Nek1 (NIMA-related kinase 1) - Rat Genome Database

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Gene: Nek1 (NIMA-related kinase 1) Rattus norvegicus
Analyze
Symbol: Nek1
Name: NIMA-related kinase 1
RGD ID: 1309375
Description: Predicted to enable 14-3-3 protein binding activity and protein kinase activity. Predicted to be involved in cilium assembly and regulation of DNA damage checkpoint. Predicted to act upstream of or within several processes, including DNA damage response; response to ionizing radiation; and spermatogenesis. Predicted to be located in centrosome; cytosol; and nucleoplasm. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 24; asphyxiating thoracic dystrophy; orofaciodigital syndrome; and short-rib thoracic dysplasia 6 with or without polydactyly. Orthologous to human NEK1 (NIMA related kinase 1); INTERACTS WITH bisphenol A; chloroprene; oxaliplatin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC103690126; LOC290705; NIMA (never in mitosis gene a)-related expressed kinase 1; NIMA (never in mitosis gene a)-related kinase 1; serine/threonine-protein kinase Nek1; uncharacterized LOC103690126
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81634,009,092 - 34,137,418 (-)NCBIGRCr8
mRatBN7.21628,998,229 - 29,125,426 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1628,998,231 - 29,117,723 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1632,593,117 - 32,712,602 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01636,026,844 - 36,146,328 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01632,228,326 - 32,347,844 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01632,321,010 - 32,439,421 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1632,321,010 - 32,439,421 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01632,155,914 - 32,274,325 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01631,025,718 - 31,032,968 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41632,317,987 - 32,438,010 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11632,320,904 - 32,431,386 (-)NCBI
Celera1628,993,115 - 29,112,552 (-)NCBICelera
Cytogenetic Map16p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
centriolar satellite  (IEA,ISO)
centrosome  (ISO)
cytoplasm  (ISO)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (ISO)
pericentriolar material  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. NEK1 and DYNC2H1 are both involved in short rib polydactyly Majewski type but not in Beemer Langer cases. El Hokayem J, etal., J Med Genet. 2012 Apr;49(4):227-33. doi: 10.1136/jmedgenet-2011-100717.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. NEK1 mutations cause short-rib polydactyly syndrome type majewski. Thiel C, etal., Am J Hum Genet. 2011 Jan 7;88(1):106-14. doi: 10.1016/j.ajhg.2010.12.004.
Additional References at PubMed
PMID:10618398   PMID:15604234   PMID:16267153   PMID:18843199   PMID:19158487   PMID:19699716   PMID:21399614   PMID:28235073  


Genomics

Comparative Map Data
Nek1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81634,009,092 - 34,137,418 (-)NCBIGRCr8
mRatBN7.21628,998,229 - 29,125,426 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1628,998,231 - 29,117,723 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1632,593,117 - 32,712,602 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01636,026,844 - 36,146,328 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01632,228,326 - 32,347,844 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01632,321,010 - 32,439,421 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1632,321,010 - 32,439,421 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01632,155,914 - 32,274,325 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01631,025,718 - 31,032,968 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41632,317,987 - 32,438,010 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11632,320,904 - 32,431,386 (-)NCBI
Celera1628,993,115 - 29,112,552 (-)NCBICelera
Cytogenetic Map16p12NCBI
NEK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384169,392,809 - 169,612,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4169,369,704 - 169,612,632 (-)EnsemblGRCh38hg38GRCh38
GRCh374170,313,960 - 170,533,734 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364170,551,004 - 170,770,189 (-)NCBINCBI36Build 36hg18NCBI36
Build 344170,689,158 - 170,908,344NCBI
Celera4167,647,120 - 167,866,584 (-)NCBICelera
Cytogenetic Map4q33NCBI
HuRef4166,069,151 - 166,288,552 (-)NCBIHuRef
CHM1_14170,290,871 - 170,510,372 (-)NCBICHM1_1
T2T-CHM13v2.04172,752,512 - 172,972,332 (-)NCBIT2T-CHM13v2.0
Nek1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39861,446,184 - 61,584,383 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl861,446,229 - 61,584,380 (+)EnsemblGRCm39 Ensembl
GRCm38860,993,157 - 61,131,349 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl860,993,195 - 61,131,346 (+)EnsemblGRCm38mm10GRCm38
MGSCv37863,472,017 - 63,609,031 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36863,885,335 - 64,023,496 (+)NCBIMGSCv36mm8
Celera863,560,390 - 63,696,381 (+)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map830.91NCBI
Nek1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540336,720,162 - 36,881,891 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540336,710,248 - 36,878,901 (+)NCBIChiLan1.0ChiLan1.0
NEK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23167,174,897 - 167,388,951 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14167,530,541 - 167,744,594 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04161,618,181 - 161,830,332 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14173,690,074 - 173,902,100 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4173,690,074 - 173,902,100 (-)Ensemblpanpan1.1panPan2
NEK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12520,297,190 - 20,528,537 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2520,299,079 - 20,518,483 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2520,934,647 - 21,153,217 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02520,475,506 - 20,704,356 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2520,475,503 - 20,694,127 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12520,318,819 - 20,578,371 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02520,295,186 - 20,524,672 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02520,394,714 - 20,624,101 (-)NCBIUU_Cfam_GSD_1.0
Nek1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494321,094,565 - 21,252,579 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365161,508,811 - 1,666,869 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365161,508,800 - 1,666,841 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1420,144,659 - 20,332,245 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11420,144,631 - 20,332,248 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21421,439,141 - 21,626,347 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NEK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17115,621,917 - 115,819,349 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7115,621,916 - 115,819,291 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603795,560,952 - 95,765,438 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nek1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624769945,644 - 1,147,246 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624769945,788 - 1,146,921 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nek1
542 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:318
Count of miRNA genes:186
Interacting mature miRNAs:218
Transcripts:ENSRNOT00000043100
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat

Markers in Region
BE120791  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21629,036,193 - 29,036,344 (+)MAPPERmRatBN7.2
Rnor_6.01632,358,969 - 32,359,119NCBIRnor6.0
Rnor_5.01632,193,873 - 32,194,023UniSTSRnor5.0
RGSC_v3.41632,356,042 - 32,356,192UniSTSRGSC3.4
Celera1629,031,075 - 29,031,225UniSTS
Cytogenetic Map16p12UniSTS
D8Ertd790e  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21628,998,314 - 28,998,514 (+)MAPPERmRatBN7.2
Rnor_6.01632,321,094 - 32,321,293NCBIRnor6.0
Rnor_5.01632,155,998 - 32,156,197UniSTSRnor5.0
RGSC_v3.41632,318,073 - 32,318,272UniSTSRGSC3.4
Celera1628,993,199 - 28,993,398UniSTS
Cytogenetic Map16p12UniSTS
AU048511  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21629,027,423 - 29,027,684 (+)MAPPERmRatBN7.2
Rnor_6.01632,350,199 - 32,350,459NCBIRnor6.0
Rnor_5.01632,185,103 - 32,185,363UniSTSRnor5.0
RGSC_v3.41632,347,272 - 32,347,532UniSTSRGSC3.4
Celera1629,022,305 - 29,022,565UniSTS
Cytogenetic Map16p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 9 15 66 6 28 8
Low 3 43 48 41 4 41 8 10 8 29 13 3 8
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000043100   ⟹   ENSRNOP00000043277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1628,998,231 - 29,117,723 (-)Ensembl
Rnor_6.0 Ensembl1632,321,010 - 32,439,421 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082712   ⟹   ENSRNOP00000073376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1628,998,231 - 29,117,723 (-)Ensembl
Rnor_6.0 Ensembl1632,321,837 - 32,421,005 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098175   ⟹   ENSRNOP00000081562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1628,998,231 - 29,117,723 (-)Ensembl
RefSeq Acc Id: NM_001106082   ⟹   NP_001099552
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,009,094 - 34,128,576 (-)NCBI
mRatBN7.21628,998,231 - 29,117,723 (-)NCBI
Rnor_6.01632,321,010 - 32,439,421 (-)NCBI
Rnor_5.01632,155,914 - 32,274,325 (-)NCBI
RGSC_v3.41632,317,987 - 32,438,010 (-)RGD
Celera1628,993,115 - 29,112,552 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039094359   ⟹   XP_038950287
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,009,092 - 34,129,095 (-)NCBI
mRatBN7.21628,998,229 - 29,118,170 (-)NCBI
RefSeq Acc Id: XM_039094360   ⟹   XP_038950288
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,009,092 - 34,136,270 (-)NCBI
mRatBN7.21628,998,229 - 29,125,426 (-)NCBI
RefSeq Acc Id: XM_039094361   ⟹   XP_038950289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,009,092 - 34,129,050 (-)NCBI
mRatBN7.21628,998,229 - 29,118,171 (-)NCBI
RefSeq Acc Id: XM_039094362   ⟹   XP_038950290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,009,092 - 34,129,050 (-)NCBI
mRatBN7.21628,998,229 - 29,118,170 (-)NCBI
RefSeq Acc Id: XM_039094363   ⟹   XP_038950291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,009,092 - 34,129,050 (-)NCBI
mRatBN7.21628,998,229 - 29,118,169 (-)NCBI
RefSeq Acc Id: XM_039094364   ⟹   XP_038950292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,009,092 - 34,129,049 (-)NCBI
mRatBN7.21628,998,229 - 29,118,168 (-)NCBI
RefSeq Acc Id: XM_039094365   ⟹   XP_038950293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,009,092 - 34,113,493 (-)NCBI
mRatBN7.21628,998,229 - 29,110,964 (-)NCBI
RefSeq Acc Id: XM_039094367   ⟹   XP_038950295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,009,092 - 34,088,448 (-)NCBI
mRatBN7.21628,998,229 - 29,077,598 (-)NCBI
RefSeq Acc Id: XM_039094368   ⟹   XP_038950296
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,009,092 - 34,081,703 (-)NCBI
mRatBN7.21628,998,229 - 29,070,841 (-)NCBI
RefSeq Acc Id: XM_039094369   ⟹   XP_038950297
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,009,092 - 34,081,703 (-)NCBI
mRatBN7.21628,998,229 - 29,070,839 (-)NCBI
RefSeq Acc Id: XM_063275214   ⟹   XP_063131284
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,009,092 - 34,137,418 (-)NCBI
RefSeq Acc Id: XM_063275216   ⟹   XP_063131286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,009,092 - 34,137,418 (-)NCBI
RefSeq Acc Id: XM_063275217   ⟹   XP_063131287
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,009,092 - 34,129,050 (-)NCBI
RefSeq Acc Id: XM_063275218   ⟹   XP_063131288
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,009,092 - 34,137,418 (-)NCBI
RefSeq Acc Id: XM_063275219   ⟹   XP_063131289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,009,092 - 34,129,050 (-)NCBI
RefSeq Acc Id: XM_063275220   ⟹   XP_063131290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,009,092 - 34,129,050 (-)NCBI
RefSeq Acc Id: XM_063275222   ⟹   XP_063131292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,009,092 - 34,137,418 (-)NCBI
RefSeq Acc Id: XM_063275223   ⟹   XP_063131293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,009,092 - 34,088,448 (-)NCBI
RefSeq Acc Id: XR_010058284
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,074,511 - 34,129,051 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001099552   ⟸   NM_001106082
- UniProtKB: D3ZB99 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073376   ⟸   ENSRNOT00000082712
RefSeq Acc Id: ENSRNOP00000043277   ⟸   ENSRNOT00000043100
RefSeq Acc Id: XP_038950288   ⟸   XM_039094360
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038950289   ⟸   XM_039094361
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038950290   ⟸   XM_039094362
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038950287   ⟸   XM_039094359
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038950291   ⟸   XM_039094363
- Peptide Label: isoform X4
- UniProtKB: A0A0G2K5C7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950292   ⟸   XM_039094364
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038950293   ⟸   XM_039094365
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038950295   ⟸   XM_039094367
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038950296   ⟸   XM_039094368
- Peptide Label: isoform X12
RefSeq Acc Id: XP_038950297   ⟸   XM_039094369
- Peptide Label: isoform X13
RefSeq Acc Id: ENSRNOP00000081562   ⟸   ENSRNOT00000098175
RefSeq Acc Id: XP_063131292   ⟸   XM_063275222
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063131288   ⟸   XM_063275218
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063131286   ⟸   XM_063275216
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063131284   ⟸   XM_063275214
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063131290   ⟸   XM_063275220
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063131287   ⟸   XM_063275217
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063131289   ⟸   XM_063275219
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZRX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131293   ⟸   XM_063275223
- Peptide Label: isoform X11
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZB99-F1-model_v2 AlphaFold D3ZB99 1-1199 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309375 AgrOrtholog
BioCyc Gene G2FUF-11578 BioCyc
Ensembl Genes ENSRNOG00000010418 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043100 ENTREZGENE
  ENSRNOT00000043100.6 UniProtKB/TrEMBL
  ENSRNOT00000082712.2 UniProtKB/TrEMBL
  ENSRNOT00000098175.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:290705 UniProtKB/TrEMBL
NCBI Gene 290705 ENTREZGENE
PANTHER CAMK FAMILY PROTEIN KINASE UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE NEK1 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Nek1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010418 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A0G2K5C7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZRX9 ENTREZGENE, UniProtKB/TrEMBL
  D3ZB99 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Nek1  NIMA-related kinase 1  LOC103690126  uncharacterized LOC103690126  Data merged from RGD:9083566 737654 PROVISIONAL
2014-08-25 LOC103690126  uncharacterized LOC103690126      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-11-21 Nek1  NIMA-related kinase 1  Nek1  NIMA (never in mitosis gene a)-related kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-01-13 Nek1  NIMA (never in mitosis gene a)-related kinase 1  Nek1  NIMA (never in mitosis gene a)-related expressed kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Nek1  NIMA (never in mitosis gene a)-related expressed kinase 1   Nek1_predicted  NIMA (never in mitosis gene a)-related expressed kinase 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Nek1_predicted  NIMA (never in mitosis gene a)-related expressed kinase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED