Lama2 (laminin subunit alpha 2) - Rat Genome Database

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Gene: Lama2 (laminin subunit alpha 2) Rattus norvegicus
Analyze
Symbol: Lama2
Name: laminin subunit alpha 2
RGD ID: 1308889
Description: Predicted to be an extracellular matrix structural constituent. Involved in Schwann cell differentiation. Located in basement membrane and dendritic spine. Biomarker of renovascular hypertension. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; muscular dystrophy; and myopia. Orthologous to human LAMA2 (laminin subunit alpha 2); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; cell-extracellular matrix signaling pathway; dilated cardiomyopathy pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: laminin subunit alpha-2; laminin, alpha 2; LOC309368
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Lama2Tn(sb-T2/Bart3)2.2013Mcwi  
Genetic Models: F344-Lama2Tn(sb-T2/Bart3)2.2013Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8119,492,126 - 20,140,056 (+)NCBIGRCr8
mRatBN7.2117,672,675 - 18,320,641 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl117,672,536 - 18,320,530 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0118,491,264 - 19,143,486 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl118,491,384 - 19,143,269 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0120,002,787 - 20,647,256 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4118,203,466 - 18,885,462 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1118,324,930 - 18,885,310 (+)NCBI
Celera116,078,601 - 16,724,118 (+)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
9-cis-retinoic acid  (ISO)
aflatoxin B1  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amphetamine  (EXP)
arsenite(3-)  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
calcitriol  (ISO)
cantharidin  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
Cuprizon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fonofos  (ISO)
inulin  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
mifepristone  (ISO)
mitoxantrone  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-ethyl-N-nitrosourea  (ISO)
nickel atom  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenytoin  (EXP)
pioglitazone  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
Ptaquiloside  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sotorasib  (ISO)
terbufos  (ISO)
tetrachloromethane  (ISO)
topotecan  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Mutations in the laminin alpha 2-chain gene (LAMA2) cause merosin-deficient congenital muscular dystrophy. Helbling-Leclerc A, etal., Nat Genet. 1995 Oct;11(2):216-8.
4. Correction of a splicing defect in a mouse model of congenital muscular dystrophy type 1A using a homology-directed-repair-independent mechanism. Kemaladewi DU, etal., Nat Med. 2017 Aug;23(8):984-989. doi: 10.1038/nm.4367. Epub 2017 Jul 17.
5. Expression of laminin-2 by normal and neoplastic rat C cells during the development of medullary thyroid carcinoma. Lekmine F, etal., Virchows Arch. 1999 Apr;434(4):325-32.
6. Expression of dystroglycan complex in satellite cells of dorsal root ganglia. Masaki T, etal., Acta Neuropathol (Berl). 2001 Feb;101(2):174-8.
7. Expression of dystroglycan and the laminin-alpha 2 chain in the rat peripheral nerve during development. Masaki T, etal., Exp Neurol. 2002 Mar;174(1):109-17.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Expression of laminin alpha2 chain during normal and pathological growth of myocardium in rat and human. Oliviero P, etal., Cardiovasc Res. 2000 May;46(2):346-55.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Laminin-alpha2 chain-like antigens in CNS dendritic spines. Tian M, etal., Brain Res. 1997 Aug 1;764(1-2):28-38.
17. When do myopia genes have their effect? Comparison of genetic risks between children and adults. Tideman JW, etal., Genet Epidemiol. 2016 Dec;40(8):756-766. doi: 10.1002/gepi.21999. Epub 2016 Sep 9.
Additional References at PubMed
PMID:2099832   PMID:8568931   PMID:9264260   PMID:9396756   PMID:9524190   PMID:11115849   PMID:12051813   PMID:14557481   PMID:15895400   PMID:18757743   PMID:19295126   PMID:19739104  
PMID:22654118   PMID:23376485   PMID:24006456   PMID:27068509   PMID:27559042   PMID:27815338  


Genomics

Comparative Map Data
Lama2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8119,492,126 - 20,140,056 (+)NCBIGRCr8
mRatBN7.2117,672,675 - 18,320,641 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl117,672,536 - 18,320,530 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0118,491,264 - 19,143,486 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl118,491,384 - 19,143,269 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0120,002,787 - 20,647,256 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4118,203,466 - 18,885,462 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1118,324,930 - 18,885,310 (+)NCBI
Celera116,078,601 - 16,724,118 (+)NCBICelera
Cytogenetic Map1p12NCBI
LAMA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386128,883,138 - 129,516,566 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6128,883,138 - 129,516,566 (+)EnsemblGRCh38hg38GRCh38
GRCh376129,204,283 - 129,837,711 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366129,245,979 - 129,879,404 (+)NCBINCBI36Build 36hg18NCBI36
Build 346129,246,034 - 129,879,401NCBI
Celera6129,950,556 - 130,583,793 (+)NCBICelera
Cytogenetic Map6q22.33NCBI
HuRef6126,785,527 - 127,418,362 (+)NCBIHuRef
CHM1_16129,468,357 - 130,101,369 (+)NCBICHM1_1
T2T-CHM13v2.06130,076,331 - 130,710,229 (+)NCBIT2T-CHM13v2.0
Lama2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391026,857,281 - 27,493,021 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1026,856,032 - 27,495,754 (-)EnsemblGRCm39 Ensembl
GRCm381026,981,285 - 27,617,191 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1026,980,036 - 27,619,758 (-)EnsemblGRCm38mm10GRCm38
MGSCv371026,701,091 - 27,336,748 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361026,670,819 - 27,306,267 (-)NCBIMGSCv36mm8
Celera1027,907,208 - 28,541,586 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1014.23NCBI
Lama2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554369,830,030 - 10,399,891 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554369,829,777 - 10,400,101 (+)NCBIChiLan1.0ChiLan1.0
LAMA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25148,876,669 - 149,513,805 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16146,784,037 - 147,421,936 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06126,672,013 - 127,307,870 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16130,781,676 - 131,415,549 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6130,781,781 - 131,415,337 (+)Ensemblpanpan1.1panPan2
LAMA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1167,645,461 - 68,096,506 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl167,611,122 - 68,095,914 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha168,254,521 - 68,844,637 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0167,721,690 - 68,305,337 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl167,721,701 - 68,304,715 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1167,644,723 - 68,228,165 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0167,427,961 - 68,011,313 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0168,070,825 - 68,654,877 (+)NCBIUU_Cfam_GSD_1.0
Lama2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946117,593,991 - 118,159,491 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936639259,889 - 825,065 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936639259,662 - 825,170 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LAMA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl133,866,850 - 34,359,698 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1133,765,412 - 34,359,741 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2137,284,919 - 37,545,503 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LAMA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11344,074,128 - 44,688,187 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1344,073,525 - 44,531,889 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604016,239,880 - 16,874,460 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lama2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247533,336,227 - 3,793,940 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247533,194,678 - 3,794,145 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lama2
1431 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:115
Count of miRNA genes:92
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000014917
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124744506Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128736750Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1592587724697545Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)11532110019121980Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat

Markers in Region
D1Got23  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2118,212,061 - 18,212,241 (+)MAPPERmRatBN7.2
Rnor_6.0119,034,627 - 19,034,806NCBIRnor6.0
Rnor_5.0120,539,064 - 20,539,243UniSTSRnor5.0
RGSC_v3.4118,776,338 - 18,776,518RGDRGSC3.4
RGSC_v3.4118,776,339 - 18,776,518UniSTSRGSC3.4
RGSC_v3.1118,776,401 - 18,776,580RGD
Celera116,616,775 - 16,616,954UniSTS
RH 3.4 Map1179.2UniSTS
RH 3.4 Map1179.2RGD
RH 2.0 Map1105.5RGD
Cytogenetic Map1p12UniSTS
RH129016  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2118,320,436 - 18,320,616 (+)MAPPERmRatBN7.2
Rnor_6.0119,143,282 - 19,143,461NCBIRnor6.0
Rnor_5.0120,647,052 - 20,647,231UniSTSRnor5.0
RGSC_v3.4118,885,258 - 18,885,437UniSTSRGSC3.4
Celera116,723,914 - 16,724,093UniSTS
RH 3.4 Map1178.2UniSTS
Cytogenetic Map1p12UniSTS
RH138034  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2117,910,359 - 17,910,570 (+)MAPPERmRatBN7.2
Rnor_6.0118,730,287 - 18,730,497NCBIRnor6.0
Rnor_5.0120,238,082 - 20,238,292UniSTSRnor5.0
RGSC_v3.4118,442,358 - 18,442,568UniSTSRGSC3.4
Celera116,316,149 - 16,316,359UniSTS
RH 3.4 Map1178.3UniSTS
Cytogenetic Map1p12UniSTS
EST-CFZ97756  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2117,718,112 - 17,718,464 (+)MAPPERmRatBN7.2
Rnor_6.0118,535,680 - 18,536,031NCBIRnor6.0
Rnor_5.0120,047,158 - 20,047,509UniSTSRnor5.0
RGSC_v3.4118,249,000 - 18,249,351UniSTSRGSC3.4
Celera116,124,057 - 16,124,408UniSTS
Cytogenetic Map1p12UniSTS
AU049510  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2117,870,999 - 17,871,286 (+)MAPPERmRatBN7.2
Rnor_6.0118,690,967 - 18,691,253NCBIRnor6.0
Rnor_5.0120,199,031 - 20,199,317UniSTSRnor5.0
RGSC_v3.4118,402,537 - 18,402,823UniSTSRGSC3.4
Celera116,276,775 - 16,277,061UniSTS
Cytogenetic Map1p12UniSTS


Genetic Models
This gene Lama2 is modified in the following models/strains:
F344-Lama2Tn(sb-T2/Bart3)2.2013Mcwi    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 33 9 2 10 2 8 10 5 24 30 11 8
Low 3 8 46 37 9 37 1 69 11 11
Below cutoff 2 2 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014917   ⟹   ENSRNOP00000014917
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl117,672,536 - 18,320,530 (+)Ensembl
Rnor_6.0 Ensembl118,491,384 - 19,143,269 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000079138   ⟹   ENSRNOP00000070049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl117,672,714 - 18,320,530 (+)Ensembl
Rnor_6.0 Ensembl118,491,384 - 19,143,269 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102071   ⟹   ENSRNOP00000078909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl117,672,536 - 18,320,530 (+)Ensembl
RefSeq Acc Id: NM_001427039   ⟹   NP_001413968
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8119,492,146 - 20,140,056 (+)NCBI
RefSeq Acc Id: XM_063264627   ⟹   XP_063120697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8119,492,126 - 20,140,056 (+)NCBI
RefSeq Acc Id: XM_063264628   ⟹   XP_063120698
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8119,492,126 - 20,140,056 (+)NCBI
RefSeq Acc Id: XM_063264629   ⟹   XP_063120699
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8119,492,126 - 20,140,056 (+)NCBI
RefSeq Acc Id: XM_063264630   ⟹   XP_063120700
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8119,492,126 - 20,140,056 (+)NCBI
RefSeq Acc Id: XM_063264632   ⟹   XP_063120702
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8119,492,126 - 20,140,056 (+)NCBI
RefSeq Acc Id: XM_063264637   ⟹   XP_063120707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8119,492,126 - 20,140,056 (+)NCBI
RefSeq Acc Id: XM_063264642   ⟹   XP_063120712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8119,492,126 - 20,140,056 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000070049   ⟸   ENSRNOT00000079138
RefSeq Acc Id: ENSRNOP00000014917   ⟸   ENSRNOT00000014917
RefSeq Acc Id: ENSRNOP00000078909   ⟸   ENSRNOT00000102071
RefSeq Acc Id: XP_063120697   ⟸   XM_063264627
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063120698   ⟸   XM_063264628
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063120700   ⟸   XM_063264630
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063120702   ⟸   XM_063264632
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063120699   ⟸   XM_063264629
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063120707   ⟸   XM_063264637
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063120712   ⟸   XM_063264642
- Peptide Label: isoform X7
RefSeq Acc Id: NP_001413968   ⟸   NM_001427039
- Peptide Label: precursor
- UniProtKB: A0A0G2JWX2 (UniProtKB/TrEMBL),   F1M614 (UniProtKB/TrEMBL)
Protein Domains
Laminin EGF-like   Laminin G   Laminin IV type A   Laminin N-terminal

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308889 AgrOrtholog
BioCyc Gene G2FUF-62164 BioCyc
Ensembl Genes ENSRNOG00000011134 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014917.8 UniProtKB/TrEMBL
  ENSRNOT00000079138.2 UniProtKB/TrEMBL
  ENSRNOT00000102071.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
  Methyl-accepting chemotaxis protein UniProtKB/TrEMBL
  Tie2 ligand-binding domain superfamily UniProtKB/TrEMBL
InterPro ConA-like_subgrp UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF_laminin UniProtKB/TrEMBL
  Growth_fac_rcpt_N_dom UniProtKB/TrEMBL
  Laminin_B_type_IV UniProtKB/TrEMBL
  Laminin_G UniProtKB/TrEMBL
  Laminin_I UniProtKB/TrEMBL
  Laminin_II UniProtKB/TrEMBL
  Laminin_N UniProtKB/TrEMBL
NCBI Gene 309368 ENTREZGENE
PANTHER LAMININ SUBUNIT GAMMA-1 UniProtKB/TrEMBL
  NETRIN/LAMININ-RELATED UniProtKB/TrEMBL
Pfam Laminin_B UniProtKB/TrEMBL
  Laminin_EGF UniProtKB/TrEMBL
  Laminin_G_1 UniProtKB/TrEMBL
  Laminin_G_2 UniProtKB/TrEMBL
  Laminin_I UniProtKB/TrEMBL
  Laminin_II UniProtKB/TrEMBL
  Laminin_N UniProtKB/TrEMBL
PhenoGen Lama2 PhenoGen
PRINTS EGFLAMININ UniProtKB/TrEMBL
PROSITE EGF_LAM_1 UniProtKB/TrEMBL
  EGF_LAM_2 UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/TrEMBL
  LAMININ_IVA UniProtKB/TrEMBL
  LAMININ_NTER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011134 RatGTEx
SMART EGF UniProtKB/TrEMBL
  EGF_Lam UniProtKB/TrEMBL
  LamB UniProtKB/TrEMBL
  LamG UniProtKB/TrEMBL
  LamNT UniProtKB/TrEMBL
Superfamily-SCOP ConA_like_lec_gl UniProtKB/TrEMBL
  EGF/Laminin UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A0G2JWX2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZPP7_RAT UniProtKB/TrEMBL
  F1M614 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Lama2  laminin, alpha 2   Lama2_predicted  laminin, alpha 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Lama2_predicted  laminin, alpha 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED