Gene: Smarca5 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5) Rattus norvegicus
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Symbol:
Smarca5
Name:
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
RGD ID:
1308832
Description:
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and histone octamer slider activity. Predicted to contribute to histone binding activity. Predicted to be involved in several processes, including chromatin remodeling; regulation of histone modification; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within cellular response to leukemia inhibitory factor; chromatin remodeling; and positive regulation of DNA-templated transcription. Predicted to be located in condensed chromosome; fibrillar center; and nucleoplasm. Predicted to be part of chromatin and chromatin silencing complex. Predicted to be active in nucleus and site of double-strand break. Predicted to colocalize with nuclear replication fork. Orthologous to human SMARCA5 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5); PARTICIPATES IN ISWI family mediated chromatin remodeling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; bisphenol A.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Previously known as:
LOC307766; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
RGD Orthologs
Alliance Genes
More Info
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More Info
Species
Gene symbol and name
Data Source
Assertion derived from
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Orthologs 1
Homo sapiens (human):
SMARCA5 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5)
HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Treefam
Mus musculus (house mouse):
Smarca5 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Smarca5 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SMARCA5 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SMARCA5 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Smarca5 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SMARCA5 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
SMARCA5 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Smarca5 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
RNF31 (ring finger protein 31)
HGNC
OMA
Alliance orthologs 3
Homo sapiens (human):
SMARCA5 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Smarca5 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
smarca5 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5)
Alliance
DIOPT (Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):
ISW1
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Drosophila melanogaster (fruit fly):
Iswi
Alliance
DIOPT (Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Caenorhabditis elegans (roundworm):
isw-1
Alliance
DIOPT (Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):
ISW2
Alliance
DIOPT (Ensembl Compara|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
smarca5
Alliance
DIOPT (Ensembl Compara|OMA|OrthoFinder|PANTHER)
Latest Assembly:
mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl mRatBN7.2 19 27,271,918 - 27,304,594 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 19 27,271,148 - 27,304,594 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 19 34,130,292 - 34,162,927 (+) NCBI Rnor_SHR UTH_Rnor_SHRSP_BbbUtx_1.0 19 34,784,348 - 34,816,983 (+) NCBI Rnor_SHRSP UTH_Rnor_WKY_Bbb_1.0 19 37,004,248 - 37,036,904 (+) NCBI Rnor_WKY Rnor_6.0 19 30,936,703 - 30,969,454 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 19 30,936,703 - 30,969,454 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 19 41,840,174 - 41,873,900 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 19 29,122,301 - 29,155,293 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 19 29,126,640 - 29,160,112 (+) NCBI Celera 19 26,788,347 - 26,821,018 (+) NCBI Celera Cytogenetic Map 19 q11 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Disease Annotations - ClinVar
Only show annotations with direct experimental evidence (0 objects hidden)
1,2-dimethylhydrazine affects expression ISO RGD:1623060 6480464 1, 2-Dimethylhydrazine affects the expression of SMARCA5 mRNA CTD PMID:22206623 1,2-dimethylhydrazine multiple interactions ISO RGD:1623060 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of SMARCA5 mRNA CTD PMID:22206623 17alpha-ethynylestradiol increases expression ISO RGD:1623060 6480464 Ethinyl Estradiol results in increased expression of SMARCA5 mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO RGD:1623060 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMARCA5 mRNA CTD PMID:17942748 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:1623060 6480464 2 more ... CTD PMID:32352317 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1623060 6480464 [Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of SMARCA5 mRNA, [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMARCA5 mRNA CTD PMID:15251184 , PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of SMARCA5 mRNA CTD PMID:33387578 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of SMARCA5 mRNA CTD PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1623060 6480464 Tetrachlorodibenzodioxin affects the expression of SMARCA5 mRNA CTD PMID:24680724 2,4,6-tribromophenol increases expression ISO RGD:1318831 6480464 2 more ... CTD PMID:31675489 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of SMARCA5 mRNA CTD PMID:21346803 2-methylcholine affects expression ISO RGD:1318831 6480464 beta-methylcholine affects the expression of SMARCA5 mRNA CTD PMID:21179406 3,3',5,5'-tetrabromobisphenol A increases expression ISO RGD:1318831 6480464 tetrabromobisphenol A results in increased expression of SMARCA5 protein CTD PMID:31675489 4,4'-sulfonyldiphenol multiple interactions ISO RGD:1318831 6480464 [bis(4-hydroxyphenyl)sulfone co-treated with Fulvestrant] results in increased methylation of SMARCA5 gene CTD PMID:31601247 5-aza-2'-deoxycytidine increases expression ISO RGD:1623060 6480464 Decitabine results in increased expression of SMARCA5 mRNA CTD PMID:15251184 5-aza-2'-deoxycytidine multiple interactions ISO RGD:1623060 6480464 [Tetrachlorodibenzodioxin co-treated with Decitabine] results in increased expression of SMARCA5 mRNA CTD PMID:15251184 all-trans-retinoic acid decreases expression ISO RGD:1318831 6480464 Tretinoin results in decreased expression of SMARCA5 mRNA CTD PMID:17045167 aristolochic acid A decreases expression ISO RGD:1318831 6480464 aristolochic acid I results in decreased expression of SMARCA5 mRNA CTD PMID:33212167 arsenite(3-) multiple interactions ISO RGD:1318831 6480464 arsenite inhibits the reaction [G3BP1 protein binds to SMARCA5 mRNA] CTD PMID:32406909 bisphenol A increases expression ISO RGD:1623060 6480464 bisphenol A results in increased expression of SMARCA5 mRNA CTD PMID:26063408 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SMARCA5 mRNA CTD PMID:25181051 caffeine decreases phosphorylation ISO RGD:1318831 6480464 Caffeine results in decreased phosphorylation of SMARCA5 protein CTD PMID:35688186 cisplatin multiple interactions ISO RGD:1318831 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of SMARCA5 mRNA CTD PMID:27392435 cocaine increases expression ISO RGD:1623060 6480464 Cocaine results in increased expression of SMARCA5 mRNA CTD PMID:27053203 cocaine multiple interactions ISO RGD:1623060 6480464 [SMARCA5 protein co-treated with BAZ1B protein] results in increased susceptibility to Cocaine CTD PMID:27053203 cyclosporin A increases expression ISO RGD:1318831 6480464 Cyclosporine results in increased expression of SMARCA5 mRNA CTD PMID:20106945 decabromodiphenyl ether increases expression ISO RGD:1318831 6480464 decabromobiphenyl ether results in increased expression of SMARCA5 protein CTD PMID:31675489 dibutyl phthalate decreases expression ISO RGD:1623060 6480464 Dibutyl Phthalate results in decreased expression of SMARCA5 mRNA CTD PMID:21266533 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of SMARCA5 mRNA CTD PMID:21266533 diclofenac increases expression ISO RGD:1623060 6480464 Diclofenac results in increased expression of SMARCA5 mRNA CTD PMID:26934552 doxorubicin decreases expression ISO RGD:1318831 6480464 Doxorubicin results in decreased expression of SMARCA5 mRNA CTD PMID:29803840 elemental selenium decreases expression ISO RGD:1318831 6480464 Selenium results in decreased expression of SMARCA5 mRNA CTD PMID:19244175 epoxiconazole increases expression ISO RGD:1623060 6480464 epoxiconazole results in increased expression of SMARCA5 mRNA CTD PMID:35436446 folic acid multiple interactions ISO RGD:1623060 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of SMARCA5 mRNA CTD PMID:22206623 formaldehyde decreases expression ISO RGD:1318831 6480464 Formaldehyde results in decreased expression of SMARCA5 mRNA CTD PMID:23649840 fulvestrant multiple interactions ISO RGD:1318831 6480464 [bis(4-hydroxyphenyl)sulfone co-treated with Fulvestrant] results in increased methylation of SMARCA5 gene CTD PMID:31601247 genistein increases expression ISO RGD:1623060 6480464 Genistein results in increased expression of SMARCA5 mRNA CTD PMID:16169203 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of SMARCA5 mRNA CTD PMID:22061828 hydrogen peroxide decreases expression ISO RGD:1318831 6480464 Hydrogen Peroxide results in decreased expression of SMARCA5 mRNA CTD PMID:18951874 hydrogen peroxide affects expression ISO RGD:1318831 6480464 Hydrogen Peroxide affects the expression of SMARCA5 mRNA CTD PMID:21179406 hypochlorous acid increases expression ISO RGD:1623060 6480464 Hypochlorous Acid results in increased expression of SMARCA5 mRNA CTD PMID:19376150 ivermectin decreases expression ISO RGD:1318831 6480464 Ivermectin results in decreased expression of SMARCA5 protein CTD PMID:32959892 lead(0) affects expression ISO RGD:1318831 6480464 Lead affects the expression of SMARCA5 mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:1318831 6480464 Lead affects the expression of SMARCA5 mRNA CTD PMID:28903495 miconazole decreases expression ISO RGD:1623060 6480464 Miconazole results in decreased expression of SMARCA5 mRNA CTD PMID:27462272 motexafin gadolinium decreases expression ISO RGD:1318831 6480464 motexafin gadolinium results in decreased expression of SMARCA5 mRNA CTD PMID:16357179 motexafin gadolinium multiple interactions ISO RGD:1318831 6480464 [Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SMARCA5 mRNA CTD PMID:16357179 N-methyl-4-phenylpyridinium increases expression ISO RGD:1623060 6480464 1-Methyl-4-phenylpyridinium results in increased expression of SMARCA5 protein CTD PMID:26558463 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of SMARCA5 mRNA CTD PMID:19041683 N-nitrosomorpholine increases expression EXP 6480464 N-nitrosomorpholine results in increased expression of SMARCA5 protein CTD PMID:19716841 oxaliplatin decreases expression EXP 6480464 oxaliplatin results in decreased expression of SMARCA5 mRNA CTD PMID:25729387 paracetamol decreases expression ISO RGD:1318831 6480464 Acetaminophen results in decreased expression of SMARCA5 mRNA CTD PMID:21420995 phenobarbital decreases expression ISO RGD:1623060 6480464 Phenobarbital results in decreased expression of SMARCA5 mRNA CTD PMID:23091169 phenytoin increases expression EXP 6480464 Phenytoin results in increased expression of SMARCA5 mRNA CTD PMID:20345932 piroxicam decreases expression ISO RGD:1318831 6480464 Piroxicam results in decreased expression of SMARCA5 mRNA CTD PMID:21858171 resveratrol decreases expression ISO RGD:1623060 6480464 resveratrol results in decreased expression of SMARCA5 protein CTD PMID:25505154 resveratrol multiple interactions ISO RGD:1318831 6480464 [Plant Extracts co-treated with Resveratrol] results in increased expression of SMARCA5 mRNA CTD PMID:23557933 selenium atom decreases expression ISO RGD:1318831 6480464 Selenium results in decreased expression of SMARCA5 mRNA CTD PMID:19244175 silicon dioxide increases methylation ISO RGD:1318831 6480464 Silicon Dioxide results in increased methylation of SMARCA5 gene CTD PMID:34973136 sodium arsenite affects methylation ISO RGD:1318831 6480464 sodium arsenite affects the methylation of SMARCA5 gene CTD PMID:28589171 Soman increases expression EXP 6480464 Soman results in increased expression of SMARCA5 mRNA CTD PMID:19281266 tetrachloromethane increases expression ISO RGD:1623060 6480464 Carbon Tetrachloride results in increased expression of SMARCA5 mRNA CTD PMID:27339419 , PMID:31919559 tetrahydropalmatine decreases expression ISO RGD:1318831 6480464 tetrahydropalmatine results in decreased expression of SMARCA5 protein CTD PMID:20109541 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of SMARCA5 mRNA CTD PMID:34492290 trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of SMARCA5 mRNA CTD PMID:33387578 trimellitic anhydride increases expression ISO RGD:1623060 6480464 trimellitic anhydride results in increased expression of SMARCA5 mRNA CTD PMID:19042947 triptonide increases expression ISO RGD:1623060 6480464 triptonide results in increased expression of SMARCA5 mRNA CTD PMID:33045310 tungsten decreases expression ISO RGD:1623060 6480464 Tungsten results in decreased expression of SMARCA5 mRNA CTD PMID:30912803 valproic acid decreases expression ISO RGD:1318831 6480464 Valproic Acid results in decreased expression of SMARCA5 mRNA CTD PMID:23179753 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of SMARCA5 mRNA CTD PMID:18042343 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of SMARCA5 mRNA CTD PMID:23034163 vitamin E decreases expression ISO RGD:1318831 6480464 Vitamin E results in decreased expression of SMARCA5 mRNA CTD PMID:19244175 zinc acetate multiple interactions ISO RGD:1318831 6480464 [Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SMARCA5 mRNA CTD PMID:16357179 zinc acetate decreases expression ISO RGD:1318831 6480464 Zinc Acetate results in decreased expression of SMARCA5 mRNA CTD PMID:16357179