Car1 (carbonic anhydrase 1) - Rat Genome Database

Name: Car1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Car1 (carbonic anhydrase 1) Rattus norvegicus

Analyze

Symbol:

Car1

Name:

carbonic anhydrase 1

RGD ID:

1309780

Description:

Predicted to enable arylesterase activity; carbonate dehydratase activity; and cyanamide hydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be located in cytoplasm. Orthologous to human CA1 (carbonic anhydrase 1); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine pharmacodynamics pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

CA-I; Ca1; Carbonate dehydratase I; carbonic anhydrase I; cyanamide hydratase CA1; LOC310218; LOC679649; similar to betaine-homocysteine methyltransferase 2

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CA1 (carbonic anhydrase 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Car1 (carbonic anhydrase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ca1 (carbonic anhydrase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CA1 (carbonic anhydrase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CA1 (carbonic anhydrase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ca1 (carbonic anhydrase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CA1 (carbonic anhydrase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CA1 (carbonic anhydrase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ca1 (carbonic anhydrase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	CA1 (carbonic anhydrase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Car1 (carbonic anhydrase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cahz (carbonic anhydrase)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	ca2 (carbonic anhydrase II)	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CAH1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cah-4	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	cah-5	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ca1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	88,550,681 - 88,593,454 (+)	NCBI		GRCr8
mRatBN7.2	2	86,829,436 - 86,872,209 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	86,861,897 - 86,872,208 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	93,154,953 - 93,195,719 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	91,275,953 - 91,316,725 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	86,332,778 - 86,373,541 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	88,185,204 - 88,227,486 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	88,217,188 - 88,227,479 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	107,958,483 - 108,000,765 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	88,166,412 - 88,210,693 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	88,143,727 - 88,155,654 (+)	NCBI
Celera	2	82,427,032 - 82,469,698 (+)	NCBI		Celera
Cytogenetic Map	2	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenocarcinoma (ISO)

esophagus squamous cell carcinoma (ISO)

genetic disease (ISO)

inherited metabolic disorder (ISO)

metabolic acidosis (ISO)

pneumoconiosis (ISO)

Stomach Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

1H-1,2,4-triazole (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-di-tert-butylphenol (ISO)

2,6-Dimethylphenol (ISO)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acetazolamide (ISO)

aflatoxin B1 (ISO)

anthocyanin (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bleomycin A2 (EXP)

bromobenzene (EXP)

butylated hydroxyanisole (ISO)

C60 fullerene (EXP)

cadmium dichloride (EXP)

candesartan (ISO)

carbon nanotube (ISO)

carbonates (ISO)

CGP 52608 (ISO)

chalcone (ISO)

chloric acid (ISO)

cobalt atom (ISO)

cobalt dichloride (ISO)

coumarin (ISO)

dibutyl phthalate (ISO)

diclofenac (ISO)

epoxiconazole (ISO)

erythromycin estolate (EXP)

ethanol (EXP,ISO)

ethoxzolamide (ISO)

ferroheme b (EXP)

flavonoids (ISO)

gentamycin (EXP)

guaiacol (ISO)

heme b (EXP)

hydrazinecarbothioamide (ISO)

hydrogencarbonate (ISO)

indometacin (ISO)

irbesartan (ISO)

lead(0) (ISO)

malvidin 3-O-beta-D-glucoside (ISO)

malvin (ISO)

mercury atom (ISO)

mercury(0) (ISO)

methamphetamine (EXP)

Methazolamide (ISO)

methylamines (ISO)

N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide (ISO)

N-nitrosodiethylamine (ISO)

N-phenylthiourea (ISO)

nitric acid (ISO)

nitrofen (EXP)

orphenadrine (EXP)

oryzalin (ISO)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

pelargonidin 3-O-beta-D-glucoside (ISO)

pelargonidin 3-O-beta-D-glucoside chloride (ISO)

perchlorate (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phenylephrine (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

propofol (ISO)

pyrimidines (ISO)

rac-lactic acid (ISO)

rifampicin (ISO)

rotenone (EXP)

senecionine (ISO)

silychristin (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sodium fluoride (ISO)

sulfamic acid (ISO)

sulfates (ISO)

synephrine (ISO)

tetrachloromethane (EXP,ISO)

thiazolidines (ISO)

thioacetamide (EXP)

thiophenes (ISO)

thiourea (ISO)

topiramate (ISO)

topotecan (EXP)

trans-chalcone (ISO)

triazoles (ISO)

triphenyl phosphate (EXP)

Triptolide (EXP)

tungstate (ISO)

valproic acid (ISO)

vanillin (ISO)

voriconazole (ISO)

zinc atom (ISO)

zinc(0) (ISO)

zonisamide (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

one-carbon metabolic process (IBA)

Cellular Component

cytoplasm (IEA)

Molecular Function

arylesterase activity (ISO)

carbonate dehydratase activity (ISO,ISS)

cyanamide hydratase activity (ISO,ISS)

hydro-lyase activity (IBA,ISO)

protein binding (ISO)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

cimetidine pharmacodynamics pathway (ISO)

esomeprazole pharmacodynamics pathway (ISO)

famotidine pharmacodynamics pathway (ISO)

lansoprazole pharmacodynamics pathway (ISO)

nizatidine pharmacodynamics pathway (ISO)

omeprazole pharmacodynamics pathway (ISO)

pantoprazole pharmacodynamics pathway (ISO)

pirenzepine pharmacodynamics pathway (ISO)

rabeprazole pharmacodynamics pathway (ISO)

ranitidine pharmacodynamics pathway (ISO)

roxatidine acetate pharmacodynamics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:2114290	PMID:7758465	PMID:12477932	PMID:14760703	PMID:15489334	PMID:22206666	PMID:23376485	PMID:23533145	PMID:24670789

Genomics

Comparative Map Data

Car1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	88,550,681 - 88,593,454 (+)	NCBI		GRCr8
mRatBN7.2	2	86,829,436 - 86,872,209 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	86,861,897 - 86,872,208 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	93,154,953 - 93,195,719 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	91,275,953 - 91,316,725 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	86,332,778 - 86,373,541 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	88,185,204 - 88,227,486 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	88,217,188 - 88,227,479 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	107,958,483 - 108,000,765 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	88,166,412 - 88,210,693 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	88,143,727 - 88,155,654 (+)	NCBI
Celera	2	82,427,032 - 82,469,698 (+)	NCBI		Celera
Cytogenetic Map	2	q23	NCBI

CA1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	85,327,608 - 85,378,113 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	85,327,608 - 85,379,014 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	86,239,837 - 86,290,342 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	86,427,709 - 86,477,594 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	86,427,708 - 86,477,594	NCBI
Celera	8	82,245,509 - 82,295,378 (-)	NCBI		Celera
Cytogenetic Map	8	q21.2	NCBI
HuRef	8	81,734,656 - 81,784,498 (-)	NCBI		HuRef
CHM1_1	8	86,292,190 - 86,342,023 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	85,766,342 - 85,816,813 (-)	NCBI		T2T-CHM13v2.0

Car1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	14,831,274 - 14,873,425 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	14,831,276 - 14,873,428 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	14,766,214 - 14,808,365 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	14,766,216 - 14,808,368 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	14,766,214 - 14,808,365 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	14,742,975 - 14,767,557 (-)	NCBI		MGSCv36	mm8
Celera	3	14,771,712 - 14,813,913 (-)	NCBI		Celera
Cytogenetic Map	3	A1	NCBI
cM Map	3	3.18	NCBI

Ca1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955417	3,270,619 - 3,305,756 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955417	3,270,619 - 3,313,261 (-)	NCBI	ChiLan1.0	ChiLan1.0

CA1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	101,062,861 - 101,095,648 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	76,698,568 - 76,728,323 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	81,854,390 - 81,905,728 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	83,464,680 - 83,515,359 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	83,463,434 - 83,526,899 (-)	Ensembl	panpan1.1		panPan2

CA1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	29	31,858,644 - 31,868,135 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	29	31,858,636 - 31,868,158 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	29	32,144,441 - 32,154,240 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	29	32,007,771 - 32,017,260 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	29	32,007,763 - 32,029,748 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	29	32,058,957 - 32,068,728 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	29	32,080,387 - 32,089,882 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	29	32,466,958 - 32,476,446 (-)	NCBI		UU_Cfam_GSD_1.0

Ca1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	47,504,905 - 47,545,941 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936544	246,797 - 257,650 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936544	246,797 - 257,798 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CA1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	51,302,406 - 51,353,126 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	51,343,548 - 51,353,127 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	56,358,354 - 56,367,895 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CA1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	80,699,114 - 80,729,932 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	80,699,651 - 80,712,858 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	60,349,417 - 60,401,053 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ca1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624744	6,314,872 - 6,333,003 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624744	6,244,872 - 6,324,722 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Car1
194 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	27
Count of miRNA genes:	27
Interacting mature miRNAs:	27
Transcripts:	ENSRNOT00000014267
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	5873687	102844969	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	25413423	143657569	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	26917817	127469484	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	26917817	136917119	Rat
61371	Edpm1	Estrogen-dependent pituitary mass QTL 1	4	0.05	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	35134841	88029593	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	40067944	102785628	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	40067944	102785628	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	40067944	102785628	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	40067944	102785628	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	40067944	102785628	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	157142209	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	182042367	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	43154682	202446871	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43154682	202446871	Rat
2293676	Bmd19	Bone mineral density QTL 19	10.7	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	2	43162366	111362592	Rat
2293682	Bmd24	Bone mineral density QTL 24	8.9	0.0001	femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	2	43162366	111362592	Rat
2293671	Bss44	Bone structure and strength QTL 44	10.97	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	2	43162366	148478373	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43171017	184114403	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46123260	202447032	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56043031	202447032	Rat
1558648	Smcn1	Smooth muscle cell number QTL 1		0.039	blood vessel smooth muscle cell quantity (VT:0010525)	aorta smooth muscle cell count per unit vessel length (CMO:0001646)	2	59134147	127460910	Rat
5684990	Bmd82	Bone mineral density QTL 82	2.8		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	2	59324377	103795077	Rat
5684996	Bmd85	Bone mineral density QTL 85	4.7	0.024	tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	2	59324377	103795077	Rat
61438	Cia7	Collagen induced arthritis QTL 7	4.6	0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	2	59324377	141596857	Rat
631500	Bp99	Blood pressure QTL 99	2.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	59324719	102755241	Rat
1578777	Stresp15	Stress response QTL 15	2	0.05	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	2	59846005	104846005	Rat
2306903	Bp336	Blood pressure QTL 336		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	64366971	109366971	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118275	202447032	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
7411551	Bw131	Body weight QTL 131	29.6	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	2	67942638	112942638	Rat
1558653	Prcr1	Prostate cancer resistance QTL 1	5		prostate integrity trait (VT:0010571)	area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)	2	72532993	157142209	Rat
1359034	Bp274	Blood pressure QTL 274			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	74786664	94359546	Rat
1359034	Bp274	Blood pressure QTL 274			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	74786664	94359546	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	74786664	206665859	Rat
61465	Bp13	Blood pressure QTL 13	3.3		blood pressure trait (VT:0000183)	diastolic blood pressure (CMO:0000005)	2	76539322	102785628	Rat
61465	Bp13	Blood pressure QTL 13	3.3		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	76539322	102785628	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	76539322	150540526	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	76539322	202447032	Rat
2299162	Iddm32	Insulin dependent diabetes mellitus QTL 32	2.36		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	78665616	143657569	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	78665619	219826953	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
61392	Bp6	Blood pressure QTL 6	7		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	80270434	125270434	Rat
1598865	Bp296	Blood pressure QTL 296	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	81018907	126018907	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	81689826	221035911	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	81754530	222436696	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
1578772	Stresp14	Stress response QTL 14	5	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	2	82345893	130923501	Rat

Markers in Region

RH129986

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	86,871,927 - 86,872,111 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	88,227,205 - 88,227,388	NCBI	Rnor6.0
Rnor_5.0	2	108,000,484 - 108,000,667	UniSTS	Rnor5.0
RGSC_v3.4	2	88,210,412 - 88,210,595	UniSTS	RGSC3.4
Celera	2	82,469,417 - 82,469,600	UniSTS
RH 3.4 Map	2	533.6	UniSTS
Cytogenetic Map	2	q23	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High	2		8	8		8
Medium		2	16	16	11	16					4
Low		22	23	13	4	13	3	5	34	16	15	8	3
Below cutoff	1	12	9	3	4	3	5	6	35	13	15	3	5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107660	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760842	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC158888	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225390	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225569	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225719	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ231425	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ233411	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ235246	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000014267 ⟹ ENSRNOP00000014267

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	86,861,897 - 86,872,208 (+)	Ensembl
Rnor_6.0 Ensembl	2	88,217,188 - 88,227,479 (+)	Ensembl

RefSeq Acc Id:

NM_001107660 ⟹ NP_001101130

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	88,550,681 - 88,593,454 (+)	NCBI
mRatBN7.2	2	86,829,436 - 86,872,209 (+)	NCBI
Rnor_6.0	2	88,185,204 - 88,227,486 (+)	NCBI
Rnor_5.0	2	107,958,483 - 108,000,765 (+)	NCBI
RGSC_v3.4	2	88,166,412 - 88,210,693 (+)	RGD
Celera	2	82,427,032 - 82,469,698 (+)	RGD

Sequence:

show sequence

TGCTGTACCCATACTCAGGAGAGAGCCACTGGGTAACCTGGCCAGCAACCTTCTCTGAAGCTGA
ATCAAAAACTAAATAGGAGAATATGGCAAGTGCAGACTGGGGATATGATAGCAAAAATGGTCCT
GACCAATGGAGCAAACTATATCCCATTGCCAATGGAAACAACCAGTCTCCTATTGATATTAAAA
CCAGCGAAGCCAAACATGATTCCTCTCTGAAACCAGTCAGCGTCTCCTACAATCCTGCAACTGC
CAAAGAAATTGTTAATGTGGGACATTCTTTCCATGTAGTTTTTGATGACAGTAGCAACCAGTCA
GTGCTGAAAGGTGGCCCTCTTGCTGATAGCTATCGGCTCACCCAGTTCCATTTTCACTGGGGCA
ACTCAAACGACCATGGCTCTGAACACACCGTGGATGGAGCCAAATATTCTGGAGAGCTTCACTT
AGTTCACTGGAATTCAGCCAAGTACTCCAGTGCTGCTGAAGCCATCTCGAAGGCTGATGGGCTG
GCAATCATTGGGGTTTTGATGAAGGTTGGTCCAGCCAACCCAAACCTGCAGAAAGTACTGGATG
CCCTAAGCTCAGTTAAAACTAAGGGAAAACGAGCCCCATTCACCAATTTTGACCCTTCCAGTCT
CCTTCCTTCGTCTCTGGATTACTGGACCTACTTTGGCTCTCTGACCCACCCTCCTCTTCATGAA
AGCGTGACTTGGGTGATCTGCAAGGAGAGCATCAGTCTAAGCCCAGAACAGCTGGCACAGCTCC
GTGGTCTTCTGTCAAGTGCCGAGGGAGAGCCTGCGGTTCCAGTTCTGAGCAACCACCGTCCACC
ACAGCCCCTGAAGGGCAGAACAGTCAGAGCCTCATTTTGAGTCCTAGCAAAGAGTGAGTCCTCA
GTTAGGACCTGGCCTCCCTGCAACAGCACCCAGTAAAGCAATCACTTTTAAGAAACAGAATTAT
TTCAGTGCTAAGACAGTATACCTGCAAATTAATCCATAGAACTAAAAAGCATTCATTTTAATTC
CTGATGCTTAATGCAAATAATCCATAAGCTTGCTTACTATAATCTTTAAGCATGTGTTTGTGCT
TAAAGCCACCTAGTTTTTTGAGGAATGTTCCATAATTGCAACTAAGTGGTTTTTTTTATATTTC
CTCTCTCTTCATTTTAAATGGATCAATAAATTGACTTTATCCCTTCT

hide sequence

RefSeq Acc Id:

XM_008760842 ⟹ XP_008759064

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	88,581,975 - 88,593,453 (+)	NCBI
mRatBN7.2	2	86,860,786 - 86,872,208 (+)	NCBI
Rnor_6.0	2	88,216,063 - 88,227,485 (+)	NCBI

Sequence:

show sequence

GTGTGAGTAAGTGAGCAAGGAATCAAAAACTAAATAGGAGAATATGGCAAGTGCAGACTGGGGA
TATGATAGCAAAAATGGTCCTGACCAATGGAGCAAACTATATCCCATTGCCAATGGAAACAACC
AGTCTCCTATTGATATTAAAACCAGCGAAGCCAAACATGATTCCTCTCTGAAACCAGTCAGCGT
CTCCTACAATCCTGCAACTGCCAAAGAAATTGTTAATGTGGGACATTCTTTCCATGTAGTTTTT
GATGACAGTAGCAACCAGTCAGTGCTGAAAGGTGGCCCTCTTGCTGATAGCTATCGGCTCACCC
AGTTCCATTTTCACTGGGGCAACTCAAACGACCATGGCTCTGAACACACCGTGGATGGAGCCAA
ATATTCTGGAGAGCTTCACTTAGTTCACTGGAATTCAGCCAAGTACTCCAGTGCTGCTGAAGCC
ATCTCGAAGGCTGATGGGCTGGCAATCATTGGGGTTTTGATGAAGGTTGGTCCAGCCAACCCAA
ACCTGCAGAAAGTACTGGATGCCCTAAGCTCAGTTAAAACTAAGGGAAAACGAGCCCCATTCAC
CAATTTTGACCCTTCCAGTCTCCTTCCTTCGTCTCTGGATTACTGGACCTACTTTGGCTCTCTG
ACCCACCCTCCTCTTCATGAAAGCGTGACTTGGGTGATCTGCAAGGAGAGCATCAGTCTAAGCC
CAGAACAGCTGGCACAGCTCCGTGGTCTTCTGTCAAGTGCCGAGGGAGAGCCTGCGGTTCCAGT
TCTGAGCAACCACCGTCCACCACAGCCCCTGAAGGGCAGAACAGTCAGAGCCTCATTTTGAGTC
CTAGCAAAGAGTGAGTCCTCAGTTAGGACCTGGCCTCCCTGCAACAGCACCCAGTAAAGCAATC
ACTTTTAAGAAACAGAATTATTTCAGTGCTAAGACAGTATACCTGCAAATTAATCCATAGAACT
AAAAAGCATTCATTTTAATTCCTGATGCTTAATGCAAATAATCCATAAGCTTGCTTACTATAAT
CTTTAAGCATGTGTTTGTGCTTAAAGCCACCTAGTTTTTTGAGGAATGTTCCATAATTGCAACT
AAGTGGTTTTTTTTATATTTCCTCTCTCTTCATTTTAAATGGATCAATAAATTGACTTTATCCC
TTC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001101130	(Get FASTA)	NCBI Sequence Viewer
	XP_008759064	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI58889	(Get FASTA)	NCBI Sequence Viewer
	B0BNN3	(Get FASTA)	NCBI Sequence Viewer
	EDM00961	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000014267
	ENSRNOP00000014267.4

RefSeq Acc Id:

NP_001101130 ⟸ NM_001107660

- UniProtKB:

B0BNN3 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MASADWGYDSKNGPDQWSKLYPIANGNNQSPIDIKTSEAKHDSSLKPVSVSYNPATAKEIVNVG
HSFHVVFDDSSNQSVLKGGPLADSYRLTQFHFHWGNSNDHGSEHTVDGAKYSGELHLVHWNSAK
YSSAAEAISKADGLAIIGVLMKVGPANPNLQKVLDALSSVKTKGKRAPFTNFDPSSLLPSSLDY
WTYFGSLTHPPLHESVTWVICKESISLSPEQLAQLRGLLSSAEGEPAVPVLSNHRPPQPLKGRT
VRASF

hide sequence

RefSeq Acc Id:	XP_008759064 ⟸ XM_008760842
- Peptide Label:	isoform X1
- UniProtKB:	B0BNN3 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MASADWGYDSKNGPDQWSKLYPIANGNNQSPIDIKTSEAKHDSSLKPVSVSYNPATAKEIVNVG HSFHVVFDDSSNQSVLKGGPLADSYRLTQFHFHWGNSNDHGSEHTVDGAKYSGELHLVHWNSAK YSSAAEAISKADGLAIIGVLMKVGPANPNLQKVLDALSSVKTKGKRAPFTNFDPSSLLPSSLDY WTYFGSLTHPPLHESVTWVICKESISLSPEQLAQLRGLLSSAEGEPAVPVLSNHRPPQPLKGRT VRASF hide sequence

RefSeq Acc Id:

ENSRNOP00000014267 ⟸ ENSRNOT00000014267

Protein Domains

Alpha-carbonic anhydrase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B0BNN3-F1-model_v2	AlphaFold	B0BNN3	1-261	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691223

Promoter ID:

EPDNEW_R1746

Type:

single initiation site

Name:

Car1_1

Description:

carbonic anhydrase I

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	88,217,176 - 88,217,236	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309780	AgrOrtholog
BioCyc Gene	G2FUF-53807	BioCyc
Ensembl Genes	ENSRNOG00000010698	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000014267.6	UniProtKB/Swiss-Prot
Gene3D-CATH	3.10.200.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:8373855	IMAGE-MGC_LOAD
InterPro	CA_dom	UniProtKB/Swiss-Prot
	CA_dom_sf	UniProtKB/Swiss-Prot
	Carbonic_anhydrase_a-class	UniProtKB/Swiss-Prot
	Carbonic_anhydrase_a-class_CS	UniProtKB/Swiss-Prot
KEGG Report	rno:310218	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:188619	IMAGE-MGC_LOAD
NCBI Gene	310218	ENTREZGENE
PANTHER	CARBONIC ANHYDRASE 1	UniProtKB/Swiss-Prot
	PTHR18952	UniProtKB/Swiss-Prot
Pfam	Carb_anhydrase	UniProtKB/Swiss-Prot
PhenoGen	Car1	PhenoGen
PROSITE	ALPHA_CA_1	UniProtKB/Swiss-Prot
	ALPHA_CA_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000010698	RatGTEx
SMART	Carb_anhydrase	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF51069	UniProtKB/Swiss-Prot
UniProt	B0BNN3	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-08-21	Car1	carbonic anhydrase 1	Car1	carbonic anhydrase I	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-07-29	Car1	carbonic anhydrase I	LOC679649	similar to betaine-homocysteine methyltransferase 2	Data merged from RGD:1585940	737654	PROVISIONAL
2014-08-04	Car1	carbonic anhydrase I	Ca1	carbonic anhydrase I	Symbol changed	629549	APPROVED
2013-02-21	Ca1	carbonic anhydrase I	Car1	carbonic anhydrase 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Car1	carbonic anhydrase 1	Car1_predicted	carbonic anhydrase 1 (predicted)	'predicted' is removed	2292626	APPROVED
2006-11-19	LOC679649	similar to betaine-homocysteine methyltransferase 2			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-03-30	Car1_predicted	carbonic anhydrase 1 (predicted)	Ca1_predicted	carbonic anhydrase I (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-12	Ca1_predicted	carbonic anhydrase I (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB