Prkcsh (protein kinase C substrate 80K-H)

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Gene: Prkcsh (protein kinase C substrate 80K-H) Rattus norvegicus

Analyze

Symbol:

Prkcsh

Name:

protein kinase C substrate 80K-H

RGD ID:

1309628

Description:

Predicted to enable several functions, including calcium ion binding activity; protein kinase C binding activity; and transmembrane transporter binding activity. Predicted to be involved in N-glycan processing and liver development. Predicted to act upstream of or within in utero embryonic development; negative regulation of neuron projection development; and nitrogen compound metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be part of glucosidase II complex. Human ortholog(s) of this gene implicated in liver disease and polycystic liver disease. Orthologous to human PRKCSH (protein kinase C substrate 80K-H); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

glucosidase 2 subunit beta; LOC300445

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PRKCSH (protein kinase C substrate 80K-H)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Prkcsh (protein kinase C substrate 80K-H)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Prkcsh (protein kinase C substrate 80K-H)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PRKCSH (protein kinase C substrate 80K-H)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PRKCSH (protein kinase C substrate 80K-H)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Prkcsh (protein kinase C substrate 80K-H)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PRKCSH (protein kinase C substrate 80K-H)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PRKCSH (protein kinase C substrate 80K-H)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Prkcsh (protein kinase C substrate 80K-H)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PRKCSH (protein kinase C substrate 80K-H)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Prkcsh (protein kinase C substrate 80K-H)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	prkcsh (protein kinase C substrate 80K-H)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	GTB1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	GCS2beta	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ZK1307.8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	prkcsh	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	20,534,787 - 20,546,493 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	20,534,880 - 20,546,492 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	24,563,846 - 24,575,397 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	8	22,860,989 - 22,872,540 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	8	20,764,484 - 20,776,034 (+)	NCBI	Rnor_WKY
Rnor_6.0	8	23,014,802 - 23,026,507 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	23,014,956 - 23,026,503 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	23,069,586 - 23,081,291 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	21,107,041 - 21,144,270 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	21,106,881 - 21,117,476 (+)	NCBI
Celera	8	21,925,450 - 21,937,160 (+)	NCBI		Celera
Cytogenetic Map	8	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alpha-mannosidosis (ISO)

Charcot-Marie-Tooth disease dominant intermediate B (ISO)

episodic ataxia type 2 (ISO)

genetic disease (ISO)

glutaric acidemia I (ISO)

hepatitis B (ISO)

liver disease (ISO)

polycystic kidney disease (ISO)

polycystic liver disease (ISO)

Polycystic Liver Disease 1 (ISO)

primary ciliary dyskinesia 30 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(S)-nicotine (ISO)

14-Deoxy-11,12-didehydroandrographolide (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

2,5-hexanedione (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

acrolein (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

alpha-pinene (ISO)

asbestos (ISO)

benzatropine (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

Brodifacoum (EXP)

butan-1-ol (ISO)

cadmium atom (ISO)

caffeine (ISO)

carfilzomib (ISO)

clofibrate (ISO)

CU-O LINKAGE (ISO)

Cuprizon (ISO)

decabromodiphenyl ether (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

diethylstilbestrol (ISO)

doxorubicin (ISO)

endosulfan (EXP)

enzyme inhibitor (ISO)

flutamide (EXP)

gentamycin (EXP)

glafenine (EXP)

haloperidol (ISO)

hydralazine (ISO)

ivermectin (ISO)

Monobutylphthalate (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

N-methyl-4-phenylpyridinium (ISO)

nicotine (ISO)

ochratoxin A (ISO)

ozone (ISO)

paracetamol (ISO)

phenobarbital (ISO)

potassium chromate (ISO)

serpentine asbestos (ISO)

sodium arsenite (ISO)

sulindac sulfide (ISO)

titanium dioxide (ISO)

Triptolide (EXP)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

in utero embryonic development (ISO)

liver development (IBA,ISO)

N-glycan processing (IBA,ISO)

negative regulation of neuron projection development (ISO)

nitrogen compound metabolic process (ISO)

Cellular Component

endoplasmic reticulum (ISO)

glucosidase II complex (IBA,ISO)

intracellular membrane-bounded organelle (ISO)

plasma membrane (TAS)

Molecular Function

calcium ion binding (ISO)

phosphoprotein binding (ISO)

protein binding (ISO)

protein kinase C binding (ISO)

protein-containing complex binding (IPI)

RNA binding (ISO)

transmembrane transporter binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Endoplasmic Reticulum-associated degradation pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Abnormal hepatocystin caused by truncating PRKCSH mutations leads to autosomal dominant polycystic liver disease.	Drenth JP, etal., Hepatology. 2004 Apr;39(4):924-31. doi: 10.1002/hep.20141.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking.	Hodgkinson CP, etal., Biochem J. 2005 Jun 15;388(Pt 3):785-93.
5.	Mutations in PRKCSH cause isolated autosomal dominant polycystic liver disease.	Li A, etal., Am J Hum Genet. 2003 Mar;72(3):691-703. Epub 2003 Jan 15.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	GOA pipeline	RGD automated data pipeline
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Comprehensive gene review and curation	RGD comprehensive gene curation
13.	Hepatocystin contributes to interferon-mediated antiviral response to hepatitis B virus by regulating hepatocyte nuclear factor 4α.	Shin GC, etal., Biochim Biophys Acta. 2014 Sep;1842(9):1648-57. doi: 10.1016/j.bbadis.2014.04.016. Epub 2014 Apr 25.

Additional References at PubMed

PMID:8702988	PMID:9148925	PMID:10929008	PMID:12477932	PMID:16706842	PMID:19801576	PMID:21685914	PMID:22337885	PMID:27462106

Genomics

Comparative Map Data

Prkcsh
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	20,534,787 - 20,546,493 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	20,534,880 - 20,546,492 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	24,563,846 - 24,575,397 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	8	22,860,989 - 22,872,540 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	8	20,764,484 - 20,776,034 (+)	NCBI	Rnor_WKY
Rnor_6.0	8	23,014,802 - 23,026,507 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	23,014,956 - 23,026,503 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	23,069,586 - 23,081,291 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	21,107,041 - 21,144,270 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	21,106,881 - 21,117,476 (+)	NCBI
Celera	8	21,925,450 - 21,937,160 (+)	NCBI		Celera
Cytogenetic Map	8	q13	NCBI

PRKCSH
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	11,435,635 - 11,450,968 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	19	11,435,284 - 11,450,968 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	11,546,456 - 11,561,783 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	11,407,269 - 11,422,783 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	11,407,268 - 11,422,783	NCBI
Celera	19	11,441,004 - 11,456,521 (+)	NCBI		Celera
Cytogenetic Map	19	p13.2	NCBI
HuRef	19	11,121,465 - 11,136,774 (+)	NCBI		HuRef
CHM1_1	19	11,546,291 - 11,561,813 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	11,563,157 - 11,578,487 (+)	NCBI		T2T-CHM13v2.0

Prkcsh
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	21,914,284 - 21,925,541 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	21,914,102 - 21,925,518 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	22,002,988 - 22,014,245 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	22,002,806 - 22,014,222 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	21,807,479 - 21,818,666 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	21,753,437 - 21,764,624 (+)	NCBI		MGSCv36	mm8
Celera	9	19,272,723 - 19,283,910 (+)	NCBI		Celera
Cytogenetic Map	9	A3	NCBI
cM Map	9	8.04	NCBI

Prkcsh
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	2,331,569 - 2,337,946 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	2,331,075 - 2,338,479 (+)	NCBI	ChiLan1.0	ChiLan1.0

PRKCSH
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	19	15,347,265 - 15,364,284 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	10,981,398 - 10,997,062 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	11,693,620 - 11,707,610 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	11,693,620 - 11,707,728 (+)	Ensembl	panpan1.1		panPan2

PRKCSH
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	49,905,246 - 49,916,551 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	49,905,248 - 49,916,463 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	49,775,959 - 49,787,692 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	50,423,129 - 50,434,871 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	50,423,115 - 50,434,799 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	49,633,425 - 49,645,158 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	50,059,568 - 50,071,314 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	50,302,755 - 50,314,497 (-)	NCBI		UU_Cfam_GSD_1.0

Prkcsh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	208,843,072 - 208,853,320 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936659	1,501,419 - 1,511,625 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936659	1,501,425 - 1,511,634 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PRKCSH
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	70,097,444 - 70,114,446 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	70,097,424 - 70,114,460 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	70,332,429 - 70,349,468 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PRKCSH
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	10,360,392 - 10,375,785 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	10,360,751 - 10,374,208 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666074	9,511,189 - 9,526,419 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Prkcsh
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	3,219,216 - 3,227,369 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624828	3,219,105 - 3,227,369 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Prkcsh
24 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	205
Count of miRNA genes:	127
Interacting mature miRNAs:	143
Transcripts:	ENSRNOT00000018009
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9590084	Insglur5	Insulin/glucose ratio QTL 5	18.54	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	8	1	24597739	Rat
2317882	Alcrsp24	Alcohol response QTL 24	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	8	1	25902202	Rat
12880023	Bw184	Body weight QTL 184		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	2097640	47097640	Rat
12880025	Cm102	Cardiac mass QTL 102		0.044	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	8	2097640	47097640	Rat
12880028	Cm103	Cardiac mass QTL 103		0.02	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	2097640	47097640	Rat
12880044	Am9	Aortic mass QTL 9		0.007	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	2097640	47097640	Rat
2317032	Ginf2	Gastrointestinal inflammation QTL 2	3.21	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	8	4705810	49705810	Rat
2317036	Livw3	Liver weight QTL 3	2.43	0.01	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	8	4705810	49705810	Rat
2317048	Ginf1	Gastrointestinal inflammation QTL 1	3.52	0.005	cecum mucosa thickness (VT:0010234)	enterocolitis severity score (CMO:0002138)	8	4705810	49705810	Rat
2301416	Bp315	Blood pressure QTL 315		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	7670578	52670578	Rat
1354595	Despr4	Despair related QTL 4	2.16	0.0036	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	8	7688955	52688955	Rat
1354627	Despr14	Despair related QTL 14		0.0056	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	7688955	52688955	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
2317030	Wbc5	White blood cell count QTL 5	3.21	0.005	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	8	8736635	53736635	Rat
2317051	Aia18	Adjuvant induced arthritis QTL 18	2.42		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	8	8736635	53736635	Rat
1598824	Memor4	Memory QTL 4	2.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	8	9712220	53356647	Rat
1357398	Slep3	Serum leptin concentration QTL 3	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	9712463	41866876	Rat
2302367	Slep5	Serum leptin concentration QTL 5	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	9712463	41866876	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
1558646	Swd5	Spike wave discharge measurement QTL 5	3.45	0.00036	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge frequency (CMO:0001742)	8	14906751	59906751	Rat
61373	Mcs4	Mammary carcinoma susceptibility QTL 4	1.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	8	16290444	61290444	Rat
631271	Lecl1	Lens clarity QTL 1		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	8	18984168	84531599	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	19331152	93965294	Rat

Markers in Region

RH128469

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	20,546,338 - 20,546,488 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	23,026,353 - 23,026,502	NCBI	Rnor6.0
Rnor_5.0	8	23,081,137 - 23,081,286	UniSTS	Rnor5.0
Celera	8	21,937,008 - 21,937,157	UniSTS
Cytogenetic Map	8	q13	UniSTS

RH129453

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	20,546,305 - 20,546,465 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	23,026,320 - 23,026,479	NCBI	Rnor6.0
Rnor_5.0	8	23,081,104 - 23,081,263	UniSTS	Rnor5.0
Celera	8	21,936,975 - 21,937,134	UniSTS
RH 3.4 Map	8	183.7	UniSTS
Cytogenetic Map	8	q13	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106806	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006242633	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006242634	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC161987	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473993	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000190	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X95091	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000018009 ⟹ ENSRNOP00000018009

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	20,534,880 - 20,546,491 (+)	Ensembl
Rnor_6.0 Ensembl	8	23,014,956 - 23,026,503 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000095656 ⟹ ENSRNOP00000081881

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	20,534,880 - 20,546,492 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000103948 ⟹ ENSRNOP00000086800

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	20,534,890 - 20,546,487 (+)	Ensembl

RefSeq Acc Id:

NM_001106806 ⟹ NP_001100276

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	20,534,941 - 20,546,491 (+)	NCBI
Rnor_6.0	8	23,014,956 - 23,026,505 (+)	NCBI
Rnor_5.0	8	23,069,586 - 23,081,291 (+)	NCBI
RGSC_v3.4	8	21,107,041 - 21,144,270 (+)	RGD
Celera	8	21,925,450 - 21,937,160 (+)	RGD

Sequence:

show sequence

ATTGACCTTTGCTTCTGCCTCGTTGAAAGGACATCGCGTATCTTCCTGCCGCAGAACACACTTC
CGGTCTCGGCCCGGACGGGATGTTGCTGCTGCTGCTGCTGCTACCCCTCTGTTGGGCAGTAGAA
GTTAAGAGACCCCGGGGCGTTTCCCTCAGCAACCATCACTTCTATGACGAATCTAAACCTTTCA
CGTGTTTGGATGGCACAGCCACTATCCCCTTCGATCAGGTGAACGATGATTACTGCGACTGTAA
GGATGGTTCTGATGAGCCTGGCACAGCTGCGTGTCCCAATGGCAGCTTTCACTGCACCAACACT
GGGTATAAGCCTTTGTACATCCTCTCTAGCCGGGTCAATGATGGGGTGTGTGACTGCTGTGATG
GGACGGACGAGTACAACAGTGGCACCGTCTGTGAGAACACCTGCAGAGAGAAGGGTCGCAAGGA
AAAAGAGTCCCTGCAGCAGCTGGCCGAGGTCACCCGAGAAGGGTTCCGTCTCAAGAAGATACTC
ATTGAGGAGTGGAAGACAGCTCGGGAAGAAAAGCAGAGTAAGCTTCTTGAGCTTCAGGCTGGAA
AGAAGTCTCTGGAAGACCAGGTAGAAACGCTGCGGACAGCGAAAGAGGAAGCAGAGAGGCCAGA
GAAGGAGGCCAAGGACCAGCACCGGAAGCTGTGGGAAGAGCAGCAGGCTGCTGCCAAGGCCCGG
CGGGAACAGGAGCTGGCAGCCAGTGCCTTCCAGGAACTGGACGACAACATGGATGGGCTGGTCT
CACTGGCTGAGTTACAGACTCACCCAGAGCTGGACACAGATGGAGATGGAGGACTGTCGGAGGA
GGAGGCCCAGGCTCTTCTCAGTGGAGACACACAGACTGACACTACCTCCTTCTATGACCGTGTC
TGGGCTGCCATCAGGGACAAGTACCGCTCTGAGGTCCCACCCACGGACATACCTGTTCCTGAGG
TCACCGAACCCAAAGAAGAAAAGCTGCCAGTGTTGCCCCCCATGGAAGAGGAGGAGGAAGAGGA
GGAGCCAGAGGAGGAAGAGGAGGAGGAGGAGGAGGAGGTGCCGGGGGAGCAGCCCAAGGAGGTC
CCGCCCCCACAGCAGCCCCTACGGCCTCCCAGTCCTGCTGAGGATGAGAAGATGCCACCCTATG
ATGAGGAGACACAGGCTATCATCGATGCCGCACAAGAGGCCCGGAACAAGTTTGAGGAGGTCGA
ACGGTCCTTGAAAGAGATGGAGGAGTCCATCAGGAGTTTGGAACAAGAGATCTCCTTTGATTTC
GGTCCCTCTGGAGAGTTTGCATACCTCTACAGCCAATGCTACGAGCTCACCACCAATGAGTATG
TCTACCGGCTTTGCCCCTTCAAACTTGTCTCCCAGAAACCCAAACATGGGGGCTCCCCGACCAG
TCTGGGTACATGGGGCTCCTGGGCTGGCCCAGATGACGACAAGTTCAGCGCAATGAAGTACGAG
CAGGGCACAGGCTGCTGGCAGGGCCCCAACCGCTCCACCACAGTACGCCTCCTGTGTGGCAAGG
AGACTGTGGTGACCAGTACCACAGAGCCCAGTCGCTGCGAGTACCTCATGGAGCTGATGACACC
AGCAGCCTGCCCAGAGCCGCCTCCAGAAGTACCCACTGATGGAGACCATGATGAACTGTAGCCG
GAACCTCAAGGCCTACAGATAGTCTACCGATCCCATAGTCTGCGGACCAATGCCTGCCCACCCT
GGGGTCTCTGGCCATTCTCCAGGCAGCAGGAACCCGAGGGGCTCTAAGCCCCACTTCTGGCCCA
GGCTAGCCAAGCCATGTTCCTGAGGCCCCAGCGGCCTCCAGAGATGGATAATGAGCTCACCTAC
CTTGGATTCCTGAGAGGAGTTAATCCCTGCACCCCACCTCACCCCTGTCTCCCTAGCTGGTGGG
AGATGGATGTATGACTTGACCTGTGACCTCAGAACAATAAATGTGACTTGTCCACACAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006242633 ⟹ XP_006242695

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	20,534,881 - 20,546,493 (+)	NCBI
Rnor_6.0	8	23,014,907 - 23,026,507 (+)	NCBI
Rnor_5.0	8	23,069,586 - 23,081,291 (+)	NCBI

Sequence:

show sequence

CTTTCTGCTGCAGGAACCGTGGCTGCTGAGCTAACCTGGTGTGGTGGCTATTGACCTTTGCTTC
TGCCTCGTGTAGGTGATGAAGTACAGTGAAAGGACATCGCGTATCTTCCTGCCGCAGAACACAC
TTCCGGTCTCGGCCCGGACGGGATGTTGCTGCTGCTGCTGCTGCTACCCCTCTGTTGGGCAGTA
GAAGTTAAGAGACCCCGGGGCGTTTCCCTCAGCAACCATCACTTCTATGACGAATCTAAACCTT
TCACGTGTTTGGATGGCACAGCCACTATCCCCTTCGATCAGGTGAACGATGATTACTGCGACTG
TAAGGATGGTTCTGATGAGCCTGGCACAGCTGCGTGTCCCAATGGCAGCTTTCACTGCACCAAC
ACTGGGTATAAGCCTTTGTACATCCTCTCTAGCCGGGTCAATGATGGGGTGTGTGACTGCTGTG
ATGGGACGGACGAGTACAACAGTGGCACCGTCTGTGAGAACACCTGCAGAGAGAAGGGTCGCAA
GGAAAAAGAGTCCCTGCAGCAGCTGGCCGAGGTCACCCGAGAAGGGTTCCGTCTCAAGAAGATA
CTCATTGAGGAGTGGAAGACAGCTCGGGAAGAAAAGCAGAGTAAGCTTCTTGAGCTTCAGGCTG
GAAAGAAGTCTCTGGAAGACCAGGTAGAAACGCTGCGGACAGCGAAAGAGGAAGCAGAGAGGCC
AGAGAAGGAGGCCAAGGACCAGCACCGGAAGCTGTGGGAAGAGCAGCAGGCTGCTGCCAAGGCC
CGGCGGGAACAGGAGCTGGCAGCCAGTGCCTTCCAGGAACTGGACGACAACATGGATGGGCTGG
TCTCACTGGCTGAGTTACAGACTCACCCAGAGCTGGACACAGATGGAGATGGAGGACTGTCGGA
GGAGGAGGCCCAGGCTCTTCTCAGTGGAGACACACAGACTGACACTACCTCCTTCTATGACCGT
GTCTGGGCTGCCATCAGGGACAAGTACCGCTCTGAGGTCCCACCCACGGACATACCTGTTCCTG
AGGTCACCGAACCCAAAGAAGAAAAGCTGCCAGTGTTGCCCCCCATGGAAGAGGAGGAGGAAGA
GGAGGAGCCAGAGGAGGAAGAGGAGGAGGAGGAGGAGGAGGTGCCGGGGGAGCAGCCCAAGGAG
GTCCCGCCCCCACAGCAGCCCCTACGGCCTCCCAGTCCTGCTGAGGATGAGAAGATGCCACCCT
ATGATGAGGAGACACAGGCTATCATCGATGCCGCACAAGAGGCCCGGAACAAGTTTGAGGAGGT
CGAACGGTCCTTGAAAGAGATGGAGGAGTCCATCAGGAGTTTGGAACAAGAGATCTCCTTTGAT
TTCGGTCCCTCTGGAGAGTTTGCATACCTCTACAGCCAATGCTACGAGCTCACCACCAATGAGT
ATGTCTACCGGCTTTGCCCCTTCAAACTTGTCTCCCAGAAACCCAAACATGGGGGCTCCCCGAC
CAGTCTGGGTACATGGGGCTCCTGGGCTGGCCCAGATGACGACAAGTTCAGCGCAATGAAGTAC
GAGCAGGGCACAGGCTGCTGGCAGGGCCCCAACCGCTCCACCACAGTACGCCTCCTGTGTGGCA
AGGAGACTGTGGTGACCAGTACCACAGAGCCCAGTCGCTGCGAGTACCTCATGGAGCTGATGAC
ACCAGCAGCCTGCCCAGAGCCGCCTCCAGAAGTACCCACTGATGGAGACCATGATGAACTGTAG
CCGGAACCTCAAGGCCTACAGATAGTCTACCGATCCCATAGTCTGCGGACCAATGCCTGCCCAC
CCTGGGGTCTCTGGCCATTCTCCAGGCAGCAGGAACCCGAGGGGCTCTAAGCCCCACTTCTGGC
CCAGGCTAGCCAAGCCATGTTCCTGAGGCCCCAGCGGCCTCCAGAGATGGATAATGAGCTCACC
TACCTTGGATTCCTGAGAGGAGTTAATCCCTGCACCCCACCTCACCCCTGTCTCCCTAGCTGGT
GGGAGATGGATGTATGACTTGACCTGTGACCTCAGAACAATAAATGTGACTTGTCCACACTG

hide sequence

RefSeq Acc Id:

XM_006242634 ⟹ XP_006242696

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	20,534,787 - 20,546,493 (+)	NCBI
Rnor_6.0	8	23,014,802 - 23,026,507 (+)	NCBI
Rnor_5.0	8	23,069,586 - 23,081,291 (+)	NCBI

Sequence:

show sequence

TCTGGCACTCGCACTCTTGCCACTCCTAACATGGCGTCCTCGAGTTGCCGTTCGCCAAGCGTGG
TGAGCAAAACGGAAGTGACGTACCCTAGAGCGTTCCGTTCTCTTTCTGCTGCAGGAACCGTGGC
TGCTGAGCTAACCTGGTGTGGTGGCTATTGACCTTTGCTTCTGCCTCGTTGAAAGGACATCGCG
TATCTTCCTGCCGCAGAACACACTTCCGGTCTCGGCCCGGACGGGATGTTGCTGCTGCTGCTGC
TGCTACCCCTCTGTTGGGCAGTAGAAGTTAAGAGACCCCGGGGCGTTTCCCTCAGCAACCATCA
CTTCTATGACGAATCTAAACCTTTCACGTGTTTGGATGGCACAGCCACTATCCCCTTCGATCAG
GTGAACGATGATTACTGCGACTGTAAGGATGGTTCTGATGAGCCTGGCACAGCTGCGTGTCCCA
ATGGCAGCTTTCACTGCACCAACACTGGGTATAAGCCTTTGTACATCCTCTCTAGCCGGGTCAA
TGATGGGGTGTGTGACTGCTGTGATGGGACGGACGAGTACAACAGTGGCACCGTCTGTGAGAAC
ACCTGCAGAGAGAAGGGTCGCAAGGAAAAAGAGTCCCTGCAGCAGCTGGCCGAGGTCACCCGAG
AAGGGTTCCGTCTCAAGAAGATACTCATTGAGGAGTGGAAGACAGCTCGGGAAGAAAAGCAGAG
TAAGCTTCTTGAGCTTCAGGCTGGAAAGAAGTCTCTGGAAGACCAGGTAGAAACGCTGCGGACA
GCGAAAGAGGAAGCAGAGAGGCCAGAGAAGGAGGCCAAGGACCAGCACCGGAAGCTGTGGGAAG
AGCAGCAGGCTGCTGCCAAGGCCCGGCGGGAACAGGAGCTGGCAGCCAGTGCCTTCCAGGAACT
GGACGACAACATGGATGGGCTGGTCTCACTGGCTGAGTTACAGACTCACCCAGAGCTGGACACA
GATGGAGATGGAGGACTGTCGGAGGAGGAGGCCCAGGCTCTTCTCAGTGGAGACACACAGACTG
ACACTACCTCCTTCTATGACCGTGTCTGGGCTGCCATCAGGGACAAGTACCGCTCTGAGGTCCC
ACCCACGGACATACCTGTTCCTGAGGTCACCGAACCCAAAGAAGAAAAGCTGCCAGTGTTGCCC
CCCATGGAAGAGGAGGAGGAAGAGGAGGAGCCAGAGGAGGAAGAGGAGGAGGAGGAGGAGGAGG
AGGTCCCGCCCCCACAGCAGCCCCTACGGCCTCCCAGTCCTGCTGAGGATGAGAAGATGCCACC
CTATGATGAGGAGACACAGGCTATCATCGATGCCGCACAAGAGGCCCGGAACAAGTTTGAGGAG
GTCGAACGGTCCTTGAAAGAGATGGAGGAGTCCATCAGGAGTTTGGAACAAGAGATCTCCTTTG
ATTTCGGTCCCTCTGGAGAGTTTGCATACCTCTACAGCCAATGCTACGAGCTCACCACCAATGA
GTATGTCTACCGGCTTTGCCCCTTCAAACTTGTCTCCCAGAAACCCAAACATGGGGGCTCCCCG
ACCAGTCTGGGTACATGGGGCTCCTGGGCTGGCCCAGATGACGACAAGTTCAGCGCAATGAAGT
ACGAGCAGGGCACAGGCTGCTGGCAGGGCCCCAACCGCTCCACCACAGTACGCCTCCTGTGTGG
CAAGGAGACTGTGGTGACCAGTACCACAGAGCCCAGTCGCTGCGAGTACCTCATGGAGCTGATG
ACACCAGCAGCCTGCCCAGAGCCGCCTCCAGAAGTACCCACTGATGGAGACCATGATGAACTGT
AGCCGGAACCTCAAGGCCTACAGATAGTCTACCGATCCCATAGTCTGCGGACCAATGCCTGCCC
ACCCTGGGGTCTCTGGCCATTCTCCAGGCAGCAGGAACCCGAGGGGCTCTAAGCCCCACTTCTG
GCCCAGGCTAGCCAAGCCATGTTCCTGAGGCCCCAGCGGCCTCCAGAGATGGATAATGAGCTCA
CCTACCTTGGATTCCTGAGAGGAGTTAATCCCTGCACCCCACCTCACCCCTGTCTCCCTAGCTG
GTGGGAGATGGATGTATGACTTGACCTGTGACCTCAGAACAATAAATGTGACTTGTCCACACTG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001100276	(Get FASTA)	NCBI Sequence Viewer
	XP_006242695	(Get FASTA)	NCBI Sequence Viewer
	XP_006242696	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI61987	(Get FASTA)	NCBI Sequence Viewer
	EDL78242	(Get FASTA)	NCBI Sequence Viewer
	EDL78243	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001100276 ⟸ NM_001106806
- Peptide Label:	precursor
- UniProtKB:	B1WC34 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLLLLLLLPLCWAVEVKRPRGVSLSNHHFYDESKPFTCLDGTATIPFDQVNDDYCDCKDGSDEP GTAACPNGSFHCTNTGYKPLYILSSRVNDGVCDCCDGTDEYNSGTVCENTCREKGRKEKESLQQ LAEVTREGFRLKKILIEEWKTAREEKQSKLLELQAGKKSLEDQVETLRTAKEEAERPEKEAKDQ HRKLWEEQQAAAKARREQELAASAFQELDDNMDGLVSLAELQTHPELDTDGDGGLSEEEAQALL SGDTQTDTTSFYDRVWAAIRDKYRSEVPPTDIPVPEVTEPKEEKLPVLPPMEEEEEEEEPEEEE EEEEEEVPGEQPKEVPPPQQPLRPPSPAEDEKMPPYDEETQAIIDAAQEARNKFEEVERSLKEM EESIRSLEQEISFDFGPSGEFAYLYSQCYELTTNEYVYRLCPFKLVSQKPKHGGSPTSLGTWGS WAGPDDDKFSAMKYEQGTGCWQGPNRSTTVRLLCGKETVVTSTTEPSRCEYLMELMTPAACPEP PPEVPTDGDHDEL hide sequence

RefSeq Acc Id:

XP_006242696 ⟸ XM_006242634

- Peptide Label:

isoform X2

- Sequence:

show sequence

MLLLLLLLPLCWAVEVKRPRGVSLSNHHFYDESKPFTCLDGTATIPFDQVNDDYCDCKDGSDEP
GTAACPNGSFHCTNTGYKPLYILSSRVNDGVCDCCDGTDEYNSGTVCENTCREKGRKEKESLQQ
LAEVTREGFRLKKILIEEWKTAREEKQSKLLELQAGKKSLEDQVETLRTAKEEAERPEKEAKDQ
HRKLWEEQQAAAKARREQELAASAFQELDDNMDGLVSLAELQTHPELDTDGDGGLSEEEAQALL
SGDTQTDTTSFYDRVWAAIRDKYRSEVPPTDIPVPEVTEPKEEKLPVLPPMEEEEEEEEPEEEE
EEEEEEEVPPPQQPLRPPSPAEDEKMPPYDEETQAIIDAAQEARNKFEEVERSLKEMEESIRSL
EQEISFDFGPSGEFAYLYSQCYELTTNEYVYRLCPFKLVSQKPKHGGSPTSLGTWGSWAGPDDD
KFSAMKYEQGTGCWQGPNRSTTVRLLCGKETVVTSTTEPSRCEYLMELMTPAACPEPPPEVPTD
GDHDEL

hide sequence

RefSeq Acc Id:	XP_006242695 ⟸ XM_006242633
- Peptide Label:	isoform X1
- UniProtKB:	B1WC34 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLLLLLLLPLCWAVEVKRPRGVSLSNHHFYDESKPFTCLDGTATIPFDQVNDDYCDCKDGSDEP GTAACPNGSFHCTNTGYKPLYILSSRVNDGVCDCCDGTDEYNSGTVCENTCREKGRKEKESLQQ LAEVTREGFRLKKILIEEWKTAREEKQSKLLELQAGKKSLEDQVETLRTAKEEAERPEKEAKDQ HRKLWEEQQAAAKARREQELAASAFQELDDNMDGLVSLAELQTHPELDTDGDGGLSEEEAQALL SGDTQTDTTSFYDRVWAAIRDKYRSEVPPTDIPVPEVTEPKEEKLPVLPPMEEEEEEEEPEEEE EEEEEEVPGEQPKEVPPPQQPLRPPSPAEDEKMPPYDEETQAIIDAAQEARNKFEEVERSLKEM EESIRSLEQEISFDFGPSGEFAYLYSQCYELTTNEYVYRLCPFKLVSQKPKHGGSPTSLGTWGS WAGPDDDKFSAMKYEQGTGCWQGPNRSTTVRLLCGKETVVTSTTEPSRCEYLMELMTPAACPEP PPEVPTDGDHDEL hide sequence

RefSeq Acc Id:

ENSRNOP00000018009 ⟸ ENSRNOT00000018009

RefSeq Acc Id:

ENSRNOP00000086800 ⟸ ENSRNOT00000103948

RefSeq Acc Id:

ENSRNOP00000081881 ⟸ ENSRNOT00000095656

Protein Domains

EF-hand MRH

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B1WC34-F1-model_v2	AlphaFold	B1WC34	1-525	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695802

Promoter ID:

EPDNEW_R6324

Type:

multiple initiation site

Name:

Prkcsh_1

Description:

protein kinase C substrate 80K-H

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R6325

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	23,014,905 - 23,014,965	EPDNEW

RGD ID:

13695801

Promoter ID:

EPDNEW_R6325

Type:

multiple initiation site

Name:

Prkcsh_2

Description:

protein kinase C substrate 80K-H

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R6324

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	23,015,312 - 23,015,372	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309628	AgrOrtholog
BioCyc Gene	G2FUF-31396	BioCyc
Ensembl Genes	ENSRNOG00000013360	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000018009	ENTREZGENE
	ENSRNOP00000018009.5	UniProtKB/TrEMBL
	ENSRNOP00000081881.1	UniProtKB/TrEMBL
	ENSRNOP00000086800	ENTREZGENE
	ENSRNOP00000086800.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000018009	ENTREZGENE
	ENSRNOT00000018009.7	UniProtKB/TrEMBL
	ENSRNOT00000095656.1	UniProtKB/TrEMBL
	ENSRNOT00000103948	ENTREZGENE
	ENSRNOT00000103948.1	UniProtKB/TrEMBL
Gene3D-CATH	2.70.130.10	UniProtKB/TrEMBL
	4.10.400.10	UniProtKB/TrEMBL
	EF-hand	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:9030870	IMAGE-MGC_LOAD
InterPro	EF-hand-dom_pair	UniProtKB/TrEMBL
	EF_Hand_1_Ca_BS	UniProtKB/TrEMBL
	EF_hand_Ca-bd	UniProtKB/TrEMBL
	Gtb1-like	UniProtKB/TrEMBL
	LDL_receptor-like_sf	UniProtKB/TrEMBL
	LDrepeatLR_classA_rpt	UniProtKB/TrEMBL
	Man6P_isomerase_rcpt_bd	UniProtKB/TrEMBL
	MRH_dom	UniProtKB/TrEMBL
	PRKCSH	UniProtKB/TrEMBL
	PRKCSH_N	UniProtKB/TrEMBL
KEGG Report	rno:300445	UniProtKB/TrEMBL
MGC_CLONE	MGC:187806	IMAGE-MGC_LOAD
NCBI Gene	300445	ENTREZGENE
PANTHER	GLUCOSIDASE 2 SUBUNIT BETA	UniProtKB/TrEMBL
	PTHR12630	UniProtKB/TrEMBL
Pfam	EF_hand_3	UniProtKB/TrEMBL
	PRKCSH-like	UniProtKB/TrEMBL
	PRKCSH_1	UniProtKB/TrEMBL
PhenoGen	Prkcsh	PhenoGen
PROSITE	EF_HAND_1	UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/TrEMBL
	MRH	UniProtKB/TrEMBL
SMART	LDLa	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47473	UniProtKB/TrEMBL
	SSF50911	UniProtKB/TrEMBL
	SSF57424	UniProtKB/TrEMBL
UniProt	A0A8I6ADW9_RAT	UniProtKB/TrEMBL
	A0A8I6G8K5_RAT	UniProtKB/TrEMBL
	B1WC34	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Prkcsh	protein kinase C substrate 80K-H	Prkcsh_predicted	protein kinase C substrate 80K-H (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Prkcsh_predicted	protein kinase C substrate 80K-H (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)