Gene: Als2 (ALS2, alsin Rho guanine nucleotide exchange factor) Rattus norvegicus
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Symbol: Als2
Name: ALS2, alsin Rho guanine nucleotide exchange factor
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); protein homodimerization activity (ortholog); protein serine/threonine kinase activator activity (ortholog); INVOLVED IN axonogenesis; cell death; in utero embryonic development; PARTICIPATES IN amyotrophic lateral sclerosis pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); amyotrophic lateral sclerosis type 2 (ortholog); Amyotrophic Lateral Sclerosis, Autosomal Recessive (ortholog); FOUND IN axon; cytoplasm; dendrite; INTERACTS WITH bisphenol A; N,N-diethyl-m-toluamide; permethrin
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: alsin; alsin Rho guanine nucleotide exchange factor; amyotrophic lateral sclerosis 2 (juvenile); amyotrophic lateral sclerosis 2 (juvenile) homolog (human); amyotrophic lateral sclerosis 2 protein homolog; amyotrophic lateral sclerosis protein 2 homolog; LOC363235
Orthologs:
Homo sapiens (human) : ALS2 (ALS2, alsin Rho guanine nucleotide exchange factor)  HGNC  Alliance
Mus musculus (house mouse) : Als2 (alsin Rho guanine nucleotide exchange factor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Als2 (ALS2, alsin Rho guanine nucleotide exchange factor)
Pan paniscus (bonobo/pygmy chimpanzee) : ALS2 (ALS2, alsin Rho guanine nucleotide exchange factor)
Canis lupus familiaris (dog) : ALS2 (ALS2, alsin Rho guanine nucleotide exchange factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Als2 (ALS2, alsin Rho guanine nucleotide exchange factor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0965,961,361 - 66,034,396 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0965,768,594 - 65,841,938 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4957,741,679 - 57,812,652 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1957,887,443 - 57,959,517 (-)NCBI
Celera958,052,438 - 58,123,222 (-)NCBICelera
Cytogenetic Map9q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Als2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1310372
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2018-08-08
Status: ACTIVE