Rarres2 (retinoic acid receptor responder 2) - Rat Genome Database

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Gene: Rarres2 (retinoic acid receptor responder 2) Rattus norvegicus
Analyze
Symbol: Rarres2
Name: retinoic acid receptor responder 2
RGD ID: 1309874
Description: Predicted to enable signaling receptor binding activity. Involved in several processes, including cellular response to insulin stimulus; response to activity; and response to caloric restriction. Located in extracellular space. Biomarker of metabolic dysfunction-associated steatotic liver disease; obesity; polycystic ovary syndrome; and type 2 diabetes mellitus. Orthologous to human RARRES2 (retinoic acid receptor responder 2); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: chemerin; LOC297073; MGC108804; retinoic acid receptor responder (tazarotene induced) 2; retinoic acid receptor responder protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Rarres2em1Msu  
Genetic Models: SD-Rarres2em1Msu
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8478,853,450 - 78,856,652 (-)NCBIGRCr8
mRatBN7.2477,522,549 - 77,525,733 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl477,522,535 - 77,525,556 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx482,729,894 - 82,732,878 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0478,505,395 - 78,508,379 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0476,945,676 - 76,948,660 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0478,205,809 - 78,208,956 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl478,205,812 - 78,208,767 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04142,869,493 - 142,872,619 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4476,659,507 - 76,662,465 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1476,935,636 - 76,938,595 (-)NCBI
Celera472,460,060 - 72,463,020 (-)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
Aroclor 1254  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
colforsin daropate hydrochloride  (EXP)
copper(II) sulfate  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
flutamide  (EXP)
fructose  (ISO)
fulvestrant  (ISO)
glucose  (ISO)
GW 4064  (ISO)
ketoconazole  (EXP)
Licochalcone B  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
MK-2206  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
oxaliplatin  (EXP)
p-toluidine  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
quercetin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
tributylstannane  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification of chemerin as a novel FXR target gene down-regulated in the progression of nonalcoholic steatohepatitis. Deng Y, etal., Endocrinology. 2013 May;154(5):1794-801. doi: 10.1210/en.2012-2126. Epub 2013 Mar 18.
2. Different blood pressure responses in hypertensive rats following chemerin mRNA inhibition in dietary high fat compared to dietary high-salt conditions. Ferland DJ, etal., Physiol Genomics. 2019 Nov 1;51(11):553-561. doi: 10.1152/physiolgenomics.00050.2019. Epub 2019 Oct 7.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Chemerin is associated with inflammatory markers and metabolic syndrome phenotypes in hypertension patients. Gu P, etal., Clin Exp Hypertens. 2014;36(5):326-32. doi: 10.3109/10641963.2013.827697. Epub 2013 Sep 18.
6. Beneficial effects of pioglitazone and metformin in murine model of polycystic ovaries via improvement of chemerin gene up-regulation. Kabiri N, etal., Daru. 2014 Apr 24;22:39. doi: 10.1186/2008-2231-22-39.
7. Aerobic exercise decreases chemerin/CMKLR1 in the serum and peripheral metabolic organs of obesity and diabetes rats by increasing PPARγ. Lin X, etal., Nutr Metab (Lond). 2019 Mar 5;16:17. doi: 10.1186/s12986-019-0344-9. eCollection 2019.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Chemerin gene expression is regulated by food restriction and food restriction-refeeding in rat adipose tissue but not in liver. Stelmanska E, etal., Regul Pept. 2013 Feb 10;181:22-9. doi: 10.1016/j.regpep.2012.12.001. Epub 2013 Jan 14.
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14. The chemerin knockout rat reveals chemerin dependence in female, but not male, experimental hypertension. Watts SW, etal., FASEB J. 2018 Jun 15:fj201800479. doi: 10.1096/fj.201800479.
15. Probiotics Improve Chemerin Levels and Metabolic Syndrome Parameters in Obese Rats Çelik MN and Ünlü Söğüt M, Balkan Med J. 2019 Aug 22;36(5):270-275. doi: 10.4274/balkanmedj.galenos.2019.2019.2.61. Epub 2019 Jul 9.
Additional References at PubMed
PMID:9204961   PMID:14530373   PMID:17635925   PMID:18242188   PMID:18492766   PMID:19443732   PMID:22521290   PMID:22948218   PMID:23154239   PMID:23254195   PMID:23376485   PMID:23527010  
PMID:23559624   PMID:24006456   PMID:24269538   PMID:24301613   PMID:25471554   PMID:27225311   PMID:27371688   PMID:27612613   PMID:27742615   PMID:27792753   PMID:29467310   PMID:29688269  
PMID:31835675   PMID:31905805   PMID:31965243   PMID:32092101   PMID:34450172   PMID:34461109   PMID:37294893  


Genomics

Comparative Map Data
Rarres2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8478,853,450 - 78,856,652 (-)NCBIGRCr8
mRatBN7.2477,522,549 - 77,525,733 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl477,522,535 - 77,525,556 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx482,729,894 - 82,732,878 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0478,505,395 - 78,508,379 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0476,945,676 - 76,948,660 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0478,205,809 - 78,208,956 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl478,205,812 - 78,208,767 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04142,869,493 - 142,872,619 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4476,659,507 - 76,662,465 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1476,935,636 - 76,938,595 (-)NCBI
Celera472,460,060 - 72,463,020 (-)NCBICelera
Cytogenetic Map4q24NCBI
RARRES2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387150,338,329 - 150,341,629 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7150,338,317 - 150,341,662 (-)EnsemblGRCh38hg38GRCh38
GRCh377150,035,418 - 150,038,718 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367149,666,351 - 149,669,639 (-)NCBINCBI36Build 36hg18NCBI36
Build 347149,473,066 - 149,476,354NCBI
Celera7144,592,497 - 144,595,853 (-)NCBICelera
Cytogenetic Map7q36.1NCBI
HuRef7143,851,911 - 143,855,271 (-)NCBIHuRef
CHM1_17150,042,248 - 150,045,604 (-)NCBICHM1_1
T2T-CHM13v2.07151,516,581 - 151,519,881 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27149,373,258 - 149,376,614 (-)NCBI
Rarres2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39648,546,630 - 48,549,778 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl648,546,630 - 48,549,723 (-)EnsemblGRCm39 Ensembl
GRCm38648,569,696 - 48,572,845 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl648,569,696 - 48,572,789 (-)EnsemblGRCm38mm10GRCm38
MGSCv37648,519,697 - 48,522,669 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36648,499,284 - 48,502,256 (-)NCBIMGSCv36mm8
Celera649,080,699 - 49,083,671 (-)NCBICelera
Cytogenetic Map6B2.3NCBI
cM Map623.55NCBI
Rarres2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554914,955,068 - 4,956,956 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554914,954,809 - 4,957,724 (-)NCBIChiLan1.0ChiLan1.0
RARRES2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26186,784,917 - 186,788,469 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1738,795,181 - 38,798,579 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07141,953,600 - 141,956,991 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17154,106,275 - 154,109,635 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7154,106,275 - 154,109,635 (-)Ensemblpanpan1.1panPan2
RARRES2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11614,671,345 - 14,675,000 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1614,671,130 - 14,674,926 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1615,279,856 - 15,283,838 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01616,386,098 - 16,390,089 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1616,386,104 - 16,389,726 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11614,766,189 - 14,770,162 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01615,347,148 - 15,351,121 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01615,397,620 - 15,401,605 (-)NCBIUU_Cfam_GSD_1.0
Rarres2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051186,951,051 - 6,954,267 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365275,947,960 - 5,952,579 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365275,949,161 - 5,952,367 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RARRES2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1855,903,699 - 55,906,945 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11855,903,693 - 55,906,976 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RARRES2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121118,487,199 - 118,490,561 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21118,487,506 - 118,489,516 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607214,446,853 - 14,450,217 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rarres2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248006,139,006 - 6,140,679 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248006,138,236 - 6,140,922 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rarres2
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:38
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000033918
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45664777678882945Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45664777678882945Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45664777678882945Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45664777678882945Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45711443281266970Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711470578881294Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45843213392991462Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45863587778886137Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46293326987483707Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)46293350882490359Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in mean arterial blood pressure (CMO:0002035)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in systolic blood pressure (CMO:0000747)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in pulse pressure (CMO:0001882)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)46588210796130297Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)470808386115808386Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)47735672177687411Rat

Markers in Region
AI072016  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2477,522,613 - 77,522,902 (+)MAPPERmRatBN7.2
Rnor_6.0478,205,874 - 78,206,162NCBIRnor6.0
Rnor_5.04142,869,558 - 142,869,846UniSTSRnor5.0
RGSC_v3.4476,659,572 - 76,659,860UniSTSRGSC3.4
Celera472,460,125 - 72,460,413UniSTS
Cytogenetic Map4q24UniSTS


Genetic Models
This gene Rarres2 is modified in the following models/strains:
SD-Rarres2em1Msu    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 8 8 8
Medium 3 33 47 31 19 31 6 9 32 35 36 11 6
Low 10 2 2 2 2 2 40 5 2
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000033918   ⟹   ENSRNOP00000038525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl477,522,535 - 77,525,556 (-)Ensembl
Rnor_6.0 Ensembl478,205,812 - 78,208,767 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096206   ⟹   ENSRNOP00000091959
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl477,524,222 - 77,525,556 (-)Ensembl
RefSeq Acc Id: NM_001013427   ⟹   NP_001013445
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8478,853,450 - 78,856,408 (-)NCBI
mRatBN7.2477,522,549 - 77,525,507 (-)NCBI
Rnor_6.0478,205,809 - 78,208,767 (-)NCBI
Rnor_5.04142,869,493 - 142,872,619 (-)NCBI
RGSC_v3.4476,659,507 - 76,662,465 (-)RGD
Celera472,460,060 - 72,463,020 (-)RGD
Sequence:
RefSeq Acc Id: XM_006236415   ⟹   XP_006236477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8478,853,450 - 78,856,652 (-)NCBI
mRatBN7.2477,522,549 - 77,525,733 (-)NCBI
Rnor_6.0478,205,809 - 78,208,956 (-)NCBI
Rnor_5.04142,869,493 - 142,872,619 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006236416   ⟹   XP_006236478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8478,853,450 - 78,856,511 (-)NCBI
mRatBN7.2477,522,549 - 77,525,595 (-)NCBI
Rnor_6.0478,205,809 - 78,208,855 (-)NCBI
Rnor_5.04142,869,493 - 142,872,619 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063285767   ⟹   XP_063141837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8478,853,450 - 78,856,639 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001013445   ⟸   NM_001013427
- Peptide Label: precursor
- UniProtKB: Q5BK77 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236477   ⟸   XM_006236415
- Peptide Label: isoform X1
- UniProtKB: Q5BK77 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236478   ⟸   XM_006236416
- Peptide Label: isoform X2
- UniProtKB: F7FP65 (UniProtKB/TrEMBL),   A6K0G1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000038525   ⟸   ENSRNOT00000033918
RefSeq Acc Id: ENSRNOP00000091959   ⟸   ENSRNOT00000096206
RefSeq Acc Id: XP_063141837   ⟸   XM_063285767
- Peptide Label: isoform X2
- UniProtKB: F7FP65 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BK77-F1-model_v2 AlphaFold Q5BK77 1-163 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693026
Promoter ID:EPDNEW_R3549
Type:multiple initiation site
Name:Rarres2_1
Description:retinoic acid receptor responder 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0478,208,785 - 78,208,845EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309874 AgrOrtholog
BioCyc Gene G2FUF-44954 BioCyc
Ensembl Genes ENSRNOG00000024705 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033918.6 UniProtKB/TrEMBL
  ENSRNOT00000096206.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7323591 IMAGE-MGC_LOAD
InterPro Chemerin UniProtKB/TrEMBL
  Cystatin_sf UniProtKB/TrEMBL
KEGG Report rno:297073 UniProtKB/TrEMBL
MGC_CLONE MGC:108804 IMAGE-MGC_LOAD
NCBI Gene 297073 ENTREZGENE
PANTHER PTHR15106 UniProtKB/TrEMBL
  RETINOIC ACID RECEPTOR RESPONDER PROTEIN 2 UniProtKB/TrEMBL
PhenoGen Rarres2 PhenoGen
RatGTEx ENSRNOG00000024705 RatGTEx
Superfamily-SCOP SSF54403 UniProtKB/TrEMBL
UniProt A0A8I6AUZ6_RAT UniProtKB/TrEMBL
  A6K0G0_RAT UniProtKB/TrEMBL
  A6K0G1 ENTREZGENE, UniProtKB/TrEMBL
  F7FP65 ENTREZGENE, UniProtKB/TrEMBL
  Q5BK77 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Rarres2  retinoic acid receptor responder 2  Rarres2  retinoic acid receptor responder (tazarotene induced) 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Rarres2  retinoic acid receptor responder (tazarotene induced) 2  Rarres2_predicted  retinoic acid receptor responder (tazarotene induced) 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Rarres2_predicted  retinoic acid receptor responder (tazarotene induced) 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED