Cops5 (COP9 signalosome subunit 5)

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Gene: Cops5 (COP9 signalosome subunit 5) Rattus norvegicus

Analyze

Symbol:

Cops5

Name:

COP9 signalosome subunit 5

RGD ID:

1310301

Description:

Predicted to enable enzyme binding activity; macrophage migration inhibitory factor binding activity; and ubiquitin-like protein peptidase activity. Predicted to be involved in several processes, including protein modification by small protein removal; regulation of DNA-templated transcription; and regulation of cellular response to stress. Predicted to act upstream of or within regulation of cell cycle. Predicted to be located in several cellular components, including nucleoplasm; perinuclear region of cytoplasm; and synaptic vesicle. Predicted to be part of COP9 signalosome. Predicted to be active in cytoplasm. Orthologous to human COPS5 (COP9 signalosome subunit 5); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 2,4-dinitrotoluene; bisphenol A; C60 fullerene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

COP9 (constitutive photomorphogenic) homolog, subunit 5; COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana); COP9 constitutive photomorphogenic homolog subunit 5; COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis); COP9 signalosome complex subunit 5; LOC312916; MGC112728

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	COPS5 (COP9 signalosome subunit 5)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Cops5 (COP9 signalosome subunit 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cops5 (COP9 signalosome subunit 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	COPS5 (COP9 signalosome subunit 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	COPS5 (COP9 signalosome subunit 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cops5 (COP9 signalosome subunit 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	COPS5 (COP9 signalosome subunit 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	COPS5 (COP9 signalosome subunit 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cops5 (COP9 signalosome subunit 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ARHGEF17 (Rho guanine nucleotide exchange factor 17)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	COPS5 (COP9 signalosome subunit 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cops5 (COP9 signalosome subunit 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cops5 (COP9 signalosome subunit 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CSN5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	RRI1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	csn-5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cops5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	9,192,233 - 9,210,498 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	9,192,100 - 9,210,731 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	11,344,273 - 11,362,693 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	5	12,971,568 - 12,989,792 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	5	12,678,930 - 12,697,346 (+)	NCBI	Rnor_WKY
Rnor_6.0	5	8,876,090 - 8,894,345 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	8,876,044 - 8,894,339 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	13,684,111 - 13,702,378 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	8,709,214 - 8,727,277 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	8,709,213 - 8,727,277 (+)	NCBI
Celera	5	8,703,366 - 8,721,421 (+)	NCBI		Celera
Cytogenetic Map	5	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Neoplasms (IEP)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

Joubert syndrome 21 (ISO)

Stevens-Johnson syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2-methylcholine (ISO)

amphetamine (ISO)

antimycin A (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

C60 fullerene (EXP)

captan (ISO)

carboplatin (ISO)

cisplatin (ISO)

cylindrospermopsin (ISO)

deguelin (ISO)

diarsenic trioxide (ISO)

dicrotophos (ISO)

disodium selenite (ISO)

emodin (ISO)

fenpyroximate (ISO)

ferroheme b (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

folpet (ISO)

heme b (ISO)

hydrogen peroxide (ISO)

ivermectin (ISO)

methidathion (ISO)

nefazodone (EXP)

nimesulide (EXP)

ozone (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

quercetin (ISO)

resveratrol (ISO)

rotenone (ISO)

tebufenpyrad (ISO)

trimellitic anhydride (ISO)

valdecoxib (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (ISO)

exosomal secretion (ISO)

negative regulation of apoptotic process (ISO)

positive regulation of apoptotic process (ISO)

positive regulation of DNA-binding transcription factor activity (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

protein deneddylation (IBA,ISO)

protein deubiquitination (ISO)

regulation of cell cycle (ISO)

regulation of IRE1-mediated unfolded protein response (ISO)

regulation of JNK cascade (ISO)

Cellular Component

chromatin (IEA,ISO)

COP9 signalosome (IBA,ISO)

cytoplasm (IBA,ISO)

cytosol (ISO)

mitochondrion (ISO)

nucleoplasm (IEA,ISO)

nucleus (ISO)

perinuclear region of cytoplasm (ISO)

synaptic vesicle (ISO)

Molecular Function

deNEDDylase activity (IBA)

enzyme binding (ISO)

macrophage migration inhibitory factor binding (ISO)

metal-dependent deubiquitinase activity (ISO)

metallopeptidase activity (IBA,ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

hypoxia inducible factor pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Down-regulation of the cyclin-dependent kinase inhibitor p57 is mediated by Jab1/Csn5 in hepatocarcinogenesis.	Guo H, etal., Hepatology. 2016 Mar;63(3):898-913. doi: 10.1002/hep.28372. Epub 2016 Jan 14.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9707402	PMID:12477932	PMID:15234121	PMID:15299027	PMID:16300740	PMID:16410250	PMID:17050680	PMID:18850735	PMID:19141280	PMID:19214193	PMID:19246649	PMID:20093369
PMID:20978819	PMID:21102408	PMID:21817065	PMID:24091666

Genomics

Comparative Map Data

Cops5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	9,192,233 - 9,210,498 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	9,192,100 - 9,210,731 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	11,344,273 - 11,362,693 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	5	12,971,568 - 12,989,792 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	5	12,678,930 - 12,697,346 (+)	NCBI	Rnor_WKY
Rnor_6.0	5	8,876,090 - 8,894,345 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	8,876,044 - 8,894,339 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	13,684,111 - 13,702,378 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	8,709,214 - 8,727,277 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	8,709,213 - 8,727,277 (+)	NCBI
Celera	5	8,703,366 - 8,721,421 (+)	NCBI		Celera
Cytogenetic Map	5	q11	NCBI

COPS5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	67,043,079 - 67,062,133 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	8	67,043,079 - 67,083,783 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	67,955,314 - 67,974,368 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	68,117,868 - 68,137,116 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	68,117,869 - 68,137,116	NCBI
Celera	8	63,948,870 - 63,967,877 (-)	NCBI		Celera
Cytogenetic Map	8	q13.1	NCBI
HuRef	8	63,447,901 - 63,467,140 (-)	NCBI		HuRef
CHM1_1	8	68,010,363 - 68,029,584 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	67,469,560 - 67,488,599 (-)	NCBI		T2T-CHM13v2.0

Cops5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	10,094,825 - 10,108,384 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	10,094,826 - 10,108,393 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	10,024,600 - 10,038,159 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	10,024,601 - 10,038,168 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	10,014,911 - 10,027,979 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	10,010,044 - 10,023,120 (-)	NCBI		MGSCv36	mm8
Celera	1	9,998,994 - 10,012,139 (-)	NCBI		Celera
Cytogenetic Map	1	A2	NCBI
cM Map	1	2.29	NCBI

Cops5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955444	12,217,337 - 12,234,193 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955444	12,217,337 - 12,233,570 (+)	NCBI	ChiLan1.0	ChiLan1.0

COPS5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	8	58,422,637 - 58,444,975 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	63,586,062 - 63,605,213 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	65,247,796 - 65,266,736 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	65,247,950 - 65,266,511 (-)	Ensembl	panpan1.1		panPan2

COPS5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	29	16,562,234 - 16,579,082 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	29	16,562,234 - 16,578,847 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	29	16,878,268 - 16,895,114 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	29	16,643,359 - 16,660,206 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	29	16,643,362 - 16,660,004 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	29	16,674,884 - 16,691,721 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	29	16,775,204 - 16,792,055 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	29	17,031,587 - 17,048,439 (-)	NCBI		UU_Cfam_GSD_1.0

Cops5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	67,734,939 - 67,749,504 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936496	7,035,924 - 7,050,786 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936496	7,035,973 - 7,050,538 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

COPS5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	67,739,251 - 67,758,150 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	67,740,528 - 67,758,153 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	73,801,311 - 73,818,936 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

COPS5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	62,905,924 - 62,925,205 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	62,905,906 - 62,925,201 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	78,579,728 - 78,598,284 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cops5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624744	24,287,443 - 24,308,024 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624744	24,287,278 - 24,308,171 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Cops5
129 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	104
Count of miRNA genes:	87
Interacting mature miRNAs:	95
Transcripts:	ENSRNOT00000008877
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	1	90450412	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	1	131345958	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	729470	86724018	Rat
2312562	Pur18	Proteinuria QTL 18	2.6	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	5	2138965	32656739	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
8662454	Vetf3	Vascular elastic tissue fragility QTL 3	27.4		artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	5	2282226	69540447	Rat
2313085	Bss59	Bone structure and strength QTL 59	2.9	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	5	3844018	26141981	Rat
1300117	Hrtrt8	Heart rate QTL 8	3.49		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	3844018	47869213	Rat
61462	Niddm10	Non-insulin dependent diabetes mellitus QTL 10	3.9	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	5	5112159	47171491	Rat
631827	Alc4	Alcohol consumption QTL 4	3.5		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	5	8187501	18616199	Rat
2293666	Bmd38	Bone mineral density QTL 38	4.4		femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	5	8948228	53948228	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001025695	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006237758	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC098736	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473984	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214411	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ215612	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ215908	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216401	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ227775	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232542	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000157	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000008877 ⟹ ENSRNOP00000008877

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	9,192,100 - 9,210,731 (+)	Ensembl
Rnor_6.0 Ensembl	5	8,876,044 - 8,894,339 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000099954 ⟹ ENSRNOP00000084575

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	9,192,100 - 9,210,731 (+)	Ensembl

RefSeq Acc Id:

NM_001025695 ⟹ NP_001020866

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	9,192,431 - 9,210,498 (+)	NCBI
Rnor_6.0	5	8,876,281 - 8,894,342 (+)	NCBI
Rnor_5.0	5	13,684,111 - 13,702,378 (+)	NCBI
RGSC_v3.4	5	8,709,214 - 8,727,277 (+)	RGD
Celera	5	8,703,366 - 8,721,421 (+)	RGD

Sequence:

show sequence

TGAGAGTCTAGTGAGTGTGCACCCGTGGTGGGGAAGGTGCAAAGCCCGCACGCTGAGGCCCAGT
AGAATAAAGTTGCATCTTGGTTGTGGAGACTACAGCTTCTCCGGTCCCTCGGCCATGACAGCTT
CCGGGAGTGGTATGGCCCAGAAGACCTGGGAATTGGCCAACAACATGCAGGAAGCGCAGAGTAT
CGATGAAATCTACAAATATGACAAAAAACAACAACAAGAAATCCTGGCGGCGAAACCCTGGACT
AAGGATCACCACTACTTTAAATACTGCAAAATCTCTGCGTTGGCACTGCTGAAAATGGTGATGC
ATGCCAGGTCAGGAGGCAACCTGGAGGTGATGGGTTTGATGCTCGGGAAAGTGGATGGAGAGAC
CATGATCATCATGGACAGCTTTGCTTTGCCTGTAGAGGGCACTGAAACCCGAGTAAATGCCCAG
GCTGCTGCATACGAGTACATGGCTGCATACATAGAAAATGCCAAACAGGTTGGCCGCCTTGAGA
ATGCAATTGGTTGGTATCACAGCCACCCTGGTTATGGCTGCTGGCTCTCCGGAATTGATGTTAG
TACACAGATGCTTAACCAGCAGTTTCAGGAACCATTTGTAGCAGTGGTGATTGACCCAACCAGA
ACAATATCTGCAGGGAAGGTGAATCTTGGCGCCTTTAGGACATATCCAAAGGGCTATAAGCCTC
CTGATGAAGGACCTTCAGAGTACCAGACTATCCCACTCAATAAAATAGAAGATTTTGGCGTGCA
CTGCAAACAATATTATGCCTTAGAAGTCTCATATTTCAAATCCTCTTTGGATCGTAAACTACTT
GAGCTCTTGTGGAATAAATACTGGGTGAACACCCTGAGTTCCTCTAGCTTGCTTACCAATGCTG
ACTATACCACAGGCCAGGTGTTTGATCTGTCTGAGAAGTTAGAGCAGTCGGAAGCCCAGCTGGG
GCGTGGGAGTTTCATGTTGGGTTTAGAAACACATGACCGCAAGTCAGAAGACAAACTTGCCAAA
GCTACGAGAGACAGCTGTAAAACCACCATAGAAGCCATCCATGGACTGATGTCTCAGGTTATTA
AGGATAAACTGTTTAATCAAATTAACGTTGCTTAGTTACTGCTGAGTACTCTTCCTCAGAGCTG
GCGTGCGGAAGGAGAAGAAGCTCAAGGAACATTCTAACCCAGTTACCAGAACTCAGATAGAAGA
CTAAGGTGCTGTGTGACGTCCTGAGTATTAGCACTGTAATAAAACTGTCACATGAAAAAAAAAA
AAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006237758 ⟹ XP_006237820

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	9,192,233 - 9,210,498 (+)	NCBI
Rnor_6.0	5	8,876,090 - 8,894,345 (+)	NCBI
Rnor_5.0	5	13,684,111 - 13,702,378 (+)	NCBI

Sequence:

show sequence

TTTGCGTCCCTCCCAGTTCACACGTACGGATTTCAGAGCCAGCATGTCCTCGTTTCGTTCGCAA
AACTATTATTAGCCGAGCCGAGCGGACCCCTAGGAAGTGTTTTCTATGTCGCTACGCCGCCGCC
GCGCCCCGACGCGCGAATGGTCTGGACCAACGTCACCTCCGGTCTCAAGTGTCATGGCTGCCTT
GAGAGTCTATCACCACTACTTTAAATACTGCAAAATCTCTGCGTTGGCACTGCTGAAAATGGTG
ATGCATGCCAGGTCAGGAGGCAACCTGGAGGTGATGGGTTTGATGCTCGGGAAAGTGGATGGAG
AGACCATGATCATCATGGACAGCTTTGCTTTGCCTGTAGAGGGCACTGAAACCCGAGTAAATGC
CCAGGCTGCTGCATACGAGTACATGGCTGCATACATAGAAAATGCCAAACAGGTTGGCCGCCTT
GAGAATGCAATTGGTTGGTATCACAGCCACCCTGGTTATGGCTGCTGGCTCTCCGGAATTGATG
TTAGTACACAGATGCTTAACCAGCAGTTTCAGGAACCATTTGTAGCAGTGGTGATTGACCCAAC
CAGAACAATATCTGCAGGGAAGGTGAATCTTGGCGCCTTTAGGACATATCCAAAGGGCTATAAG
CCTCCTGATGAAGGACCTTCAGAGTACCAGACTATCCCACTCAATAAAATAGAAGATTTTGGCG
TGCACTGCAAACAATATTATGCCTTAGAAGTCTCATATTTCAAATCCTCTTTGGATCGTAAACT
ACTTGAGCTCTTGTGGAATAAATACTGGGTGAACACCCTGAGTTCCTCTAGCTTGCTTACCAAT
GCTGACTATACCACAGGCCAGGTGTTTGATCTGTCTGAGAAGTTAGAGCAGTCGGAAGCCCAGC
TGGGGCGTGGGAGTTTCATGTTGGGTTTAGAAACACATGACCGCAAGTCAGAAGACAAACTTGC
CAAAGCTACGAGAGACAGCTGTAAAACCACCATAGAAGCCATCCATGGACTGATGTCTCAGGTT
ATTAAGGATAAACTGTTTAATCAAATTAACGTTGCTTAGTTACTGCTGAGTACTCTTCCTCAGA
GCTGGCGTGCGGAAGGAGAAGAAGCTCAAGGAACATTCTAACCCAGTTACCAGAACTCAGATAG
AAGACTAAGGTGCTGTGTGACGTCCTGAGTATTAGCACTGTAATAAAACTGTCACATGAAATTG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001020866	(Get FASTA)	NCBI Sequence Viewer
	XP_006237820	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98736	(Get FASTA)	NCBI Sequence Viewer
	EDM11550	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001020866 ⟸ NM_001025695

- UniProtKB:

Q4KM69 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLK
MVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVG
RLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKG
YKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLL
TNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMS
QVIKDKLFNQINVA

hide sequence

RefSeq Acc Id:

XP_006237820 ⟸ XM_006237758

- Peptide Label:

isoform X1

- Sequence:

show sequence

MSLRRRRAPTREWSGPTSPPVSSVMAALRVYHHYFKYCKISALALLKMVMHARSGGNLEVMGLM
LGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGC
WLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLN
KIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKL
EQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQINVA

hide sequence

RefSeq Acc Id:

ENSRNOP00000008877 ⟸ ENSRNOT00000008877

RefSeq Acc Id:

ENSRNOP00000084575 ⟸ ENSRNOT00000099954

Protein Domains

MPN

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F7EUU4-F1-model_v2	AlphaFold	F7EUU4	1-389	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693534

Promoter ID:

EPDNEW_R4059

Type:

initiation region

Name:

Cops5_1

Description:

COP9 signalosome subunit 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	8,876,051 - 8,876,111	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310301	AgrOrtholog
BioCyc Gene	G2FUF-42210	BioCyc
Ensembl Genes	ENSRNOG00000006499	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000008877	ENTREZGENE
	ENSRNOP00000008877.5	UniProtKB/TrEMBL
	ENSRNOP00000084575.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000008877	ENTREZGENE
	ENSRNOT00000008877.7	UniProtKB/TrEMBL
	ENSRNOT00000099954.1	UniProtKB/TrEMBL
Gene3D-CATH	Cytidine Deaminase, domain 2	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7385252	IMAGE-MGC_LOAD
InterPro	CSN5_C	UniProtKB/TrEMBL
	Mov34_MPN_PAD1	UniProtKB/TrEMBL
	MPN	UniProtKB/TrEMBL
KEGG Report	rno:312916	UniProtKB/TrEMBL
MGC_CLONE	MGC:112728	IMAGE-MGC_LOAD
NCBI Gene	312916	ENTREZGENE
PANTHER	EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED	UniProtKB/TrEMBL
	PTHR10410:SF6	UniProtKB/TrEMBL
Pfam	CSN5_C	UniProtKB/TrEMBL
	Mov34	UniProtKB/TrEMBL
PhenoGen	Cops5	PhenoGen
PROSITE	MPN	UniProtKB/TrEMBL
SMART	JAB_MPN	UniProtKB/TrEMBL
Superfamily-SCOP	JAB1/MPN domain	UniProtKB/TrEMBL
UniProt	A0A8I5ZYE7_RAT	UniProtKB/TrEMBL
	F7EUU4_RAT	UniProtKB/TrEMBL
	Q4KM69	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-03-20	Cops5	COP9 signalosome subunit 5	Cops5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-10-23	Cops5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	Cops5	COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Cops5	COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)	Cops5_predicted	COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana) (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Cops5_predicted	COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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