937 (-)NCBICelera
Cytogenetic Map17q12.3NCBI
ARHGAP21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1024,583,609 - 24,723,887 (-)EnsemblGRCh38hg38GRCh38
GRCh381024,583,610 - 24,725,421 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371024,872,543 - 25,012,816 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361024,912,549 - 25,052,550 (-)NCBINCBI36hg18NCBI36
Build 341024,912,550 - 25,052,550NCBI
Celera1024,564,446 - 24,712,895 (-)NCBI
Cytogenetic Map10p12.1NCBI
HuRef1024,534,090 - 24,673,492 (-)NCBIHuRef
CHM1_11024,872,464 - 25,013,653 (-)NCBICHM1_1
Arhgap21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39220,852,730 - 20,973,761 (-)NCBIGRCm39mm39
GRCm39 Ensembl220,852,730 - 20,973,692 (-)Ensembl
GRCm38220,847,919 - 20,968,691 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl220,847,919 - 20,968,881 (-)EnsemblGRCm38mm10GRCm38
MGSCv37220,769,546 - 20,889,348 (-)NCBIGRCm37mm9NCBIm37
MGSCv36220,765,673 - 20,886,635 (-)NCBImm8
Celera220,722,855 - 20,850,910 (-)NCBICelera
Cytogenetic Map2A3NCBI
Arhgap21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554294,424,425 - 4,559,596 (+)NCBIChiLan1.0ChiLan1.0
ARHGAP21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11025,131,262 - 25,267,188 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1025,132,054 - 25,266,378 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01024,761,427 - 24,898,572 (-)NCBIMhudiblu_PPA_v0panPan3
ARHGAP21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.128,740,760 - 8,877,399 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl28,740,119 - 8,877,016 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha27,492,699 - 7,570,795 (+)NCBI
ROS_Cfam_1.026,941,316 - 7,076,212 (+)NCBI
UMICH_Zoey_3.126,367,333 - 6,445,123 (+)NCBI
UNSW_CanFamBas_1.026,386,800 - 6,529,731 (+)NCBI
UU_Cfam_GSD_1.026,612,602 - 6,694,835 (+)NCBI
Arhgap21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934424,183,514 - 24,257,210 (-)NCBI
SpeTri2.0NW_004936484348,671 - 393,993 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGAP21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1050,540,556 - 50,680,154 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11050,541,582 - 50,680,156 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21055,994,406 - 56,132,994 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGAP21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1924,325,648 - 24,459,006 (-)NCBI
ChlSab1.1 Ensembl924,326,454 - 24,406,743 (-)Ensembl
Vero_WHO_p1.0NW_02366605130,261,895 - 30,397,345 (-)NCBI
Arhgap21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247964,201,335 - 4,321,307 (+)NCBI

Position Markers
D17Got104  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21783,401,813 - 83,402,021 (+)MAPPER
mRatBN7.21783,401,813 - 83,402,199 (+)MAPPER
Rnor_6.01787,778,558 - 87,779,021NCBIRnor6.0
Rnor_6.01787,778,558 - 87,778,765NCBIRnor6.0
Rnor_5.01789,467,667 - 89,467,874UniSTSRnor5.0
Rnor_5.01789,467,667 - 89,468,130UniSTSRnor5.0
RGSC_v3.41794,870,697 - 94,870,904UniSTSRGSC3.4
RGSC_v3.41794,870,696 - 94,870,904RGDRGSC3.4
RGSC_v3.11794,881,530 - 94,881,737RGD
Celera1782,662,922 - 82,663,129UniSTS
RH 3.4 Map17872.1UniSTS
RH 3.4 Map17872.1RGD
RH 2.0 Map17725.2RGD
Cytogenetic Map17q12.3UniSTS
RH144578  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21783,466,473 - 83,466,687 (+)MAPPER
Rnor_6.01787,843,978 - 87,844,191NCBIRnor6.0
Rnor_5.01789,533,087 - 89,533,300UniSTSRnor5.0
RGSC_v3.41794,935,360 - 94,935,573UniSTSRGSC3.4
Celera1782,727,257 - 82,727,470UniSTS
Cytogenetic Map17q12.3UniSTS
RH134054  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2173,396,949 - 73,397,159 (+)MAPPER
mRatBN7.21783,348,778 - 83,348,988 (-)MAPPER
mRatBN7.2173,396,949 - 73,397,159 (-)MAPPER
mRatBN7.21783,348,778 - 83,348,988 (+)MAPPER
Rnor_6.01787,726,084 - 87,726,293NCBIRnor6.0
Rnor_6.0165,806,400 - 65,806,609NCBIRnor6.0
Rnor_5.0166,617,538 - 66,617,747UniSTSRnor5.0
Rnor_5.01789,415,193 - 89,415,402UniSTSRnor5.0
RGSC_v3.4172,686,261 - 72,686,470UniSTSRGSC3.4
RGSC_v3.41794,817,664 - 94,817,873UniSTSRGSC3.4
Celera1782,609,929 - 82,610,138UniSTS
Celera160,434,515 - 60,434,724UniSTS
RH 3.4 Map17833.7UniSTS
Cytogenetic Map17q12.3UniSTS
Cytogenetic Map1q21UniSTS
RH142975  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21783,458,908 - 83,459,178 (+)MAPPER
Rnor_6.01787,836,412 - 87,836,681NCBIRnor6.0
Rnor_5.01789,525,521 - 89,525,790UniSTSRnor5.0
RGSC_v3.41794,927,794 - 94,928,063UniSTSRGSC3.4
Celera1782,719,691 - 82,719,960UniSTS
RH 3.4 Map17874.61UniSTS
Cytogenetic Map17q12.3UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174435615789356157Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)175241095790843779Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)175241095790843779Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175347518090690466Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175387148890843779Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175399194790843779Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176751265790843779Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:496
Count of miRNA genes:265
Interacting mature miRNAs:308
Transcripts:ENSRNOT00000068156
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 43 35 25 10 25 1 1 74 35 35 11 1
Low 1 22 16 9 16 7 10 6 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001191693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACYVU010000294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000068156   ⟹   ENSRNOP00000060787
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1787,725,867 - 87,826,421 (-)Ensembl
RefSeq Acc Id: NM_001191693   ⟹   NP_001178622
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21783,348,673 - 83,472,202 (-)NCBI
Rnor_6.01787,725,978 - 87,797,436 (-)NCBI
Rnor_5.01789,415,087 - 89,486,545 (-)NCBI
Celera1782,609,823 - 82,732,937 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178622 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001178622   ⟸   NM_001191693
- Sequence:
RefSeq Acc Id: ENSRNOP00000060787   ⟸   ENSRNOT00000068156
Protein Domains
PDZ   PH   Rho-GAP

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311028 AgrOrtholog
Ensembl Genes ENSRNOG00000008659 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000060787 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068156 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
InterPro PDZ/DHR/GLGF UniProtKB/TrEMBL
  PDZ_6 UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/TrEMBL
NCBI Gene 307178 ENTREZGENE
Pfam PDZ_6 UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
PhenoGen Arhgap21 PhenoGen
PROSITE PDZ UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  RHOGAP UniProtKB/TrEMBL
SMART PDZ UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PDZ UniProtKB/TrEMBL
  Rho_GAP UniProtKB/TrEMBL
UniProt F1LXQ7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Arhgap21  Rho GTPase activating protein 21   Arhgap21_predicted  Rho GTPase activating protein 21 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Arhgap21_predicted  Rho GTPase activating protein 21 (predicted)      Symbol and Name status set to approved 70820 APPROVED