Irak3 (interleukin-1 receptor-associated kinase 3) - Rat Genome Database

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Gene: Irak3 (interleukin-1 receptor-associated kinase 3) Rattus norvegicus
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Symbol: Irak3
Name: interleukin-1 receptor-associated kinase 3
RGD ID: 1308846
Description: Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and protein dimerization activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; regulation of cytokine production; and regulation of signal transduction. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IRAK3 (interleukin 1 receptor associated kinase 3); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; apoptotic cell death pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC314870
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8757,538,522 - 57,600,166 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl757,539,557 - 57,598,706 (-)EnsemblGRCr8
mRatBN7.2755,653,949 - 55,714,371 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl755,653,962 - 55,713,121 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx757,560,397 - 57,619,471 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0759,763,565 - 59,822,652 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0759,540,938 - 59,599,993 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0764,922,830 - 64,982,224 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl764,923,615 - 64,982,281 (-)Ensemblrn6Rnor6.0
Rnor_5.0765,142,540 - 65,201,013 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4759,408,198 - 59,467,821 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera752,409,359 - 52,468,444 (-)NCBICelera
RGSC_v3.1759,429,927 - 59,488,412 (-)NCBI
Cytogenetic Map7q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
all-trans-retinoic acid  (EXP)
alpha-Zearalanol  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
crocidolite asbestos  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dieldrin  (EXP)
dioxygen  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
ferulic acid  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyphosate  (EXP)
hyaluronic acid  (ISO)
imiquimod  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
lipoarabinomannan  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methoxyacetic acid  (EXP)
methyl methanesulfonate  (ISO)
mifepristone  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-palmitoyl-S-[2,3-bis(palmitoyloxy)propyl]-Cys-Ser-Lys-Lys-Lys-Lys  (ISO)
nitrates  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
prostaglandin E2  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium sulfate  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
valproic acid  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc protoporphyrin  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
biological_process  (ND)
cytokine-mediated signaling pathway  (IEA,ISO)
interleukin-1-mediated signaling pathway  (IBA,IEA,ISO)
intracellular signal transduction  (IBA)
lipopolysaccharide-mediated signaling pathway  (IBA,IEA,ISO)
negative regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
negative regulation of cytokine-mediated signaling pathway  (IEA)
negative regulation of innate immune response  (IEA,ISO)
negative regulation of interleukin-12 production  (IEA,ISO)
negative regulation of interleukin-6 production  (IEA,ISO)
negative regulation of macrophage cytokine production  (IEA,ISO)
negative regulation of MAPK cascade  (IEA,ISO)
negative regulation of protein catabolic process  (IEA,ISO)
negative regulation of protein-containing complex disassembly  (IEA,ISO)
negative regulation of toll-like receptor signaling pathway  (IEA,ISO)
negative regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IBA)
positive regulation of cytokine production  (IEA,ISO)
positive regulation of immune system process  (IEA)
positive regulation of macrophage tolerance induction  (IEA,ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
protein autophosphorylation  (ISO)
protein phosphorylation  (ISO)
regulation of innate immune response  (IEA)
regulation of protein-containing complex disassembly  (IEA,ISO)
response to exogenous dsRNA  (IEA,ISO)
response to Gram-negative bacterium  (ISO)
response to Gram-positive bacterium  (ISO)
response to interleukin-1  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to peptidoglycan  (IEA,ISO)
response to virus  (IEA)
signal transduction  (IEA)
Toll signaling pathway  (IBA)
toll-like receptor signaling pathway  (ISO)

Cellular Component
cytoplasm  (IBA,IEA,ISO)
nucleus  (IBA,IEA,ISO)
plasma membrane  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Tuberculosis is associated with a down-modulatory lung immune response that impairs Th1-type immunity. Almeida AS, etal., J Immunol. 2009 Jul 1;183(1):718-31. doi: 10.4049/jimmunol.0801212. Epub 2009 Jun 17.
2. Peripheral blood leucocytes show differential expression of tumour progression-related genes in colorectal cancer patients who have a postoperative intra-abdominal infection: a prospective matched cohort study. Alonso S, etal., Colorectal Dis. 2017 May;19(5):O115-O125. doi: 10.1111/codi.13635.
3. Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M. Deng JC, etal., J Clin Invest. 2006 Sep;116(9):2532-42. doi: 10.1172/JCI28054. Epub 2006 Aug 17.
4. Calcineurin inhibitor Tacrolimus impairs host immune response against urinary tract infection. Emal D, etal., Sci Rep. 2019 Jan 14;9(1):106. doi: 10.1038/s41598-018-37482-x.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Interleukin-1 receptor-associated kinase M-deficient mice demonstrate an improved host defense during Gram-negative pneumonia. Hoogerwerf JJ, etal., Mol Med. 2012 Sep 25;18:1067-75. doi: 10.2119/molmed.2011.00450.
8. Plasminogen activator inhibitor type-1 deficiency exaggerates LPS-induced acute lung injury through enhancing Toll-like receptor 4 signaling pathway. Hua F, etal., Blood Coagul Fibrinolysis. 2011 Sep;22(6):480-6. doi: 10.1097/MBC.0b013e328346ef56.
9. Pretreatment of Pam3CSK4 attenuates inflammatory responses caused by systemic infection of methicillin-resistant Staphylococcus aureus in mice. Huang Z, etal., Biomed Pharmacother. 2017 Nov;95:1684-1692. doi: 10.1016/j.biopha.2017.09.058. Epub 2017 Oct 6.
10. A role for IL-1 receptor-associated kinase-M in prostaglandin E2-induced immunosuppression post-bone marrow transplantation. Hubbard LL, etal., J Immunol. 2010 Jun 1;184(11):6299-308. doi: 10.4049/jimmunol.0902828. Epub 2010 May 3.
11. A novel mouse model of conditional IRAK-M deficiency in myeloid cells: application in lung Pseudomonas aeruginosa infection. Jiang D, etal., Innate Immun. 2017 Feb;23(2):206-215. doi: 10.1177/1753425916684202. Epub 2016 Dec 18.
12. Tolerance and Cross-Tolerance following Toll-Like Receptor (TLR)-4 and -9 Activation Are Mediated by IRAK-M and Modulated by IL-7 in Murine Splenocytes. Julian MW, etal., PLoS One. 2015 Jul 28;10(7):e0132921. doi: 10.1371/journal.pone.0132921. eCollection 2015.
13. Inhibition of autoimmune diabetes by TLR2 tolerance. Kim DH, etal., J Immunol. 2011 Nov 15;187(10):5211-20. doi: 10.4049/jimmunol.1001388. Epub 2011 Oct 12.
14. Endogenous HMGB1 is required in endotoxin tolerance. Li S, etal., J Surg Res. 2013 Nov;185(1):319-28. doi: 10.1016/j.jss.2013.05.062. Epub 2013 Jun 10.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M. Miyata M, etal., Nat Commun. 2015 Jan 14;6:6062. doi: 10.1038/ncomms7062.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Rg6, a rare ginsenoside, inhibits systemic inflammation through the induction of interleukin-10 and microRNA-146a. Paik S, etal., Sci Rep. 2019 Mar 13;9(1):4342. doi: 10.1038/s41598-019-40690-8.
19. Mycobacterium tuberculosis lipoarabinomannan-mediated IRAK-M induction negatively regulates Toll-like receptor-dependent interleukin-12 p40 production in macrophages. Pathak SK, etal., J Biol Chem. 2005 Dec 30;280(52):42794-800. doi: 10.1074/jbc.M506471200. Epub 2005 Nov 1.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Comprehensive gene review and curation RGD comprehensive gene curation
25. TGF-β-induced IRAK-M expression in tumor-associated macrophages regulates lung tumor growth. Standiford TJ, etal., Oncogene. 2011 May 26;30(21):2475-84. doi: 10.1038/onc.2010.619. Epub 2011 Jan 31.
26. mRNA-based approach to monitor recombinant gamma-interferon restoration of LPS-induced endotoxin tolerance. Turrel-Davin F, etal., Crit Care. 2011;15(5):R252. doi: 10.1186/cc10513. Epub 2011 Oct 25.
27. Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model. van 't Veer C, etal., J Immunol. 2007 Nov 15;179(10):7110-20. doi: 10.4049/jimmunol.179.10.7110.
28. CD44 deficiency is associated with increased bacterial clearance but enhanced lung inflammation during Gram-negative pneumonia. van der Windt GJ, etal., Am J Pathol. 2010 Nov;177(5):2483-94. doi: 10.2353/ajpath.2010.100562. Epub 2010 Sep 23.
29. Interleukin 1 receptor-associated kinase m impairs host defense during pneumococcal pneumonia. van der Windt GJ, etal., J Infect Dis. 2012 Jun 15;205(12):1849-57. doi: 10.1093/infdis/jis290. Epub 2012 Apr 5.
30. Immunosuppression associated with interleukin-1R-associated-kinase-M upregulation predicts mortality in Gram-negative sepsis (melioidosis). Wiersinga WJ, etal., Crit Care Med. 2009 Feb;37(2):569-76. doi: 10.1097/CCM.0b013e318194b1bf.
31. Induction of endotoxin tolerance in vivo inhibits activation of IRAK4 and increases negative regulators IRAK-M, SHIP-1, and A20. Xiong Y and Medvedev AE, J Leukoc Biol. 2011 Dec;90(6):1141-8. doi: 10.1189/jlb.0611273. Epub 2011 Sep 20.
32. Expression of IRAK‑3 is associated with colitis‑associated tumorigenesis in mice. Xu D, etal., Mol Med Rep. 2017 Sep;16(3):3415-3420. doi: 10.3892/mmr.2017.6958. Epub 2017 Jul 12.
Additional References at PubMed
PMID:10383454   PMID:12054681   PMID:12150927   PMID:12477932   PMID:15728517   PMID:17379480   PMID:18156187   PMID:18497707   PMID:34757596  


Genomics

Comparative Map Data
Irak3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8757,538,522 - 57,600,166 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl757,539,557 - 57,598,706 (-)EnsemblGRCr8
mRatBN7.2755,653,949 - 55,714,371 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl755,653,962 - 55,713,121 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx757,560,397 - 57,619,471 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0759,763,565 - 59,822,652 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0759,540,938 - 59,599,993 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0764,922,830 - 64,982,224 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl764,923,615 - 64,982,281 (-)Ensemblrn6Rnor6.0
Rnor_5.0765,142,540 - 65,201,013 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4759,408,198 - 59,467,821 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera752,409,359 - 52,468,444 (-)NCBICelera
RGSC_v3.1759,429,927 - 59,488,412 (-)NCBI
Cytogenetic Map7q22NCBI
IRAK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381266,189,214 - 66,254,622 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1266,188,995 - 66,254,622 (+)Ensemblhg38GRCh38
GRCh371266,582,994 - 66,648,402 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361264,869,284 - 64,928,652 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341264,869,283 - 64,928,652NCBI
Celera1266,247,192 - 66,312,632 (+)NCBICelera
Cytogenetic Map12q14.3NCBI
HuRef1263,633,632 - 63,699,237 (+)NCBIHuRef
CHM1_11266,549,846 - 66,615,516 (+)NCBICHM1_1
T2T-CHM13v2.01266,168,706 - 66,234,159 (+)NCBIT2T-CHM13v2.0
Irak3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910119,977,553 - 120,038,035 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10119,977,553 - 120,038,035 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3810120,141,648 - 120,202,130 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10120,141,648 - 120,202,130 (-)Ensemblmm10GRCm38
MGSCv3710119,578,710 - 119,638,593 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610119,544,714 - 119,604,597 (-)NCBIMGSCv36mm8
Celera10122,502,683 - 122,562,840 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1067.94NCBI
Irak3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545812,846,237 - 12,879,316 (+)Ensembl
ChiLan1.0NW_00495545812,839,995 - 12,880,285 (+)NCBIChiLan1.0ChiLan1.0
IRAK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21028,101,928 - 28,166,967 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11228,098,693 - 28,163,716 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01222,661,613 - 22,721,203 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11223,168,346 - 23,282,903 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1223,168,346 - 23,227,148 (-)EnsemblpanPan2panpan1.1
IRAK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1108,683,541 - 8,730,757 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl108,684,242 - 8,729,268 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha108,615,238 - 8,661,295 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0108,796,309 - 8,841,957 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl108,796,309 - 8,842,463 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1108,672,755 - 8,718,373 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0108,918,266 - 8,964,392 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0109,039,804 - 9,085,368 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Irak3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494549,820,793 - 49,925,781 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365454,233,358 - 4,282,806 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365454,233,353 - 4,284,324 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRAK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl530,526,793 - 30,609,921 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1530,524,704 - 30,601,067 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2533,798,256 - 33,873,173 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IRAK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11161,868,817 - 61,920,896 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1161,869,173 - 61,920,406 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037183,796,994 - 183,855,987 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irak3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248022,047,409 - 2,098,545 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248022,042,486 - 2,098,921 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Irak3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11198,121,101 - 198,180,038 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Irak3
358 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:207
Count of miRNA genes:151
Interacting mature miRNAs:168
Transcripts:ENSRNOT00000005686
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74913799967614020Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)74968283263890004Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74299622658678836Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
RH141464  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2755,654,036 - 55,654,220 (+)MAPPERmRatBN7.2
Rnor_6.0764,923,839 - 64,924,022NCBIRnor6.0
Rnor_5.0765,142,628 - 65,142,811UniSTSRnor5.0
RGSC_v3.4759,408,286 - 59,408,469UniSTSRGSC3.4
Celera752,409,447 - 52,409,630UniSTS
RH 3.4 Map7477.91UniSTS
Cytogenetic Map7q22UniSTS
RH133525  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2755,657,876 - 55,658,056 (+)MAPPERmRatBN7.2
Rnor_6.0764,927,679 - 64,927,858NCBIRnor6.0
Rnor_5.0765,146,468 - 65,146,647UniSTSRnor5.0
RGSC_v3.4759,412,126 - 59,412,305UniSTSRGSC3.4
Celera752,413,287 - 52,413,466UniSTS
RH 3.4 Map7478.0UniSTS
Cytogenetic Map7q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000005686   ⟹   ENSRNOP00000005686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl757,539,557 - 57,598,706 (-)Ensembl
mRatBN7.2 Ensembl755,653,962 - 55,713,121 (-)Ensembl
Rnor_6.0 Ensembl764,923,615 - 64,982,281 (-)Ensembl
RefSeq Acc Id: NM_001108101   ⟹   NP_001101571
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8757,539,544 - 57,598,631 (-)NCBI
mRatBN7.2755,653,949 - 55,713,046 (-)NCBI
Rnor_6.0764,923,751 - 64,982,224 (-)NCBI
Rnor_5.0765,142,540 - 65,201,013 (-)NCBI
RGSC_v3.4759,408,198 - 59,467,821 (-)RGD
Celera752,409,359 - 52,468,444 (-)RGD
Sequence:
RefSeq Acc Id: XM_017594854   ⟹   XP_017450343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8757,538,522 - 57,593,122 (-)NCBI
mRatBN7.2755,653,953 - 55,707,364 (-)NCBI
Rnor_6.0764,922,830 - 64,974,863 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079132   ⟹   XP_038935060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8757,538,522 - 57,581,600 (-)NCBI
mRatBN7.2755,653,953 - 55,691,910 (-)NCBI
RefSeq Acc Id: XM_039079133   ⟹   XP_038935061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8757,538,522 - 57,593,124 (-)NCBI
mRatBN7.2755,653,953 - 55,707,368 (-)NCBI
RefSeq Acc Id: XM_039079134   ⟹   XP_038935062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8757,538,522 - 57,577,023 (-)NCBI
mRatBN7.2755,653,953 - 55,691,910 (-)NCBI
RefSeq Acc Id: XM_039079135   ⟹   XP_038935063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8757,538,522 - 57,575,502 (-)NCBI
mRatBN7.2755,653,953 - 55,689,913 (-)NCBI
RefSeq Acc Id: XM_039079136   ⟹   XP_038935064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8757,550,330 - 57,600,166 (-)NCBI
mRatBN7.2755,664,748 - 55,714,371 (-)NCBI
RefSeq Acc Id: XM_063263500   ⟹   XP_063119570
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8757,549,097 - 57,600,166 (-)NCBI
RefSeq Acc Id: XM_063263501   ⟹   XP_063119571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8757,538,522 - 57,576,945 (-)NCBI
RefSeq Acc Id: XR_005486627
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8757,543,331 - 57,600,166 (-)NCBI
mRatBN7.2755,657,734 - 55,714,369 (-)NCBI
RefSeq Acc Id: NP_001101571   ⟸   NM_001108101
- UniProtKB: B2RYC8 (UniProtKB/TrEMBL),   F6QZN4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450343   ⟸   XM_017594854
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000005686   ⟸   ENSRNOT00000005686
RefSeq Acc Id: XP_038935061   ⟸   XM_039079133
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038935060   ⟸   XM_039079132
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038935062   ⟸   XM_039079134
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038935063   ⟸   XM_039079135
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038935064   ⟸   XM_039079136
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063119571   ⟸   XM_063263501
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063119570   ⟸   XM_063263500
- Peptide Label: isoform X5
Protein Domains
Death   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RYC8-F1-model_v2 AlphaFold B2RYC8 1-610 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695233
Promoter ID:EPDNEW_R5758
Type:initiation region
Name:Irak3_1
Description:interleukin-1 receptor-associated kinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0764,982,167 - 64,982,227EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308846 AgrOrtholog
BioCyc Gene G2FUF-33914 BioCyc
Ensembl Genes ENSRNOG00000004226 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005686 ENTREZGENE
  ENSRNOT00000005686.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7934689 IMAGE-MGC_LOAD
InterPro Death UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  IRAK3_death UniProtKB/TrEMBL
  IRAK3_PK UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
KEGG Report rno:314870 UniProtKB/TrEMBL
MGC_CLONE MGC:188449 IMAGE-MGC_LOAD
NCBI Gene 314870 ENTREZGENE
PANTHER INTERLEUKIN 1 RECEPTOR-ASSOCIATED KINASE 1 UniProtKB/TrEMBL
  OS01G0253100 PROTEIN UniProtKB/TrEMBL
Pfam Death UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Irak3 PhenoGen
PROSITE DEATH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004226 RatGTEx
SMART DEATH UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
UniProt B2RYC8 ENTREZGENE, UniProtKB/TrEMBL
  F6QZN4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Irak3  interleukin-1 receptor-associated kinase 3   Irak3_predicted  interleukin-1 receptor-associated kinase 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Irak3_predicted  interleukin-1 receptor-associated kinase 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED