Mthfd2l (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like) - Rat Genome Database

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Gene: Mthfd2l (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like) Rattus norvegicus
Analyze
Symbol: Mthfd2l
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
RGD ID: 1310879
Description: Enables methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; and methylenetetrahydrofolate dehydrogenase (NADP+) activity. Involved in 10-formyltetrahydrofolate metabolic process and tetrahydrofolate interconversion. Located in mitochondrial inner membrane and mitochondrial matrix. Orthologous to human MTHFD2L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like); PARTICIPATES IN folate cycle metabolic pathway; folate mediated one-carbon metabolic pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial; LOC305248; methylenetetrahydrofolate dehydrogenase 2-like; MTHFD2-like; NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein; probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2; RGD1310879; similar to methylenetetrahydrofolate dehydrogenase (NAD) (EC 1.5.1.15) / methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) precursor - mouse
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,374,139 - 17,455,508 (-)NCBIGRCr8
mRatBN7.21417,089,947 - 17,170,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,089,952 - 17,170,112 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,090,791 - 17,171,009 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,409,714 - 18,489,945 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,101,828 - 17,182,065 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,640,274 - 18,721,298 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,640,277 - 18,720,357 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,548,222 - 18,629,209 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,585,147 - 18,665,534 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,585,141 - 18,665,478 (-)NCBI
Celera1416,467,710 - 16,547,256 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mammalian MTHFD2L encodes a mitochondrial methylenetetrahydrofolate dehydrogenase isozyme expressed in adult tissues. Bolusani S, etal., J Biol Chem. 2011 Feb 18;286(7):5166-74. doi: 10.1074/jbc.M110.196840. Epub 2010 Dec 16.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Mitochondrial MTHFD2L is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase expressed in both adult and embryonic tissues. Shin M, etal., J Biol Chem. 2014 May 30;289(22):15507-17. doi: 10.1074/jbc.M114.555573. Epub 2014 Apr 14.
7. Update and new concepts in vitamin responsive disorders of folate transport and metabolism. Watkins D and Rosenblatt DS, J Inherit Metab Dis. 2012 Jul;35(4):665-70. doi: 10.1007/s10545-011-9418-1. Epub 2011 Nov 23.

Genomics

Comparative Map Data
Mthfd2l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,374,139 - 17,455,508 (-)NCBIGRCr8
mRatBN7.21417,089,947 - 17,170,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,089,952 - 17,170,112 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,090,791 - 17,171,009 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,409,714 - 18,489,945 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,101,828 - 17,182,065 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,640,274 - 18,721,298 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,640,277 - 18,720,357 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,548,222 - 18,629,209 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,585,147 - 18,665,534 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,585,141 - 18,665,478 (-)NCBI
Celera1416,467,710 - 16,547,256 (-)NCBICelera
Cytogenetic Map14p22NCBI
MTHFD2L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38474,114,560 - 74,303,099 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl474,114,174 - 74,303,099 (+)EnsemblGRCh38hg38GRCh38
GRCh37474,988,990 - 75,168,816 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36475,207,855 - 75,387,680 (+)NCBINCBI36Build 36hg18NCBI36
Build 34475,430,545 - 75,533,847NCBI
Celera472,383,935 - 72,529,069 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef470,834,750 - 70,979,763 (+)NCBIHuRef
CHM1_1475,059,669 - 75,204,651 (+)NCBICHM1_1
T2T-CHM13v2.0477,457,787 - 77,646,724 (+)NCBIT2T-CHM13v2.0
Mthfd2l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39591,078,704 - 91,169,227 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl591,078,976 - 91,169,227 (+)EnsemblGRCm39 Ensembl
GRCm38590,930,873 - 91,021,368 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,931,117 - 91,021,368 (+)EnsemblGRCm38mm10GRCm38
MGSCv37591,360,222 - 91,450,394 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36592,006,454 - 92,096,568 (+)NCBIMGSCv36mm8
Celera589,066,224 - 89,157,002 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
Mthfd2l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955474450,680 - 558,716 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955474450,676 - 558,659 (+)NCBIChiLan1.0ChiLan1.0
MTHFD2L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2355,757,607 - 55,903,608 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1455,946,632 - 56,091,887 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0449,889,607 - 50,034,860 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1455,722,237 - 55,901,553 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl455,722,237 - 55,867,117 (-)Ensemblpanpan1.1panPan2
MTHFD2L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11362,670,543 - 62,803,270 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1362,670,462 - 62,803,519 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1362,354,053 - 62,490,793 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01363,497,174 - 63,632,656 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1363,496,510 - 63,626,257 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11363,110,477 - 63,247,437 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01362,593,854 - 62,729,238 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01363,734,925 - 63,872,301 (+)NCBIUU_Cfam_GSD_1.0
Mthfd2l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528512,944,176 - 13,062,375 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365981,401,402 - 1,514,357 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365981,401,392 - 1,514,314 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTHFD2L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl870,179,658 - 70,290,047 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1870,179,701 - 70,288,356 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2874,332,406 - 74,457,356 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MTHFD2L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1722,696,362 - 22,838,955 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl722,696,309 - 22,838,967 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037977,622 - 1,128,997 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mthfd2l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247301,416,186 - 1,520,509 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247301,416,239 - 1,520,087 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mthfd2l
566 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:146
Count of miRNA genes:104
Interacting mature miRNAs:123
Transcripts:ENSRNOT00000047708
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat

Markers in Region
RH138232  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21417,090,022 - 17,090,184 (+)MAPPERmRatBN7.2
Rnor_6.01418,640,350 - 18,640,511NCBIRnor6.0
Rnor_5.01418,548,293 - 18,548,454UniSTSRnor5.0
RGSC_v3.41418,585,218 - 18,585,380UniSTSRGSC3.4
RH 3.4 Map14214.3UniSTS
Cytogenetic Map14p22UniSTS
BF390183  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21417,127,831 - 17,127,994 (+)MAPPERmRatBN7.2
Rnor_6.01418,678,156 - 18,678,318NCBIRnor6.0
Rnor_5.01418,587,034 - 18,587,196UniSTSRnor5.0
RGSC_v3.41418,623,428 - 18,623,590UniSTSRGSC3.4
Celera1416,505,536 - 16,505,698UniSTS
RH 3.4 Map14210.2UniSTS
Cytogenetic Map14p22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23
Low 3 41 40 25 19 25 5 8 51 32 36 11 5
Below cutoff 2 17 16 16 3 3 3 5 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000047708   ⟹   ENSRNOP00000044342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1417,089,952 - 17,170,036 (-)Ensembl
Rnor_6.0 Ensembl1418,640,279 - 18,720,357 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081455   ⟹   ENSRNOP00000075471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1418,640,277 - 18,704,059 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116598   ⟹   ENSRNOP00000077349
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1417,167,564 - 17,170,112 (-)Ensembl
RefSeq Acc Id: NM_001107211   ⟹   NP_001100681
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81417,374,144 - 17,454,220 (-)NCBI
mRatBN7.21417,089,952 - 17,170,036 (-)NCBI
Rnor_6.01418,640,279 - 18,720,357 (-)NCBI
Rnor_5.01418,548,222 - 18,629,209 (-)NCBI
RGSC_v3.41418,585,147 - 18,665,534 (-)RGD
Celera1416,467,710 - 16,547,256 (-)RGD
Sequence:
RefSeq Acc Id: XM_017599176   ⟹   XP_017454665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81417,374,139 - 17,454,112 (-)NCBI
mRatBN7.21417,089,947 - 17,169,928 (-)NCBI
Rnor_6.01418,640,274 - 18,720,231 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063273069   ⟹   XP_063129139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81417,374,139 - 17,455,508 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001100681   ⟸   NM_001107211
- UniProtKB: D3ZUA0 (UniProtKB/Swiss-Prot),   A6KKD2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454665   ⟸   XM_017599176
- Peptide Label: isoform X2
- UniProtKB: A6KKD2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000044342   ⟸   ENSRNOT00000047708
RefSeq Acc Id: ENSRNOP00000075471   ⟸   ENSRNOT00000081455
RefSeq Acc Id: ENSRNOP00000077349   ⟸   ENSRNOT00000116598
RefSeq Acc Id: XP_063129139   ⟸   XM_063273069
- Peptide Label: isoform X1
Protein Domains
Tetrahydrofolate dehydrogenase/cyclohydrolase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZUA0-F1-model_v2 AlphaFold D3ZUA0 1-338 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699224
Promoter ID:EPDNEW_R9748
Type:single initiation site
Name:Mthfd2l_1
Description:methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01418,720,301 - 18,720,361EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310879 AgrOrtholog
BioCyc Gene G2FUF-16213 BioCyc
BioCyc Pathway 1CMET2-PWY [folate transformations III (E. coli)] BioCyc
  PWY-5030 [L-histidine degradation III] BioCyc
BioCyc Pathway Image 1CMET2-PWY BioCyc
  PWY-5030 BioCyc
Ensembl Genes ENSRNOG00000021347 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055006399 UniProtKB/Swiss-Prot
  ENSRNOG00060018107 UniProtKB/Swiss-Prot
  ENSRNOG00065017090 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000047708 ENTREZGENE
  ENSRNOT00000047708.6 UniProtKB/Swiss-Prot
  ENSRNOT00000116598.1 UniProtKB/TrEMBL
  ENSRNOT00055010397 UniProtKB/Swiss-Prot
  ENSRNOT00060031064 UniProtKB/Swiss-Prot
  ENSRNOT00065028528 UniProtKB/Swiss-Prot
Gene3D-CATH Leucine Dehydrogenase, chain A, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aminiacid_DH-like_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THF_DH/CycHdrlase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THF_DH/CycHdrlase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THF_DH/CycHdrlase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THF_DH/CycHdrlase_NAD-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:305248 UniProtKB/Swiss-Prot
NCBI Gene 305248 ENTREZGENE
PANTHER BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE 2-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam THF_DHG_CYH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THF_DHG_CYH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mthfd2l PhenoGen
PRINTS THFDHDRGNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THF_DHG_CYH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021347 RatGTEx
  ENSRNOG00055006399 RatGTEx
  ENSRNOG00060018107 RatGTEx
  ENSRNOG00065017090 RatGTEx
Superfamily-SCOP Aminoacid dehydrogenase-like, N-terminal domain UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-fold domains UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SSF53223 UniProtKB/Swiss-Prot
UniProt A0A8I5Y1G5_RAT UniProtKB/TrEMBL
  A6KKD2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZUA0 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Mthfd2l  methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like   Mthfd2l_predicted  methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like (predicted)  'predicted' is removed 2292626 APPROVED
2007-09-11 Mthfd2l_predicted  methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like (predicted)  RGD1310879_predicted  similar to methylenetetrahydrofolate dehydrogenase (NAD) (EC 1.5.1.15) / methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) precursor - mouse (predicted)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1310879_predicted  similar to methylenetetrahydrofolate dehydrogenase (NAD) (EC 1.5.1.15) / methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) precursor - mouse (predicted)  LOC305248_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC305248_predicted  similar to methylenetetrahydrofolate dehydrogenase (NAD) (EC 1.5.1.15) / methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) precursor - mouse (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL