Pias4 (protein inhibitor of activated STAT, 4)

Gene: Pias4 (protein inhibitor of activated STAT, 4) Rattus norvegicus

Analyze

Symbol:

Pias4

Name:

protein inhibitor of activated STAT, 4

RGD ID:

1308737

Description:

Predicted to enable several functions, including SUMO ligase activity; transcription corepressor activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including positive regulation of keratinocyte apoptotic process; positive regulation of protein sumoylation; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; regulation of signal transduction; and skin epidermis development. Predicted to be located in cytoplasm; nuclear matrix; and nucleoplasm. Predicted to be part of transferase complex. Orthologous to human PIAS4 (protein inhibitor of activated STAT 4); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; Jak-Stat signaling pathway; type II interferon signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

E3 SUMO-protein ligase PIAS4; LOC362827

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PIAS4 (protein inhibitor of activated STAT 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Pias4 (protein inhibitor of activated STAT 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pias4 (protein inhibitor of activated STAT 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PIAS4 (protein inhibitor of activated STAT 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PIAS4 (protein inhibitor of activated STAT 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pias4 (protein inhibitor of activated STAT 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PIAS4 (protein inhibitor of activated STAT 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PIAS4 (protein inhibitor of activated STAT 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pias4 (protein inhibitor of activated STAT 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TEX54 (testis expressed 54)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	PIAS4 (protein inhibitor of activated STAT 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pias4 (protein inhibitor of activated STAT 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pias4a (protein inhibitor of activated STAT, 4a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pias4b (protein inhibitor of activated STAT, 4b)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	NFI1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Su(var)2-10	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	gei-17	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SIZ1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pias4	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	9,197,032 - 9,210,557 (+)	NCBI		GRCr8
mRatBN7.2	7	8,546,312 - 8,559,838 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	8,546,312 - 8,559,808 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	11,431,397 - 11,444,919 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	13,306,884 - 13,320,406 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	11,173,320 - 11,186,850 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	11,414,565 - 11,428,090 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	11,414,446 - 11,428,552 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	11,581,929 - 11,595,454 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	10,030,125 - 10,043,650 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	10,029,966 - 10,042,933 (+)	NCBI
Celera	7	6,734,179 - 6,747,704 (+)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amenorrhea (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

4,4'-sulfonyldiphenol (EXP,ISO)

aflatoxin B1 (ISO)

atrazine (ISO)

bisphenol A (EXP)

bisphenol F (EXP)

chlorpyrifos (ISO)

cobalt dichloride (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

dicrotophos (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fenthion (ISO)

folic acid (ISO)

gentamycin (EXP)

hydrogen cyanide (ISO)

mercury atom (EXP)

mercury(0) (EXP)

methidathion (ISO)

Nor-9-carboxy-delta9-THC (ISO)

pentachlorophenol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

potassium cyanide (ISO)

propiconazole (ISO)

selenium atom (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

central nervous system development (ISO)

hair follicle development (ISO)

limb epidermis development (ISO)

negative regulation of DNA-templated transcription (ISO)

negative regulation of protein localization to chromatin (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

negative regulation of tumor necrosis factor-mediated signaling pathway (ISO)

positive regulation of double-strand break repair via homologous recombination (ISO)

positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage (ISO)

positive regulation of keratinocyte apoptotic process (ISO)

positive regulation of protein sumoylation (ISO)

protein sumoylation (IBA,IEA,ISO)

regulation of mRNA stability (ISO)

regulation of transcription by RNA polymerase II (IBA)

Cellular Component

cytoplasm (ISO)

nuclear matrix (ISO)

nucleoplasm (ISO)

nucleus (ISO)

transferase complex (ISO)

Molecular Function

DNA binding (ISO)

protein binding (IPI,ISO)

SUMO ligase activity (IBA,ISO)

SUMO transferase activity (ISO)

transcription coregulator activity (IBA)

transcription corepressor activity (ISO)

ubiquitin protein ligase binding (ISO)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

ataxia telangiectasia-mutated (ATM) signaling pathway (ISO)

hepatitis C pathway (IEA)

Jak-Stat signaling pathway (IEA,ISO)

small cell lung carcinoma pathway (IEA)

type II interferon signaling pathway (ISO)

ubiquitin/proteasome degradation pathway (IEA)

External Pathway Database Links

KEGG Pathway	Hepatitis C
	Small cell lung cancer

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Push back to respond better: regulatory inhibition of the DNA double-strand break response.	Panier S and Durocher D, Nat Rev Mol Cell Biol. 2013 Oct;14(10):661-72. doi: 10.1038/nrm3659. Epub 2013 Sep 4.
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Comprehensive gene review and curation	RGD comprehensive gene curation
10.	Pias1 interaction and sumoylation of metabotropic glutamate receptor 8.	Tang Z, etal., J Biol Chem. 2005 Nov 18;280(46):38153-9. Epub 2005 Sep 6.
11.	JAK/STAT signal transduction: regulators and implication in hematological malignancies.	Valentino L and Pierre J, Biochem Pharmacol. 2006 Mar 14;71(6):713-21. Epub 2006 Jan 19.
12.	Inhibitors of cytokine signal transduction.	Wormald S and Hilton DJ, J Biol Chem 2004 Jan 9;279(2):821-4. Epub 2003 Nov 7.

Additional References at PubMed

PMID:11248056	PMID:11731474	PMID:12477932	PMID:12511558	PMID:15572666	PMID:16162816	PMID:16816390	PMID:17696781	PMID:18579533	PMID:19955185	PMID:20016603	PMID:20054338
PMID:20471636	PMID:21454665	PMID:21965678	PMID:22082260	PMID:22508508	PMID:37014755

Genomics

Comparative Map Data

Pias4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	9,197,032 - 9,210,557 (+)	NCBI		GRCr8
mRatBN7.2	7	8,546,312 - 8,559,838 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	8,546,312 - 8,559,808 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	11,431,397 - 11,444,919 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	13,306,884 - 13,320,406 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	11,173,320 - 11,186,850 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	11,414,565 - 11,428,090 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	11,414,446 - 11,428,552 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	11,581,929 - 11,595,454 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	10,030,125 - 10,043,650 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	10,029,966 - 10,042,933 (+)	NCBI
Celera	7	6,734,179 - 6,747,704 (+)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

PIAS4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	4,007,736 - 4,039,386 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	4,007,736 - 4,039,386 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	4,007,734 - 4,039,384 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	3,958,749 - 3,989,067 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	3,958,748 - 3,989,066	NCBI
Celera	19	3,947,561 - 3,977,562 (+)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	3,801,741 - 3,802,439 (+)	NCBI		HuRef
HuRef	19	3,773,215 - 3,799,042 (+)	NCBI		HuRef
CHM1_1	19	4,007,373 - 4,037,381 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	3,989,995 - 4,022,498 (+)	NCBI		T2T-CHM13v2.0

Pias4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	80,989,795 - 81,003,554 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	80,989,100 - 81,003,757 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	81,153,961 - 81,167,720 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	81,153,266 - 81,167,923 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	80,616,706 - 80,630,465 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	80,557,090 - 80,571,052 (-)	NCBI		MGSCv36	mm8
Celera	10	82,174,317 - 82,188,076 (-)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

Pias4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	4,761,862 - 4,791,490 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	4,760,576 - 4,791,422 (-)	NCBI	ChiLan1.0	ChiLan1.0

PIAS4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	8,403,736 - 8,436,580 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	7,634,962 - 7,666,709 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	3,030,885 - 3,062,642 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	3,983,200 - 4,012,686 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	3,982,555 - 4,015,167 (+)	Ensembl	panpan1.1		panPan2

PIAS4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	55,529,841 - 55,553,604 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	55,524,443 - 55,553,525 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	55,255,747 - 55,279,377 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	56,189,988 - 56,213,507 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	56,190,023 - 56,214,314 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	55,246,339 - 55,269,941 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	55,727,726 - 55,751,327 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	55,926,678 - 55,950,158 (-)	NCBI		UU_Cfam_GSD_1.0

Pias4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	215,531,908 - 215,546,879 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	2,287,996 - 2,302,691 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	2,287,941 - 2,302,875 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PIAS4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	74,702,945 - 74,729,775 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	74,702,915 - 74,729,792 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	75,247,311 - 75,274,180 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PIAS4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	3,768,100 - 3,797,377 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666081	4,446,258 - 4,476,734 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pias4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	5,551,749 - 5,572,570 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624828	5,551,538 - 5,572,647 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pias4
34 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	102
Count of miRNA genes:	71
Interacting mature miRNAs:	91
Transcripts:	ENSRNOT00000027441
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	27829089	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	31962314	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	31962314	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34000259	Rat
2317047	Wbc4	White blood cell count QTL 4		0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	7	1	35342956	Rat
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	44782185	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1	44822433	Rat
1300176	Hrtrt10	Heart rate QTL 10	3.19		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	664270	26029351	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
10755438	Coatc9	Coat color QTL 9		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	3529280	48529280	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	5329019	50329019	Rat
10755440	Coatc10	Coat color QTL 10		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	7496499	52496499	Rat
10059592	Kidm45	Kidney mass QTL 45	3.95	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	7573985	52573985	Rat

Markers in Region

RH130259

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	8,558,911 - 8,559,112 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	11,427,165 - 11,427,365	NCBI	Rnor6.0
Rnor_5.0	7	11,594,529 - 11,594,729	UniSTS	Rnor5.0
RGSC_v3.4	7	10,042,725 - 10,042,925	UniSTS	RGSC3.4
Celera	7	6,746,779 - 6,746,979	UniSTS
RH 3.4 Map	7	16.4	UniSTS
Cytogenetic Map	7	q11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	27	19	17	5	17			66	23	38	5
Low		16	38	24	14	24	8	11	8	12	3	6	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001100757	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC120292	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098772	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC169045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000027441 ⟹ ENSRNOP00000027441

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	8,548,664 - 8,559,808 (+)	Ensembl
Rnor_6.0 Ensembl	7	11,414,446 - 11,428,552 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000099030 ⟹ ENSRNOP00000087739

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	8,546,312 - 8,559,808 (+)	Ensembl

RefSeq Acc Id:

NM_001100757 ⟹ NP_001094227

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	9,197,032 - 9,210,557 (+)	NCBI
mRatBN7.2	7	8,546,312 - 8,559,838 (+)	NCBI
Rnor_6.0	7	11,414,565 - 11,428,090 (+)	NCBI
Rnor_5.0	7	11,581,929 - 11,595,454 (+)	NCBI
RGSC_v3.4	7	10,030,125 - 10,043,650 (+)	RGD
Celera	7	6,734,179 - 6,747,704 (+)	RGD

Sequence:

show sequence

CCTCACGTGACGCGACGGCTGGGGCCTCCCGGCGCGGGGGACGCTAGTGGCCAAGATGGCGGCA
GAGCTGGTGGAGGCCAAAAACATGGTGATGAGCTTCCGAGTGTCAGACCTGCAGATGCTGCTGG
GCTTTGTAGGTCGTAGCAAGAGCGGGCTGAAGCATGAGCTGGTGACCAGGGCCTTGCAGCTGGT
GCAGTTTGACTGTAGCCCGGAGCTTTTCAAGAAGATCAAAGAGCTGTATGAGACTCGCTATGCC
AAGAAGAGTGCAGAGCCCGGCCCACAGGCGCCACGGCCCCTGGATCCCCTGGCACTACACTCCA
TGCCCAGGACTCCCCTGTCAGGACCCACCGTGGACTACCCCGTGCTGTACGGGAAGTACTTGAA
TGGACTGGGGCGCCTGCCCACCAAGGCCCTTAAGCCGGAGGTACGCCTGGTAAAGCTGCCTTTC
TTCAACATGCTGGACGAGTTGCTGAAGCCCACTGAGCTGGTCCCACAGAGTGCTGAGAAGCTGC
AAGAGAGCCCGTGCATCTTCGCGCTGACCCCTCGGCAGGTGGAGATGATCCGCAACTCCAGGGA
GCTGCAGCCTGGAGTGAAAGCAGTGCAGGTGGTACTGAGGATCTGTTACTCTGACACCAGCTGT
CCACAGGAGGACCAGTATCCACCCAACATCGCTGTGAAAGTCAACCACAGCTACTGTTCAGTGC
CGGGCTACTATCCCTCCAACAAGCCTGGTGTGGAACCCAAGAGGCCCTGCCGCCCCATCAACCT
TACCCACCTCATGTATCTGTCCTCGGCCACCAACCGCATTACTGTTACCTGGGGCAACTATGGC
AAGAGCTACTCTGTGGCTTTGTACCTGGTGCGACAGCTGACCTCCTCAGACCTGCTACAGAGGT
TGAAGACGATTGGGGTGAAGCATCCTGAGCTCTGCAAGGCTCTGGTCAAGGAGAAGCTTCGCCT
AGACCCTGACAGCGAGATCGCTACTACCGGAGTGCGAGTGTCCCTCATCTGCCCACTGGTGAAG
ATGCGGCTCTCGGTGCCCTGCCGTGCAGAGACCTGCGCACACCTGCAGTGCTTTGATGCCGTGT
TCTACCTACAAATGAATGAGAAGAAGCCCACGTGGATGTGCCCTGTGTGTGACAAGCCCGCAGC
TTATGACCAGCTCATCATAGATGGGCTGCTGTCGAAGATCCTGAGTGAGTGTGAGGACGCAGAT
GAGATTGAGTTCCTGGCGGAAGGTTCATGGCGCCCAATACGTGCAGAGAAGGAACCAAGCTGCA
GCCCACAGGGCCCCATCCTGGTGCTAGGCACCTCGGACGCCAACGGGCTCGCACCAGCCTCCAG
CACCCCGGGCATGGGAAGTGGCCTGAGTGGCCCAGGCGGCGCCGGCGGCGGGGCGGGGGCGGCC
GGTGGCCTGGAGAACGGCAAGACAGGCGCAGACGTGGTGGACCTCACACTGGACAGCTCGTCGT
CCTCAGAAGATGAGGATGAGGACGAGGACGACGATGAGGACGATGACGAGGGCCCCCGGCCGAA
GCGCCGCTGCCCGTTCCAGAAGGGACTGGTGCCCGCTTGCTGACGCCGCTGCGGGGCGCTGGAG
GGCGGGAGCCGCTCCCGTCCATCATTCCCTCGCCCACCCCTCCCCGGCTCCCGGCTCCTGTACT
TCTGGACTCTCCTCTTGGGGGGGATTAAAAAAAAAGTAAAATGACAAAAAAAAAAAAAACAACC
AAACAAACAAAAAAAAAAACGAGAAAATAAACACTTACACGGGCCGGCAGCCTGCACGCCACCT
CCCGGAGCAGCCCGCGGGGCGCGGGGACCTCGGACACTGGACAGCGGCCGGCGGCTGTCCCCGC
TCCCTGCGTTGAGGCCGAGCCCTGACCCCGGAGTGCTGGCCTGGTCGCAACCAGTTTTAGTTGA
GAAGCCATGGTGGGGCGGCGGGCCGGGGACGGTGGCCACAATGTGCAATAACGTGGTGTCCCGG
GGCCGGGCGCGGCGGCAGACCCGGGTGGCATGGGGGGGTGTCGTTTCTAGCCAGCTACCTCGGT
AACTCCAATTCATTCAGGTTAACTTCCCCATGGGGCAGCCGGCCGCGGGCTTGGGCGCTGTCGC
TCTGCTCTTGTGTGGCCCGCGGCATGGGGCTCCCCGGCTGCCTCCTTACCCTCCGGAGCCTCGC
TCTTCCAACGCCCCGCTGCCAGGCAGACCTCGGGGCATCCTGCCGCCCTCCCCACCCGACTCTG
TCAGGAAGCAATACCGGGTCCGGTCTGGAGCTGGGCGGCCTGGCGGTGTCACCGCATGAACTCG
CTGGGAGGCCGGGGCCCTGGCCAGCCACACGGCACTCTTTTCTAATATTTGTATTCTAATTTAA
TTGTTTTTTAAAAATGCAAATAAAAAAAAAGAACGAAGAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001094227	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98772	(Get FASTA)	NCBI Sequence Viewer
	AAI69045	(Get FASTA)	NCBI Sequence Viewer
	EDL89188	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000027441.6
	ENSRNOP00000087739
	ENSRNOP00000087739.1

RefSeq Acc Id:

NP_001094227 ⟸ NM_001100757

- UniProtKB:

B5DFF9 (UniProtKB/TrEMBL), A0A8I6A8J3 (UniProtKB/TrEMBL), F7F3J5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAELVEAKNMVMSFRVSDLQMLLGFVGRSKSGLKHELVTRALQLVQFDCSPELFKKIKELYET
RYAKKSAEPGPQAPRPLDPLALHSMPRTPLSGPTVDYPVLYGKYLNGLGRLPTKALKPEVRLVK
LPFFNMLDELLKPTELVPQSAEKLQESPCIFALTPRQVEMIRNSRELQPGVKAVQVVLRICYSD
TSCPQEDQYPPNIAVKVNHSYCSVPGYYPSNKPGVEPKRPCRPINLTHLMYLSSATNRITVTWG
NYGKSYSVALYLVRQLTSSDLLQRLKTIGVKHPELCKALVKEKLRLDPDSEIATTGVRVSLICP
LVKMRLSVPCRAETCAHLQCFDAVFYLQMNEKKPTWMCPVCDKPAAYDQLIIDGLLSKILSECE
DADEIEFLAEGSWRPIRAEKEPSCSPQGPILVLGTSDANGLAPASSTPGMGSGLSGPGGAGGGA
GAAGGLENGKTGADVVDLTLDSSSSSEDEDEDEDDDEDDDEGPRPKRRCPFQKGLVPAC

hide sequence

RefSeq Acc Id:

ENSRNOP00000027441 ⟸ ENSRNOT00000027441

RefSeq Acc Id:

ENSRNOP00000087739 ⟸ ENSRNOT00000099030

Protein Domains

PINIT SAP SP-RING-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B5DFF9-F1-model_v2	AlphaFold	B5DFF9	1-507	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694987

Promoter ID:

EPDNEW_R5511

Type:

multiple initiation site

Name:

Pias4_1

Description:

protein inhibitor of activated STAT, 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	11,414,610 - 11,414,670	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308737	AgrOrtholog
BioCyc Gene	G2FUF-34998	BioCyc
Ensembl Genes	ENSRNOG00000020230	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000027441.7	UniProtKB/TrEMBL
	ENSRNOT00000099030	ENTREZGENE
	ENSRNOT00000099030.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.720.30	UniProtKB/TrEMBL
	2.60.120.780	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7373572	IMAGE-MGC_LOAD
InterPro	PINIT	UniProtKB/TrEMBL
	PINIT_sf	UniProtKB/TrEMBL
	SAP_dom	UniProtKB/TrEMBL
	SAP_dom_sf	UniProtKB/TrEMBL
	Znf_MIZ	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
KEGG Report	rno:362827	UniProtKB/TrEMBL
MGC_CLONE	MGC:112802	IMAGE-MGC_LOAD
NCBI Gene	362827	ENTREZGENE
PANTHER	PTHR10782:SF9	UniProtKB/TrEMBL
	ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
Pfam	PINIT	UniProtKB/TrEMBL
	zf-MIZ	UniProtKB/TrEMBL
PhenoGen	Pias4	PhenoGen
PROSITE	PINIT	UniProtKB/TrEMBL
	SAP	UniProtKB/TrEMBL
	ZF_SP_RING	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000020230	RatGTEx
SMART	SAP	UniProtKB/TrEMBL
Superfamily-SCOP	SSF68906	UniProtKB/TrEMBL
UniProt	A0A8I6A8J3	ENTREZGENE, UniProtKB/TrEMBL
	B5DFF9	ENTREZGENE, UniProtKB/TrEMBL
	F7F3J5	ENTREZGENE, UniProtKB/TrEMBL
	Q4G041_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Pias4	protein inhibitor of activated STAT, 4	Pias4_predicted	protein inhibitor of activated STAT, 4 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Pias4_predicted	protein inhibitor of activated STAT, 4 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

External Pathway Database Links

External Pathway Database Links

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

External Pathway Database Links

External Pathway Database Links