Kank3 (KN motif and ankyrin repeat domains 3) - Rat Genome Database

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Gene: Kank3 (KN motif and ankyrin repeat domains 3) Rattus norvegicus
Analyze
Symbol: Kank3
Name: KN motif and ankyrin repeat domains 3
RGD ID: 1308853
Description: Predicted to be involved in negative regulation of actin filament polymerization. Predicted to be active in cytoplasm and cytoskeleton. Orthologous to human KANK3 (KN motif and ankyrin repeat domains 3); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ankrd47; ankyrin repeat domain 47; KN motif and ankyrin repeat domain-containing protein 3; LOC366848; RGD1308853; similar to NG28
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8715,296,538 - 15,309,838 (+)NCBIGRCr8
mRatBN7.2714,594,358 - 14,607,675 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl714,594,422 - 14,607,675 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx717,602,977 - 17,616,241 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0719,468,258 - 19,481,514 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0717,348,606 - 17,361,870 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0718,668,665 - 18,681,945 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl718,668,692 - 18,681,939 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0718,846,292 - 18,859,545 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4716,305,681 - 16,319,593 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1716,311,651 - 16,319,388 (+)NCBI
Celera713,492,821 - 13,505,074 (+)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytoskeleton  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Kank3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8715,296,538 - 15,309,838 (+)NCBIGRCr8
mRatBN7.2714,594,358 - 14,607,675 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl714,594,422 - 14,607,675 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx717,602,977 - 17,616,241 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0719,468,258 - 19,481,514 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0717,348,606 - 17,361,870 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0718,668,665 - 18,681,945 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl718,668,692 - 18,681,939 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0718,846,292 - 18,859,545 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4716,305,681 - 16,319,593 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1716,311,651 - 16,319,388 (+)NCBI
Celera713,492,821 - 13,505,074 (+)NCBICelera
Cytogenetic Map7q13NCBI
KANK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38198,322,584 - 8,343,262 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl198,322,584 - 8,343,262 (-)EnsemblGRCh38hg38GRCh38
GRCh37198,387,468 - 8,408,146 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36198,293,468 - 8,314,146 (-)NCBINCBI36Build 36hg18NCBI36
Celera198,243,994 - 8,264,638 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef198,041,505 - 8,061,817 (-)NCBIHuRef
CHM1_1198,386,970 - 8,407,570 (-)NCBICHM1_1
T2T-CHM13v2.0198,309,103 - 8,329,720 (-)NCBIT2T-CHM13v2.0
Kank3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,029,497 - 34,041,894 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,029,493 - 34,041,892 (+)EnsemblGRCm39 Ensembl
GRCm381733,810,523 - 33,822,920 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1733,810,519 - 33,822,918 (+)EnsemblGRCm38mm10GRCm38
MGSCv371733,947,468 - 33,959,859 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361733,416,632 - 33,428,874 (+)NCBIMGSCv36mm8
Celera1736,567,935 - 36,580,327 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
Kank3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555631,056,084 - 1,073,391 (+)NCBIChiLan1.0ChiLan1.0
KANK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22012,990,200 - 13,010,825 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11912,106,875 - 12,127,496 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0197,608,301 - 7,628,936 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1198,459,438 - 8,470,922 (-)NCBIpanpan1.1PanPan1.1panPan2
KANK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,903,376 - 52,916,250 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2052,903,372 - 53,102,139 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2052,704,716 - 52,717,589 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02053,431,281 - 53,444,168 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2053,431,452 - 53,629,820 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12052,633,748 - 52,646,584 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,079,221 - 53,092,071 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02053,310,788 - 53,323,647 (-)NCBIUU_Cfam_GSD_1.0
Kank3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118212,666,089 - 212,678,955 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365885,156,095 - 5,164,627 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365885,155,833 - 5,168,656 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KANK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl270,938,787 - 70,953,543 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1270,938,732 - 70,953,543 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2271,305,401 - 71,320,232 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KANK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.167,685,785 - 7,717,105 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl67,686,039 - 7,701,534 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607412,582,730 - 12,604,200 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kank3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248281,117,071 - 1,129,860 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kank3
16 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:30
Count of miRNA genes:29
Interacting mature miRNAs:30
Transcripts:ENSRNOT00000009532
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat

Markers in Region
RH129344  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2714,607,447 - 14,607,643 (+)MAPPERmRatBN7.2
Rnor_6.0718,681,718 - 18,681,913NCBIRnor6.0
Rnor_5.0718,859,318 - 18,859,513UniSTSRnor5.0
RGSC_v3.4716,319,366 - 16,319,561UniSTSRGSC3.4
Celera713,504,847 - 13,505,042UniSTS
Cytogenetic Map7q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 32 7 11 1 1 10 29 36 11 1
Low 3 11 50 41 8 41 7 10 64 6 5 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009532   ⟹   ENSRNOP00000009532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl714,594,422 - 14,607,675 (+)Ensembl
Rnor_6.0 Ensembl718,668,692 - 18,681,939 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000120241   ⟹   ENSRNOP00000096794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl714,594,422 - 14,607,675 (+)Ensembl
RefSeq Acc Id: NM_001108989   ⟹   NP_001102459
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8715,296,585 - 15,309,838 (+)NCBI
mRatBN7.2714,594,422 - 14,607,675 (+)NCBI
Rnor_6.0718,668,692 - 18,681,945 (+)NCBI
Rnor_5.0718,846,292 - 18,859,545 (+)NCBI
RGSC_v3.4716,305,681 - 16,319,593 (+)RGD
Celera713,492,821 - 13,505,074 (+)RGD
Sequence:
RefSeq Acc Id: XM_008765202   ⟹   XP_008763424
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8715,296,539 - 15,309,838 (+)NCBI
mRatBN7.2714,594,373 - 14,607,675 (+)NCBI
Rnor_6.0718,668,665 - 18,681,945 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039079670   ⟹   XP_038935598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8715,296,538 - 15,306,403 (+)NCBI
mRatBN7.2714,594,358 - 14,604,240 (+)NCBI
RefSeq Acc Id: XM_039079671   ⟹   XP_038935599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8715,296,538 - 15,306,283 (+)NCBI
mRatBN7.2714,594,358 - 14,604,125 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001102459   ⟸   NM_001108989
- UniProtKB: B2RYN8 (UniProtKB/TrEMBL),   A0A8I6AQY0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763424   ⟸   XM_008765202
- Peptide Label: isoform X1
- UniProtKB: F7FCJ4 (UniProtKB/TrEMBL),   A0A8I6AQY0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009532   ⟸   ENSRNOT00000009532
RefSeq Acc Id: XP_038935598   ⟸   XM_039079670
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038935599   ⟸   XM_039079671
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000096794   ⟸   ENSRNOT00000120241

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RYN8-F1-model_v2 AlphaFold B2RYN8 1-808 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695087
Promoter ID:EPDNEW_R5611
Type:single initiation site
Name:Kank3_1
Description:KN motif and ankyrin repeat domains 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0718,668,691 - 18,668,751EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308853 AgrOrtholog
BioCyc Gene G2FUF-34708 BioCyc
Ensembl Genes ENSRNOG00000007230 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009532.7 UniProtKB/TrEMBL
  ENSRNOT00000120241 ENTREZGENE
  ENSRNOT00000120241.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9030846 IMAGE-MGC_LOAD
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  KANK1-4 UniProtKB/TrEMBL
  KN_motif UniProtKB/TrEMBL
KEGG Report rno:366848 UniProtKB/TrEMBL
MGC_CLONE MGC:188740 IMAGE-MGC_LOAD
NCBI Gene 366848 ENTREZGENE
PANTHER KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING UniProtKB/TrEMBL
  KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 3 UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  KN_motif UniProtKB/TrEMBL
PhenoGen Kank3 PhenoGen
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007230 RatGTEx
SMART ANK UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
UniProt A0A8I6AQY0 ENTREZGENE, UniProtKB/TrEMBL
  B2RYN8 ENTREZGENE, UniProtKB/TrEMBL
  F7FCJ4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-03 Kank3  KN motif and ankyrin repeat domains 3  Ankrd47_predicted  ankyrin repeat domain 47 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ankrd47_predicted  ankyrin repeat domain 47 (predicted)  RGD1308853_predicted  similar to NG28 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1308853_predicted  similar to NG28 (predicted)  LOC366848_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC366848_predicted  similar to NG28 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL