Ascc3 (activating signal cointegrator 1 complex subunit 3) - Rat Genome Database

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Gene: Ascc3 (activating signal cointegrator 1 complex subunit 3) Rattus norvegicus
Analyze
Symbol: Ascc3
Name: activating signal cointegrator 1 complex subunit 3
RGD ID: 1307995
Description: Predicted to enable 3'-5' DNA helicase activity and ATP hydrolysis activity. Predicted to be involved in several processes, including DNA dealkylation involved in DNA repair; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be part of DNA repair complex and activating signal cointegrator 1 complex. Predicted to be active in cytosolic ribosome and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human ASCC3 (activating signal cointegrator 1 complex subunit 3); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Helic1; helicase, ATP binding 1; LOC309887; MGC189522
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82055,089,430 - 55,372,374 (+)NCBIGRCr8
mRatBN7.22053,510,137 - 53,795,446 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2053,510,184 - 53,790,165 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2055,224,947 - 55,504,975 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02054,874,662 - 55,154,704 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02055,566,701 - 55,846,785 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02055,253,670 - 55,557,249 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2055,253,686 - 55,556,473 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02056,856,631 - 57,157,620 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42054,581,641 - 54,869,456 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12054,629,602 - 54,897,551 (+)NCBI
Celera2046,374,387 - 46,653,574 (-)NCBICelera
Cytogenetic Map20q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
mercury dibromide  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
pentachlorophenol  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
tetraphene  (ISO)
topotecan  (EXP)
tungsten  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12077347   PMID:12477932   PMID:19946888   PMID:22055184   PMID:22681889   PMID:30361391   PMID:31505169  


Genomics

Comparative Map Data
Ascc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82055,089,430 - 55,372,374 (+)NCBIGRCr8
mRatBN7.22053,510,137 - 53,795,446 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2053,510,184 - 53,790,165 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2055,224,947 - 55,504,975 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02054,874,662 - 55,154,704 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02055,566,701 - 55,846,785 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02055,253,670 - 55,557,249 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2055,253,686 - 55,556,473 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02056,856,631 - 57,157,620 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42054,581,641 - 54,869,456 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12054,629,602 - 54,897,551 (+)NCBI
Celera2046,374,387 - 46,653,574 (-)NCBICelera
Cytogenetic Map20q13NCBI
ASCC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386100,508,194 - 100,881,329 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6100,508,194 - 100,881,372 (-)EnsemblGRCh38hg38GRCh38
GRCh376100,956,070 - 101,329,205 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366101,063,329 - 101,435,945 (-)NCBINCBI36Build 36hg18NCBI36
Build 346101,063,330 - 101,422,632NCBI
Celera6101,600,815 - 101,973,409 (-)NCBICelera
Cytogenetic Map6q16.3NCBI
HuRef698,395,506 - 98,771,546 (-)NCBIHuRef
CHM1_16101,218,626 - 101,591,172 (-)NCBICHM1_1
T2T-CHM13v2.06101,681,937 - 102,055,217 (-)NCBIT2T-CHM13v2.0
Ascc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391050,468,756 - 50,727,300 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1050,468,765 - 50,727,581 (+)EnsemblGRCm39 Ensembl
GRCm381050,592,663 - 50,851,202 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1050,592,669 - 50,851,485 (+)EnsemblGRCm38mm10GRCm38
MGSCv371050,312,475 - 50,571,008 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361050,281,084 - 50,539,617 (+)NCBIMGSCv36mm8
Celera1051,441,982 - 51,700,475 (+)NCBICelera
Cytogenetic Map10B3NCBI
cM Map1024.87NCBI
Ascc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541126,302,597 - 26,598,824 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541126,305,103 - 26,599,375 (-)NCBIChiLan1.0ChiLan1.0
ASCC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25120,550,608 - 120,925,972 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16118,431,998 - 118,807,918 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0698,345,023 - 98,720,332 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16102,224,820 - 102,599,521 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6102,224,820 - 102,599,521 (-)Ensemblpanpan1.1panPan2
ASCC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11258,590,888 - 58,932,677 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1258,592,025 - 58,932,615 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1258,345,682 - 58,685,818 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01259,419,550 - 59,766,286 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1259,424,275 - 59,766,260 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11258,772,232 - 59,112,625 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01258,613,343 - 58,954,346 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01258,858,694 - 59,195,100 (-)NCBIUU_Cfam_GSD_1.0
Ascc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494693,497,171 - 93,835,719 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366511,953,240 - 2,275,756 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366511,952,594 - 2,291,143 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASCC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl167,331,948 - 67,657,085 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1167,331,939 - 67,657,080 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ASCC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11373,044,869 - 73,411,481 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1373,044,986 - 73,412,752 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604045,340,597 - 45,708,878 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ascc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248104,123,746 - 4,431,003 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248104,112,072 - 4,432,639 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ascc3
1161 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:334
Count of miRNA genes:198
Interacting mature miRNAs:238
Transcripts:ENSRNOT00000057016
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat

Markers in Region
RH139501  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22053,789,714 - 53,789,919 (+)MAPPERmRatBN7.2
Rnor_6.02055,556,023 - 55,556,227NCBIRnor6.0
Rnor_5.02057,156,394 - 57,156,598UniSTSRnor5.0
RGSC_v3.42054,869,013 - 54,869,217UniSTSRGSC3.4
Celera2046,374,633 - 46,374,837UniSTS
Cytogenetic Map20q13UniSTS
MARC_10283-10284:998926151:3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22053,685,953 - 53,687,143 (+)MAPPERmRatBN7.2
Rnor_6.02055,454,269 - 55,455,458NCBIRnor6.0
Rnor_5.02057,054,640 - 57,055,829UniSTSRnor5.0
RGSC_v3.42054,765,768 - 54,766,957UniSTSRGSC3.4
Celera2046,476,682 - 46,477,871UniSTS
Cytogenetic Map20q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 27 44 28 19 28 6 6 73 30 38 11 6
Low 2 16 13 13 13 2 5 1 5 3 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001277057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010060704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC169103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000057016   ⟹   ENSRNOP00000053848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2053,510,184 - 53,790,165 (+)Ensembl
Rnor_6.0 Ensembl2055,253,686 - 55,556,473 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107212   ⟹   ENSRNOP00000082272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2053,510,184 - 53,790,165 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109030   ⟹   ENSRNOP00000076420
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2053,673,309 - 53,790,165 (+)Ensembl
RefSeq Acc Id: NM_001277057   ⟹   NP_001263986
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82055,092,383 - 55,372,374 (+)NCBI
mRatBN7.22053,510,184 - 53,790,165 (+)NCBI
Rnor_6.02055,253,686 - 55,556,473 (+)NCBI
Rnor_5.02056,856,631 - 57,157,620 (+)NCBI
Celera2046,374,387 - 46,653,574 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256602   ⟹   XP_006256664
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82055,092,347 - 55,372,371 (+)NCBI
mRatBN7.22053,510,139 - 53,789,556 (+)NCBI
Rnor_6.02055,253,670 - 55,557,249 (+)NCBI
Rnor_5.02056,856,631 - 57,157,620 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256603   ⟹   XP_006256665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82055,092,361 - 55,372,371 (+)NCBI
mRatBN7.22053,510,139 - 53,789,556 (+)NCBI
Rnor_6.02055,253,670 - 55,557,249 (+)NCBI
Rnor_5.02056,856,631 - 57,157,620 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008772992   ⟹   XP_008771214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82055,092,359 - 55,372,371 (+)NCBI
mRatBN7.22053,510,139 - 53,789,556 (+)NCBI
Rnor_6.02055,253,670 - 55,557,249 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008772993   ⟹   XP_008771215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82055,092,372 - 55,372,371 (+)NCBI
mRatBN7.22053,510,139 - 53,789,556 (+)NCBI
Rnor_6.02055,253,670 - 55,557,249 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098773   ⟹   XP_038954701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82055,092,370 - 55,372,371 (+)NCBI
mRatBN7.22053,510,139 - 53,789,556 (+)NCBI
RefSeq Acc Id: XM_063279180   ⟹   XP_063135250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82055,092,347 - 55,372,371 (+)NCBI
RefSeq Acc Id: XM_063279181   ⟹   XP_063135251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82055,089,430 - 55,372,371 (+)NCBI
RefSeq Acc Id: XM_063279183   ⟹   XP_063135253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82055,092,372 - 55,372,371 (+)NCBI
RefSeq Acc Id: XM_063279184   ⟹   XP_063135254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82055,092,347 - 55,372,371 (+)NCBI
RefSeq Acc Id: XR_010060704
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82055,092,347 - 55,273,560 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001263986   ⟸   NM_001277057
- UniProtKB: A0A0A0MY43 (UniProtKB/TrEMBL),   A6K6T5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256665   ⟸   XM_006256603
- Peptide Label: isoform X1
- UniProtKB: A0A0A0MY43 (UniProtKB/TrEMBL),   A6K6T5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256664   ⟸   XM_006256602
- Peptide Label: isoform X1
- UniProtKB: A0A0A0MY43 (UniProtKB/TrEMBL),   A6K6T5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771214   ⟸   XM_008772992
- Peptide Label: isoform X1
- UniProtKB: A0A0A0MY43 (UniProtKB/TrEMBL),   A6K6T5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771215   ⟸   XM_008772993
- Peptide Label: isoform X1
- UniProtKB: A0A0A0MY43 (UniProtKB/TrEMBL),   A6K6T5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000053848   ⟸   ENSRNOT00000057016
RefSeq Acc Id: XP_038954701   ⟸   XM_039098773
- Peptide Label: isoform X1
- UniProtKB: A0A0A0MY43 (UniProtKB/TrEMBL),   A6K6T5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000082272   ⟸   ENSRNOT00000107212
RefSeq Acc Id: ENSRNOP00000076420   ⟸   ENSRNOT00000109030
RefSeq Acc Id: XP_063135251   ⟸   XM_063279181
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063135250   ⟸   XM_063279180
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063135254   ⟸   XM_063279184
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063135253   ⟸   XM_063279183
- Peptide Label: isoform X1
Protein Domains
Helicase ATP-binding   Helicase C-terminal   SEC63

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LPQ2-F1-model_v2 AlphaFold F1LPQ2 1-2197 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701686
Promoter ID:EPDNEW_R12209
Type:initiation region
Name:Ascc3_2
Description:activating signal cointegrator 1 complex subunit 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12210  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02055,253,678 - 55,253,738EPDNEW
RGD ID:13701687
Promoter ID:EPDNEW_R12210
Type:single initiation site
Name:Ascc3_1
Description:activating signal cointegrator 1 complex subunit 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12209  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02055,253,847 - 55,253,907EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307995 AgrOrtholog
BioCyc Gene G2FUF-3230 BioCyc
Ensembl Genes ENSRNOG00000037604 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057016 ENTREZGENE
  ENSRNOT00000057016.5 UniProtKB/TrEMBL
  ENSRNOT00000107212.1 UniProtKB/TrEMBL
  ENSRNOT00000109030.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  5' to 3' exonuclease, C-terminal subdomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec63 N-terminal domain-like domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEAD/DEAH_box_helicase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec63-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:309887 UniProtKB/TrEMBL
NCBI Gene 309887 ENTREZGENE
PANTHER ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3 UniProtKB/TrEMBL
  DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEC63 DOMAIN-CONTAINING UniProtKB/TrEMBL
  SEC63 DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DEAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec63 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ascc3 PhenoGen
PIRSF BRR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HELICASE_ATP_BIND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000037604 RatGTEx
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEXDc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec63 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Sec63 N-terminal domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MY43 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZK28_RAT UniProtKB/TrEMBL
  A0A8I5ZWJ5_RAT UniProtKB/TrEMBL
  A6K6T5 ENTREZGENE, UniProtKB/TrEMBL
  ASCC3_RAT UniProtKB/Swiss-Prot
  B5DFL2_RAT UniProtKB/TrEMBL
  F1LPQ2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Ascc3  activating signal cointegrator 1 complex subunit 3   Ascc3_predicted  activating signal cointegrator 1 complex subunit 3 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Ascc3_predicted  activating signal cointegrator 1 complex subunit 3 (predicted)  Helic1_predicted  helicase, ATP binding 1 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Helic1_predicted  helicase, ATP binding 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED