Serpina1f (serpin family A member 1F) - Rat Genome Database

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Gene: Serpina1f (serpin family A member 1F) Rattus norvegicus
Analyze
Symbol: Serpina1f
Name: serpin family A member 1F
RGD ID: 1307899
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in endoplasmic reticulum. Predicted to be active in extracellular space. Orthologous to human SERPINA2 (serpin family A member 2 (gene/pseudogene)); INTERACTS WITH 17beta-estradiol 3-benzoate; bisphenol A; 1,2-dichloroethane (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alpha-1-antitrypsin 1-6; LOC314406; RGD1307899; serine (or cysteine) peptidase inhibitor, clade A, member 1F; similar to Alpha-1-antitrypsin-related protein precursor
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,585,697 - 128,591,902 (-)NCBIGRCr8
mRatBN7.26122,820,752 - 122,827,112 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6122,820,907 - 122,827,112 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6122,961,569 - 122,967,774 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06123,256,845 - 123,263,050 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06122,593,734 - 122,599,939 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06127,564,811 - 127,571,016 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,564,811 - 127,571,016 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06136,783,583 - 136,789,788 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46127,952,484 - 127,958,689 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16127,956,329 - 127,997,803 (-)NCBI
Celera6120,301,254 - 120,307,459 (-)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23826168  


Genomics

Comparative Map Data
Serpina1f
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,585,697 - 128,591,902 (-)NCBIGRCr8
mRatBN7.26122,820,752 - 122,827,112 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6122,820,907 - 122,827,112 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6122,961,569 - 122,967,774 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06123,256,845 - 123,263,050 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06122,593,734 - 122,599,939 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06127,564,811 - 127,571,016 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,564,811 - 127,571,016 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06136,783,583 - 136,789,788 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46127,952,484 - 127,958,689 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16127,956,329 - 127,997,803 (-)NCBI
Celera6120,301,254 - 120,307,459 (-)NCBICelera
Cytogenetic Map6q32NCBI
SERPINA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381494,364,318 - 94,366,702 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1494,364,316 - 94,366,698 (-)EnsemblGRCh38hg38GRCh38
GRCh371494,830,655 - 94,833,039 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361493,900,404 - 93,902,896 (-)NCBINCBI36Build 36hg18NCBI36
Celera1474,883,597 - 74,894,647 (-)NCBICelera
Cytogenetic Map14q32.13NCBI
HuRef1475,010,214 - 75,012,602 (-)NCBIHuRef
CHM1_11494,768,456 - 94,770,844 (-)NCBICHM1_1
T2T-CHM13v2.01488,593,837 - 88,596,220 (-)NCBIT2T-CHM13v2.0
Serpina1f
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912103,654,303 - 103,661,788 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12103,654,303 - 103,661,788 (-)EnsemblGRCm39 Ensembl
GRCm3812103,688,044 - 103,695,529 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12103,688,044 - 103,695,529 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712104,926,254 - 104,933,739 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612104,090,683 - 104,096,579 (-)NCBIMGSCv36mm8
Celera12104,904,196 - 104,911,688 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1252.98NCBI

Variants

.
Variants in Serpina1f
12 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:37
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000057322
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system musculoskeletal system reproductive system respiratory system
High
Medium
Low 2
Below cutoff 1 6 2 5 2 1 4 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000057322   ⟹   ENSRNOP00000054139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6122,820,907 - 122,827,112 (-)Ensembl
Rnor_6.0 Ensembl6127,564,811 - 127,571,016 (-)Ensembl
RefSeq Acc Id: NM_001108054   ⟹   NP_001101524
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86128,585,697 - 128,591,902 (-)NCBI
mRatBN7.26122,820,907 - 122,827,112 (-)NCBI
Rnor_6.06127,564,811 - 127,571,016 (-)NCBI
Rnor_5.06136,783,583 - 136,789,788 (-)NCBI
RGSC_v3.46127,952,484 - 127,958,689 (-)RGD
Celera6120,301,254 - 120,307,459 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101524 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL81785 (Get FASTA)   NCBI Sequence Viewer  
  EDL81786 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054139
  ENSRNOP00000054139.2
Reference Protein Sequences
RefSeq Acc Id: NP_001101524   ⟸   NM_001108054
- Peptide Label: precursor
- UniProtKB: D4A4R7 (UniProtKB/TrEMBL),   A6JEP1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000054139   ⟸   ENSRNOT00000057322
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A4R7-F1-model_v2 AlphaFold D4A4R7 1-412 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694800
Promoter ID:EPDNEW_R5324
Type:single initiation site
Name:Serpina1f_1
Description:serine peptidase inhibitor, clade A, member 1F
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06127,571,029 - 127,571,089EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307899 AgrOrtholog
BioCyc Gene G2FUF-36404 BioCyc
Ensembl Genes ENSRNOG00000037762 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057322 ENTREZGENE
  ENSRNOT00000057322.3 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Protease_inhib_I4_serpin UniProtKB/TrEMBL
  Protease_inhib_I4_serpin_CS UniProtKB/TrEMBL
  Sepin_dom UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
KEGG Report rno:314406 UniProtKB/TrEMBL
NCBI Gene 314406 ENTREZGENE
PANTHER ALPHA-1-ANTITRYPSIN 1-6 UniProtKB/TrEMBL
  Prot_inh_serpin UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PhenoGen Serpina1f PhenoGen
PROSITE SERPIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000037762 RatGTEx
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_serpin UniProtKB/TrEMBL
UniProt A6JEP1 ENTREZGENE, UniProtKB/TrEMBL
  D4A4R7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-08-13 Serpina1f  serpin family A member 1F  Serpina1f  serine (or cysteine) peptidase inhibitor, clade A, member 1F  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Serpina1f  serine (or cysteine) peptidase inhibitor, clade A, member 1F  RGD1307899_predicted  similar to Alpha-1-antitrypsin-related protein precursor (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1307899_predicted  similar to Alpha-1-antitrypsin-related protein precursor (predicted)  LOC314406_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC314406_predicted  similar to Alpha-1-antitrypsin-related protein precursor (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL