Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | ISO | Sema4d (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of SEMA4D mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | ISO | SEMA4D (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in increased expression of SEMA4D mRNA and [Estradiol co-treated with TGFB1 protein] results in decreased expression of SEMA4D mRNA | CTD | PMID:20660070 and PMID:30165855 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Sema4d (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SEMA4D promoter] | CTD | PMID:19654925 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SEMA4D mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SEMA4D mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Sema4d (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SEMA4D mRNA | CTD | PMID:26377647 | 2-hydroxypropanoic acid | decreases expression | ISO | SEMA4D (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of SEMA4D mRNA | CTD | PMID:30851411 | 2-methylcholine | affects expression | ISO | SEMA4D (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of SEMA4D mRNA | CTD | PMID:21179406 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Sema4d (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of SEMA4D mRNA | CTD | PMID:20188158 and PMID:26251327 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Sema4d (Mus musculus) | 6480464 | bisphenol S affects the methylation of SEMA4D gene | CTD | PMID:31683443 | 4-hydroxyphenyl retinamide | increases expression | ISO | Sema4d (Mus musculus) | 6480464 | Fenretinide results in increased expression of SEMA4D mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of SEMA4D mRNA | CTD | PMID:24780913 | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of SEMA4D mRNA | CTD | PMID:31881176 | aflatoxin B1 | affects methylation | ISO | SEMA4D (Homo sapiens) | 6480464 | Aflatoxin B1 affects the methylation of SEMA4D intron | CTD | PMID:30157460 | all-trans-retinoic acid | increases expression | ISO | SEMA4D (Homo sapiens) | 6480464 | Tretinoin results in increased expression of SEMA4D mRNA | CTD | PMID:33167477 | amiodarone | increases expression | ISO | SEMA4D (Homo sapiens) | 6480464 | Amiodarone results in increased expression of SEMA4D mRNA | CTD | PMID:19774075 | antirheumatic drug | decreases expression | ISO | SEMA4D (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of SEMA4D mRNA | CTD | PMID:24449571 | arsane | multiple interactions | ISO | SEMA4D (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of SEMA4D mRNA | CTD | PMID:32525701 | arsenic atom | multiple interactions | ISO | SEMA4D (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of SEMA4D mRNA | CTD | PMID:32525701 | arsenite(3-) | decreases expression | ISO | Sema4d (Mus musculus) | 6480464 | arsenite results in decreased expression of SEMA4D mRNA | CTD | PMID:33053406 | arsenite(3-) | increases methylation | ISO | SEMA4D (Homo sapiens) | 6480464 | arsenite results in increased methylation of SEMA4D promoter | CTD | PMID:23974009 | atrazine | increases expression | ISO | SEMA4D (Homo sapiens) | 6480464 | Atrazine results in increased expression of SEMA4D mRNA | CTD | PMID:18585445 | benzo[a]pyrene | multiple interactions | ISO | Sema4d (Mus musculus) | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to SEMA4D promoter] | CTD | PMID:19654925 | benzo[a]pyrene | affects methylation | ISO | SEMA4D (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SEMA4D intron | CTD | PMID:30157460 | benzo[a]pyrene | increases methylation | ISO | SEMA4D (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of SEMA4D 5' UTR | CTD | PMID:27901495 | benzo[e]pyrene | increases methylation | ISO | SEMA4D (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of SEMA4D intron | CTD | PMID:30157460 | bis(2-chloroethyl) sulfide | increases expression | ISO | Sema4d (Mus musculus) | 6480464 | Mustard Gas results in increased expression of SEMA4D mRNA | CTD | PMID:15674843 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SEMA4D mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SEMA4D mRNA | CTD | PMID:32145629 | buta-1,3-diene | decreases expression | ISO | Sema4d (Mus musculus) | 6480464 | 1 and 3-butadiene results in decreased expression of SEMA4D mRNA | CTD | PMID:29038090 | butanal | decreases expression | ISO | SEMA4D (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of SEMA4D mRNA | CTD | PMID:26079696 | cadmium dichloride | increases expression | ISO | Sema4d (Mus musculus) | 6480464 | Cadmium Chloride results in increased expression of SEMA4D mRNA | CTD | PMID:18974090 | carbamazepine | affects expression | ISO | SEMA4D (Homo sapiens) | 6480464 | Carbamazepine affects the expression of SEMA4D mRNA | CTD | PMID:25979313 | carbon nanotube | increases expression | ISO | Sema4d (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | SEMA4D (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to SEMA4D gene] | CTD | PMID:28238834 | chloroprene | decreases expression | ISO | Sema4d (Mus musculus) | 6480464 | Chloroprene results in decreased expression of SEMA4D mRNA | CTD | PMID:23125180 | cisplatin | decreases expression | ISO | SEMA4D (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of SEMA4D mRNA | CTD | PMID:19561079 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of SEMA4D mRNA | CTD | PMID:15691709 | copper atom | multiple interactions | ISO | SEMA4D (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of SEMA4D mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | SEMA4D (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of SEMA4D mRNA | CTD | PMID:20971185 | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of SEMA4D mRNA | CTD | PMID:27523638 | dioxygen | increases expression | ISO | Sema4d (Mus musculus) | 6480464 | Oxygen deficiency results in increased expression of SEMA4D mRNA | CTD | PMID:24205000 | dorsomorphin | multiple interactions | ISO | SEMA4D (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | SEMA4D (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of SEMA4D mRNA | CTD | PMID:29803840 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of SEMA4D mRNA | CTD | PMID:29391264 | folic acid | multiple interactions | ISO | Sema4d (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of SEMA4D mRNA | CTD | PMID:22206623 | FR900359 | decreases phosphorylation | ISO | SEMA4D (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of SEMA4D protein | CTD | PMID:37730182 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of SEMA4D mRNA | CTD | PMID:22061828 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of SEMA4D mRNA | CTD | PMID:33387578 | hydrogen peroxide | increases expression | ISO | SEMA4D (Homo sapiens) | 6480464 | Hydrogen Peroxide results in increased expression of SEMA4D mRNA | CTD | PMID:18951874 | kainic acid | increases expression | EXP | | 6480464 | Kainic Acid results in increased expression of SEMA4D mRNA | CTD | PMID:19700661 | lipopolysaccharide | decreases expression | ISO | Sema4d (Mus musculus) | 6480464 | Lipopolysaccharides results in decreased expression of SEMA4D mRNA | CTD | PMID:12057914 | lipopolysaccharide | multiple interactions | ISO | SEMA4D (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of SEMA4D mRNA | CTD | PMID:35811015 | lycorine | decreases expression | ISO | SEMA4D (Homo sapiens) | 6480464 | lycorine results in decreased expression of SEMA4D mRNA | CTD | PMID:23376478 | maneb | multiple interactions | ISO | Sema4d (Mus musculus) | 6480464 | [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of SEMA4D mRNA | CTD | PMID:23017109 | methapyrilene | increases methylation | ISO | SEMA4D (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of SEMA4D intron | CTD | PMID:30157460 | methotrexate | affects expression | ISO | Sema4d (Mus musculus) | 6480464 | Methotrexate affects the expression of SEMA4D mRNA | CTD | PMID:18502557 | Monobutylphthalate | increases expression | EXP | | 6480464 | monobutyl phthalate results in increased expression of SEMA4D mRNA | CTD | PMID:29162477 | nickel atom | increases expression | ISO | SEMA4D (Homo sapiens) | 6480464 | Nickel results in increased expression of SEMA4D mRNA | CTD | PMID:24768652 and PMID:25583101 | nickel sulfate | increases expression | ISO | SEMA4D (Homo sapiens) | 6480464 | nickel sulfate results in increased expression of SEMA4D mRNA | CTD | PMID:22714537 | ozone | multiple interactions | ISO | Sema4d (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of SEMA4D mRNA | CTD | PMID:34911549 | ozone | multiple interactions | ISO | SEMA4D (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of SEMA4D mRNA | CTD | PMID:35430440 | paracetamol | affects expression | ISO | Sema4d (Mus musculus) | 6480464 | Acetaminophen affects the expression of SEMA4D mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of SEMA4D mRNA | CTD | PMID:33387578 | paraquat | multiple interactions | ISO | Sema4d (Mus musculus) | 6480464 | [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of SEMA4D mRNA | CTD | PMID:23017109 | perfluorohexanesulfonic acid | decreases expression | ISO | Sema4d (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in decreased expression of SEMA4D mRNA | CTD | PMID:37995155 | phenylmercury acetate | decreases expression | ISO | SEMA4D (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of SEMA4D mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | SEMA4D (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEMA4D mRNA | CTD | PMID:27188386 | pirinixic acid | decreases expression | ISO | Sema4d (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of SEMA4D mRNA | CTD | PMID:17426115 | potassium chromate | increases expression | ISO | SEMA4D (Homo sapiens) | 6480464 | potassium chromate(VI) results in increased expression of SEMA4D mRNA | CTD | PMID:22714537 | progesterone | multiple interactions | ISO | SEMA4D (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in increased expression of SEMA4D mRNA | CTD | PMID:20660070 | rac-lactic acid | decreases expression | ISO | SEMA4D (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of SEMA4D mRNA | CTD | PMID:30851411 | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of SEMA4D mRNA | CTD | PMID:28374803 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | SEMA4D (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of SEMA4D mRNA | CTD | PMID:35811015 | SB 431542 | multiple interactions | ISO | SEMA4D (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | increases expression | EXP | | 6480464 | Silicon Dioxide results in increased expression of SEMA4D mRNA | CTD | PMID:32721576 | silicon dioxide | increases expression | ISO | Sema4d (Mus musculus) | 6480464 | Silicon Dioxide results in increased expression of SEMA4D mRNA | CTD | PMID:29341224 | sodium arsenate | multiple interactions | ISO | SEMA4D (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of SEMA4D mRNA | CTD | PMID:32525701 | sodium arsenite | increases expression | ISO | Sema4d (Mus musculus) | 6480464 | sodium arsenite results in increased expression of SEMA4D mRNA | CTD | PMID:37682722 | sunitinib | decreases expression | ISO | SEMA4D (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of SEMA4D mRNA | CTD | PMID:31533062 | temozolomide | increases expression | ISO | SEMA4D (Homo sapiens) | 6480464 | Temozolomide results in increased expression of SEMA4D mRNA | CTD | PMID:31758290 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of SEMA4D mRNA | CTD | PMID:34492290 | titanium dioxide | decreases expression | ISO | Sema4d (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of SEMA4D mRNA | CTD | PMID:29264374 | trichostatin A | decreases expression | ISO | SEMA4D (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of SEMA4D mRNA | CTD | PMID:24935251 and PMID:26272509 | trichostatin A | multiple interactions | ISO | SEMA4D (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEMA4D mRNA | CTD | PMID:27188386 | triptonide | affects expression | ISO | Sema4d (Mus musculus) | 6480464 | triptonide affects the expression of SEMA4D mRNA | CTD | PMID:33045310 | tungsten | decreases expression | ISO | Sema4d (Mus musculus) | 6480464 | Tungsten results in decreased expression of SEMA4D mRNA | CTD | PMID:30912803 | valproic acid | increases methylation | ISO | SEMA4D (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of SEMA4D gene | CTD | PMID:29154799 | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of SEMA4D mRNA | CTD | PMID:23034163 | vorinostat | multiple interactions | ISO | SEMA4D (Homo sapiens) | 6480464 | [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression 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Gene Ontology Annotations Click to see Annotation Detail View
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